GtrA domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QIF3_LEIMA

TriTrypDb:

LmjF.08.0160 , LMJLV39_080006600 , LMJSD75_080006600

Length:

233

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4QIF3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIF3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	26	28	PF00675	0.474
CLV_PCSK_KEX2_1	26	28	PF00082	0.472
CLV_PCSK_SKI1_1	175	179	PF00082	0.524
DEG_APCC_DBOX_1	174	182	PF00400	0.329
DEG_Nend_Nbox_1	1	3	PF02207	0.701
DOC_CDC14_PxL_1	199	207	PF14671	0.345
DOC_CYCLIN_yCln2_LP_2	205	211	PF00134	0.407
DOC_MAPK_gen_1	105	115	PF00069	0.512
DOC_MAPK_MEF2A_6	105	113	PF00069	0.578
DOC_USP7_MATH_1	44	48	PF00917	0.693
DOC_USP7_MATH_1	54	58	PF00917	0.712
DOC_USP7_MATH_1	81	85	PF00917	0.762
DOC_USP7_MATH_1	93	97	PF00917	0.657
DOC_WW_Pin1_4	170	175	PF00397	0.346
DOC_WW_Pin1_4	228	233	PF00397	0.510
DOC_WW_Pin1_4	52	57	PF00397	0.765
DOC_WW_Pin1_4	75	80	PF00397	0.685
LIG_FHA_1	131	137	PF00498	0.339
LIG_FHA_1	19	25	PF00498	0.593
LIG_FHA_1	199	205	PF00498	0.403
LIG_LIR_Gen_1	118	128	PF02991	0.362
LIG_LIR_Gen_1	158	168	PF02991	0.445
LIG_LIR_Nem_3	118	123	PF02991	0.369
LIG_LIR_Nem_3	158	163	PF02991	0.496
LIG_LYPXL_S_1	187	191	PF13949	0.562
LIG_LYPXL_yS_3	188	191	PF13949	0.385
LIG_NRBOX	131	137	PF00104	0.354
LIG_SH2_CRK	120	124	PF00017	0.368
LIG_SH2_STAT3	168	171	PF00017	0.414
LIG_SH2_STAT5	122	125	PF00017	0.296
LIG_SH2_STAT5	134	137	PF00017	0.318
LIG_SH2_STAT5	180	183	PF00017	0.367
LIG_SH3_3	150	156	PF00018	0.337
LIG_SH3_3	186	192	PF00018	0.382
LIG_SH3_3	222	228	PF00018	0.464
LIG_SUMO_SIM_par_1	16	21	PF11976	0.680
LIG_TYR_ITIM	178	183	PF00017	0.348
LIG_TYR_ITSM	116	123	PF00017	0.359
MOD_CDK_SPK_2	170	175	PF00069	0.346
MOD_CK1_1	42	48	PF00069	0.760
MOD_CK1_1	52	58	PF00069	0.797
MOD_CK1_1	77	83	PF00069	0.747
MOD_CK1_1	84	90	PF00069	0.761
MOD_CK1_1	92	98	PF00069	0.613
MOD_GlcNHglycan	228	231	PF01048	0.620
MOD_GlcNHglycan	46	49	PF01048	0.476
MOD_GlcNHglycan	56	59	PF01048	0.524
MOD_GlcNHglycan	79	82	PF01048	0.570
MOD_GlcNHglycan	83	86	PF01048	0.563
MOD_GlcNHglycan	91	94	PF01048	0.380
MOD_GlcNHglycan	95	98	PF01048	0.456
MOD_GSK3_1	226	233	PF00069	0.412
MOD_GSK3_1	38	45	PF00069	0.676
MOD_GSK3_1	48	55	PF00069	0.684
MOD_GSK3_1	71	78	PF00069	0.689
MOD_GSK3_1	89	96	PF00069	0.700
MOD_N-GLC_2	184	186	PF02516	0.578
MOD_NEK2_1	124	129	PF00069	0.391
MOD_NEK2_1	130	135	PF00069	0.346
MOD_NEK2_1	18	23	PF00069	0.690
MOD_NEK2_1	216	221	PF00069	0.514
MOD_PK_1	16	22	PF00069	0.644
MOD_PKA_2	38	44	PF00069	0.708
MOD_PKA_2	71	77	PF00069	0.683
MOD_Plk_4	115	121	PF00069	0.466
MOD_Plk_4	130	136	PF00069	0.357
MOD_Plk_4	145	151	PF00069	0.369
MOD_Plk_4	163	169	PF00069	0.369
MOD_ProDKin_1	170	176	PF00069	0.343
MOD_ProDKin_1	52	58	PF00069	0.765
MOD_ProDKin_1	75	81	PF00069	0.685
TRG_DiLeu_BaLyEn_6	211	216	PF01217	0.466
TRG_ENDOCYTIC_2	120	123	PF00928	0.314
TRG_ENDOCYTIC_2	180	183	PF00928	0.394
TRG_ENDOCYTIC_2	188	191	PF00928	0.354
TRG_ER_diArg_1	2	5	PF00400	0.683

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAL2	Leptomonas seymouri	48%	100%
A0A0S4IR53	Bodo saltans	34%	100%
A0A1X0NNX7	Trypanosomatidae	33%	88%
A0A3S7WQ61	Leishmania donovani	91%	100%
A4H583	Leishmania braziliensis	73%	100%
A4HTG7	Leishmania infantum	91%	100%
E9AM95	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%