Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QIF2_LEIMA

TriTrypDb:

LmjF.08.0170 , LMJLV39_080006700 , LMJSD75_080006700

Length:

644

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 5
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	7
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	7

Expansion

Sequence features

Q4QIF2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIF2

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	5
GO:0006952	defense response	3	5
GO:0050896	response to stimulus	1	5

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	578	584	PF00089	0.420
CLV_NRD_NRD_1	170	172	PF00675	0.534
CLV_NRD_NRD_1	230	232	PF00675	0.487
CLV_NRD_NRD_1	29	31	PF00675	0.500
CLV_NRD_NRD_1	314	316	PF00675	0.607
CLV_NRD_NRD_1	317	319	PF00675	0.601
CLV_NRD_NRD_1	341	343	PF00675	0.438
CLV_NRD_NRD_1	373	375	PF00675	0.397
CLV_NRD_NRD_1	634	636	PF00675	0.449
CLV_NRD_NRD_1	638	640	PF00675	0.450
CLV_NRD_NRD_1	76	78	PF00675	0.459
CLV_PCSK_FUR_1	312	316	PF00082	0.611
CLV_PCSK_KEX2_1	170	172	PF00082	0.534
CLV_PCSK_KEX2_1	230	232	PF00082	0.488
CLV_PCSK_KEX2_1	29	31	PF00082	0.533
CLV_PCSK_KEX2_1	314	316	PF00082	0.613
CLV_PCSK_KEX2_1	317	319	PF00082	0.609
CLV_PCSK_KEX2_1	341	343	PF00082	0.434
CLV_PCSK_KEX2_1	634	636	PF00082	0.449
CLV_PCSK_KEX2_1	638	640	PF00082	0.450
CLV_PCSK_PC7_1	630	636	PF00082	0.377
CLV_PCSK_SKI1_1	14	18	PF00082	0.596
CLV_PCSK_SKI1_1	147	151	PF00082	0.434
CLV_PCSK_SKI1_1	204	208	PF00082	0.468
CLV_PCSK_SKI1_1	230	234	PF00082	0.473
CLV_PCSK_SKI1_1	24	28	PF00082	0.461
CLV_PCSK_SKI1_1	355	359	PF00082	0.432
CLV_PCSK_SKI1_1	374	378	PF00082	0.271
CLV_PCSK_SKI1_1	400	404	PF00082	0.373
CLV_PCSK_SKI1_1	477	481	PF00082	0.335
CLV_PCSK_SKI1_1	630	634	PF00082	0.436
DEG_APCC_DBOX_1	419	427	PF00400	0.382
DEG_APCC_DBOX_1	629	637	PF00400	0.397
DEG_Nend_Nbox_1	1	3	PF02207	0.753
DEG_ODPH_VHL_1	58	70	PF01847	0.610
DEG_SPOP_SBC_1	298	302	PF00917	0.644
DOC_CDC14_PxL_1	413	421	PF14671	0.351
DOC_CDC14_PxL_1	490	498	PF14671	0.362
DOC_CDC14_PxL_1	585	593	PF14671	0.324
DOC_CYCLIN_RxL_1	312	323	PF00134	0.623
DOC_CYCLIN_RxL_1	471	483	PF00134	0.411
DOC_CYCLIN_yCln2_LP_2	196	202	PF00134	0.450
DOC_MAPK_gen_1	144	154	PF00069	0.410
DOC_MAPK_gen_1	170	178	PF00069	0.588
DOC_MAPK_gen_1	312	321	PF00069	0.671
DOC_MAPK_gen_1	371	381	PF00069	0.417
DOC_MAPK_gen_1	49	58	PF00069	0.493
DOC_MAPK_gen_1	634	643	PF00069	0.451
DOC_MAPK_MEF2A_6	170	178	PF00069	0.471
DOC_PP1_RVXF_1	409	416	PF00149	0.384
DOC_PP2B_LxvP_1	457	460	PF13499	0.354
DOC_PP2B_LxvP_1	618	621	PF13499	0.315
DOC_USP7_MATH_1	139	143	PF00917	0.403
DOC_USP7_MATH_1	206	210	PF00917	0.478
DOC_USP7_MATH_1	297	301	PF00917	0.595
DOC_USP7_MATH_1	340	344	PF00917	0.462
DOC_USP7_MATH_1	440	444	PF00917	0.646
DOC_USP7_MATH_1	464	468	PF00917	0.422
DOC_USP7_MATH_1	470	474	PF00917	0.389
DOC_USP7_MATH_1	621	625	PF00917	0.405
DOC_USP7_UBL2_3	214	218	PF12436	0.481
DOC_WW_Pin1_4	129	134	PF00397	0.544
DOC_WW_Pin1_4	163	168	PF00397	0.422
DOC_WW_Pin1_4	195	200	PF00397	0.453
DOC_WW_Pin1_4	208	213	PF00397	0.447
DOC_WW_Pin1_4	257	262	PF00397	0.607
DOC_WW_Pin1_4	287	292	PF00397	0.593
DOC_WW_Pin1_4	429	434	PF00397	0.402
DOC_WW_Pin1_4	516	521	PF00397	0.368
DOC_WW_Pin1_4	6	11	PF00397	0.579
LIG_14-3-3_CanoR_1	123	127	PF00244	0.464
LIG_14-3-3_CanoR_1	183	193	PF00244	0.488
LIG_14-3-3_CanoR_1	204	213	PF00244	0.405
LIG_14-3-3_CanoR_1	230	236	PF00244	0.604
LIG_14-3-3_CanoR_1	24	33	PF00244	0.554
LIG_14-3-3_CanoR_1	320	329	PF00244	0.544
LIG_14-3-3_CanoR_1	341	345	PF00244	0.527
LIG_14-3-3_CanoR_1	355	360	PF00244	0.292
LIG_14-3-3_CanoR_1	374	380	PF00244	0.508
LIG_14-3-3_CanoR_1	400	405	PF00244	0.399
LIG_14-3-3_CanoR_1	526	534	PF00244	0.535
LIG_14-3-3_CanoR_1	581	585	PF00244	0.411
LIG_Actin_WH2_2	145	163	PF00022	0.409
LIG_Actin_WH2_2	186	203	PF00022	0.452
LIG_Actin_WH2_2	386	402	PF00022	0.407
LIG_Actin_WH2_2	406	422	PF00022	0.343
LIG_DCNL_PONY_1	1	4	PF03556	0.519
LIG_FHA_1	105	111	PF00498	0.503
LIG_FHA_1	205	211	PF00498	0.446
LIG_FHA_1	262	268	PF00498	0.552
LIG_FHA_1	314	320	PF00498	0.670
LIG_FHA_1	375	381	PF00498	0.423
LIG_FHA_2	126	132	PF00498	0.362
LIG_FHA_2	232	238	PF00498	0.595
LIG_FHA_2	473	479	PF00498	0.331
LIG_FHA_2	567	573	PF00498	0.391
LIG_LIR_Gen_1	422	433	PF02991	0.387
LIG_LIR_Gen_1	480	490	PF02991	0.358
LIG_LIR_Gen_1	567	578	PF02991	0.392
LIG_LIR_Nem_3	386	390	PF02991	0.342
LIG_LIR_Nem_3	422	428	PF02991	0.362
LIG_LIR_Nem_3	488	493	PF02991	0.370
LIG_LIR_Nem_3	567	573	PF02991	0.387
LIG_LIR_Nem_3	605	609	PF02991	0.343
LIG_MYND_3	496	500	PF01753	0.340
LIG_PCNA_PIPBox_1	186	195	PF02747	0.442
LIG_PCNA_yPIPBox_3	179	193	PF02747	0.487
LIG_PTB_Apo_2	358	365	PF02174	0.447
LIG_PTB_Phospho_1	358	364	PF10480	0.443
LIG_SH2_NCK_1	364	368	PF00017	0.463
LIG_SH2_SRC	570	573	PF00017	0.386
LIG_SH2_STAT3	508	511	PF00017	0.304
LIG_SH2_STAT5	127	130	PF00017	0.357
LIG_SH2_STAT5	227	230	PF00017	0.477
LIG_SH2_STAT5	425	428	PF00017	0.354
LIG_SH2_STAT5	570	573	PF00017	0.321
LIG_SH3_3	232	238	PF00018	0.595
LIG_SH3_3	491	497	PF00018	0.370
LIG_SH3_3	617	623	PF00018	0.366
LIG_SH3_3	7	13	PF00018	0.524
LIG_SUMO_SIM_anti_2	580	586	PF11976	0.335
LIG_SUMO_SIM_par_1	172	177	PF11976	0.612
LIG_SUMO_SIM_par_1	262	268	PF11976	0.547
LIG_TYR_ITIM	423	428	PF00017	0.356
LIG_TYR_ITIM	568	573	PF00017	0.323
LIG_UBA3_1	110	115	PF00899	0.347
LIG_Vh1_VBS_1	469	487	PF01044	0.374
LIG_WRC_WIRS_1	465	470	PF05994	0.357
LIG_WRC_WIRS_1	5	10	PF05994	0.583
MOD_CDC14_SPxK_1	198	201	PF00782	0.462
MOD_CDC14_SPxK_1	211	214	PF00782	0.429
MOD_CDK_SPK_2	516	521	PF00069	0.368
MOD_CDK_SPxK_1	195	201	PF00069	0.449
MOD_CDK_SPxK_1	208	214	PF00069	0.447
MOD_CDK_SPxxK_3	163	170	PF00069	0.497
MOD_CDK_SPxxK_3	287	294	PF00069	0.594
MOD_CK1_1	129	135	PF00069	0.532
MOD_CK1_1	195	201	PF00069	0.449
MOD_CK1_1	257	263	PF00069	0.607
MOD_CK1_1	300	306	PF00069	0.647
MOD_CK1_1	313	319	PF00069	0.596
MOD_CK1_1	35	41	PF00069	0.534
MOD_CK1_1	369	375	PF00069	0.372
MOD_CK1_1	441	447	PF00069	0.422
MOD_CK1_1	458	464	PF00069	0.393
MOD_CK1_1	472	478	PF00069	0.288
MOD_CK1_1	488	494	PF00069	0.326
MOD_CK1_1	555	561	PF00069	0.293
MOD_CK2_1	447	453	PF00069	0.454
MOD_CK2_1	472	478	PF00069	0.374
MOD_CK2_1	580	586	PF00069	0.420
MOD_CK2_1	621	627	PF00069	0.377
MOD_Cter_Amidation	636	639	PF01082	0.436
MOD_Cter_Amidation	75	78	PF01082	0.499
MOD_GlcNHglycan	134	137	PF01048	0.559
MOD_GlcNHglycan	322	325	PF01048	0.618
MOD_GlcNHglycan	338	341	PF01048	0.363
MOD_GlcNHglycan	371	374	PF01048	0.426
MOD_GlcNHglycan	440	443	PF01048	0.529
MOD_GlcNHglycan	449	452	PF01048	0.328
MOD_GlcNHglycan	472	475	PF01048	0.392
MOD_GlcNHglycan	487	490	PF01048	0.313
MOD_GSK3_1	122	129	PF00069	0.520
MOD_GSK3_1	204	211	PF00069	0.532
MOD_GSK3_1	257	264	PF00069	0.586
MOD_GSK3_1	297	304	PF00069	0.723
MOD_GSK3_1	306	313	PF00069	0.575
MOD_GSK3_1	336	343	PF00069	0.534
MOD_GSK3_1	434	441	PF00069	0.608
MOD_GSK3_1	528	535	PF00069	0.444
MOD_N-GLC_1	257	262	PF02516	0.643
MOD_N-GLC_1	455	460	PF02516	0.415
MOD_N-GLC_1	485	490	PF02516	0.342
MOD_N-GLC_1	597	602	PF02516	0.428
MOD_N-GLC_2	551	553	PF02516	0.400
MOD_NEK2_1	134	139	PF00069	0.498
MOD_NEK2_1	192	197	PF00069	0.470
MOD_NEK2_1	219	224	PF00069	0.407
MOD_NEK2_1	319	324	PF00069	0.720
MOD_NEK2_1	334	339	PF00069	0.407
MOD_NEK2_1	4	9	PF00069	0.677
MOD_NEK2_1	419	424	PF00069	0.432
MOD_NEK2_1	435	440	PF00069	0.369
MOD_NEK2_1	447	452	PF00069	0.404
MOD_NEK2_1	455	460	PF00069	0.297
MOD_NEK2_1	485	490	PF00069	0.385
MOD_NEK2_1	534	539	PF00069	0.280
MOD_NEK2_1	571	576	PF00069	0.384
MOD_NEK2_1	68	73	PF00069	0.425
MOD_NEK2_2	139	144	PF00069	0.364
MOD_NEK2_2	552	557	PF00069	0.287
MOD_PIKK_1	274	280	PF00454	0.599
MOD_PIKK_1	525	531	PF00454	0.354
MOD_PK_1	375	381	PF00069	0.379
MOD_PKA_1	230	236	PF00069	0.518
MOD_PKA_1	374	380	PF00069	0.371
MOD_PKA_2	122	128	PF00069	0.468
MOD_PKA_2	230	236	PF00069	0.520
MOD_PKA_2	313	319	PF00069	0.688
MOD_PKA_2	340	346	PF00069	0.535
MOD_PKA_2	419	425	PF00069	0.359
MOD_PKA_2	525	531	PF00069	0.378
MOD_PKA_2	580	586	PF00069	0.420
MOD_PKB_1	318	326	PF00069	0.581
MOD_PKB_1	353	361	PF00069	0.314
MOD_Plk_1	411	417	PF00069	0.449
MOD_Plk_1	455	461	PF00069	0.471
MOD_Plk_1	477	483	PF00069	0.329
MOD_Plk_1	597	603	PF00069	0.518
MOD_Plk_4	122	128	PF00069	0.580
MOD_Plk_4	37	43	PF00069	0.387
MOD_Plk_4	375	381	PF00069	0.423
MOD_Plk_4	383	389	PF00069	0.364
MOD_Plk_4	411	417	PF00069	0.474
MOD_Plk_4	477	483	PF00069	0.350
MOD_Plk_4	566	572	PF00069	0.438
MOD_Plk_4	580	586	PF00069	0.282
MOD_Plk_4	621	627	PF00069	0.347
MOD_ProDKin_1	129	135	PF00069	0.555
MOD_ProDKin_1	163	169	PF00069	0.421
MOD_ProDKin_1	195	201	PF00069	0.449
MOD_ProDKin_1	208	214	PF00069	0.447
MOD_ProDKin_1	257	263	PF00069	0.611
MOD_ProDKin_1	287	293	PF00069	0.595
MOD_ProDKin_1	429	435	PF00069	0.399
MOD_ProDKin_1	516	522	PF00069	0.360
MOD_ProDKin_1	6	12	PF00069	0.571
TRG_DiLeu_BaEn_2	187	193	PF01217	0.397
TRG_DiLeu_BaLyEn_6	543	548	PF01217	0.395
TRG_ENDOCYTIC_2	364	367	PF00928	0.373
TRG_ENDOCYTIC_2	425	428	PF00928	0.354
TRG_ENDOCYTIC_2	570	573	PF00928	0.321
TRG_ER_diArg_1	169	171	PF00400	0.540
TRG_ER_diArg_1	229	231	PF00400	0.521
TRG_ER_diArg_1	312	315	PF00400	0.616
TRG_ER_diArg_1	317	320	PF00400	0.603
TRG_ER_diArg_1	417	420	PF00400	0.402
TRG_ER_diArg_1	633	635	PF00400	0.383
TRG_NES_CRM1_1	164	177	PF08389	0.428
TRG_Pf-PMV_PEXEL_1	170	175	PF00026	0.440

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P939	Leptomonas seymouri	46%	98%
A0A3S5H632	Leishmania donovani	92%	100%
A4H584	Leishmania braziliensis	73%	100%
A4HTG8	Leishmania infantum	92%	100%
E9AM96	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%