Lipase_3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QIF0_LEIMA

TriTrypDb:

LmjF.08.0190 , LMJLV39_080006900 , LMJSD75_080006900

Length:

930

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4QIF0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIF0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	148	152	PF00656	0.403
CLV_NRD_NRD_1	377	379	PF00675	0.394
CLV_NRD_NRD_1	565	567	PF00675	0.413
CLV_NRD_NRD_1	74	76	PF00675	0.317
CLV_NRD_NRD_1	846	848	PF00675	0.580
CLV_PCSK_KEX2_1	377	379	PF00082	0.346
CLV_PCSK_KEX2_1	596	598	PF00082	0.526
CLV_PCSK_KEX2_1	629	631	PF00082	0.425
CLV_PCSK_KEX2_1	74	76	PF00082	0.317
CLV_PCSK_KEX2_1	846	848	PF00082	0.660
CLV_PCSK_KEX2_1	927	929	PF00082	0.437
CLV_PCSK_PC1ET2_1	596	598	PF00082	0.446
CLV_PCSK_PC1ET2_1	629	631	PF00082	0.425
CLV_PCSK_PC1ET2_1	927	929	PF00082	0.437
CLV_PCSK_SKI1_1	137	141	PF00082	0.592
CLV_PCSK_SKI1_1	2	6	PF00082	0.592
CLV_PCSK_SKI1_1	377	381	PF00082	0.341
CLV_PCSK_SKI1_1	634	638	PF00082	0.441
CLV_PCSK_SKI1_1	894	898	PF00082	0.465
DEG_APCC_DBOX_1	155	163	PF00400	0.284
DEG_APCC_DBOX_1	376	384	PF00400	0.596
DEG_Nend_UBRbox_1	1	4	PF02207	0.415
DOC_CDC14_PxL_1	264	272	PF14671	0.369
DOC_CKS1_1	138	143	PF01111	0.381
DOC_CKS1_1	315	320	PF01111	0.616
DOC_CKS1_1	351	356	PF01111	0.264
DOC_CKS1_1	431	436	PF01111	0.369
DOC_CKS1_1	572	577	PF01111	0.624
DOC_CYCLIN_yCln2_LP_2	488	494	PF00134	0.480
DOC_MAPK_gen_1	193	201	PF00069	0.596
DOC_MAPK_gen_1	374	383	PF00069	0.553
DOC_MAPK_gen_1	564	572	PF00069	0.597
DOC_MAPK_gen_1	629	635	PF00069	0.624
DOC_MAPK_gen_1	693	703	PF00069	0.519
DOC_MAPK_MEF2A_6	131	138	PF00069	0.324
DOC_MAPK_MEF2A_6	374	383	PF00069	0.591
DOC_MAPK_MEF2A_6	564	572	PF00069	0.597
DOC_MAPK_MEF2A_6	785	792	PF00069	0.375
DOC_MAPK_MEF2A_6	795	802	PF00069	0.282
DOC_MAPK_NFAT4_5	785	793	PF00069	0.315
DOC_PP1_RVXF_1	697	704	PF00149	0.666
DOC_PP2B_LxvP_1	199	202	PF13499	0.650
DOC_PP4_FxxP_1	449	452	PF00568	0.436
DOC_PP4_FxxP_1	572	575	PF00568	0.617
DOC_USP7_MATH_1	160	164	PF00917	0.325
DOC_USP7_MATH_1	223	227	PF00917	0.677
DOC_USP7_MATH_1	352	356	PF00917	0.340
DOC_USP7_MATH_1	514	518	PF00917	0.402
DOC_USP7_MATH_1	622	626	PF00917	0.699
DOC_USP7_MATH_1	680	684	PF00917	0.295
DOC_USP7_MATH_1	686	690	PF00917	0.319
DOC_USP7_MATH_1	738	742	PF00917	0.693
DOC_USP7_MATH_1	80	84	PF00917	0.598
DOC_USP7_MATH_1	837	841	PF00917	0.433
DOC_USP7_MATH_2	64	70	PF00917	0.582
DOC_WW_Pin1_4	137	142	PF00397	0.369
DOC_WW_Pin1_4	226	231	PF00397	0.671
DOC_WW_Pin1_4	314	319	PF00397	0.566
DOC_WW_Pin1_4	350	355	PF00397	0.264
DOC_WW_Pin1_4	388	393	PF00397	0.658
DOC_WW_Pin1_4	430	435	PF00397	0.475
DOC_WW_Pin1_4	448	453	PF00397	0.363
DOC_WW_Pin1_4	498	503	PF00397	0.480
DOC_WW_Pin1_4	571	576	PF00397	0.639
LIG_14-3-3_CanoR_1	146	155	PF00244	0.402
LIG_14-3-3_CanoR_1	156	160	PF00244	0.226
LIG_14-3-3_CanoR_1	2	8	PF00244	0.409
LIG_14-3-3_CanoR_1	387	392	PF00244	0.660
LIG_14-3-3_CanoR_1	401	411	PF00244	0.569
LIG_14-3-3_CanoR_1	415	425	PF00244	0.467
LIG_14-3-3_CanoR_1	506	514	PF00244	0.411
LIG_14-3-3_CanoR_1	74	80	PF00244	0.526
LIG_14-3-3_CanoR_1	742	752	PF00244	0.624
LIG_14-3-3_CanoR_1	795	801	PF00244	0.340
LIG_14-3-3_CanoR_1	850	858	PF00244	0.448
LIG_Actin_WH2_2	772	787	PF00022	0.340
LIG_AP2alpha_1	445	449	PF02296	0.431
LIG_BIR_III_2	61	65	PF00653	0.588
LIG_Clathr_ClatBox_1	269	273	PF01394	0.302
LIG_Clathr_ClatBox_1	904	908	PF01394	0.627
LIG_deltaCOP1_diTrp_1	409	417	PF00928	0.611
LIG_deltaCOP1_diTrp_1	509	515	PF00928	0.410
LIG_EH1_1	542	550	PF00400	0.369
LIG_EH1_1	785	793	PF00400	0.315
LIG_eIF4E_1	543	549	PF01652	0.369
LIG_EVH1_2	568	572	PF00568	0.642
LIG_FHA_1	21	27	PF00498	0.248
LIG_FHA_1	314	320	PF00498	0.567
LIG_FHA_1	343	349	PF00498	0.353
LIG_FHA_1	358	364	PF00498	0.236
LIG_FHA_1	572	578	PF00498	0.670
LIG_FHA_1	743	749	PF00498	0.632
LIG_FHA_1	764	770	PF00498	0.332
LIG_FHA_1	774	780	PF00498	0.268
LIG_FHA_1	810	816	PF00498	0.624
LIG_FHA_1	887	893	PF00498	0.528
LIG_FHA_1	9	15	PF00498	0.300
LIG_FHA_2	138	144	PF00498	0.381
LIG_FHA_2	146	152	PF00498	0.386
LIG_FHA_2	442	448	PF00498	0.482
LIG_FHA_2	56	62	PF00498	0.615
LIG_GBD_Chelix_1	252	260	PF00786	0.252
LIG_GBD_Chelix_1	287	295	PF00786	0.369
LIG_LIR_Apic_2	447	452	PF02991	0.467
LIG_LIR_Apic_2	571	575	PF02991	0.613
LIG_LIR_Gen_1	158	169	PF02991	0.437
LIG_LIR_Gen_1	397	407	PF02991	0.575
LIG_LIR_Gen_1	444	452	PF02991	0.431
LIG_LIR_Gen_1	6	14	PF02991	0.263
LIG_LIR_Gen_1	776	784	PF02991	0.679
LIG_LIR_Nem_3	158	164	PF02991	0.325
LIG_LIR_Nem_3	326	330	PF02991	0.524
LIG_LIR_Nem_3	444	448	PF02991	0.426
LIG_LIR_Nem_3	508	513	PF02991	0.412
LIG_LIR_Nem_3	537	543	PF02991	0.484
LIG_LIR_Nem_3	6	10	PF02991	0.263
LIG_LIR_Nem_3	776	780	PF02991	0.302
LIG_LIR_Nem_3	805	809	PF02991	0.600
LIG_LIR_Nem_3	89	95	PF02991	0.570
LIG_MAD2	378	386	PF02301	0.607
LIG_NRBOX	181	187	PF00104	0.578
LIG_NRBOX	255	261	PF00104	0.240
LIG_NRBOX	826	832	PF00104	0.369
LIG_PAM2_1	768	780	PF00658	0.302
LIG_PCNA_yPIPBox_3	641	655	PF02747	0.467
LIG_Pex14_1	289	293	PF04695	0.369
LIG_Pex14_1	372	376	PF04695	0.551
LIG_Pex14_2	445	449	PF04695	0.431
LIG_PTB_Apo_2	471	478	PF02174	0.397
LIG_REV1ctd_RIR_1	325	333	PF16727	0.520
LIG_SH2_CRK	376	380	PF00017	0.544
LIG_SH2_CRK	872	876	PF00017	0.419
LIG_SH2_CRK	92	96	PF00017	0.561
LIG_SH2_GRB2like	494	497	PF00017	0.484
LIG_SH2_GRB2like	532	535	PF00017	0.404
LIG_SH2_PTP2	543	546	PF00017	0.369
LIG_SH2_SRC	119	122	PF00017	0.325
LIG_SH2_SRC	532	535	PF00017	0.368
LIG_SH2_SRC	85	88	PF00017	0.586
LIG_SH2_STAP1	81	85	PF00017	0.577
LIG_SH2_STAT3	578	581	PF00017	0.663
LIG_SH2_STAT5	119	122	PF00017	0.282
LIG_SH2_STAT5	399	402	PF00017	0.613
LIG_SH2_STAT5	532	535	PF00017	0.419
LIG_SH2_STAT5	543	546	PF00017	0.369
LIG_SH2_STAT5	644	647	PF00017	0.568
LIG_SH2_STAT5	762	765	PF00017	0.369
LIG_SH2_STAT5	85	88	PF00017	0.577
LIG_SH3_3	167	173	PF00018	0.282
LIG_SH3_3	212	218	PF00018	0.700
LIG_SH3_3	380	386	PF00018	0.590
LIG_SH3_3	428	434	PF00018	0.369
LIG_SH3_3	449	455	PF00018	0.474
LIG_SH3_3	562	568	PF00018	0.687
LIG_SH3_3	603	609	PF00018	0.699
LIG_SH3_3	92	98	PF00018	0.552
LIG_SUMO_SIM_anti_2	258	264	PF11976	0.369
LIG_SUMO_SIM_anti_2	345	350	PF11976	0.369
LIG_SUMO_SIM_anti_2	556	561	PF11976	0.369
LIG_SUMO_SIM_anti_2	681	686	PF11976	0.340
LIG_SUMO_SIM_anti_2	796	802	PF11976	0.369
LIG_SUMO_SIM_anti_2	8	14	PF11976	0.267
LIG_SUMO_SIM_par_1	18	23	PF11976	0.324
LIG_SUMO_SIM_par_1	267	273	PF11976	0.302
LIG_SUMO_SIM_par_1	343	350	PF11976	0.362
LIG_SUMO_SIM_par_1	427	433	PF11976	0.369
LIG_SUMO_SIM_par_1	544	550	PF11976	0.381
LIG_SUMO_SIM_par_1	799	805	PF11976	0.357
LIG_TRAF2_1	246	249	PF00917	0.582
LIG_TRAF2_1	640	643	PF00917	0.627
LIG_TRAF2_1	906	909	PF00917	0.670
LIG_TYR_ITIM	541	546	PF00017	0.369
LIG_TYR_ITIM	870	875	PF00017	0.419
LIG_UBA3_1	19	24	PF00899	0.296
LIG_WRC_WIRS_1	4	9	PF05994	0.401
LIG_WRC_WIRS_1	442	447	PF05994	0.424
MOD_CDC14_SPxK_1	451	454	PF00782	0.495
MOD_CDK_SPK_2	137	142	PF00069	0.369
MOD_CDK_SPxK_1	448	454	PF00069	0.488
MOD_CK1_1	226	232	PF00069	0.678
MOD_CK1_1	258	264	PF00069	0.340
MOD_CK1_1	350	356	PF00069	0.252
MOD_CK1_1	390	396	PF00069	0.657
MOD_CK1_1	571	577	PF00069	0.648
MOD_CK1_1	657	663	PF00069	0.347
MOD_CK1_1	732	738	PF00069	0.634
MOD_CK1_1	768	774	PF00069	0.302
MOD_CK1_1	839	845	PF00069	0.481
MOD_CK2_1	137	143	PF00069	0.378
MOD_CK2_1	226	232	PF00069	0.669
MOD_CK2_1	637	643	PF00069	0.637
MOD_CMANNOS	126	129	PF00535	0.419
MOD_GlcNHglycan	211	214	PF01048	0.409
MOD_GlcNHglycan	357	360	PF01048	0.305
MOD_GlcNHglycan	368	371	PF01048	0.439
MOD_GlcNHglycan	418	421	PF01048	0.270
MOD_GlcNHglycan	457	460	PF01048	0.705
MOD_GlcNHglycan	49	52	PF01048	0.486
MOD_GlcNHglycan	536	539	PF01048	0.588
MOD_GlcNHglycan	624	627	PF01048	0.497
MOD_GlcNHglycan	656	659	PF01048	0.500
MOD_GlcNHglycan	661	664	PF01048	0.420
MOD_GlcNHglycan	714	717	PF01048	0.508
MOD_GlcNHglycan	723	727	PF01048	0.457
MOD_GlcNHglycan	839	842	PF01048	0.701
MOD_GlcNHglycan	92	95	PF01048	0.388
MOD_GSK3_1	226	233	PF00069	0.667
MOD_GSK3_1	340	347	PF00069	0.338
MOD_GSK3_1	386	393	PF00069	0.636
MOD_GSK3_1	524	531	PF00069	0.416
MOD_GSK3_1	618	625	PF00069	0.679
MOD_GSK3_1	738	745	PF00069	0.644
MOD_GSK3_1	75	82	PF00069	0.590
MOD_GSK3_1	765	772	PF00069	0.289
MOD_GSK3_1	86	93	PF00069	0.550
MOD_N-GLC_1	473	478	PF02516	0.678
MOD_N-GLC_1	528	533	PF02516	0.658
MOD_N-GLC_2	414	416	PF02516	0.367
MOD_NEK2_1	155	160	PF00069	0.359
MOD_NEK2_1	20	25	PF00069	0.296
MOD_NEK2_1	255	260	PF00069	0.369
MOD_NEK2_1	26	31	PF00069	0.448
MOD_NEK2_1	282	287	PF00069	0.302
MOD_NEK2_1	313	318	PF00069	0.563
MOD_NEK2_1	342	347	PF00069	0.435
MOD_NEK2_1	357	362	PF00069	0.381
MOD_NEK2_1	402	407	PF00069	0.611
MOD_NEK2_1	429	434	PF00069	0.369
MOD_NEK2_1	475	480	PF00069	0.469
MOD_NEK2_1	528	533	PF00069	0.379
MOD_NEK2_1	656	661	PF00069	0.302
MOD_NEK2_1	763	768	PF00069	0.311
MOD_NEK2_1	775	780	PF00069	0.285
MOD_NEK2_1	802	807	PF00069	0.514
MOD_NEK2_2	418	423	PF00069	0.369
MOD_NEK2_2	874	879	PF00069	0.369
MOD_PIKK_1	75	81	PF00454	0.534
MOD_PKA_2	145	151	PF00069	0.412
MOD_PKA_2	155	161	PF00069	0.226
MOD_PKA_2	194	200	PF00069	0.614
MOD_PKA_2	386	392	PF00069	0.616
MOD_PKA_2	407	413	PF00069	0.610
MOD_PKA_2	505	511	PF00069	0.410
MOD_PKA_2	794	800	PF00069	0.340
MOD_PKA_2	849	855	PF00069	0.445
MOD_Plk_1	230	236	PF00069	0.650
MOD_Plk_1	473	479	PF00069	0.427
MOD_Plk_1	528	534	PF00069	0.458
MOD_Plk_1	55	61	PF00069	0.649
MOD_Plk_4	230	236	PF00069	0.618
MOD_Plk_4	255	261	PF00069	0.369
MOD_Plk_4	26	32	PF00069	0.405
MOD_Plk_4	282	288	PF00069	0.302
MOD_Plk_4	344	350	PF00069	0.381
MOD_Plk_4	357	363	PF00069	0.302
MOD_Plk_4	38	44	PF00069	0.559
MOD_Plk_4	407	413	PF00069	0.636
MOD_Plk_4	418	424	PF00069	0.257
MOD_Plk_4	441	447	PF00069	0.469
MOD_Plk_4	49	55	PF00069	0.716
MOD_Plk_4	490	496	PF00069	0.483
MOD_Plk_4	528	534	PF00069	0.458
MOD_Plk_4	553	559	PF00069	0.302
MOD_Plk_4	66	72	PF00069	0.491
MOD_Plk_4	680	686	PF00069	0.302
MOD_Plk_4	765	771	PF00069	0.302
MOD_Plk_4	796	802	PF00069	0.454
MOD_Plk_4	8	14	PF00069	0.299
MOD_Plk_4	80	86	PF00069	0.566
MOD_ProDKin_1	137	143	PF00069	0.378
MOD_ProDKin_1	226	232	PF00069	0.669
MOD_ProDKin_1	314	320	PF00069	0.567
MOD_ProDKin_1	350	356	PF00069	0.264
MOD_ProDKin_1	388	394	PF00069	0.654
MOD_ProDKin_1	430	436	PF00069	0.475
MOD_ProDKin_1	448	454	PF00069	0.366
MOD_ProDKin_1	498	504	PF00069	0.480
MOD_ProDKin_1	571	577	PF00069	0.643
MOD_SUMO_for_1	330	333	PF00179	0.622
MOD_SUMO_for_1	614	617	PF00179	0.741
TRG_DiLeu_BaEn_1	8	13	PF01217	0.325
TRG_DiLeu_BaEn_1	900	905	PF01217	0.639
TRG_DiLeu_BaLyEn_6	181	186	PF01217	0.563
TRG_DiLeu_BaLyEn_6	265	270	PF01217	0.302
TRG_DiLeu_BaLyEn_6	335	340	PF01217	0.369
TRG_ENDOCYTIC_2	376	379	PF00928	0.548
TRG_ENDOCYTIC_2	399	402	PF00928	0.582
TRG_ENDOCYTIC_2	543	546	PF00928	0.369
TRG_ENDOCYTIC_2	762	765	PF00928	0.369
TRG_ENDOCYTIC_2	872	875	PF00928	0.419
TRG_ENDOCYTIC_2	92	95	PF00928	0.557
TRG_ER_diArg_1	376	378	PF00400	0.644
TRG_ER_diArg_1	563	566	PF00400	0.592
TRG_ER_diArg_1	630	633	PF00400	0.690
TRG_ER_diArg_1	73	75	PF00400	0.518
TRG_ER_diArg_1	846	848	PF00400	0.380
TRG_Pf-PMV_PEXEL_1	57	61	PF00026	0.528
TRG_Pf-PMV_PEXEL_1	693	698	PF00026	0.437
TRG_Pf-PMV_PEXEL_1	868	873	PF00026	0.515

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9F4	Leptomonas seymouri	46%	100%
A0A3S5H633	Leishmania donovani	91%	100%
A4HTH0	Leishmania infantum	92%	100%
E9AM98	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	97%