Inositol phosphosphingolipid phospholipase C-Like

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Inositol phosphosphingolipids phospholipase C

Species:

Leishmania major

UniProt:

Q4QIE9_LEIMA

TriTrypDb:

LmjF.08.0200 , LMJLV39_080007000 , LMJSD75_080007000

Length:

653

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0005783	endoplasmic reticulum	5	2
GO:0016020	membrane	2	6
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0071944	cell periphery	2	2
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4QIE9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIE9

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	2
GO:0006643	membrane lipid metabolic process	4	2
GO:0006644	phospholipid metabolic process	4	2
GO:0006665	sphingolipid metabolic process	4	2
GO:0006672	ceramide metabolic process	4	2
GO:0006684	sphingomyelin metabolic process	4	2
GO:0006685	sphingomyelin catabolic process	5	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0008610	lipid biosynthetic process	4	2
GO:0009056	catabolic process	2	2
GO:0009058	biosynthetic process	2	2
GO:0009268	response to pH	3	2
GO:0009395	phospholipid catabolic process	5	2
GO:0009628	response to abiotic stimulus	2	2
GO:0009987	cellular process	1	2
GO:0010447	response to acidic pH	4	2
GO:0016042	lipid catabolic process	4	2
GO:0019637	organophosphate metabolic process	3	2
GO:0030148	sphingolipid biosynthetic process	5	2
GO:0030149	sphingolipid catabolic process	5	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043603	amide metabolic process	3	2
GO:0043604	amide biosynthetic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044242	cellular lipid catabolic process	4	2
GO:0044248	cellular catabolic process	3	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044255	cellular lipid metabolic process	3	2
GO:0044271	cellular nitrogen compound biosynthetic process	4	2
GO:0046434	organophosphate catabolic process	4	2
GO:0046466	membrane lipid catabolic process	5	2
GO:0046467	membrane lipid biosynthetic process	4	2
GO:0046513	ceramide biosynthetic process	5	2
GO:0050896	response to stimulus	1	2
GO:0051716	cellular response to stimulus	2	2
GO:0071214	cellular response to abiotic stimulus	3	2
GO:0071467	cellular response to pH	4	2
GO:0071468	cellular response to acidic pH	5	2
GO:0071704	organic substance metabolic process	2	2
GO:0104004	cellular response to environmental stimulus	3	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901565	organonitrogen compound catabolic process	4	2
GO:1901566	organonitrogen compound biosynthetic process	4	2
GO:1901575	organic substance catabolic process	3	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004620	phospholipase activity	5	11
GO:0004767	sphingomyelin phosphodiesterase activity	6	11
GO:0008081	phosphoric diester hydrolase activity	5	11
GO:0016298	lipase activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0042578	phosphoric ester hydrolase activity	4	11
GO:0003676	nucleic acid binding	3	3
GO:0003743	translation initiation factor activity	4	3
GO:0005488	binding	1	3
GO:0008135	translation factor activity, RNA binding	3	3
GO:0045182	translation regulator activity	1	3
GO:0090079	translation regulator activity, nucleic acid binding	2	3
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	133	137	PF00656	0.290
CLV_C14_Caspase3-7	300	304	PF00656	0.391
CLV_C14_Caspase3-7	396	400	PF00656	0.372
CLV_NRD_NRD_1	166	168	PF00675	0.443
CLV_NRD_NRD_1	438	440	PF00675	0.571
CLV_NRD_NRD_1	467	469	PF00675	0.461
CLV_NRD_NRD_1	76	78	PF00675	0.494
CLV_PCSK_KEX2_1	166	168	PF00082	0.491
CLV_PCSK_KEX2_1	218	220	PF00082	0.547
CLV_PCSK_KEX2_1	344	346	PF00082	0.729
CLV_PCSK_KEX2_1	467	469	PF00082	0.461
CLV_PCSK_KEX2_1	579	581	PF00082	0.575
CLV_PCSK_KEX2_1	76	78	PF00082	0.462
CLV_PCSK_PC1ET2_1	218	220	PF00082	0.547
CLV_PCSK_PC1ET2_1	344	346	PF00082	0.721
CLV_PCSK_PC1ET2_1	579	581	PF00082	0.575
CLV_PCSK_SKI1_1	15	19	PF00082	0.526
CLV_PCSK_SKI1_1	249	253	PF00082	0.519
CLV_PCSK_SKI1_1	268	272	PF00082	0.497
CLV_PCSK_SKI1_1	287	291	PF00082	0.532
CLV_PCSK_SKI1_1	579	583	PF00082	0.572
DEG_SPOP_SBC_1	363	367	PF00917	0.396
DEG_SPOP_SBC_1	398	402	PF00917	0.434
DEG_SPOP_SBC_1	570	574	PF00917	0.676
DOC_CYCLIN_RxL_1	166	176	PF00134	0.291
DOC_CYCLIN_RxL_1	263	275	PF00134	0.344
DOC_MAPK_gen_1	166	173	PF00069	0.320
DOC_MAPK_gen_1	28	36	PF00069	0.313
DOC_MAPK_MEF2A_6	121	130	PF00069	0.256
DOC_PP1_RVXF_1	13	20	PF00149	0.359
DOC_PP2B_LxvP_1	228	231	PF13499	0.348
DOC_PP4_FxxP_1	285	288	PF00568	0.346
DOC_USP7_MATH_1	363	367	PF00917	0.396
DOC_USP7_MATH_1	548	552	PF00917	0.776
DOC_USP7_MATH_1	559	563	PF00917	0.684
DOC_USP7_MATH_1	611	615	PF00917	0.585
DOC_USP7_UBL2_3	358	362	PF12436	0.566
DOC_WW_Pin1_4	417	422	PF00397	0.428
DOC_WW_Pin1_4	534	539	PF00397	0.710
DOC_WW_Pin1_4	544	549	PF00397	0.697
DOC_WW_Pin1_4	581	586	PF00397	0.731
DOC_WW_Pin1_4	63	68	PF00397	0.318
LIG_14-3-3_CanoR_1	15	20	PF00244	0.346
LIG_14-3-3_CanoR_1	174	181	PF00244	0.256
LIG_14-3-3_CanoR_1	249	254	PF00244	0.279
LIG_14-3-3_CanoR_1	256	260	PF00244	0.279
LIG_14-3-3_CanoR_1	425	431	PF00244	0.418
LIG_14-3-3_CanoR_1	580	585	PF00244	0.767
LIG_14-3-3_CanoR_1	71	76	PF00244	0.358
LIG_14-3-3_CanoR_1	77	83	PF00244	0.327
LIG_14-3-3_CanoR_1	92	100	PF00244	0.273
LIG_Actin_WH2_2	220	237	PF00022	0.365
LIG_APCC_ABBA_1	111	116	PF00400	0.334
LIG_APCC_Cbox_1	168	174	PF00515	0.334
LIG_BIR_II_1	1	5	PF00653	0.501
LIG_BRCT_BRCA1_1	381	385	PF00533	0.365
LIG_BRCT_BRCA1_1	613	617	PF00533	0.454
LIG_BRCT_BRCA1_1	95	99	PF00533	0.268
LIG_Clathr_ClatBox_1	269	273	PF01394	0.346
LIG_EH1_1	384	392	PF00400	0.369
LIG_FHA_1	100	106	PF00498	0.240
LIG_FHA_1	147	153	PF00498	0.267
LIG_FHA_1	16	22	PF00498	0.243
LIG_FHA_1	190	196	PF00498	0.270
LIG_FHA_1	351	357	PF00498	0.541
LIG_FHA_1	400	406	PF00498	0.531
LIG_FHA_1	412	418	PF00498	0.346
LIG_FHA_1	493	499	PF00498	0.746
LIG_FHA_1	524	530	PF00498	0.658
LIG_FHA_1	618	624	PF00498	0.403
LIG_FHA_2	131	137	PF00498	0.291
LIG_FHA_2	250	256	PF00498	0.245
LIG_FHA_2	318	324	PF00498	0.408
LIG_FHA_2	37	43	PF00498	0.343
LIG_FHA_2	418	424	PF00498	0.342
LIG_FHA_2	512	518	PF00498	0.584
LIG_FHA_2	581	587	PF00498	0.695
LIG_LIR_Gen_1	180	186	PF02991	0.294
LIG_LIR_Gen_1	258	267	PF02991	0.323
LIG_LIR_Gen_1	335	341	PF02991	0.491
LIG_LIR_Gen_1	42	49	PF02991	0.306
LIG_LIR_Gen_1	447	458	PF02991	0.354
LIG_LIR_Gen_1	56	65	PF02991	0.201
LIG_LIR_Nem_3	168	173	PF02991	0.242
LIG_LIR_Nem_3	180	184	PF02991	0.244
LIG_LIR_Nem_3	264	270	PF02991	0.346
LIG_LIR_Nem_3	303	308	PF02991	0.311
LIG_LIR_Nem_3	330	336	PF02991	0.508
LIG_LIR_Nem_3	42	47	PF02991	0.306
LIG_LIR_Nem_3	447	453	PF02991	0.354
LIG_LIR_Nem_3	56	61	PF02991	0.201
LIG_LIR_Nem_3	594	598	PF02991	0.607
LIG_LIR_Nem_3	72	78	PF02991	0.259
LIG_LYPXL_yS_3	108	111	PF13949	0.330
LIG_LYPXL_yS_3	305	308	PF13949	0.301
LIG_Pex14_1	337	341	PF04695	0.351
LIG_Pex14_2	58	62	PF04695	0.383
LIG_Pex14_2	78	82	PF04695	0.196
LIG_Pex14_2	99	103	PF04695	0.334
LIG_REV1ctd_RIR_1	115	125	PF16727	0.346
LIG_REV1ctd_RIR_1	282	287	PF16727	0.291
LIG_SH2_CRK	44	48	PF00017	0.256
LIG_SH2_CRK	450	454	PF00017	0.408
LIG_SH2_NCK_1	156	160	PF00017	0.291
LIG_SH2_NCK_1	485	489	PF00017	0.601
LIG_SH2_STAP1	148	152	PF00017	0.267
LIG_SH2_STAP1	44	48	PF00017	0.256
LIG_SH2_STAP1	485	489	PF00017	0.640
LIG_SH2_STAP1	608	612	PF00017	0.655
LIG_SH2_STAT5	148	151	PF00017	0.312
LIG_SH2_STAT5	170	173	PF00017	0.240
LIG_SH2_STAT5	266	269	PF00017	0.396
LIG_SH2_STAT5	437	440	PF00017	0.367
LIG_SH2_STAT5	73	76	PF00017	0.256
LIG_SH3_3	125	131	PF00018	0.308
LIG_SH3_3	188	194	PF00018	0.204
LIG_SH3_3	224	230	PF00018	0.254
LIG_SH3_3	321	327	PF00018	0.370
LIG_SH3_3	495	501	PF00018	0.725
LIG_SH3_3	555	561	PF00018	0.803
LIG_Sin3_3	289	296	PF02671	0.248
LIG_SUMO_SIM_anti_2	45	51	PF11976	0.259
LIG_SUMO_SIM_anti_2	455	461	PF11976	0.427
LIG_SUMO_SIM_par_1	149	157	PF11976	0.310
LIG_SUMO_SIM_par_1	45	51	PF11976	0.256
LIG_SUMO_SIM_par_1	455	461	PF11976	0.225
LIG_TRAF2_1	240	243	PF00917	0.269
LIG_TRAF2_1	420	423	PF00917	0.358
LIG_TRAF2_1	471	474	PF00917	0.635
LIG_UBA3_1	212	218	PF00899	0.313
LIG_UBA3_1	390	397	PF00899	0.326
LIG_WRC_WIRS_1	16	21	PF05994	0.265
LIG_WW_3	229	233	PF00397	0.334
MOD_CK1_1	160	166	PF00069	0.327
MOD_CK1_1	189	195	PF00069	0.274
MOD_CK1_1	2	8	PF00069	0.489
MOD_CK1_1	204	210	PF00069	0.292
MOD_CK1_1	261	267	PF00069	0.375
MOD_CK1_1	408	414	PF00069	0.511
MOD_CK1_1	531	537	PF00069	0.688
MOD_CK2_1	317	323	PF00069	0.409
MOD_CK2_1	36	42	PF00069	0.346
MOD_CK2_1	362	368	PF00069	0.531
MOD_CK2_1	417	423	PF00069	0.305
MOD_CK2_1	467	473	PF00069	0.647
MOD_CK2_1	580	586	PF00069	0.763
MOD_Cter_Amidation	342	345	PF01082	0.706
MOD_GlcNHglycan	329	332	PF01048	0.669
MOD_GlcNHglycan	341	344	PF01048	0.569
MOD_GlcNHglycan	370	373	PF01048	0.736
MOD_GlcNHglycan	407	410	PF01048	0.712
MOD_GlcNHglycan	469	472	PF01048	0.493
MOD_GlcNHglycan	476	479	PF01048	0.478
MOD_GlcNHglycan	609	612	PF01048	0.485
MOD_GlcNHglycan	614	617	PF01048	0.390
MOD_GlcNHglycan	84	87	PF01048	0.474
MOD_GSK3_1	143	150	PF00069	0.338
MOD_GSK3_1	157	164	PF00069	0.265
MOD_GSK3_1	173	180	PF00069	0.200
MOD_GSK3_1	185	192	PF00069	0.275
MOD_GSK3_1	251	258	PF00069	0.293
MOD_GSK3_1	364	371	PF00069	0.516
MOD_GSK3_1	404	411	PF00069	0.529
MOD_GSK3_1	440	447	PF00069	0.405
MOD_GSK3_1	544	551	PF00069	0.772
MOD_GSK3_1	565	572	PF00069	0.787
MOD_GSK3_1	607	614	PF00069	0.623
MOD_GSK3_1	78	85	PF00069	0.346
MOD_N-GLC_1	201	206	PF02516	0.470
MOD_N-GLC_1	350	355	PF02516	0.747
MOD_N-GLC_1	617	622	PF02516	0.347
MOD_N-GLC_1	63	68	PF02516	0.411
MOD_N-GLC_2	543	545	PF02516	0.430
MOD_NEK2_1	147	152	PF00069	0.256
MOD_NEK2_1	173	178	PF00069	0.310
MOD_NEK2_1	184	189	PF00069	0.275
MOD_NEK2_1	201	206	PF00069	0.198
MOD_NEK2_1	262	267	PF00069	0.310
MOD_NEK2_1	283	288	PF00069	0.227
MOD_NEK2_1	404	409	PF00069	0.504
MOD_NEK2_1	458	463	PF00069	0.414
MOD_NEK2_1	607	612	PF00069	0.641
MOD_NEK2_1	617	622	PF00069	0.352
MOD_NEK2_1	78	83	PF00069	0.289
MOD_NEK2_1	99	104	PF00069	0.314
MOD_NEK2_2	504	509	PF00069	0.703
MOD_NEK2_2	523	528	PF00069	0.531
MOD_PIKK_1	157	163	PF00454	0.311
MOD_PIKK_1	173	179	PF00454	0.204
MOD_PIKK_1	201	207	PF00454	0.270
MOD_PIKK_1	275	281	PF00454	0.337
MOD_PIKK_1	440	446	PF00454	0.403
MOD_PIKK_1	93	99	PF00454	0.302
MOD_PKA_1	467	473	PF00069	0.613
MOD_PKA_1	579	585	PF00069	0.773
MOD_PKA_2	173	179	PF00069	0.256
MOD_PKA_2	189	195	PF00069	0.256
MOD_PKA_2	255	261	PF00069	0.247
MOD_PKA_2	467	473	PF00069	0.601
MOD_PKA_2	492	498	PF00069	0.698
MOD_PKA_2	579	585	PF00069	0.768
MOD_Plk_1	143	149	PF00069	0.286
MOD_Plk_2-3	51	57	PF00069	0.260
MOD_Plk_4	143	149	PF00069	0.314
MOD_Plk_4	223	229	PF00069	0.309
MOD_Plk_4	262	268	PF00069	0.338
MOD_Plk_4	332	338	PF00069	0.470
MOD_Plk_4	426	432	PF00069	0.359
MOD_Plk_4	78	84	PF00069	0.346
MOD_ProDKin_1	417	423	PF00069	0.421
MOD_ProDKin_1	534	540	PF00069	0.711
MOD_ProDKin_1	544	550	PF00069	0.696
MOD_ProDKin_1	581	587	PF00069	0.730
MOD_ProDKin_1	63	69	PF00069	0.318
MOD_SUMO_for_1	270	273	PF00179	0.334
MOD_SUMO_for_1	471	474	PF00179	0.647
TRG_DiLeu_BaEn_1	56	61	PF01217	0.346
TRG_ENDOCYTIC_2	108	111	PF00928	0.330
TRG_ENDOCYTIC_2	156	159	PF00928	0.315
TRG_ENDOCYTIC_2	170	173	PF00928	0.200
TRG_ENDOCYTIC_2	266	269	PF00928	0.325
TRG_ENDOCYTIC_2	305	308	PF00928	0.301
TRG_ENDOCYTIC_2	333	336	PF00928	0.384
TRG_ENDOCYTIC_2	378	381	PF00928	0.396
TRG_ENDOCYTIC_2	44	47	PF00928	0.256
TRG_ENDOCYTIC_2	450	453	PF00928	0.372
TRG_ER_diArg_1	165	167	PF00400	0.204
TRG_ER_diArg_1	466	468	PF00400	0.609
TRG_ER_diArg_1	75	77	PF00400	0.312
TRG_Pf-PMV_PEXEL_1	206	211	PF00026	0.470
TRG_Pf-PMV_PEXEL_1	232	236	PF00026	0.546
TRG_Pf-PMV_PEXEL_1	439	444	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	596	600	PF00026	0.500

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P935	Leptomonas seymouri	57%	100%
A0A1X0NNY2	Trypanosomatidae	40%	100%
A0A3S5H634	Leishmania donovani	93%	100%
A0A422NTR5	Trypanosoma rangeli	37%	100%
A4H587	Leishmania braziliensis	70%	99%
A4HTH1	Leishmania infantum	94%	100%
C9ZPP9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AM99	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5BLM5	Trypanosoma cruzi	37%	100%