Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QIE8_LEIMA

TriTrypDb:

LmjF.08.0210 , LMJLV39_080007100 , LMJSD75_080007100

Length:

503

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QIE8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIE8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	173	177	PF00656	0.668
CLV_C14_Caspase3-7	322	326	PF00656	0.666
CLV_NRD_NRD_1	178	180	PF00675	0.823
CLV_NRD_NRD_1	191	193	PF00675	0.585
CLV_NRD_NRD_1	299	301	PF00675	0.707
CLV_NRD_NRD_1	415	417	PF00675	0.635
CLV_NRD_NRD_1	5	7	PF00675	0.645
CLV_PCSK_FUR_1	413	417	PF00082	0.636
CLV_PCSK_KEX2_1	117	119	PF00082	0.810
CLV_PCSK_KEX2_1	178	180	PF00082	0.823
CLV_PCSK_KEX2_1	191	193	PF00082	0.585
CLV_PCSK_KEX2_1	298	300	PF00082	0.766
CLV_PCSK_KEX2_1	4	6	PF00082	0.644
CLV_PCSK_KEX2_1	415	417	PF00082	0.635
CLV_PCSK_KEX2_1	463	465	PF00082	0.623
CLV_PCSK_PC1ET2_1	117	119	PF00082	0.712
CLV_PCSK_PC1ET2_1	463	465	PF00082	0.623
CLV_PCSK_SKI1_1	114	118	PF00082	0.585
CLV_PCSK_SKI1_1	184	188	PF00082	0.690
DEG_SPOP_SBC_1	287	291	PF00917	0.652
DEG_SPOP_SBC_1	429	433	PF00917	0.577
DOC_ANK_TNKS_1	104	111	PF00023	0.656
DOC_MAPK_gen_1	413	423	PF00069	0.635
DOC_MAPK_MEF2A_6	244	251	PF00069	0.686
DOC_PP2B_LxvP_1	270	273	PF13499	0.675
DOC_PP2B_LxvP_1	358	361	PF13499	0.724
DOC_PP4_FxxP_1	252	255	PF00568	0.629
DOC_USP7_MATH_1	15	19	PF00917	0.623
DOC_USP7_MATH_1	171	175	PF00917	0.647
DOC_USP7_MATH_1	264	268	PF00917	0.749
DOC_USP7_MATH_1	287	291	PF00917	0.702
DOC_USP7_MATH_1	39	43	PF00917	0.692
DOC_USP7_MATH_1	44	48	PF00917	0.685
DOC_USP7_MATH_1	54	58	PF00917	0.589
DOC_WW_Pin1_4	217	222	PF00397	0.663
DOC_WW_Pin1_4	265	270	PF00397	0.725
DOC_WW_Pin1_4	272	277	PF00397	0.649
DOC_WW_Pin1_4	437	442	PF00397	0.621
DOC_WW_Pin1_4	449	454	PF00397	0.584
DOC_WW_Pin1_4	476	481	PF00397	0.489
LIG_14-3-3_CanoR_1	288	293	PF00244	0.632
LIG_14-3-3_CanoR_1	51	61	PF00244	0.586
LIG_ActinCP_TwfCPI_2	252	259	PF01115	0.636
LIG_APCC_ABBA_1	120	125	PF00400	0.723
LIG_BIR_III_2	218	222	PF00653	0.620
LIG_BIR_III_2	263	267	PF00653	0.660
LIG_BRCT_BRCA1_1	441	445	PF00533	0.676
LIG_FHA_1	27	33	PF00498	0.740
LIG_FHA_2	171	177	PF00498	0.712
LIG_FHA_2	468	474	PF00498	0.660
LIG_Integrin_RGD_1	107	109	PF01839	0.679
LIG_Integrin_RGD_1	192	194	PF01839	0.642
LIG_LIR_Apic_2	31	36	PF02991	0.664
LIG_LIR_Apic_2	406	412	PF02991	0.644
LIG_LIR_Gen_1	479	490	PF02991	0.625
LIG_LIR_Nem_3	442	448	PF02991	0.673
LIG_LIR_Nem_3	479	485	PF02991	0.625
LIG_MYND_1	269	273	PF01753	0.673
LIG_Pex14_2	445	449	PF04695	0.671
LIG_PTAP_UEV_1	93	98	PF05743	0.688
LIG_SH2_CRK	33	37	PF00017	0.620
LIG_SH2_SRC	409	412	PF00017	0.665
LIG_SH2_STAT5	409	412	PF00017	0.665
LIG_SH3_1	33	39	PF00018	0.618
LIG_SH3_3	263	269	PF00018	0.672
LIG_SH3_3	270	276	PF00018	0.628
LIG_SH3_3	33	39	PF00018	0.618
LIG_SH3_3	451	457	PF00018	0.644
LIG_SH3_3	91	97	PF00018	0.712
LIG_SUMO_SIM_par_1	267	275	PF11976	0.721
LIG_TRAF2_1	122	125	PF00917	0.721
LIG_TRAF2_1	56	59	PF00917	0.714
LIG_TRAF2_1	83	86	PF00917	0.677
LIG_TRFH_1	408	412	PF08558	0.665
LIG_WW_3	1	5	PF00397	0.643
LIG_WW_3	143	147	PF00397	0.670
MOD_CK1_1	101	107	PF00069	0.677
MOD_CK1_1	275	281	PF00069	0.785
MOD_CK1_1	282	288	PF00069	0.594
MOD_CK1_1	313	319	PF00069	0.609
MOD_CK1_1	349	355	PF00069	0.654
MOD_CK1_1	435	441	PF00069	0.686
MOD_CK1_1	452	458	PF00069	0.499
MOD_CK2_1	299	305	PF00069	0.689
MOD_CK2_1	317	323	PF00069	0.777
MOD_CK2_1	367	373	PF00069	0.600
MOD_CK2_1	52	58	PF00069	0.694
MOD_Cter_Amidation	176	179	PF01082	0.672
MOD_DYRK1A_RPxSP_1	265	269	PF00069	0.652
MOD_GlcNHglycan	100	103	PF01048	0.734
MOD_GlcNHglycan	124	130	PF01048	0.657
MOD_GlcNHglycan	162	165	PF01048	0.685
MOD_GlcNHglycan	17	20	PF01048	0.546
MOD_GlcNHglycan	173	176	PF01048	0.677
MOD_GlcNHglycan	283	287	PF01048	0.725
MOD_GlcNHglycan	301	304	PF01048	0.632
MOD_GlcNHglycan	319	322	PF01048	0.759
MOD_GlcNHglycan	348	351	PF01048	0.754
MOD_GlcNHglycan	353	356	PF01048	0.718
MOD_GlcNHglycan	369	372	PF01048	0.552
MOD_GlcNHglycan	442	445	PF01048	0.630
MOD_GlcNHglycan	54	57	PF01048	0.660
MOD_GlcNHglycan	78	81	PF01048	0.748
MOD_GSK3_1	271	278	PF00069	0.757
MOD_GSK3_1	282	289	PF00069	0.747
MOD_GSK3_1	310	317	PF00069	0.778
MOD_GSK3_1	319	326	PF00069	0.729
MOD_GSK3_1	384	391	PF00069	0.722
MOD_GSK3_1	392	399	PF00069	0.608
MOD_GSK3_1	428	435	PF00069	0.676
MOD_GSK3_1	436	443	PF00069	0.631
MOD_GSK3_1	476	483	PF00069	0.582
MOD_N-GLC_1	279	284	PF02516	0.680
MOD_NEK2_1	137	142	PF00069	0.574
MOD_NEK2_1	310	315	PF00069	0.718
MOD_NEK2_1	428	433	PF00069	0.654
MOD_NEK2_2	112	117	PF00069	0.681
MOD_NEK2_2	28	33	PF00069	0.695
MOD_PKA_1	299	305	PF00069	0.639
MOD_PKA_2	200	206	PF00069	0.627
MOD_PKA_2	264	270	PF00069	0.653
MOD_PKA_2	287	293	PF00069	0.633
MOD_PKA_2	299	305	PF00069	0.707
MOD_PKA_2	310	316	PF00069	0.604
MOD_PKA_2	39	45	PF00069	0.559
MOD_PKA_2	403	409	PF00069	0.636
MOD_PKB_1	182	190	PF00069	0.582
MOD_Plk_4	333	339	PF00069	0.664
MOD_ProDKin_1	217	223	PF00069	0.661
MOD_ProDKin_1	265	271	PF00069	0.726
MOD_ProDKin_1	272	278	PF00069	0.649
MOD_ProDKin_1	437	443	PF00069	0.617
MOD_ProDKin_1	449	455	PF00069	0.586
MOD_ProDKin_1	476	482	PF00069	0.485
TRG_DiLeu_BaLyEn_6	266	271	PF01217	0.676
TRG_DiLeu_BaLyEn_6	376	381	PF01217	0.661
TRG_ER_diArg_1	298	300	PF00400	0.728
TRG_ER_diArg_1	3	6	PF00400	0.643
TRG_ER_diArg_1	414	416	PF00400	0.628
TRG_NLS_MonoExtC_3	212	218	PF00514	0.700
TRG_NLS_MonoExtN_4	210	217	PF00514	0.697
TRG_Pf-PMV_PEXEL_1	259	263	PF00026	0.659
TRG_Pf-PMV_PEXEL_1	362	367	PF00026	0.669

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H635	Leishmania donovani	87%	100%
A4H588	Leishmania braziliensis	50%	95%
A4HTH2	Leishmania infantum	87%	100%
E9AMA0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	97%