ABC1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ABC1 family, putative

Species:

Leishmania major

UniProt:

Q4QIE6_LEIMA

TriTrypDb:

LmjF.08.0230 , LMJLV39_080007300 , LMJSD75_080007300

Length:

522

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 9
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QIE6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIE6

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016310	phosphorylation	5	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	269	271	PF00675	0.319
CLV_NRD_NRD_1	354	356	PF00675	0.390
CLV_NRD_NRD_1	83	85	PF00675	0.495
CLV_PCSK_KEX2_1	131	133	PF00082	0.415
CLV_PCSK_KEX2_1	269	271	PF00082	0.340
CLV_PCSK_KEX2_1	354	356	PF00082	0.390
CLV_PCSK_KEX2_1	83	85	PF00082	0.466
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.425
CLV_PCSK_SKI1_1	269	273	PF00082	0.362
CLV_PCSK_SKI1_1	42	46	PF00082	0.424
DOC_AGCK_PIF_2	212	217	PF00069	0.390
DOC_CYCLIN_RxL_1	39	46	PF00134	0.430
DOC_CYCLIN_yCln2_LP_2	392	398	PF00134	0.385
DOC_CYCLIN_yCln2_LP_2	407	413	PF00134	0.650
DOC_MAPK_DCC_7	31	39	PF00069	0.541
DOC_MAPK_MEF2A_6	31	39	PF00069	0.541
DOC_MAPK_MEF2A_6	335	343	PF00069	0.425
DOC_PP1_RVXF_1	259	265	PF00149	0.425
DOC_PP1_RVXF_1	40	46	PF00149	0.483
DOC_PP1_RVXF_1	477	483	PF00149	0.470
DOC_PP2B_LxvP_1	27	30	PF13499	0.472
DOC_USP7_MATH_1	108	112	PF00917	0.408
DOC_USP7_MATH_1	162	166	PF00917	0.305
DOC_USP7_MATH_1	206	210	PF00917	0.425
DOC_WW_Pin1_4	156	161	PF00397	0.390
DOC_WW_Pin1_4	366	371	PF00397	0.351
LIG_14-3-3_CanoR_1	147	156	PF00244	0.392
LIG_14-3-3_CanoR_1	199	204	PF00244	0.413
LIG_14-3-3_CanoR_1	270	278	PF00244	0.333
LIG_14-3-3_CanoR_1	423	431	PF00244	0.535
LIG_14-3-3_CanoR_1	501	505	PF00244	0.513
LIG_Actin_WH2_2	427	445	PF00022	0.410
LIG_BRCT_BRCA1_1	149	153	PF00533	0.338
LIG_BRCT_BRCA1_1	201	205	PF00533	0.440
LIG_BRCT_BRCA1_1	208	212	PF00533	0.405
LIG_FHA_1	198	204	PF00498	0.320
LIG_FHA_1	21	27	PF00498	0.453
LIG_FHA_1	367	373	PF00498	0.349
LIG_FHA_1	446	452	PF00498	0.487
LIG_FHA_2	300	306	PF00498	0.425
LIG_FHA_2	363	369	PF00498	0.421
LIG_FHA_2	470	476	PF00498	0.506
LIG_FHA_2	68	74	PF00498	0.580
LIG_GBD_Chelix_1	137	145	PF00786	0.390
LIG_LIR_Apic_2	154	158	PF02991	0.445
LIG_LIR_Apic_2	209	213	PF02991	0.429
LIG_LIR_Apic_2	503	508	PF02991	0.455
LIG_LIR_Gen_1	117	125	PF02991	0.355
LIG_LIR_Gen_1	150	161	PF02991	0.382
LIG_LIR_Gen_1	301	312	PF02991	0.371
LIG_LIR_Gen_1	382	392	PF02991	0.343
LIG_LIR_Gen_1	437	446	PF02991	0.349
LIG_LIR_Gen_1	472	482	PF02991	0.461
LIG_LIR_Gen_1	493	502	PF02991	0.466
LIG_LIR_Gen_1	76	86	PF02991	0.451
LIG_LIR_Nem_3	117	121	PF02991	0.374
LIG_LIR_Nem_3	150	156	PF02991	0.415
LIG_LIR_Nem_3	209	215	PF02991	0.401
LIG_LIR_Nem_3	216	220	PF02991	0.374
LIG_LIR_Nem_3	301	307	PF02991	0.371
LIG_LIR_Nem_3	382	387	PF02991	0.369
LIG_LIR_Nem_3	437	441	PF02991	0.349
LIG_LIR_Nem_3	472	477	PF02991	0.428
LIG_LIR_Nem_3	493	498	PF02991	0.440
LIG_LIR_Nem_3	76	81	PF02991	0.474
LIG_LYPXL_SIV_4	133	141	PF13949	0.452
LIG_MAD2	270	278	PF02301	0.456
LIG_MYND_1	36	40	PF01753	0.568
LIG_Pex14_2	312	316	PF04695	0.291
LIG_Pex14_2	387	391	PF04695	0.382
LIG_SH2_CRK	118	122	PF00017	0.443
LIG_SH2_CRK	438	442	PF00017	0.365
LIG_SH2_CRK	495	499	PF00017	0.492
LIG_SH2_GRB2like	474	477	PF00017	0.332
LIG_SH2_PTP2	155	158	PF00017	0.413
LIG_SH2_PTP2	187	190	PF00017	0.341
LIG_SH2_SRC	134	137	PF00017	0.452
LIG_SH2_SRC	155	158	PF00017	0.425
LIG_SH2_SRC	187	190	PF00017	0.320
LIG_SH2_STAP1	134	138	PF00017	0.452
LIG_SH2_STAP1	384	388	PF00017	0.345
LIG_SH2_STAP1	396	400	PF00017	0.430
LIG_SH2_STAP1	438	442	PF00017	0.349
LIG_SH2_STAP1	495	499	PF00017	0.528
LIG_SH2_STAP1	65	69	PF00017	0.479
LIG_SH2_STAT5	100	103	PF00017	0.351
LIG_SH2_STAT5	118	121	PF00017	0.363
LIG_SH2_STAT5	155	158	PF00017	0.425
LIG_SH2_STAT5	187	190	PF00017	0.320
LIG_SH2_STAT5	210	213	PF00017	0.425
LIG_SH2_STAT5	398	401	PF00017	0.522
LIG_SH2_STAT5	62	65	PF00017	0.409
LIG_SH3_3	127	133	PF00018	0.385
LIG_SH3_3	254	260	PF00018	0.362
LIG_SH3_3	34	40	PF00018	0.494
LIG_SUMO_SIM_anti_2	136	142	PF11976	0.393
LIG_SUMO_SIM_anti_2	200	205	PF11976	0.425
LIG_SUMO_SIM_par_1	136	142	PF11976	0.393
LIG_SUMO_SIM_par_1	337	342	PF11976	0.306
LIG_SUMO_SIM_par_1	35	41	PF11976	0.536
LIG_SUMO_SIM_par_1	87	94	PF11976	0.412
LIG_TYR_ITIM	185	190	PF00017	0.305
LIG_UBA3_1	26	31	PF00899	0.355
MOD_CDK_SPK_2	366	371	PF00069	0.452
MOD_CK1_1	402	408	PF00069	0.515
MOD_CK1_1	469	475	PF00069	0.481
MOD_CK2_1	299	305	PF00069	0.444
MOD_CK2_1	469	475	PF00069	0.488
MOD_GSK3_1	147	154	PF00069	0.455
MOD_GSK3_1	355	362	PF00069	0.330
MOD_GSK3_1	366	373	PF00069	0.298
MOD_GSK3_1	441	448	PF00069	0.470
MOD_GSK3_1	466	473	PF00069	0.408
MOD_GSK3_1	514	521	PF00069	0.584
MOD_N-GLC_1	108	113	PF02516	0.409
MOD_N-GLC_1	224	229	PF02516	0.305
MOD_NEK2_1	18	23	PF00069	0.584
MOD_NEK2_1	224	229	PF00069	0.328
MOD_NEK2_1	3	8	PF00069	0.616
MOD_NEK2_1	386	391	PF00069	0.341
MOD_NEK2_1	399	404	PF00069	0.456
MOD_NEK2_1	416	421	PF00069	0.618
MOD_NEK2_1	466	471	PF00069	0.355
MOD_NEK2_1	500	505	PF00069	0.466
MOD_NEK2_1	514	519	PF00069	0.469
MOD_PIKK_1	271	277	PF00454	0.429
MOD_PIKK_1	67	73	PF00454	0.528
MOD_PKA_2	238	244	PF00069	0.396
MOD_PKA_2	3	9	PF00069	0.585
MOD_PKA_2	416	422	PF00069	0.618
MOD_PKA_2	500	506	PF00069	0.543
MOD_Plk_1	108	114	PF00069	0.406
MOD_Plk_1	224	230	PF00069	0.311
MOD_Plk_1	514	520	PF00069	0.487
MOD_Plk_2-3	151	157	PF00069	0.382
MOD_Plk_4	206	212	PF00069	0.406
MOD_Plk_4	299	305	PF00069	0.391
MOD_Plk_4	494	500	PF00069	0.348
MOD_ProDKin_1	156	162	PF00069	0.390
MOD_ProDKin_1	366	372	PF00069	0.351
TRG_ENDOCYTIC_2	118	121	PF00928	0.447
TRG_ENDOCYTIC_2	134	137	PF00928	0.356
TRG_ENDOCYTIC_2	187	190	PF00928	0.305
TRG_ENDOCYTIC_2	384	387	PF00928	0.351
TRG_ENDOCYTIC_2	396	399	PF00928	0.381
TRG_ENDOCYTIC_2	438	441	PF00928	0.337
TRG_ENDOCYTIC_2	474	477	PF00928	0.407
TRG_ENDOCYTIC_2	495	498	PF00928	0.493
TRG_ER_diArg_1	171	174	PF00400	0.390
TRG_ER_diArg_1	269	271	PF00400	0.318
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.425
TRG_Pf-PMV_PEXEL_1	270	275	PF00026	0.381
TRG_Pf-PMV_PEXEL_1	42	46	PF00026	0.408
TRG_Pf-PMV_PEXEL_1	453	457	PF00026	0.460

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IML7	Leptomonas seymouri	76%	100%
A0A0N1PA82	Leptomonas seymouri	32%	83%
A0A0S4KEI7	Bodo saltans	44%	98%
A0A0S4KLC8	Bodo saltans	29%	90%
A0A179HKZ8	Purpureocillium lilacinum	29%	88%
A0A1X0NQM8	Trypanosomatidae	54%	96%
A0A1X0P192	Trypanosomatidae	31%	82%
A0A3Q8IPG5	Leishmania donovani	25%	98%
A0A3R7KBH2	Trypanosoma rangeli	31%	81%
A0A3R7KJM1	Trypanosoma rangeli	56%	99%
A0A3S5H636	Leishmania donovani	94%	100%
A0A3S5H7U4	Leishmania donovani	30%	80%
A4H590	Leishmania braziliensis	84%	100%
A4HLI6	Leishmania braziliensis	30%	80%
A4HTH4	Leishmania infantum	94%	100%
A4I8Z6	Leishmania infantum	30%	80%
A4IDN2	Leishmania infantum	25%	98%
C9ZPL3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	99%
D0A4Z6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	80%
E9AMA2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9B3W5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	83%
O04212	Arabidopsis thaliana	27%	97%
O42653	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	98%
O60111	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	94%
Q06567	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	92%
Q18486	Caenorhabditis elegans	24%	69%
Q3MIX3	Homo sapiens	38%	90%
Q46189	Clostridium pasteurianum	24%	98%
Q4Q0W1	Leishmania major	25%	100%
Q4Q459	Leishmania major	30%	100%
Q54P00	Dictyostelium discoideum	35%	75%
Q54TR5	Dictyostelium discoideum	31%	78%
Q5M7P6	Xenopus tropicalis	31%	100%
Q5ZMT7	Gallus gallus	30%	100%
Q6INL7	Xenopus laevis	30%	100%
Q80V03	Mus musculus	38%	90%
Q86TW2	Homo sapiens	30%	98%
Q8RWG1	Arabidopsis thaliana	28%	77%
Q9D0L4	Mus musculus	30%	99%
V5AX60	Trypanosoma cruzi	54%	99%
V5BB22	Trypanosoma cruzi	23%	78%
V5BCS0	Trypanosoma cruzi	33%	82%