ADG1-like protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

ADG1-like protein

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QIE4_LEIMA

TriTrypDb:

LmjF.08.0250 , LMJLV39_080007500 , LMJSD75_080007500

Length:

149

Annotations

LeishMANIAdb annotations

Specific to Kinetoplastids, where evolution has duplicated this protein more than one time. However, this already happened at free-living forms.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4QIE4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIE4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	121	123	PF00675	0.543
CLV_NRD_NRD_1	20	22	PF00675	0.398
CLV_PCSK_KEX2_1	121	123	PF00082	0.563
CLV_PCSK_KEX2_1	19	21	PF00082	0.401
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.401
CLV_PCSK_SKI1_1	99	103	PF00082	0.547
DEG_APCC_DBOX_1	121	129	PF00400	0.344
DEG_Nend_UBRbox_2	1	3	PF02207	0.596
DOC_CDC14_PxL_1	49	57	PF14671	0.531
DOC_CKS1_1	24	29	PF01111	0.566
DOC_CYCLIN_RxL_1	116	129	PF00134	0.384
DOC_PP2B_LxvP_1	22	25	PF13499	0.577
DOC_USP7_MATH_1	30	34	PF00917	0.702
DOC_WW_Pin1_4	23	28	PF00397	0.734
LIG_14-3-3_CanoR_1	32	36	PF00244	0.593
LIG_14-3-3_CanoR_1	77	81	PF00244	0.345
LIG_FHA_1	129	135	PF00498	0.327
LIG_FHA_1	59	65	PF00498	0.330
LIG_LIR_Nem_3	68	72	PF02991	0.356
LIG_LYPXL_yS_3	52	55	PF13949	0.405
LIG_Pex14_2	67	71	PF04695	0.361
LIG_SH2_STAP1	72	76	PF00017	0.484
LIG_SH3_1	21	27	PF00018	0.566
LIG_SH3_2	27	32	PF14604	0.557
LIG_SH3_3	21	27	PF00018	0.635
LIG_UBA3_1	41	47	PF00899	0.654
MOD_CK1_1	108	114	PF00069	0.332
MOD_CK1_1	75	81	PF00069	0.408
MOD_GlcNHglycan	138	141	PF01048	0.601
MOD_GSK3_1	108	115	PF00069	0.305
MOD_GSK3_1	51	58	PF00069	0.487
MOD_GSK3_1	71	78	PF00069	0.349
MOD_NEK2_1	31	36	PF00069	0.651
MOD_NEK2_1	55	60	PF00069	0.301
MOD_NEK2_1	80	85	PF00069	0.351
MOD_NEK2_2	72	77	PF00069	0.489
MOD_PIKK_1	80	86	PF00454	0.333
MOD_PKA_2	31	37	PF00069	0.540
MOD_PKA_2	76	82	PF00069	0.329
MOD_Plk_1	105	111	PF00069	0.370
MOD_Plk_4	31	37	PF00069	0.666
MOD_Plk_4	76	82	PF00069	0.389
MOD_ProDKin_1	23	29	PF00069	0.733
TRG_ENDOCYTIC_2	52	55	PF00928	0.342
TRG_ER_diArg_1	113	116	PF00400	0.344
TRG_ER_diArg_1	120	122	PF00400	0.319
TRG_ER_diArg_1	20	22	PF00400	0.598
TRG_NLS_MonoExtC_3	18	23	PF00514	0.593
TRG_Pf-PMV_PEXEL_1	121	126	PF00026	0.544

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFQ4	Leptomonas seymouri	90%	100%
A0A0S4KHT3	Bodo saltans	35%	97%
A0A1X0NPM0	Trypanosomatidae	48%	100%
A0A3R7KSK8	Trypanosoma rangeli	49%	100%
A0A3S7WQ48	Leishmania donovani	99%	100%
A4H592	Leishmania braziliensis	96%	100%
C9ZPK9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9AMA4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%