Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QIE3_LEIMA

TriTrypDb:

LmjF.08.0260 , LMJLV39_080007600 , LMJSD75_080007600

Length:

438

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QIE3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIE3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	124	126	PF00675	0.593
CLV_NRD_NRD_1	233	235	PF00675	0.668
CLV_NRD_NRD_1	321	323	PF00675	0.647
CLV_NRD_NRD_1	330	332	PF00675	0.674
CLV_NRD_NRD_1	346	348	PF00675	0.502
CLV_NRD_NRD_1	433	435	PF00675	0.660
CLV_PCSK_FUR_1	142	146	PF00082	0.562
CLV_PCSK_FUR_1	328	332	PF00082	0.526
CLV_PCSK_KEX2_1	144	146	PF00082	0.700
CLV_PCSK_KEX2_1	233	235	PF00082	0.670
CLV_PCSK_KEX2_1	321	323	PF00082	0.647
CLV_PCSK_KEX2_1	328	330	PF00082	0.614
CLV_PCSK_KEX2_1	344	346	PF00082	0.622
CLV_PCSK_KEX2_1	425	427	PF00082	0.656
CLV_PCSK_KEX2_1	433	435	PF00082	0.540
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.558
CLV_PCSK_PC1ET2_1	344	346	PF00082	0.584
CLV_PCSK_PC1ET2_1	425	427	PF00082	0.656
CLV_PCSK_SKI1_1	103	107	PF00082	0.592
CLV_PCSK_SKI1_1	160	164	PF00082	0.542
CLV_PCSK_SKI1_1	295	299	PF00082	0.775
CLV_PCSK_SKI1_1	333	337	PF00082	0.527
CLV_PCSK_SKI1_1	49	53	PF00082	0.617
DEG_APCC_DBOX_1	159	167	PF00400	0.561
DEG_APCC_DBOX_1	27	35	PF00400	0.657
DEG_Nend_UBRbox_1	1	4	PF02207	0.668
DEG_SCF_FBW7_1	279	284	PF00400	0.535
DEG_SPOP_SBC_1	21	25	PF00917	0.630
DOC_ANK_TNKS_1	425	432	PF00023	0.465
DOC_CYCLIN_RxL_1	408	419	PF00134	0.516
DOC_MAPK_gen_1	408	418	PF00069	0.517
DOC_PP2B_LxvP_1	301	304	PF13499	0.659
DOC_PP2B_LxvP_1	32	35	PF13499	0.637
DOC_USP7_MATH_1	124	128	PF00917	0.575
DOC_USP7_MATH_1	194	198	PF00917	0.641
DOC_USP7_MATH_1	259	263	PF00917	0.724
DOC_USP7_MATH_1	58	62	PF00917	0.698
DOC_USP7_MATH_1	98	102	PF00917	0.705
DOC_WW_Pin1_4	180	185	PF00397	0.663
DOC_WW_Pin1_4	199	204	PF00397	0.542
DOC_WW_Pin1_4	247	252	PF00397	0.689
DOC_WW_Pin1_4	277	282	PF00397	0.566
DOC_WW_Pin1_4	305	310	PF00397	0.607
DOC_WW_Pin1_4	346	351	PF00397	0.633
DOC_WW_Pin1_4	5	10	PF00397	0.637
DOC_WW_Pin1_4	72	77	PF00397	0.688
LIG_14-3-3_CanoR_1	147	152	PF00244	0.500
LIG_14-3-3_CanoR_1	195	203	PF00244	0.548
LIG_14-3-3_CanoR_1	267	274	PF00244	0.674
LIG_14-3-3_CanoR_1	333	338	PF00244	0.602
LIG_14-3-3_CanoR_1	49	58	PF00244	0.644
LIG_14-3-3_CanoR_1	90	97	PF00244	0.706
LIG_BRCT_BRCA1_1	225	229	PF00533	0.657
LIG_Clathr_ClatBox_1	415	419	PF01394	0.500
LIG_FHA_1	177	183	PF00498	0.654
LIG_FHA_1	368	374	PF00498	0.660
LIG_FHA_1	92	98	PF00498	0.532
LIG_FHA_2	22	28	PF00498	0.639
LIG_FHA_2	253	259	PF00498	0.581
LIG_FHA_2	282	288	PF00498	0.544
LIG_FHA_2	347	353	PF00498	0.651
LIG_FHA_2	422	428	PF00498	0.497
LIG_LIR_Nem_3	104	110	PF02991	0.574
LIG_LIR_Nem_3	113	118	PF02991	0.452
LIG_NRBOX	411	417	PF00104	0.511
LIG_PDZ_Class_2	433	438	PF00595	0.533
LIG_RPA_C_Fungi	334	346	PF08784	0.542
LIG_SH2_CRK	115	119	PF00017	0.507
LIG_SH2_STAP1	151	155	PF00017	0.549
LIG_SH2_STAP1	337	341	PF00017	0.530
LIG_SH3_3	182	188	PF00018	0.531
LIG_SH3_3	294	300	PF00018	0.664
LIG_SH3_3	37	43	PF00018	0.648
LIG_SH3_3	70	76	PF00018	0.702
LIG_SUMO_SIM_par_1	414	419	PF11976	0.505
LIG_WRPW_2	107	110	PF00400	0.562
LIG_WW_3	235	239	PF00397	0.668
LIG_WW_3	245	249	PF00397	0.551
LIG_WW_3	264	268	PF00397	0.501
LIG_WW_3	303	307	PF00397	0.644
MOD_CDC14_SPxK_1	8	11	PF00782	0.661
MOD_CDK_SPxK_1	5	11	PF00069	0.660
MOD_CK1_1	10	16	PF00069	0.668
MOD_CK1_1	101	107	PF00069	0.564
MOD_CK1_1	111	117	PF00069	0.615
MOD_CK1_1	183	189	PF00069	0.790
MOD_CK1_1	199	205	PF00069	0.825
MOD_CK1_1	218	224	PF00069	0.578
MOD_CK1_1	23	29	PF00069	0.520
MOD_CK1_1	89	95	PF00069	0.730
MOD_CK2_1	21	27	PF00069	0.638
MOD_CK2_1	252	258	PF00069	0.579
MOD_CK2_1	281	287	PF00069	0.674
MOD_CK2_1	346	352	PF00069	0.536
MOD_CK2_1	421	427	PF00069	0.495
MOD_GlcNHglycan	103	106	PF01048	0.668
MOD_GlcNHglycan	12	15	PF01048	0.740
MOD_GlcNHglycan	126	129	PF01048	0.592
MOD_GlcNHglycan	198	201	PF01048	0.721
MOD_GlcNHglycan	223	226	PF01048	0.664
MOD_GlcNHglycan	261	264	PF01048	0.753
MOD_GlcNHglycan	269	272	PF01048	0.743
MOD_GlcNHglycan	301	304	PF01048	0.659
MOD_GlcNHglycan	356	360	PF01048	0.646
MOD_GlcNHglycan	362	365	PF01048	0.618
MOD_GlcNHglycan	375	378	PF01048	0.518
MOD_GlcNHglycan	392	395	PF01048	0.666
MOD_GlcNHglycan	61	64	PF01048	0.624
MOD_GlcNHglycan	91	94	PF01048	0.680
MOD_GSK3_1	110	117	PF00069	0.544
MOD_GSK3_1	176	183	PF00069	0.742
MOD_GSK3_1	195	202	PF00069	0.729
MOD_GSK3_1	205	212	PF00069	0.675
MOD_GSK3_1	213	220	PF00069	0.601
MOD_GSK3_1	223	230	PF00069	0.553
MOD_GSK3_1	253	260	PF00069	0.661
MOD_GSK3_1	277	284	PF00069	0.570
MOD_GSK3_1	30	37	PF00069	0.613
MOD_GSK3_1	72	79	PF00069	0.689
MOD_GSK3_1	89	96	PF00069	0.610
MOD_N-GLC_1	101	106	PF02516	0.606
MOD_N-GLC_1	180	185	PF02516	0.761
MOD_NEK2_1	20	25	PF00069	0.705
MOD_NEK2_1	421	426	PF00069	0.492
MOD_PIKK_1	339	345	PF00454	0.546
MOD_PKA_2	124	130	PF00069	0.582
MOD_PKA_2	194	200	PF00069	0.682
MOD_PKA_2	237	243	PF00069	0.644
MOD_PKA_2	89	95	PF00069	0.722
MOD_PKB_1	145	153	PF00069	0.505
MOD_PKB_1	331	339	PF00069	0.593
MOD_Plk_4	114	120	PF00069	0.505
MOD_ProDKin_1	180	186	PF00069	0.666
MOD_ProDKin_1	199	205	PF00069	0.541
MOD_ProDKin_1	247	253	PF00069	0.690
MOD_ProDKin_1	277	283	PF00069	0.568
MOD_ProDKin_1	305	311	PF00069	0.608
MOD_ProDKin_1	346	352	PF00069	0.636
MOD_ProDKin_1	5	11	PF00069	0.640
MOD_ProDKin_1	72	78	PF00069	0.687
MOD_SUMO_rev_2	168	175	PF00179	0.500
TRG_DiLeu_BaEn_1	27	32	PF01217	0.655
TRG_DiLeu_BaLyEn_6	411	416	PF01217	0.513
TRG_ENDOCYTIC_2	115	118	PF00928	0.511
TRG_ER_diArg_1	320	322	PF00400	0.595
TRG_ER_diArg_1	328	331	PF00400	0.527
TRG_ER_diArg_1	345	347	PF00400	0.628
TRG_ER_diArg_1	432	434	PF00400	0.646
TRG_NLS_Bipartite_1	328	348	PF00514	0.547
TRG_NLS_MonoCore_2	343	348	PF00514	0.561
TRG_NLS_MonoExtC_3	343	348	PF00514	0.595
TRG_Pf-PMV_PEXEL_1	322	326	PF00026	0.537
TRG_Pf-PMV_PEXEL_1	414	419	PF00026	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H638	Leishmania donovani	89%	100%
A4HTH7	Leishmania infantum	89%	100%
E9AMA5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%