Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania major

UniProt:

Q4QIE2_LEIMA

TriTrypDb:

LmjF.08.0270 , LMJLV39_080007700 , LMJSD75_080007700

Length:

808

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QIE2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIE2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	231	235	PF00656	0.650
CLV_C14_Caspase3-7	419	423	PF00656	0.705
CLV_C14_Caspase3-7	536	540	PF00656	0.649
CLV_C14_Caspase3-7	618	622	PF00656	0.787
CLV_C14_Caspase3-7	753	757	PF00656	0.596
CLV_NRD_NRD_1	202	204	PF00675	0.649
CLV_NRD_NRD_1	380	382	PF00675	0.782
CLV_NRD_NRD_1	388	390	PF00675	0.699
CLV_NRD_NRD_1	425	427	PF00675	0.777
CLV_NRD_NRD_1	525	527	PF00675	0.707
CLV_NRD_NRD_1	553	555	PF00675	0.758
CLV_NRD_NRD_1	565	567	PF00675	0.621
CLV_NRD_NRD_1	568	570	PF00675	0.585
CLV_NRD_NRD_1	618	620	PF00675	0.633
CLV_NRD_NRD_1	748	750	PF00675	0.710
CLV_NRD_NRD_1	785	787	PF00675	0.739
CLV_NRD_NRD_1	92	94	PF00675	0.746
CLV_PCSK_FUR_1	563	567	PF00082	0.705
CLV_PCSK_FUR_1	90	94	PF00082	0.746
CLV_PCSK_KEX2_1	113	115	PF00082	0.805
CLV_PCSK_KEX2_1	117	119	PF00082	0.798
CLV_PCSK_KEX2_1	159	161	PF00082	0.623
CLV_PCSK_KEX2_1	202	204	PF00082	0.649
CLV_PCSK_KEX2_1	380	382	PF00082	0.781
CLV_PCSK_KEX2_1	388	390	PF00082	0.657
CLV_PCSK_KEX2_1	525	527	PF00082	0.707
CLV_PCSK_KEX2_1	553	555	PF00082	0.764
CLV_PCSK_KEX2_1	565	567	PF00082	0.624
CLV_PCSK_KEX2_1	568	570	PF00082	0.580
CLV_PCSK_KEX2_1	66	68	PF00082	0.665
CLV_PCSK_KEX2_1	748	750	PF00082	0.710
CLV_PCSK_KEX2_1	776	778	PF00082	0.734
CLV_PCSK_KEX2_1	785	787	PF00082	0.625
CLV_PCSK_KEX2_1	92	94	PF00082	0.746
CLV_PCSK_PC1ET2_1	113	115	PF00082	0.750
CLV_PCSK_PC1ET2_1	117	119	PF00082	0.759
CLV_PCSK_PC1ET2_1	159	161	PF00082	0.623
CLV_PCSK_PC1ET2_1	66	68	PF00082	0.672
CLV_PCSK_PC1ET2_1	776	778	PF00082	0.734
CLV_PCSK_PC7_1	155	161	PF00082	0.611
CLV_PCSK_SKI1_1	159	163	PF00082	0.572
CLV_PCSK_SKI1_1	169	173	PF00082	0.599
CLV_PCSK_SKI1_1	25	29	PF00082	0.706
CLV_PCSK_SKI1_1	389	393	PF00082	0.774
CLV_PCSK_SKI1_1	63	67	PF00082	0.651
CLV_PCSK_SKI1_1	721	725	PF00082	0.772
CLV_PCSK_SKI1_1	748	752	PF00082	0.566
DEG_ODPH_VHL_1	331	343	PF01847	0.726
DEG_SPOP_SBC_1	119	123	PF00917	0.773
DEG_SPOP_SBC_1	390	394	PF00917	0.727
DEG_SPOP_SBC_1	713	717	PF00917	0.609
DOC_CKS1_1	799	804	PF01111	0.556
DOC_CYCLIN_yCln2_LP_2	724	730	PF00134	0.700
DOC_MAPK_gen_1	790	799	PF00069	0.722
DOC_MAPK_MEF2A_6	721	730	PF00069	0.740
DOC_PP2B_LxvP_1	346	349	PF13499	0.543
DOC_PP2B_LxvP_1	458	461	PF13499	0.825
DOC_PP2B_LxvP_1	724	727	PF13499	0.703
DOC_USP7_MATH_1	119	123	PF00917	0.703
DOC_USP7_MATH_1	27	31	PF00917	0.695
DOC_USP7_MATH_1	273	277	PF00917	0.736
DOC_USP7_MATH_1	303	307	PF00917	0.822
DOC_USP7_MATH_1	333	337	PF00917	0.780
DOC_USP7_MATH_1	391	395	PF00917	0.847
DOC_USP7_MATH_1	445	449	PF00917	0.707
DOC_USP7_MATH_1	506	510	PF00917	0.796
DOC_USP7_MATH_1	532	536	PF00917	0.719
DOC_USP7_MATH_1	604	608	PF00917	0.676
DOC_USP7_MATH_1	648	652	PF00917	0.625
DOC_USP7_MATH_1	672	676	PF00917	0.723
DOC_USP7_MATH_1	713	717	PF00917	0.671
DOC_USP7_MATH_1	763	767	PF00917	0.695
DOC_USP7_MATH_1	82	86	PF00917	0.776
DOC_USP7_UBL2_3	113	117	PF12436	0.624
DOC_USP7_UBL2_3	79	83	PF12436	0.853
DOC_WW_Pin1_4	253	258	PF00397	0.821
DOC_WW_Pin1_4	325	330	PF00397	0.779
DOC_WW_Pin1_4	428	433	PF00397	0.749
DOC_WW_Pin1_4	623	628	PF00397	0.789
DOC_WW_Pin1_4	634	639	PF00397	0.652
DOC_WW_Pin1_4	646	651	PF00397	0.622
DOC_WW_Pin1_4	71	76	PF00397	0.818
DOC_WW_Pin1_4	716	721	PF00397	0.706
DOC_WW_Pin1_4	759	764	PF00397	0.714
DOC_WW_Pin1_4	798	803	PF00397	0.555
LIG_14-3-3_CanoR_1	31	36	PF00244	0.610
LIG_14-3-3_CanoR_1	318	326	PF00244	0.760
LIG_14-3-3_CanoR_1	467	477	PF00244	0.589
LIG_14-3-3_CanoR_1	497	507	PF00244	0.700
LIG_14-3-3_CanoR_1	566	574	PF00244	0.781
LIG_14-3-3_CanoR_1	643	648	PF00244	0.686
LIG_14-3-3_CanoR_1	67	75	PF00244	0.714
LIG_14-3-3_CanoR_1	749	755	PF00244	0.690
LIG_14-3-3_CanoR_1	90	99	PF00244	0.780
LIG_Actin_WH2_2	154	171	PF00022	0.718
LIG_BIR_II_1	1	5	PF00653	0.860
LIG_Clathr_ClatBox_1	453	457	PF01394	0.711
LIG_deltaCOP1_diTrp_1	740	743	PF00928	0.678
LIG_FHA_1	381	387	PF00498	0.763
LIG_FHA_1	407	413	PF00498	0.776
LIG_FHA_1	449	455	PF00498	0.787
LIG_FHA_1	656	662	PF00498	0.746
LIG_FHA_1	679	685	PF00498	0.799
LIG_FHA_1	713	719	PF00498	0.638
LIG_FHA_2	121	127	PF00498	0.840
LIG_FHA_2	398	404	PF00498	0.649
LIG_FHA_2	484	490	PF00498	0.638
LIG_FHA_2	534	540	PF00498	0.732
LIG_FHA_2	590	596	PF00498	0.769
LIG_FHA_2	751	757	PF00498	0.592
LIG_FHA_2	799	805	PF00498	0.555
LIG_IRF3_LxIS_1	802	808	PF10401	0.709
LIG_LIR_Gen_1	150	161	PF02991	0.638
LIG_LIR_Gen_1	336	346	PF02991	0.782
LIG_LIR_Gen_1	735	743	PF02991	0.668
LIG_LIR_Nem_3	150	156	PF02991	0.626
LIG_LIR_Nem_3	334	340	PF02991	0.678
LIG_LIR_Nem_3	580	584	PF02991	0.741
LIG_LIR_Nem_3	735	739	PF02991	0.697
LIG_LYPXL_S_1	724	728	PF13949	0.703
LIG_LYPXL_yS_3	725	728	PF13949	0.702
LIG_MYND_1	329	333	PF01753	0.685
LIG_PAM2_1	716	728	PF00658	0.593
LIG_Pex14_1	577	581	PF04695	0.736
LIG_SH2_CRK	338	342	PF00017	0.623
LIG_SH2_CRK	584	588	PF00017	0.747
LIG_SH2_GRB2like	584	587	PF00017	0.745
LIG_SH2_NCK_1	584	588	PF00017	0.747
LIG_SH2_NCK_1	736	740	PF00017	0.755
LIG_SH2_SRC	584	587	PF00017	0.745
LIG_SH2_STAT3	57	60	PF00017	0.541
LIG_SH2_STAT5	130	133	PF00017	0.711
LIG_SH2_STAT5	342	345	PF00017	0.644
LIG_SH2_STAT5	411	414	PF00017	0.633
LIG_SH3_1	426	432	PF00018	0.775
LIG_SH3_3	192	198	PF00018	0.759
LIG_SH3_3	422	428	PF00018	0.769
LIG_SH3_3	644	650	PF00018	0.754
LIG_SH3_3	698	704	PF00018	0.773
LIG_SH3_3	81	87	PF00018	0.754
LIG_SUMO_SIM_par_1	38	43	PF11976	0.689
LIG_SUMO_SIM_par_1	403	410	PF11976	0.756
LIG_SUMO_SIM_par_1	656	665	PF11976	0.749
LIG_TRAF2_1	122	125	PF00917	0.806
LIG_TRAF2_1	282	285	PF00917	0.695
LIG_TRAF2_1	7	10	PF00917	0.618
LIG_TRAF2_2	294	299	PF00917	0.724
MOD_CDK_SPK_2	634	639	PF00069	0.752
MOD_CDK_SPK_2	71	76	PF00069	0.701
MOD_CDK_SPK_2	716	721	PF00069	0.601
MOD_CK1_1	128	134	PF00069	0.754
MOD_CK1_1	15	21	PF00069	0.542
MOD_CK1_1	2	8	PF00069	0.780
MOD_CK1_1	240	246	PF00069	0.848
MOD_CK1_1	276	282	PF00069	0.784
MOD_CK1_1	355	361	PF00069	0.747
MOD_CK1_1	431	437	PF00069	0.635
MOD_CK1_1	448	454	PF00069	0.621
MOD_CK1_1	491	497	PF00069	0.675
MOD_CK1_1	499	505	PF00069	0.703
MOD_CK1_1	509	515	PF00069	0.567
MOD_CK1_1	607	613	PF00069	0.738
MOD_CK1_1	688	694	PF00069	0.742
MOD_CK1_1	716	722	PF00069	0.765
MOD_CK2_1	118	124	PF00069	0.807
MOD_CK2_1	303	309	PF00069	0.603
MOD_CK2_1	397	403	PF00069	0.593
MOD_CK2_1	468	474	PF00069	0.736
MOD_CK2_1	483	489	PF00069	0.582
MOD_CK2_1	590	596	PF00069	0.656
MOD_CK2_1	672	678	PF00069	0.722
MOD_GlcNHglycan	1	4	PF01048	0.861
MOD_GlcNHglycan	100	103	PF01048	0.830
MOD_GlcNHglycan	124	130	PF01048	0.729
MOD_GlcNHglycan	243	246	PF01048	0.776
MOD_GlcNHglycan	267	270	PF01048	0.707
MOD_GlcNHglycan	354	357	PF01048	0.647
MOD_GlcNHglycan	44	47	PF01048	0.645
MOD_GlcNHglycan	447	450	PF01048	0.781
MOD_GlcNHglycan	508	511	PF01048	0.648
MOD_GlcNHglycan	607	610	PF01048	0.778
MOD_GlcNHglycan	756	759	PF01048	0.729
MOD_GlcNHglycan	765	768	PF01048	0.674
MOD_GSK3_1	237	244	PF00069	0.788
MOD_GSK3_1	253	260	PF00069	0.618
MOD_GSK3_1	27	34	PF00069	0.634
MOD_GSK3_1	389	396	PF00069	0.817
MOD_GSK3_1	498	505	PF00069	0.734
MOD_GSK3_1	639	646	PF00069	0.755
MOD_GSK3_1	653	660	PF00069	0.652
MOD_GSK3_1	66	73	PF00069	0.700
MOD_GSK3_1	674	681	PF00069	0.727
MOD_GSK3_1	712	719	PF00069	0.687
MOD_GSK3_1	750	757	PF00069	0.672
MOD_GSK3_1	759	766	PF00069	0.665
MOD_GSK3_1	78	85	PF00069	0.662
MOD_GSK3_1	98	105	PF00069	0.592
MOD_N-GLC_1	240	245	PF02516	0.735
MOD_N-GLC_1	467	472	PF02516	0.850
MOD_N-GLC_1	499	504	PF02516	0.597
MOD_N-GLC_1	691	696	PF02516	0.782
MOD_NEK2_1	35	40	PF00069	0.656
MOD_NEK2_1	352	357	PF00069	0.690
MOD_NEK2_1	406	411	PF00069	0.784
MOD_NEK2_1	478	483	PF00069	0.748
MOD_NEK2_1	490	495	PF00069	0.643
MOD_NEK2_1	567	572	PF00069	0.559
MOD_NEK2_1	662	667	PF00069	0.829
MOD_NEK2_2	164	169	PF00069	0.708
MOD_PIKK_1	2	8	PF00454	0.663
MOD_PIKK_1	273	279	PF00454	0.728
MOD_PIKK_1	317	323	PF00454	0.674
MOD_PIKK_1	40	46	PF00454	0.691
MOD_PIKK_1	468	474	PF00454	0.601
MOD_PIKK_1	520	526	PF00454	0.712
MOD_PIKK_1	629	635	PF00454	0.754
MOD_PIKK_1	66	72	PF00454	0.696
MOD_PIKK_1	691	697	PF00454	0.628
MOD_PIKK_1	82	88	PF00454	0.627
MOD_PK_1	568	574	PF00069	0.715
MOD_PKA_1	380	386	PF00069	0.803
MOD_PKA_1	568	574	PF00069	0.707
MOD_PKA_1	66	72	PF00069	0.696
MOD_PKA_2	15	21	PF00069	0.769
MOD_PKA_2	317	323	PF00069	0.764
MOD_PKA_2	380	386	PF00069	0.841
MOD_PKA_2	496	502	PF00069	0.740
MOD_PKA_2	567	573	PF00069	0.789
MOD_PKA_2	66	72	PF00069	0.696
MOD_PKA_2	91	97	PF00069	0.852
MOD_PKB_1	566	574	PF00069	0.707
MOD_Plk_1	333	339	PF00069	0.716
MOD_Plk_1	685	691	PF00069	0.653
MOD_Plk_2-3	120	126	PF00069	0.804
MOD_Plk_4	35	41	PF00069	0.585
MOD_Plk_4	407	413	PF00069	0.776
MOD_Plk_4	568	574	PF00069	0.793
MOD_Plk_4	648	654	PF00069	0.669
MOD_Plk_4	657	663	PF00069	0.740
MOD_Plk_4	765	771	PF00069	0.766
MOD_ProDKin_1	253	259	PF00069	0.821
MOD_ProDKin_1	325	331	PF00069	0.776
MOD_ProDKin_1	428	434	PF00069	0.750
MOD_ProDKin_1	623	629	PF00069	0.790
MOD_ProDKin_1	634	640	PF00069	0.649
MOD_ProDKin_1	646	652	PF00069	0.621
MOD_ProDKin_1	71	77	PF00069	0.820
MOD_ProDKin_1	716	722	PF00069	0.703
MOD_ProDKin_1	759	765	PF00069	0.710
MOD_ProDKin_1	798	804	PF00069	0.555
MOD_SUMO_rev_2	612	622	PF00179	0.628
MOD_SUMO_rev_2	674	681	PF00179	0.722
TRG_ENDOCYTIC_2	337	340	PF00928	0.627
TRG_ENDOCYTIC_2	725	728	PF00928	0.797
TRG_ENDOCYTIC_2	736	739	PF00928	0.595
TRG_ER_diArg_1	201	203	PF00400	0.662
TRG_ER_diArg_1	380	382	PF00400	0.793
TRG_ER_diArg_1	387	389	PF00400	0.704
TRG_ER_diArg_1	525	527	PF00400	0.590
TRG_ER_diArg_1	552	554	PF00400	0.765
TRG_ER_diArg_1	563	566	PF00400	0.620
TRG_ER_diArg_1	567	569	PF00400	0.569
TRG_ER_diArg_1	663	666	PF00400	0.651
TRG_ER_diArg_1	785	787	PF00400	0.697
TRG_ER_diArg_1	90	93	PF00400	0.748
TRG_Pf-PMV_PEXEL_1	160	165	PF00026	0.560

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H639	Leishmania donovani	82%	97%
A4H594	Leishmania braziliensis	45%	94%
A4HTH8	Leishmania infantum	82%	97%
E9AMA6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	97%