Isochorismatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Isochorismatase family, putative

Species:

Leishmania major

UniProt:

Q4QID9_LEIMA

TriTrypDb:

LmjF.08.0300 , LMJLV39_080008000 , LMJSD75_080008000

Length:

252

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 18
NetGPI	no	yes: 0, no: 20

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QID9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QID9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	164	166	PF00675	0.291
CLV_NRD_NRD_1	180	182	PF00675	0.225
CLV_NRD_NRD_1	31	33	PF00675	0.491
CLV_NRD_NRD_1	38	40	PF00675	0.304
CLV_PCSK_KEX2_1	164	166	PF00082	0.289
CLV_PCSK_KEX2_1	180	182	PF00082	0.204
CLV_PCSK_KEX2_1	232	234	PF00082	0.537
CLV_PCSK_KEX2_1	236	238	PF00082	0.515
CLV_PCSK_KEX2_1	30	32	PF00082	0.487
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.518
CLV_PCSK_PC1ET2_1	236	238	PF00082	0.490
CLV_PCSK_SKI1_1	39	43	PF00082	0.388
CLV_PCSK_SKI1_1	45	49	PF00082	0.321
CLV_Separin_Metazoa	161	165	PF03568	0.503
DEG_SIAH_1	108	116	PF03145	0.410
DEG_SIAH_1	14	22	PF03145	0.471
DOC_CYCLIN_yClb3_PxF_3	108	114	PF00134	0.476
DOC_MAPK_gen_1	164	171	PF00069	0.474
DOC_MAPK_gen_1	180	188	PF00069	0.455
DOC_MAPK_MEF2A_6	236	245	PF00069	0.372
DOC_MAPK_RevD_3	17	31	PF00069	0.452
DOC_PP1_RVXF_1	58	65	PF00149	0.373
DOC_PP4_FxxP_1	231	234	PF00568	0.656
DOC_USP7_UBL2_3	232	236	PF12436	0.601
DOC_USP7_UBL2_3	56	60	PF12436	0.503
LIG_14-3-3_CanoR_1	30	38	PF00244	0.561
LIG_14-3-3_CanoR_1	39	48	PF00244	0.444
LIG_14-3-3_CterR_2	250	252	PF00244	0.495
LIG_Actin_WH2_2	149	166	PF00022	0.503
LIG_APCC_ABBA_1	74	79	PF00400	0.503
LIG_BIR_II_1	1	5	PF00653	0.687
LIG_BRCT_BRCA1_1	6	10	PF00533	0.436
LIG_FHA_1	198	204	PF00498	0.425
LIG_FHA_1	20	26	PF00498	0.514
LIG_FHA_1	205	211	PF00498	0.359
LIG_FHA_1	240	246	PF00498	0.391
LIG_FHA_1	32	38	PF00498	0.422
LIG_FHA_1	65	71	PF00498	0.504
LIG_FHA_2	156	162	PF00498	0.525
LIG_FHA_2	7	13	PF00498	0.488
LIG_LIR_Gen_1	75	85	PF02991	0.428
LIG_LIR_Nem_3	192	197	PF02991	0.509
LIG_LIR_Nem_3	214	220	PF02991	0.349
LIG_LIR_Nem_3	84	88	PF02991	0.466
LIG_SH2_CRK	206	210	PF00017	0.390
LIG_SH2_CRK	85	89	PF00017	0.429
LIG_SH2_SRC	129	132	PF00017	0.503
LIG_SH2_STAP1	149	153	PF00017	0.373
LIG_SH2_STAP1	206	210	PF00017	0.390
LIG_SH2_STAT5	129	132	PF00017	0.508
LIG_SH2_STAT5	206	209	PF00017	0.371
LIG_SH2_STAT5	85	88	PF00017	0.465
LIG_SH3_3	106	112	PF00018	0.419
LIG_SH3_3	213	219	PF00018	0.352
LIG_SH3_3	22	28	PF00018	0.641
LIG_SH3_3	238	244	PF00018	0.452
LIG_SH3_3	89	95	PF00018	0.542
LIG_SH3_4	218	225	PF00018	0.427
LIG_SUMO_SIM_anti_2	185	190	PF11976	0.503
LIG_TRAF2_1	244	247	PF00917	0.447
LIG_UBA3_1	188	193	PF00899	0.500
MOD_CK2_1	155	161	PF00069	0.508
MOD_GSK3_1	1	8	PF00069	0.697
MOD_GSK3_1	19	26	PF00069	0.605
MOD_GSK3_1	235	242	PF00069	0.535
MOD_GSK3_1	39	46	PF00069	0.324
MOD_GSK3_1	64	71	PF00069	0.504
MOD_N-GLC_1	64	69	PF02516	0.293
MOD_N-GLC_1	72	77	PF02516	0.298
MOD_NEK2_1	1	6	PF00069	0.697
MOD_NEK2_1	189	194	PF00069	0.520
MOD_NEK2_1	197	202	PF00069	0.367
MOD_NEK2_1	64	69	PF00069	0.495
MOD_NEK2_1	81	86	PF00069	0.416
MOD_PIKK_1	32	38	PF00454	0.496
MOD_PKA_1	31	37	PF00069	0.421
MOD_PKA_1	39	45	PF00069	0.302
MOD_PKA_2	19	25	PF00069	0.497
MOD_PKA_2	31	37	PF00069	0.383
MOD_PKA_2	68	74	PF00069	0.434
MOD_PKB_1	30	38	PF00069	0.410
MOD_Plk_1	23	29	PF00069	0.683
MOD_Plk_1	64	70	PF00069	0.414
MOD_Plk_1	72	78	PF00069	0.420
MOD_Plk_4	117	123	PF00069	0.469
MOD_Plk_4	204	210	PF00069	0.305
MOD_SUMO_for_1	115	118	PF00179	0.410
TRG_DiLeu_BaEn_1	118	123	PF01217	0.456
TRG_ENDOCYTIC_2	102	105	PF00928	0.384
TRG_ENDOCYTIC_2	206	209	PF00928	0.393
TRG_ENDOCYTIC_2	85	88	PF00928	0.584
TRG_ER_diArg_1	163	165	PF00400	0.503
TRG_ER_diArg_1	180	182	PF00400	0.503
TRG_ER_diArg_1	30	32	PF00400	0.508
TRG_Pf-PMV_PEXEL_1	180	185	PF00026	0.229

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P932	Leptomonas seymouri	70%	100%
A0A0N1HWD2	Leptomonas seymouri	31%	100%
A0A0N1I400	Leptomonas seymouri	39%	100%
A0A0N1IAK4	Leptomonas seymouri	47%	100%
A0A0S4IVV9	Bodo saltans	33%	100%
A0A1X0NQH8	Trypanosomatidae	39%	100%
A0A3S5H641	Leishmania donovani	88%	100%
A0A3S5H642	Leishmania donovani	50%	100%
A0A3S5IQS6	Trypanosoma rangeli	36%	100%
A0A3S7WQ71	Leishmania donovani	38%	82%
A0JME6	Danio rerio	29%	100%
A4H5A0	Leishmania braziliensis	76%	100%
A4H5A1	Leishmania braziliensis	39%	85%
A4H5A2	Leishmania braziliensis	53%	100%
A4H6S1	Leishmania braziliensis	30%	100%
A4HTI1	Leishmania infantum	88%	100%
A4HTI2	Leishmania infantum	38%	82%
A4HTI3	Leishmania infantum	50%	100%
A4HV50	Leishmania infantum	30%	100%
A6QLY4	Bos taurus	34%	85%
B5X0W9	Salmo salar	35%	89%
D0VWV0	Leishmania donovani	30%	100%
E9AMA9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9AMB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	92%
E9AMB1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
E9ANT2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
G4YEI5	Phytophthora sojae (strain P6497)	26%	100%
P85094	Mus musculus	30%	100%
Q08C33	Danio rerio	35%	89%
Q0IHU5	Xenopus tropicalis	33%	82%
Q32KX0	Bos taurus	28%	100%
Q4QGT7	Leishmania major	29%	100%
Q4QID7	Leishmania major	49%	100%
Q4QID8	Leishmania major	39%	81%
Q4R826	Macaca fascicularis	28%	100%
Q54NZ8	Dictyostelium discoideum	25%	100%
Q54RC7	Dictyostelium discoideum	28%	100%
Q5PQ71	Xenopus laevis	31%	100%
Q5PQA5	Xenopus laevis	33%	82%
Q5RC03	Pongo abelii	28%	100%
Q5U3Z3	Rattus norvegicus	32%	100%
Q6DF67	Xenopus tropicalis	33%	100%
Q6I7R3	Rattus norvegicus	35%	85%
Q91V64	Mus musculus	34%	85%
Q96AB3	Homo sapiens	28%	100%
Q96CN7	Homo sapiens	34%	85%
Q9DCC7	Mus musculus	32%	100%