Isochorismatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Isochorismatase family, putative

Species:

Leishmania major

UniProt:

Q4QID8_LEIMA

TriTrypDb:

LmjF.08.0310 , LMJLV39_080008100 , LMJSD75_080008100

Length:

311

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 15
NetGPI	no	yes: 0, no: 17

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QID8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QID8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	235	239	PF00656	0.365
CLV_C14_Caspase3-7	294	298	PF00656	0.475
CLV_NRD_NRD_1	18	20	PF00675	0.424
CLV_PCSK_KEX2_1	18	20	PF00082	0.424
CLV_PCSK_SKI1_1	110	114	PF00082	0.310
CLV_PCSK_SKI1_1	240	244	PF00082	0.392
CLV_PCSK_SKI1_1	70	74	PF00082	0.333
DEG_COP1_1	281	289	PF00400	0.475
DEG_Nend_UBRbox_1	1	4	PF02207	0.468
DEG_SPOP_SBC_1	84	88	PF00917	0.375
DOC_MAPK_DCC_7	143	153	PF00069	0.274
DOC_MAPK_gen_1	240	248	PF00069	0.423
DOC_MAPK_MEF2A_6	240	248	PF00069	0.385
DOC_PP1_RVXF_1	17	24	PF00149	0.427
DOC_PP2B_PxIxI_1	243	249	PF00149	0.330
DOC_PP4_FxxP_1	241	244	PF00568	0.400
DOC_USP7_MATH_1	108	112	PF00917	0.429
DOC_USP7_MATH_1	285	289	PF00917	0.521
DOC_USP7_MATH_1	301	305	PF00917	0.404
DOC_USP7_MATH_1	84	88	PF00917	0.375
DOC_WW_Pin1_4	10	15	PF00397	0.443
LIG_14-3-3_CanoR_1	143	147	PF00244	0.326
LIG_14-3-3_CanoR_1	8	16	PF00244	0.445
LIG_FHA_1	142	148	PF00498	0.360
LIG_FHA_1	187	193	PF00498	0.465
LIG_FHA_1	203	209	PF00498	0.385
LIG_FHA_1	4	10	PF00498	0.447
LIG_FHA_2	181	187	PF00498	0.524
LIG_FHA_2	233	239	PF00498	0.377
LIG_FHA_2	292	298	PF00498	0.484
LIG_LIR_Apic_2	238	244	PF02991	0.520
LIG_LIR_Nem_3	217	222	PF02991	0.465
LIG_Pex14_2	252	256	PF04695	0.345
LIG_SH3_1	45	51	PF00018	0.477
LIG_SH3_3	45	51	PF00018	0.687
LIG_SH3_4	243	250	PF00018	0.434
LIG_UBA3_1	245	251	PF00899	0.399
MOD_CK1_1	25	31	PF00069	0.457
MOD_CK1_1	57	63	PF00069	0.496
MOD_GlcNHglycan	228	231	PF01048	0.417
MOD_GlcNHglycan	26	30	PF01048	0.465
MOD_GlcNHglycan	270	273	PF01048	0.671
MOD_GlcNHglycan	287	290	PF01048	0.535
MOD_GlcNHglycan	303	306	PF01048	0.535
MOD_GlcNHglycan	56	59	PF01048	0.451
MOD_GSK3_1	10	17	PF00069	0.424
MOD_GSK3_1	222	229	PF00069	0.360
MOD_GSK3_1	285	292	PF00069	0.521
MOD_NEK2_1	214	219	PF00069	0.503
MOD_NEK2_1	222	227	PF00069	0.386
MOD_NEK2_1	232	237	PF00069	0.432
MOD_NEK2_2	108	113	PF00069	0.375
MOD_PIKK_1	256	262	PF00454	0.432
MOD_PKA_2	142	148	PF00069	0.336
MOD_PKB_1	266	274	PF00069	0.484
MOD_Plk_1	108	114	PF00069	0.349
MOD_Plk_1	25	31	PF00069	0.461
MOD_Plk_4	142	148	PF00069	0.418
MOD_ProDKin_1	10	16	PF00069	0.443
TRG_DiLeu_BaEn_2	108	114	PF01217	0.332
TRG_DiLeu_BaLyEn_6	11	16	PF01217	0.415
TRG_DiLeu_BaLyEn_6	58	63	PF01217	0.400
TRG_NES_CRM1_1	186	199	PF08389	0.517

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P932	Leptomonas seymouri	38%	100%
A0A0N1I400	Leptomonas seymouri	57%	100%
A0A3S5H641	Leishmania donovani	38%	100%
A0A3S5H642	Leishmania donovani	43%	100%
A0A3S7WQ71	Leishmania donovani	79%	100%
A4H5A0	Leishmania braziliensis	40%	100%
A4H5A1	Leishmania braziliensis	67%	100%
A4H5A2	Leishmania braziliensis	46%	100%
A4HTI1	Leishmania infantum	38%	100%
A4HTI2	Leishmania infantum	79%	100%
A4HTI3	Leishmania infantum	43%	100%
E9AMA9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9AMB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
E9AMB1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
G4YEI5	Phytophthora sojae (strain P6497)	27%	100%
Q4QID7	Leishmania major	43%	100%
Q4QID9	Leishmania major	39%	100%