Cytochrome c oxidase subunit ApiCOX24

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QID2_LEIMA

TriTrypDb:

LmjF.08.0370 , LMJLV39_080008900 , LMJSD75_080008900

Length:

220

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

Q4QID2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QID2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	4	6	PF00675	0.450
CLV_PCSK_KEX2_1	193	195	PF00082	0.632
CLV_PCSK_KEX2_1	4	6	PF00082	0.451
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.632
CLV_PCSK_SKI1_1	214	218	PF00082	0.619
CLV_PCSK_SKI1_1	71	75	PF00082	0.417
DEG_MDM2_SWIB_1	124	131	PF02201	0.362
DOC_MAPK_FxFP_2	67	70	PF00069	0.619
DOC_MAPK_MEF2A_6	103	110	PF00069	0.617
DOC_MAPK_NFAT4_5	103	111	PF00069	0.615
DOC_PP4_FxxP_1	67	70	PF00568	0.629
DOC_USP7_MATH_1	208	212	PF00917	0.494
DOC_USP7_MATH_1	22	26	PF00917	0.714
DOC_USP7_UBL2_3	189	193	PF12436	0.427
DOC_WW_Pin1_4	18	23	PF00397	0.693
LIG_14-3-3_CanoR_1	107	117	PF00244	0.479
LIG_14-3-3_CanoR_1	23	29	PF00244	0.667
LIG_14-3-3_CanoR_1	4	12	PF00244	0.603
LIG_14-3-3_CanoR_1	87	93	PF00244	0.617
LIG_APCC_ABBA_1	60	65	PF00400	0.613
LIG_deltaCOP1_diTrp_1	141	147	PF00928	0.416
LIG_deltaCOP1_diTrp_1	183	188	PF00928	0.430
LIG_deltaCOP1_diTrp_1	209	220	PF00928	0.449
LIG_FHA_1	154	160	PF00498	0.472
LIG_FHA_1	198	204	PF00498	0.511
LIG_FHA_1	7	13	PF00498	0.625
LIG_FHA_2	79	85	PF00498	0.612
LIG_FHA_2	94	100	PF00498	0.597
LIG_KLC1_Yacidic_2	163	168	PF13176	0.400
LIG_LIR_Apic_2	168	173	PF02991	0.399
LIG_LIR_Apic_2	199	204	PF02991	0.425
LIG_LIR_Apic_2	65	70	PF02991	0.628
LIG_LIR_Gen_1	141	152	PF02991	0.414
LIG_LIR_Gen_1	180	190	PF02991	0.482
LIG_LIR_Nem_3	127	131	PF02991	0.320
LIG_LIR_Nem_3	141	147	PF02991	0.381
LIG_LIR_Nem_3	177	182	PF02991	0.446
LIG_LIR_Nem_3	31	36	PF02991	0.727
LIG_LIR_Nem_3	65	69	PF02991	0.618
LIG_MYND_3	157	161	PF01753	0.422
LIG_PDZ_Class_1	215	220	PF00595	0.489
LIG_Pex14_1	117	121	PF04695	0.393
LIG_Pex14_2	116	120	PF04695	0.360
LIG_Pex14_2	121	125	PF04695	0.367
LIG_Pex14_2	74	78	PF04695	0.708
LIG_SH2_STAP1	182	186	PF00017	0.439
LIG_SH2_STAT3	166	169	PF00017	0.421
LIG_SH2_STAT5	129	132	PF00017	0.324
LIG_SH2_STAT5	166	169	PF00017	0.413
LIG_SH2_STAT5	80	83	PF00017	0.610
LIG_SH3_3	152	158	PF00018	0.393
LIG_SH3_3	51	57	PF00018	0.671
LIG_SH3_3	73	79	PF00018	0.623
LIG_SH3_4	189	196	PF00018	0.426
LIG_TRAF2_1	81	84	PF00917	0.605
LIG_TRAF2_2	204	209	PF00917	0.421
MOD_CDK_SPK_2	18	23	PF00069	0.693
MOD_CK1_1	112	118	PF00069	0.350
MOD_CK1_1	127	133	PF00069	0.220
MOD_CK1_1	6	12	PF00069	0.716
MOD_CK1_1	92	98	PF00069	0.615
MOD_CK2_1	47	53	PF00069	0.719
MOD_CK2_1	78	84	PF00069	0.614
MOD_CK2_1	93	99	PF00069	0.600
MOD_CMANNOS	117	120	PF00535	0.306
MOD_GlcNHglycan	24	27	PF01048	0.508
MOD_GlcNHglycan	39	42	PF01048	0.500
MOD_GSK3_1	108	115	PF00069	0.506
MOD_GSK3_1	14	21	PF00069	0.734
MOD_GSK3_1	6	13	PF00069	0.741
MOD_GSK3_1	78	85	PF00069	0.609
MOD_GSK3_1	89	96	PF00069	0.611
MOD_N-GLC_1	108	113	PF02516	0.387
MOD_NEK2_1	108	113	PF00069	0.604
MOD_NEK2_1	124	129	PF00069	0.375
MOD_NEK2_1	3	8	PF00069	0.589
MOD_PK_1	82	88	PF00069	0.611
MOD_PKA_2	22	28	PF00069	0.723
MOD_PKA_2	3	9	PF00069	0.589
MOD_PKA_2	86	92	PF00069	0.615
MOD_Plk_1	82	88	PF00069	0.611
MOD_Plk_1	89	95	PF00069	0.613
MOD_Plk_4	112	118	PF00069	0.466
MOD_Plk_4	124	130	PF00069	0.335
MOD_ProDKin_1	18	24	PF00069	0.695
MOD_SUMO_rev_2	31	36	PF00179	0.672
MOD_SUMO_rev_2	72	79	PF00179	0.631
TRG_ENDOCYTIC_2	135	138	PF00928	0.383
TRG_ENDOCYTIC_2	182	185	PF00928	0.427
TRG_ER_diArg_1	3	5	PF00400	0.652
TRG_ER_diArg_1	36	39	PF00400	0.765
TRG_PTS1	217	220	PF00515	0.458

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P933	Leptomonas seymouri	81%	99%
A0A0S4IVJ7	Bodo saltans	66%	100%
A0A1X0NP20	Trypanosomatidae	72%	100%
A0A3S5H645	Leishmania donovani	96%	100%
A4H5A9	Leishmania braziliensis	89%	100%
A4HTI8	Leishmania infantum	96%	100%
C9ZPJ6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	100%
E9AMB6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5DHY0	Trypanosoma cruzi	72%	100%