TFA2_Winged_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QIC6_LEIMA

TriTrypDb:

LmjF.08.0430 , LMJLV39_080009500 , LMJSD75_080009500

Length:

925

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QIC6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIC6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	179	183	PF00656	0.654
CLV_C14_Caspase3-7	249	253	PF00656	0.591
CLV_NRD_NRD_1	143	145	PF00675	0.507
CLV_NRD_NRD_1	342	344	PF00675	0.524
CLV_NRD_NRD_1	400	402	PF00675	0.410
CLV_NRD_NRD_1	423	425	PF00675	0.513
CLV_NRD_NRD_1	428	430	PF00675	0.547
CLV_NRD_NRD_1	460	462	PF00675	0.540
CLV_NRD_NRD_1	467	469	PF00675	0.547
CLV_NRD_NRD_1	601	603	PF00675	0.514
CLV_NRD_NRD_1	697	699	PF00675	0.616
CLV_NRD_NRD_1	702	704	PF00675	0.644
CLV_NRD_NRD_1	746	748	PF00675	0.684
CLV_NRD_NRD_1	790	792	PF00675	0.588
CLV_PCSK_FUR_1	421	425	PF00082	0.507
CLV_PCSK_FUR_1	695	699	PF00082	0.617
CLV_PCSK_KEX2_1	145	147	PF00082	0.517
CLV_PCSK_KEX2_1	163	165	PF00082	0.457
CLV_PCSK_KEX2_1	342	344	PF00082	0.561
CLV_PCSK_KEX2_1	400	402	PF00082	0.420
CLV_PCSK_KEX2_1	423	425	PF00082	0.686
CLV_PCSK_KEX2_1	428	430	PF00082	0.547
CLV_PCSK_KEX2_1	467	469	PF00082	0.581
CLV_PCSK_KEX2_1	496	498	PF00082	0.517
CLV_PCSK_KEX2_1	601	603	PF00082	0.558
CLV_PCSK_KEX2_1	697	699	PF00082	0.616
CLV_PCSK_KEX2_1	702	704	PF00082	0.644
CLV_PCSK_KEX2_1	746	748	PF00082	0.685
CLV_PCSK_KEX2_1	754	756	PF00082	0.689
CLV_PCSK_KEX2_1	779	781	PF00082	0.489
CLV_PCSK_KEX2_1	790	792	PF00082	0.526
CLV_PCSK_KEX2_1	845	847	PF00082	0.575
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.517
CLV_PCSK_PC1ET2_1	163	165	PF00082	0.457
CLV_PCSK_PC1ET2_1	496	498	PF00082	0.552
CLV_PCSK_PC1ET2_1	754	756	PF00082	0.648
CLV_PCSK_PC1ET2_1	779	781	PF00082	0.489
CLV_PCSK_PC1ET2_1	845	847	PF00082	0.559
CLV_PCSK_PC7_1	159	165	PF00082	0.607
CLV_PCSK_PC7_1	424	430	PF00082	0.526
CLV_PCSK_PC7_1	698	704	PF00082	0.691
CLV_PCSK_PC7_1	775	781	PF00082	0.493
CLV_PCSK_SKI1_1	149	153	PF00082	0.513
CLV_PCSK_SKI1_1	478	482	PF00082	0.595
CLV_PCSK_SKI1_1	602	606	PF00082	0.557
CLV_PCSK_SKI1_1	755	759	PF00082	0.699
CLV_PCSK_SKI1_1	810	814	PF00082	0.472
CLV_PCSK_SKI1_1	845	849	PF00082	0.642
CLV_Separin_Metazoa	332	336	PF03568	0.469
CLV_Separin_Metazoa	458	462	PF03568	0.518
DEG_APCC_DBOX_1	347	355	PF00400	0.462
DEG_COP1_1	45	53	PF00400	0.415
DEG_SCF_FBW7_2	917	924	PF00400	0.577
DEG_SPOP_SBC_1	559	563	PF00917	0.677
DOC_CYCLIN_RxL_1	806	814	PF00134	0.468
DOC_CYCLIN_yCln2_LP_2	389	395	PF00134	0.391
DOC_MAPK_gen_1	342	351	PF00069	0.468
DOC_MAPK_gen_1	494	504	PF00069	0.537
DOC_MAPK_MEF2A_6	496	505	PF00069	0.722
DOC_MAPK_MEF2A_6	65	73	PF00069	0.439
DOC_MAPK_MEF2A_6	823	830	PF00069	0.539
DOC_MAPK_NFAT4_5	823	831	PF00069	0.595
DOC_PP1_RVXF_1	4	10	PF00149	0.447
DOC_PP2B_LxvP_1	20	23	PF13499	0.486
DOC_PP2B_LxvP_1	389	392	PF13499	0.485
DOC_PP4_FxxP_1	552	555	PF00568	0.541
DOC_USP7_MATH_1	133	137	PF00917	0.629
DOC_USP7_MATH_1	212	216	PF00917	0.779
DOC_USP7_MATH_1	559	563	PF00917	0.594
DOC_USP7_MATH_1	564	568	PF00917	0.575
DOC_USP7_MATH_1	631	635	PF00917	0.663
DOC_USP7_MATH_1	64	68	PF00917	0.533
DOC_USP7_MATH_1	681	685	PF00917	0.635
DOC_USP7_MATH_1	748	752	PF00917	0.588
DOC_USP7_MATH_1	778	782	PF00917	0.481
DOC_USP7_MATH_1	829	833	PF00917	0.546
DOC_USP7_MATH_1	868	872	PF00917	0.540
DOC_USP7_UBL2_3	141	145	PF12436	0.506
DOC_USP7_UBL2_3	148	152	PF12436	0.377
DOC_USP7_UBL2_3	219	223	PF12436	0.671
DOC_USP7_UBL2_3	490	494	PF12436	0.526
DOC_USP7_UBL2_3	841	845	PF12436	0.575
DOC_WW_Pin1_4	448	453	PF00397	0.605
DOC_WW_Pin1_4	53	58	PF00397	0.514
DOC_WW_Pin1_4	568	573	PF00397	0.571
DOC_WW_Pin1_4	917	922	PF00397	0.580
LIG_14-3-3_CanoR_1	428	434	PF00244	0.573
LIG_14-3-3_CanoR_1	515	520	PF00244	0.623
LIG_14-3-3_CanoR_1	653	658	PF00244	0.735
LIG_14-3-3_CanoR_1	702	709	PF00244	0.647
LIG_14-3-3_CanoR_1	725	730	PF00244	0.606
LIG_14-3-3_CanoR_1	823	829	PF00244	0.570
LIG_14-3-3_CanoR_1	846	852	PF00244	0.509
LIG_Actin_WH2_2	835	850	PF00022	0.578
LIG_BIR_II_1	1	5	PF00653	0.489
LIG_BIR_III_4	258	262	PF00653	0.625
LIG_BRCT_BRCA1_1	561	565	PF00533	0.582
LIG_Clathr_ClatBox_1	305	309	PF01394	0.443
LIG_Clathr_ClatBox_1	41	45	PF01394	0.397
LIG_eIF4E_1	300	306	PF01652	0.406
LIG_eIF4E_1	36	42	PF01652	0.582
LIG_FHA_1	112	118	PF00498	0.685
LIG_FHA_1	2	8	PF00498	0.441
LIG_FHA_1	22	28	PF00498	0.498
LIG_FHA_1	434	440	PF00498	0.637
LIG_FHA_1	45	51	PF00498	0.419
LIG_FHA_1	515	521	PF00498	0.555
LIG_FHA_2	189	195	PF00498	0.600
LIG_FHA_2	26	32	PF00498	0.472
LIG_FHA_2	325	331	PF00498	0.488
LIG_FHA_2	430	436	PF00498	0.547
LIG_FHA_2	438	444	PF00498	0.508
LIG_FHA_2	449	455	PF00498	0.537
LIG_FHA_2	524	530	PF00498	0.587
LIG_FHA_2	906	912	PF00498	0.797
LIG_GBD_Chelix_1	333	341	PF00786	0.398
LIG_LIR_Apic_2	297	303	PF02991	0.425
LIG_LIR_Apic_2	483	489	PF02991	0.531
LIG_LIR_Apic_2	551	555	PF02991	0.539
LIG_LIR_Gen_1	228	239	PF02991	0.561
LIG_LIR_Gen_1	521	531	PF02991	0.653
LIG_LIR_Gen_1	536	546	PF02991	0.503
LIG_LIR_Gen_1	83	93	PF02991	0.580
LIG_LIR_Nem_3	228	234	PF02991	0.559
LIG_LIR_Nem_3	309	315	PF02991	0.394
LIG_LIR_Nem_3	483	488	PF02991	0.612
LIG_LIR_Nem_3	603	608	PF02991	0.516
LIG_LIR_Nem_3	684	689	PF02991	0.587
LIG_LIR_Nem_3	83	88	PF02991	0.545
LIG_LYPXL_yS_3	302	305	PF13949	0.467
LIG_LYPXL_yS_3	686	689	PF13949	0.594
LIG_SH2_CRK	12	16	PF00017	0.483
LIG_SH2_CRK	300	304	PF00017	0.410
LIG_SH2_CRK	312	316	PF00017	0.454
LIG_SH2_CRK	36	40	PF00017	0.450
LIG_SH2_CRK	486	490	PF00017	0.531
LIG_SH2_NCK_1	36	40	PF00017	0.450
LIG_SH2_SRC	16	19	PF00017	0.374
LIG_SH2_SRC	300	303	PF00017	0.478
LIG_SH2_SRC	58	61	PF00017	0.535
LIG_SH2_STAP1	36	40	PF00017	0.450
LIG_SH2_STAT3	463	466	PF00017	0.528
LIG_SH2_STAT3	519	522	PF00017	0.541
LIG_SH2_STAT5	304	307	PF00017	0.459
LIG_SH2_STAT5	350	353	PF00017	0.485
LIG_SH2_STAT5	40	43	PF00017	0.377
LIG_SH2_STAT5	463	466	PF00017	0.549
LIG_SH2_STAT5	519	522	PF00017	0.541
LIG_SH2_STAT5	688	691	PF00017	0.671
LIG_SH2_STAT5	854	857	PF00017	0.482
LIG_SH3_1	286	292	PF00018	0.609
LIG_SH3_3	12	18	PF00018	0.466
LIG_SH3_3	286	292	PF00018	0.609
LIG_SH3_3	45	51	PF00018	0.527
LIG_SH3_3	485	491	PF00018	0.537
LIG_SH3_3	54	60	PF00018	0.447
LIG_SH3_3	886	892	PF00018	0.671
LIG_SH3_4	490	497	PF00018	0.524
LIG_SUMO_SIM_anti_2	435	443	PF11976	0.516
LIG_SUMO_SIM_par_1	112	123	PF11976	0.666
LIG_SUMO_SIM_par_1	390	397	PF11976	0.440
LIG_SUMO_SIM_par_1	435	443	PF11976	0.547
LIG_SUMO_SIM_par_1	45	52	PF11976	0.482
LIG_SUMO_SIM_par_1	617	623	PF11976	0.579
LIG_TRAF2_1	23	26	PF00917	0.490
LIG_TRAF2_1	240	243	PF00917	0.627
LIG_TRAF2_1	327	330	PF00917	0.485
MOD_CDK_SPK_2	448	453	PF00069	0.605
MOD_CK1_1	131	137	PF00069	0.635
MOD_CK1_1	171	177	PF00069	0.608
MOD_CK1_1	2	8	PF00069	0.601
MOD_CK1_1	408	414	PF00069	0.568
MOD_CK1_1	437	443	PF00069	0.572
MOD_CK1_1	518	524	PF00069	0.569
MOD_CK1_1	567	573	PF00069	0.611
MOD_CK1_1	665	671	PF00069	0.600
MOD_CK1_1	675	681	PF00069	0.604
MOD_CK1_1	705	711	PF00069	0.665
MOD_CK1_1	720	726	PF00069	0.662
MOD_CK1_1	728	734	PF00069	0.703
MOD_CK2_1	133	139	PF00069	0.745
MOD_CK2_1	180	186	PF00069	0.607
MOD_CK2_1	188	194	PF00069	0.464
MOD_CK2_1	219	225	PF00069	0.666
MOD_CK2_1	237	243	PF00069	0.479
MOD_CK2_1	25	31	PF00069	0.508
MOD_CK2_1	324	330	PF00069	0.490
MOD_CK2_1	350	356	PF00069	0.463
MOD_CK2_1	437	443	PF00069	0.572
MOD_CK2_1	448	454	PF00069	0.502
MOD_CK2_1	523	529	PF00069	0.591
MOD_CK2_1	640	646	PF00069	0.646
MOD_CK2_1	711	717	PF00069	0.564
MOD_CK2_1	778	784	PF00069	0.523
MOD_CK2_1	905	911	PF00069	0.793
MOD_Cter_Amidation	216	219	PF01082	0.685
MOD_Cter_Amidation	752	755	PF01082	0.667
MOD_GlcNHglycan	1	4	PF01048	0.556
MOD_GlcNHglycan	131	134	PF01048	0.614
MOD_GlcNHglycan	170	173	PF01048	0.588
MOD_GlcNHglycan	215	218	PF01048	0.741
MOD_GlcNHglycan	279	282	PF01048	0.590
MOD_GlcNHglycan	36	39	PF01048	0.398
MOD_GlcNHglycan	407	410	PF01048	0.610
MOD_GlcNHglycan	577	580	PF01048	0.609
MOD_GlcNHglycan	679	682	PF01048	0.644
MOD_GlcNHglycan	709	712	PF01048	0.664
MOD_GlcNHglycan	730	733	PF01048	0.768
MOD_GlcNHglycan	750	753	PF01048	0.717
MOD_GlcNHglycan	870	873	PF01048	0.601
MOD_GlcNHglycan	878	881	PF01048	0.651
MOD_GlcNHglycan	89	94	PF01048	0.600
MOD_GSK3_1	129	136	PF00069	0.755
MOD_GSK3_1	167	174	PF00069	0.597
MOD_GSK3_1	21	28	PF00069	0.432
MOD_GSK3_1	369	376	PF00069	0.573
MOD_GSK3_1	401	408	PF00069	0.504
MOD_GSK3_1	429	436	PF00069	0.611
MOD_GSK3_1	514	521	PF00069	0.576
MOD_GSK3_1	554	561	PF00069	0.561
MOD_GSK3_1	564	571	PF00069	0.586
MOD_GSK3_1	60	67	PF00069	0.508
MOD_GSK3_1	640	647	PF00069	0.667
MOD_GSK3_1	649	656	PF00069	0.605
MOD_GSK3_1	665	672	PF00069	0.506
MOD_GSK3_1	677	684	PF00069	0.583
MOD_GSK3_1	701	708	PF00069	0.683
MOD_GSK3_1	717	724	PF00069	0.620
MOD_GSK3_1	755	762	PF00069	0.649
MOD_GSK3_1	89	96	PF00069	0.675
MOD_LATS_1	700	706	PF00433	0.615
MOD_N-GLC_1	282	287	PF02516	0.527
MOD_N-GLC_1	721	726	PF02516	0.656
MOD_NEK2_1	1	6	PF00069	0.479
MOD_NEK2_1	188	193	PF00069	0.475
MOD_NEK2_1	282	287	PF00069	0.547
MOD_NEK2_1	294	299	PF00069	0.545
MOD_NEK2_1	324	329	PF00069	0.432
MOD_NEK2_1	433	438	PF00069	0.599
MOD_NEK2_1	44	49	PF00069	0.490
MOD_NEK2_1	480	485	PF00069	0.533
MOD_NEK2_1	558	563	PF00069	0.587
MOD_NEK2_1	565	570	PF00069	0.642
MOD_NEK2_1	640	645	PF00069	0.675
MOD_NEK2_1	674	679	PF00069	0.692
MOD_NEK2_1	876	881	PF00069	0.711
MOD_PIKK_1	318	324	PF00454	0.385
MOD_PIKK_1	518	524	PF00454	0.544
MOD_PIKK_1	759	765	PF00454	0.642
MOD_PIKK_1	93	99	PF00454	0.717
MOD_PK_1	725	731	PF00069	0.607
MOD_PKA_1	702	708	PF00069	0.698
MOD_PKA_2	129	135	PF00069	0.740
MOD_PKA_2	427	433	PF00069	0.647
MOD_PKA_2	514	520	PF00069	0.621
MOD_PKA_2	701	707	PF00069	0.679
MOD_PKA_2	724	730	PF00069	0.603
MOD_PKA_2	837	843	PF00069	0.590
MOD_Plk_1	434	440	PF00069	0.519
MOD_Plk_1	44	50	PF00069	0.518
MOD_Plk_1	662	668	PF00069	0.663
MOD_Plk_2-3	180	186	PF00069	0.613
MOD_Plk_2-3	237	243	PF00069	0.581
MOD_Plk_2-3	246	252	PF00069	0.611
MOD_Plk_2-3	25	31	PF00069	0.486
MOD_Plk_2-3	548	554	PF00069	0.522
MOD_Plk_4	111	117	PF00069	0.642
MOD_Plk_4	350	356	PF00069	0.463
MOD_Plk_4	434	440	PF00069	0.519
MOD_Plk_4	44	50	PF00069	0.616
MOD_Plk_4	515	521	PF00069	0.576
MOD_Plk_4	548	554	PF00069	0.522
MOD_Plk_4	784	790	PF00069	0.506
MOD_Plk_4	860	866	PF00069	0.585
MOD_ProDKin_1	448	454	PF00069	0.602
MOD_ProDKin_1	53	59	PF00069	0.517
MOD_ProDKin_1	568	574	PF00069	0.570
MOD_ProDKin_1	917	923	PF00069	0.579
MOD_SUMO_for_1	162	165	PF00179	0.531
MOD_SUMO_rev_2	147	157	PF00179	0.527
MOD_SUMO_rev_2	471	475	PF00179	0.517
MOD_SUMO_rev_2	734	742	PF00179	0.633
TRG_AP2beta_CARGO_1	603	612	PF09066	0.519
TRG_DiLeu_BaEn_1	807	812	PF01217	0.528
TRG_DiLeu_LyEn_5	807	812	PF01217	0.528
TRG_ENDOCYTIC_2	12	15	PF00928	0.486
TRG_ENDOCYTIC_2	302	305	PF00928	0.467
TRG_ENDOCYTIC_2	312	315	PF00928	0.389
TRG_ENDOCYTIC_2	36	39	PF00928	0.587
TRG_ENDOCYTIC_2	524	527	PF00928	0.639
TRG_ENDOCYTIC_2	686	689	PF00928	0.594
TRG_ER_diArg_1	341	343	PF00400	0.407
TRG_ER_diArg_1	399	401	PF00400	0.406
TRG_ER_diArg_1	421	424	PF00400	0.510
TRG_ER_diArg_1	428	431	PF00400	0.556
TRG_ER_diArg_1	694	697	PF00400	0.607
TRG_ER_diArg_1	789	791	PF00400	0.589
TRG_Pf-PMV_PEXEL_1	313	317	PF00026	0.531
TRG_Pf-PMV_PEXEL_1	780	784	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	810	814	PF00026	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDP1	Leptomonas seymouri	52%	100%
A0A3S7WQ64	Leishmania donovani	93%	100%
A4HTJ2	Leishmania infantum	94%	100%
E9AMC2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%