Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QIC3_LEIMA

TriTrypDb:

LmjF.08.0460 , LMJLV39_080009800 , LMJSD75_080009800

Length:

296

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 7, no: 0
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4QIC3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIC3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.364
CLV_NRD_NRD_1	286	288	PF00675	0.496
CLV_PCSK_KEX2_1	286	288	PF00082	0.531
CLV_PCSK_SKI1_1	143	147	PF00082	0.494
CLV_PCSK_SKI1_1	2	6	PF00082	0.740
CLV_PCSK_SKI1_1	229	233	PF00082	0.622
DEG_APCC_DBOX_1	228	236	PF00400	0.303
DEG_Kelch_Keap1_1	150	155	PF01344	0.304
DEG_MDM2_SWIB_1	129	136	PF02201	0.338
DEG_SPOP_SBC_1	96	100	PF00917	0.392
DOC_USP7_MATH_1	189	193	PF00917	0.427
DOC_USP7_MATH_1	240	244	PF00917	0.384
DOC_USP7_MATH_1	96	100	PF00917	0.380
DOC_WW_Pin1_4	4	9	PF00397	0.573
DOC_WW_Pin1_4	77	82	PF00397	0.373
LIG_14-3-3_CanoR_1	143	151	PF00244	0.311
LIG_14-3-3_CanoR_1	257	261	PF00244	0.626
LIG_BRCT_BRCA1_1	104	108	PF00533	0.423
LIG_FHA_1	119	125	PF00498	0.514
LIG_FHA_1	158	164	PF00498	0.360
LIG_FHA_1	17	23	PF00498	0.655
LIG_FHA_1	218	224	PF00498	0.487
LIG_FHA_2	144	150	PF00498	0.367
LIG_FHA_2	204	210	PF00498	0.443
LIG_FHA_2	77	83	PF00498	0.290
LIG_LIR_Apic_2	209	214	PF02991	0.447
LIG_LIR_Gen_1	127	136	PF02991	0.375
LIG_LIR_Nem_3	127	132	PF02991	0.465
LIG_LIR_Nem_3	70	75	PF02991	0.373
LIG_MLH1_MIPbox_1	104	108	PF16413	0.330
LIG_Pex14_2	129	133	PF04695	0.362
LIG_SH2_CRK	72	76	PF00017	0.365
LIG_SH2_PTP2	211	214	PF00017	0.442
LIG_SH2_SRC	64	67	PF00017	0.403
LIG_SH2_STAP1	83	87	PF00017	0.372
LIG_SH2_STAT5	119	122	PF00017	0.438
LIG_SH2_STAT5	144	147	PF00017	0.482
LIG_SH2_STAT5	205	208	PF00017	0.445
LIG_SH2_STAT5	211	214	PF00017	0.448
LIG_SH2_STAT5	219	222	PF00017	0.453
LIG_SH2_STAT5	64	67	PF00017	0.403
LIG_SH3_3	166	172	PF00018	0.491
LIG_SH3_3	212	218	PF00018	0.490
LIG_SUMO_SIM_anti_2	155	161	PF11976	0.363
LIG_SUMO_SIM_par_1	27	33	PF11976	0.503
LIG_TRFH_1	50	54	PF08558	0.426
LIG_WW_2	215	218	PF00397	0.461
MOD_CK1_1	117	123	PF00069	0.466
MOD_CK1_1	164	170	PF00069	0.360
MOD_CK1_1	276	282	PF00069	0.745
MOD_CK1_1	30	36	PF00069	0.468
MOD_CK2_1	143	149	PF00069	0.304
MOD_CK2_1	276	282	PF00069	0.738
MOD_GlcNHglycan	104	107	PF01048	0.599
MOD_GlcNHglycan	111	114	PF01048	0.644
MOD_GlcNHglycan	116	119	PF01048	0.637
MOD_GlcNHglycan	152	155	PF01048	0.511
MOD_GlcNHglycan	244	247	PF01048	0.270
MOD_GlcNHglycan	32	35	PF01048	0.698
MOD_GSK3_1	114	121	PF00069	0.542
MOD_GSK3_1	157	164	PF00069	0.393
MOD_GSK3_1	272	279	PF00069	0.701
MOD_GSK3_1	91	98	PF00069	0.427
MOD_N-GLC_1	109	114	PF02516	0.689
MOD_N-GLC_1	203	208	PF02516	0.676
MOD_NEK2_1	108	113	PF00069	0.392
MOD_NEK2_1	235	240	PF00069	0.382
MOD_NEK2_1	29	34	PF00069	0.496
MOD_NEK2_1	71	76	PF00069	0.293
MOD_OFUCOSY	196	201	PF10250	0.658
MOD_PIKK_1	203	209	PF00454	0.487
MOD_PIKK_1	222	228	PF00454	0.438
MOD_PKA_2	256	262	PF00069	0.656
MOD_Plk_1	272	278	PF00069	0.624
MOD_ProDKin_1	4	10	PF00069	0.572
MOD_ProDKin_1	77	83	PF00069	0.367
TRG_DiLeu_BaLyEn_6	5	10	PF01217	0.570
TRG_ENDOCYTIC_2	72	75	PF00928	0.370
TRG_ER_diArg_1	286	289	PF00400	0.700
TRG_Pf-PMV_PEXEL_1	143	147	PF00026	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ICA2	Leptomonas seymouri	60%	100%
A0A3S7WQ91	Leishmania donovani	87%	100%
A4H604	Leishmania braziliensis	28%	100%
E9AG80	Leishmania infantum	87%	100%
E9AMC5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QHJ5	Leishmania major	24%	100%