Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QIC0_LEIMA

TriTrypDb:

LmjF.08.0490 , LMJLV39_080010100 , LMJSD75_080010100

Length:

397

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QIC0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIC0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	253	257	PF00656	0.695
CLV_C14_Caspase3-7	36	40	PF00656	0.579
CLV_NRD_NRD_1	216	218	PF00675	0.787
CLV_NRD_NRD_1	327	329	PF00675	0.530
CLV_PCSK_KEX2_1	218	220	PF00082	0.784
CLV_PCSK_KEX2_1	327	329	PF00082	0.530
CLV_PCSK_PC1ET2_1	218	220	PF00082	0.784
CLV_PCSK_SKI1_1	306	310	PF00082	0.543
DEG_Nend_Nbox_1	1	3	PF02207	0.644
DEG_SCF_FBW7_1	22	29	PF00400	0.660
DEG_SCF_FBW7_2	230	237	PF00400	0.545
DEG_SCF_TRCP1_1	166	171	PF00400	0.604
DOC_PP2B_LxvP_1	227	230	PF13499	0.713
DOC_PP2B_LxvP_1	344	347	PF13499	0.766
DOC_PP4_FxxP_1	137	140	PF00568	0.651
DOC_PP4_MxPP_1	17	20	PF00568	0.740
DOC_USP7_MATH_1	185	189	PF00917	0.585
DOC_USP7_MATH_1	210	214	PF00917	0.764
DOC_USP7_MATH_1	260	264	PF00917	0.703
DOC_USP7_MATH_1	271	275	PF00917	0.576
DOC_USP7_MATH_1	296	300	PF00917	0.729
DOC_USP7_MATH_1	55	59	PF00917	0.728
DOC_USP7_MATH_1	82	86	PF00917	0.766
DOC_WW_Pin1_4	15	20	PF00397	0.826
DOC_WW_Pin1_4	176	181	PF00397	0.799
DOC_WW_Pin1_4	183	188	PF00397	0.683
DOC_WW_Pin1_4	22	27	PF00397	0.729
DOC_WW_Pin1_4	230	235	PF00397	0.775
DOC_WW_Pin1_4	299	304	PF00397	0.750
DOC_WW_Pin1_4	44	49	PF00397	0.614
DOC_WW_Pin1_4	77	82	PF00397	0.756
DOC_WW_Pin1_4	92	97	PF00397	0.575
LIG_14-3-3_CanoR_1	151	161	PF00244	0.583
LIG_14-3-3_CanoR_1	298	303	PF00244	0.772
LIG_14-3-3_CanoR_1	327	331	PF00244	0.531
LIG_14-3-3_CanoR_1	61	67	PF00244	0.688
LIG_14-3-3_CanoR_1	83	91	PF00244	0.672
LIG_BRCT_BRCA1_1	335	339	PF00533	0.762
LIG_EVH1_2	30	34	PF00568	0.613
LIG_FHA_1	155	161	PF00498	0.794
LIG_FHA_1	194	200	PF00498	0.590
LIG_FHA_1	236	242	PF00498	0.777
LIG_FHA_1	270	276	PF00498	0.705
LIG_FHA_1	310	316	PF00498	0.607
LIG_FHA_1	327	333	PF00498	0.724
LIG_FHA_1	356	362	PF00498	0.718
LIG_FHA_2	251	257	PF00498	0.686
LIG_LIR_Gen_1	193	202	PF02991	0.759
LIG_LIR_Gen_1	261	271	PF02991	0.670
LIG_LIR_Gen_1	336	347	PF02991	0.756
LIG_LIR_Nem_3	193	197	PF02991	0.756
LIG_LIR_Nem_3	261	267	PF02991	0.674
LIG_LIR_Nem_3	336	342	PF02991	0.770
LIG_NRBOX	98	104	PF00104	0.719
LIG_PDZ_Class_2	392	397	PF00595	0.736
LIG_Pex14_1	335	339	PF04695	0.762
LIG_RPA_C_Fungi	104	116	PF08784	0.595
LIG_SH2_NCK_1	131	135	PF00017	0.663
LIG_SH2_STAP1	131	135	PF00017	0.663
LIG_SH2_STAT5	194	197	PF00017	0.809
LIG_SH2_STAT5	284	287	PF00017	0.741
LIG_SH3_2	27	32	PF14604	0.754
LIG_SH3_3	174	180	PF00018	0.775
LIG_SH3_3	199	205	PF00018	0.711
LIG_SH3_3	24	30	PF00018	0.786
LIG_SH3_3	61	67	PF00018	0.623
LIG_SUMO_SIM_anti_2	391	396	PF11976	0.730
LIG_SUMO_SIM_par_1	318	324	PF11976	0.710
LIG_ULM_U2AF65_1	217	223	PF00076	0.721
LIG_WRC_WIRS_1	91	96	PF05994	0.679
LIG_WW_3	148	152	PF00397	0.691
LIG_WW_3	29	33	PF00397	0.563
MOD_CDC14_SPxK_1	186	189	PF00782	0.663
MOD_CDC14_SPxK_1	29	32	PF00782	0.761
MOD_CDC14_SPxK_1	80	83	PF00782	0.615
MOD_CDK_SPxK_1	183	189	PF00069	0.671
MOD_CDK_SPxK_1	26	32	PF00069	0.705
MOD_CDK_SPxK_1	77	83	PF00069	0.611
MOD_CDK_SPxxK_3	299	306	PF00069	0.729
MOD_CK1_1	130	136	PF00069	0.772
MOD_CK1_1	179	185	PF00069	0.754
MOD_CK1_1	250	256	PF00069	0.712
MOD_CK1_1	263	269	PF00069	0.649
MOD_CK1_1	299	305	PF00069	0.791
MOD_CK1_1	326	332	PF00069	0.784
MOD_CK1_1	378	384	PF00069	0.679
MOD_CK1_1	6	12	PF00069	0.786
MOD_CK1_1	72	78	PF00069	0.687
MOD_CK1_1	85	91	PF00069	0.716
MOD_CK2_1	168	174	PF00069	0.691
MOD_CK2_1	376	382	PF00069	0.705
MOD_CMANNOS	222	225	PF00535	0.787
MOD_DYRK1A_RPxSP_1	176	180	PF00069	0.558
MOD_GlcNHglycan	132	135	PF01048	0.715
MOD_GlcNHglycan	166	169	PF01048	0.778
MOD_GlcNHglycan	212	215	PF01048	0.772
MOD_GlcNHglycan	285	288	PF01048	0.778
MOD_GlcNHglycan	335	338	PF01048	0.761
MOD_GlcNHglycan	386	389	PF01048	0.704
MOD_GlcNHglycan	84	87	PF01048	0.609
MOD_GSK3_1	150	157	PF00069	0.768
MOD_GSK3_1	164	171	PF00069	0.670
MOD_GSK3_1	179	186	PF00069	0.589
MOD_GSK3_1	22	29	PF00069	0.690
MOD_GSK3_1	288	295	PF00069	0.695
MOD_GSK3_1	297	304	PF00069	0.794
MOD_GSK3_1	319	326	PF00069	0.746
MOD_GSK3_1	384	391	PF00069	0.676
MOD_N-GLC_1	122	127	PF02516	0.522
MOD_N-GLC_1	6	11	PF02516	0.787
MOD_N-GLC_1	72	77	PF02516	0.557
MOD_NEK2_1	152	157	PF00069	0.637
MOD_NEK2_1	195	200	PF00069	0.700
MOD_NEK2_1	283	288	PF00069	0.742
MOD_NEK2_1	333	338	PF00069	0.761
MOD_NEK2_1	362	367	PF00069	0.548
MOD_NEK2_1	384	389	PF00069	0.724
MOD_NEK2_2	168	173	PF00069	0.738
MOD_NEK2_2	271	276	PF00069	0.726
MOD_PIKK_1	143	149	PF00454	0.769
MOD_PIKK_1	152	158	PF00454	0.654
MOD_PIKK_1	376	382	PF00454	0.661
MOD_PIKK_1	85	91	PF00454	0.790
MOD_PIKK_1	97	103	PF00454	0.548
MOD_PKA_1	217	223	PF00069	0.721
MOD_PKA_2	150	156	PF00069	0.729
MOD_PKA_2	164	170	PF00069	0.678
MOD_PKA_2	250	256	PF00069	0.745
MOD_PKA_2	297	303	PF00069	0.763
MOD_PKA_2	3	9	PF00069	0.701
MOD_PKA_2	326	332	PF00069	0.529
MOD_PKA_2	349	355	PF00069	0.540
MOD_PKA_2	82	88	PF00069	0.566
MOD_Plk_1	260	266	PF00069	0.740
MOD_Plk_4	260	266	PF00069	0.674
MOD_Plk_4	311	317	PF00069	0.578
MOD_ProDKin_1	15	21	PF00069	0.827
MOD_ProDKin_1	176	182	PF00069	0.798
MOD_ProDKin_1	183	189	PF00069	0.682
MOD_ProDKin_1	22	28	PF00069	0.728
MOD_ProDKin_1	230	236	PF00069	0.776
MOD_ProDKin_1	299	305	PF00069	0.749
MOD_ProDKin_1	44	50	PF00069	0.612
MOD_ProDKin_1	77	83	PF00069	0.758
MOD_ProDKin_1	92	98	PF00069	0.571
TRG_ENDOCYTIC_2	194	197	PF00928	0.765
TRG_ER_diArg_1	216	219	PF00400	0.789
TRG_NES_CRM1_1	193	208	PF08389	0.708
TRG_NLS_MonoExtC_3	216	221	PF00514	0.721
TRG_NLS_MonoExtN_4	216	222	PF00514	0.786

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H653	Leishmania donovani	84%	100%
A4H5B6	Leishmania braziliensis	55%	73%
A4HTJ7	Leishmania infantum	83%	95%
E9AMC8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%