Putative ribose-phosphate pyrophosphokinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ribose-phosphate pyrophosphokinase, putative

Species:

Leishmania major

UniProt:

Q4QIB8_LEIMA

TriTrypDb:

LmjF.08.0510 , LMJLV39_080010300 , LMJSD75_080010300

Length:

836

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0002189	ribose phosphate diphosphokinase complex	5	2
GO:0005737	cytoplasm	2	2
GO:0032991	protein-containing complex	1	2
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	2
GO:0110165	cellular anatomical entity	1	2
GO:1902494	catalytic complex	2	2
GO:1990234	transferase complex	3	2

Expansion

Sequence features

Q4QIB8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIB8

Function

Biological processes
Term	Name	Level	Count
GO:0006015	5-phosphoribose 1-diphosphate biosynthetic process	6	2
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006163	purine nucleotide metabolic process	5	2
GO:0006164	purine nucleotide biosynthetic process	6	2
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006753	nucleoside phosphate metabolic process	4	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009058	biosynthetic process	2	7
GO:0009117	nucleotide metabolic process	5	7
GO:0009165	nucleotide biosynthetic process	6	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0018130	heterocycle biosynthetic process	4	7
GO:0019438	aromatic compound biosynthetic process	4	7
GO:0019637	organophosphate metabolic process	3	7
GO:0019693	ribose phosphate metabolic process	4	2
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0034654	nucleobase-containing compound biosynthetic process	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044249	cellular biosynthetic process	3	7
GO:0044271	cellular nitrogen compound biosynthetic process	4	7
GO:0044281	small molecule metabolic process	2	7
GO:0046390	ribose phosphate biosynthetic process	5	2
GO:0046391	5-phosphoribose 1-diphosphate metabolic process	5	2
GO:0046483	heterocycle metabolic process	3	7
GO:0055086	nucleobase-containing small molecule metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:0072521	purine-containing compound metabolic process	4	2
GO:0072522	purine-containing compound biosynthetic process	5	2
GO:0090407	organophosphate biosynthetic process	4	7
GO:1901135	carbohydrate derivative metabolic process	3	2
GO:1901137	carbohydrate derivative biosynthetic process	4	2
GO:1901293	nucleoside phosphate biosynthetic process	5	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:1901362	organic cyclic compound biosynthetic process	4	7
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901566	organonitrogen compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0000287	magnesium ion binding	5	7
GO:0003824	catalytic activity	1	7
GO:0004749	ribose phosphate diphosphokinase activity	5	7
GO:0005488	binding	1	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016778	diphosphotransferase activity	4	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	516	520	PF00656	0.481
CLV_NRD_NRD_1	117	119	PF00675	0.645
CLV_NRD_NRD_1	232	234	PF00675	0.500
CLV_NRD_NRD_1	541	543	PF00675	0.661
CLV_NRD_NRD_1	569	571	PF00675	0.598
CLV_NRD_NRD_1	710	712	PF00675	0.790
CLV_NRD_NRD_1	804	806	PF00675	0.346
CLV_PCSK_FUR_1	175	179	PF00082	0.521
CLV_PCSK_KEX2_1	117	119	PF00082	0.645
CLV_PCSK_KEX2_1	177	179	PF00082	0.603
CLV_PCSK_KEX2_1	300	302	PF00082	0.433
CLV_PCSK_KEX2_1	541	543	PF00082	0.559
CLV_PCSK_KEX2_1	569	571	PF00082	0.598
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.603
CLV_PCSK_PC1ET2_1	300	302	PF00082	0.433
CLV_PCSK_SKI1_1	16	20	PF00082	0.630
CLV_PCSK_SKI1_1	233	237	PF00082	0.500
CLV_PCSK_SKI1_1	297	301	PF00082	0.652
CLV_PCSK_SKI1_1	350	354	PF00082	0.346
CLV_PCSK_SKI1_1	48	52	PF00082	0.555
CLV_PCSK_SKI1_1	721	725	PF00082	0.263
CLV_PCSK_SKI1_1	760	764	PF00082	0.346
CLV_Separin_Metazoa	205	209	PF03568	0.550
CLV_Separin_Metazoa	560	564	PF03568	0.805
DEG_Nend_Nbox_1	1	3	PF02207	0.675
DEG_SCF_FBW7_1	600	606	PF00400	0.628
DEG_SPOP_SBC_1	603	607	PF00917	0.704
DOC_CKS1_1	136	141	PF01111	0.553
DOC_CKS1_1	600	605	PF01111	0.761
DOC_CKS1_1	618	623	PF01111	0.587
DOC_CKS1_1	633	638	PF01111	0.611
DOC_CYCLIN_RxL_1	13	21	PF00134	0.629
DOC_MAPK_DCC_7	208	216	PF00069	0.500
DOC_MAPK_gen_1	175	183	PF00069	0.490
DOC_MAPK_gen_1	729	736	PF00069	0.530
DOC_MAPK_gen_1	805	812	PF00069	0.565
DOC_MAPK_MEF2A_6	208	216	PF00069	0.500
DOC_MAPK_MEF2A_6	274	282	PF00069	0.588
DOC_MAPK_MEF2A_6	729	736	PF00069	0.530
DOC_PP2B_LxvP_1	378	381	PF13499	0.563
DOC_PP4_FxxP_1	127	130	PF00568	0.625
DOC_PP4_FxxP_1	136	139	PF00568	0.604
DOC_PP4_FxxP_1	470	473	PF00568	0.497
DOC_USP7_MATH_1	244	248	PF00917	0.502
DOC_USP7_MATH_1	362	366	PF00917	0.516
DOC_USP7_MATH_1	395	399	PF00917	0.619
DOC_USP7_MATH_1	433	437	PF00917	0.563
DOC_USP7_MATH_1	473	477	PF00917	0.501
DOC_USP7_MATH_1	50	54	PF00917	0.564
DOC_USP7_MATH_1	603	607	PF00917	0.718
DOC_USP7_MATH_1	641	645	PF00917	0.721
DOC_USP7_MATH_1	768	772	PF00917	0.619
DOC_USP7_MATH_2	473	479	PF00917	0.470
DOC_USP7_UBL2_3	145	149	PF12436	0.598
DOC_USP7_UBL2_3	230	234	PF12436	0.522
DOC_USP7_UBL2_3	38	42	PF12436	0.514
DOC_WW_Pin1_4	106	111	PF00397	0.687
DOC_WW_Pin1_4	129	134	PF00397	0.706
DOC_WW_Pin1_4	135	140	PF00397	0.590
DOC_WW_Pin1_4	599	604	PF00397	0.809
DOC_WW_Pin1_4	617	622	PF00397	0.711
DOC_WW_Pin1_4	629	634	PF00397	0.734
DOC_WW_Pin1_4	65	70	PF00397	0.608
DOC_WW_Pin1_4	778	783	PF00397	0.619
DOC_WW_Pin1_4	93	98	PF00397	0.678
LIG_14-3-3_CanoR_1	16	26	PF00244	0.618
LIG_14-3-3_CanoR_1	289	293	PF00244	0.532
LIG_14-3-3_CanoR_1	424	432	PF00244	0.546
LIG_14-3-3_CanoR_1	687	693	PF00244	0.642
LIG_Actin_WH2_2	25	40	PF00022	0.560
LIG_APCC_ABBA_1	459	464	PF00400	0.489
LIG_BIR_III_2	324	328	PF00653	0.626
LIG_BIR_III_4	623	627	PF00653	0.838
LIG_BRCT_BRCA1_1	131	135	PF00533	0.581
LIG_BRCT_BRCA1_1	269	273	PF00533	0.613
LIG_BRCT_BRCA1_1	316	320	PF00533	0.594
LIG_BRCT_BRCA1_1	506	510	PF00533	0.482
LIG_Clathr_ClatBox_1	180	184	PF01394	0.464
LIG_CORNRBOX	732	740	PF00104	0.619
LIG_CtBP_PxDLS_1	782	786	PF00389	0.563
LIG_EH1_1	387	395	PF00400	0.546
LIG_eIF4E_1	719	725	PF01652	0.546
LIG_FHA_1	126	132	PF00498	0.615
LIG_FHA_1	317	323	PF00498	0.700
LIG_FHA_1	332	338	PF00498	0.505
LIG_FHA_1	341	347	PF00498	0.521
LIG_FHA_1	351	357	PF00498	0.475
LIG_FHA_1	424	430	PF00498	0.546
LIG_FHA_1	433	439	PF00498	0.546
LIG_FHA_1	529	535	PF00498	0.613
LIG_FHA_1	543	549	PF00498	0.513
LIG_FHA_1	611	617	PF00498	0.749
LIG_FHA_1	670	676	PF00498	0.824
LIG_FHA_1	68	74	PF00498	0.798
LIG_FHA_1	689	695	PF00498	0.576
LIG_FHA_1	764	770	PF00498	0.546
LIG_FHA_1	787	793	PF00498	0.546
LIG_FHA_2	145	151	PF00498	0.539
LIG_FHA_2	194	200	PF00498	0.526
LIG_FHA_2	2	8	PF00498	0.644
LIG_FHA_2	618	624	PF00498	0.779
LIG_FHA_2	72	78	PF00498	0.721
LIG_FHA_2	829	835	PF00498	0.546
LIG_FHA_2	97	103	PF00498	0.575
LIG_Integrin_RGD_1	383	385	PF01839	0.346
LIG_LIR_Apic_2	124	130	PF02991	0.613
LIG_LIR_Apic_2	467	473	PF02991	0.509
LIG_LIR_Gen_1	138	148	PF02991	0.522
LIG_LIR_Gen_1	163	174	PF02991	0.477
LIG_LIR_Gen_1	213	222	PF02991	0.574
LIG_LIR_Gen_1	478	487	PF02991	0.460
LIG_LIR_Gen_1	497	506	PF02991	0.497
LIG_LIR_Gen_1	531	540	PF02991	0.502
LIG_LIR_Nem_3	138	144	PF02991	0.509
LIG_LIR_Nem_3	163	169	PF02991	0.473
LIG_LIR_Nem_3	171	176	PF02991	0.398
LIG_LIR_Nem_3	213	218	PF02991	0.509
LIG_LIR_Nem_3	29	34	PF02991	0.576
LIG_LIR_Nem_3	478	484	PF02991	0.457
LIG_LIR_Nem_3	497	501	PF02991	0.538
LIG_LIR_Nem_3	531	536	PF02991	0.523
LIG_LIR_Nem_3	716	722	PF02991	0.548
LIG_OCRL_FandH_1	165	177	PF00620	0.585
LIG_PCNA_APIM_2	176	182	PF02747	0.514
LIG_Rb_pABgroove_1	827	835	PF01858	0.530
LIG_REV1ctd_RIR_1	163	172	PF16727	0.486
LIG_SH2_CRK	224	228	PF00017	0.593
LIG_SH2_CRK	284	288	PF00017	0.470
LIG_SH2_GRB2like	302	305	PF00017	0.672
LIG_SH2_GRB2like	55	58	PF00017	0.475
LIG_SH2_PTP2	173	176	PF00017	0.389
LIG_SH2_PTP2	722	725	PF00017	0.563
LIG_SH2_SRC	210	213	PF00017	0.463
LIG_SH2_SRC	517	520	PF00017	0.494
LIG_SH2_SRC	559	562	PF00017	0.728
LIG_SH2_STAP1	262	266	PF00017	0.609
LIG_SH2_STAP1	292	296	PF00017	0.518
LIG_SH2_STAP1	434	438	PF00017	0.546
LIG_SH2_STAP1	517	521	PF00017	0.494
LIG_SH2_STAP1	89	93	PF00017	0.567
LIG_SH2_STAT5	173	176	PF00017	0.446
LIG_SH2_STAT5	179	182	PF00017	0.486
LIG_SH2_STAT5	210	213	PF00017	0.463
LIG_SH2_STAT5	215	218	PF00017	0.442
LIG_SH2_STAT5	31	34	PF00017	0.571
LIG_SH2_STAT5	431	434	PF00017	0.555
LIG_SH2_STAT5	486	489	PF00017	0.468
LIG_SH2_STAT5	722	725	PF00017	0.563
LIG_SH3_1	104	110	PF00018	0.694
LIG_SH3_1	627	633	PF00018	0.607
LIG_SH3_1	808	814	PF00018	0.546
LIG_SH3_3	104	110	PF00018	0.735
LIG_SH3_3	127	133	PF00018	0.606
LIG_SH3_3	356	362	PF00018	0.546
LIG_SH3_3	500	506	PF00018	0.471
LIG_SH3_3	590	596	PF00018	0.788
LIG_SH3_3	597	603	PF00018	0.626
LIG_SH3_3	61	67	PF00018	0.716
LIG_SH3_3	615	621	PF00018	0.737
LIG_SH3_3	627	633	PF00018	0.681
LIG_SH3_3	776	782	PF00018	0.536
LIG_SH3_3	80	86	PF00018	0.446
LIG_SH3_3	808	814	PF00018	0.546
LIG_SH3_4	38	45	PF00018	0.509
LIG_SUMO_SIM_anti_2	246	252	PF11976	0.601
LIG_SUMO_SIM_anti_2	279	284	PF11976	0.576
LIG_SUMO_SIM_anti_2	409	414	PF11976	0.546
LIG_SUMO_SIM_anti_2	446	452	PF11976	0.445
LIG_SUMO_SIM_anti_2	499	505	PF11976	0.589
LIG_SUMO_SIM_anti_2	644	654	PF11976	0.787
LIG_SUMO_SIM_anti_2	759	766	PF11976	0.546
LIG_SUMO_SIM_anti_2	780	787	PF11976	0.558
LIG_SUMO_SIM_par_1	392	399	PF11976	0.619
LIG_SUMO_SIM_par_1	455	460	PF11976	0.446
LIG_SUMO_SIM_par_1	70	77	PF11976	0.727
LIG_SUMO_SIM_par_1	759	766	PF11976	0.546
LIG_SUMO_SIM_par_1	784	791	PF11976	0.546
LIG_TRFH_1	35	39	PF08558	0.532
LIG_TYR_ITIM	222	227	PF00017	0.451
LIG_TYR_ITIM	282	287	PF00017	0.581
LIG_TYR_ITIM	32	37	PF00017	0.548
LIG_WRC_WIRS_1	194	199	PF05994	0.512
MOD_CDK_SPxK_1	111	117	PF00069	0.614
MOD_CDK_SPxxK_3	111	118	PF00069	0.715
MOD_CK1_1	264	270	PF00069	0.614
MOD_CK1_1	535	541	PF00069	0.489
MOD_CK1_1	604	610	PF00069	0.759
MOD_CK1_1	632	638	PF00069	0.729
MOD_CK1_1	658	664	PF00069	0.757
MOD_CK1_1	68	74	PF00069	0.790
MOD_CK1_1	688	694	PF00069	0.660
MOD_CK2_1	144	150	PF00069	0.541
MOD_CK2_1	193	199	PF00069	0.515
MOD_CK2_1	30	36	PF00069	0.588
MOD_CK2_1	573	579	PF00069	0.787
MOD_CK2_1	71	77	PF00069	0.735
MOD_CK2_1	778	784	PF00069	0.563
MOD_GlcNHglycan	274	277	PF01048	0.596
MOD_GlcNHglycan	340	343	PF01048	0.414
MOD_GlcNHglycan	415	418	PF01048	0.383
MOD_GlcNHglycan	441	444	PF01048	0.456
MOD_GlcNHglycan	475	478	PF01048	0.478
MOD_GlcNHglycan	506	509	PF01048	0.490
MOD_GlcNHglycan	528	531	PF01048	0.677
MOD_GlcNHglycan	576	579	PF01048	0.717
MOD_GlcNHglycan	596	599	PF01048	0.725
MOD_GlcNHglycan	770	773	PF01048	0.419
MOD_GSK3_1	121	128	PF00069	0.723
MOD_GSK3_1	150	157	PF00069	0.384
MOD_GSK3_1	17	24	PF00069	0.601
MOD_GSK3_1	338	345	PF00069	0.507
MOD_GSK3_1	395	402	PF00069	0.546
MOD_GSK3_1	433	440	PF00069	0.619
MOD_GSK3_1	490	497	PF00069	0.635
MOD_GSK3_1	528	535	PF00069	0.644
MOD_GSK3_1	599	606	PF00069	0.722
MOD_GSK3_1	607	614	PF00069	0.707
MOD_GSK3_1	65	72	PF00069	0.735
MOD_GSK3_1	651	658	PF00069	0.741
MOD_GSK3_1	660	667	PF00069	0.684
MOD_GSK3_1	89	96	PF00069	0.677
MOD_LATS_1	329	335	PF00433	0.609
MOD_N-GLC_1	264	269	PF02516	0.609
MOD_N-GLC_1	303	308	PF02516	0.691
MOD_N-GLC_1	399	404	PF02516	0.419
MOD_N-GLC_1	499	504	PF02516	0.493
MOD_N-GLC_1	744	749	PF02516	0.280
MOD_N-GLC_2	364	366	PF02516	0.346
MOD_NEK2_1	1	6	PF00069	0.650
MOD_NEK2_1	154	159	PF00069	0.415
MOD_NEK2_1	169	174	PF00069	0.520
MOD_NEK2_1	340	345	PF00069	0.546
MOD_NEK2_1	413	418	PF00069	0.583
MOD_NEK2_1	432	437	PF00069	0.546
MOD_NEK2_1	51	56	PF00069	0.625
MOD_NEK2_1	548	553	PF00069	0.680
MOD_NEK2_1	565	570	PF00069	0.553
MOD_NEK2_1	685	690	PF00069	0.667
MOD_NEK2_1	763	768	PF00069	0.546
MOD_NEK2_1	88	93	PF00069	0.630
MOD_NEK2_2	342	347	PF00069	0.546
MOD_PIKK_1	264	270	PF00454	0.614
MOD_PIKK_1	314	320	PF00454	0.592
MOD_PIKK_1	528	534	PF00454	0.622
MOD_PIKK_1	542	548	PF00454	0.559
MOD_PIKK_1	6	12	PF00454	0.620
MOD_PIKK_1	651	657	PF00454	0.722
MOD_PIKK_1	96	102	PF00454	0.569
MOD_PKA_1	711	717	PF00069	0.667
MOD_PKA_2	288	294	PF00069	0.527
MOD_PKA_2	423	429	PF00069	0.546
MOD_PKA_2	686	692	PF00069	0.767
MOD_Plk_1	24	30	PF00069	0.592
MOD_Plk_1	372	378	PF00069	0.546
MOD_Plk_1	499	505	PF00069	0.486
MOD_Plk_1	51	57	PF00069	0.633
MOD_Plk_1	825	831	PF00069	0.619
MOD_Plk_1	89	95	PF00069	0.587
MOD_Plk_2-3	193	199	PF00069	0.521
MOD_Plk_2-3	494	500	PF00069	0.654
MOD_Plk_4	122	128	PF00069	0.739
MOD_Plk_4	150	156	PF00069	0.443
MOD_Plk_4	169	175	PF00069	0.570
MOD_Plk_4	210	216	PF00069	0.560
MOD_Plk_4	283	289	PF00069	0.483
MOD_Plk_4	30	36	PF00069	0.665
MOD_Plk_4	316	322	PF00069	0.605
MOD_Plk_4	342	348	PF00069	0.546
MOD_Plk_4	389	395	PF00069	0.546
MOD_Plk_4	735	741	PF00069	0.546
MOD_Plk_4	828	834	PF00069	0.546
MOD_ProDKin_1	106	112	PF00069	0.687
MOD_ProDKin_1	129	135	PF00069	0.698
MOD_ProDKin_1	599	605	PF00069	0.805
MOD_ProDKin_1	617	623	PF00069	0.713
MOD_ProDKin_1	629	635	PF00069	0.734
MOD_ProDKin_1	65	71	PF00069	0.607
MOD_ProDKin_1	778	784	PF00069	0.619
MOD_ProDKin_1	93	99	PF00069	0.677
MOD_SUMO_for_1	181	184	PF00179	0.480
MOD_SUMO_for_1	216	219	PF00179	0.430
MOD_SUMO_rev_2	33	40	PF00179	0.605
MOD_SUMO_rev_2	577	586	PF00179	0.695
TRG_DiLeu_BaEn_1	150	155	PF01217	0.539
TRG_DiLeu_BaEn_1	409	414	PF01217	0.546
TRG_DiLeu_BaEn_1	446	451	PF01217	0.481
TRG_DiLeu_BaEn_1	759	764	PF01217	0.530
TRG_DiLeu_BaLyEn_6	256	261	PF01217	0.600
TRG_DiLeu_BaLyEn_6	811	816	PF01217	0.546
TRG_ENDOCYTIC_2	173	176	PF00928	0.482
TRG_ENDOCYTIC_2	215	218	PF00928	0.469
TRG_ENDOCYTIC_2	224	227	PF00928	0.454
TRG_ENDOCYTIC_2	284	287	PF00928	0.467
TRG_ENDOCYTIC_2	34	37	PF00928	0.537
TRG_ENDOCYTIC_2	481	484	PF00928	0.463
TRG_ENDOCYTIC_2	524	527	PF00928	0.521
TRG_ENDOCYTIC_2	722	725	PF00928	0.546
TRG_ER_diArg_1	116	118	PF00400	0.661
TRG_ER_diArg_1	540	542	PF00400	0.640
TRG_NES_CRM1_1	150	163	PF08389	0.370
TRG_NES_CRM1_1	246	258	PF08389	0.516
TRG_Pf-PMV_PEXEL_1	16	21	PF00026	0.630
TRG_Pf-PMV_PEXEL_1	751	755	PF00026	0.346

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDZ8	Leptomonas seymouri	62%	98%
A0A3S5H655	Leishmania donovani	94%	100%
A4H5B8	Leishmania braziliensis	76%	100%
A4HTJ9	Leishmania infantum	94%	100%
E9AMD0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%