Complex 1 protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Complex 1 protein

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QIB5_LEIMA

TriTrypDb:

LmjF.08.0540 , LMJLV39_080010600 , LMJSD75_080010600

Length:

352

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QIB5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIB5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	69	73	PF00656	0.827
CLV_NRD_NRD_1	133	135	PF00675	0.728
CLV_NRD_NRD_1	214	216	PF00675	0.558
CLV_NRD_NRD_1	227	229	PF00675	0.533
CLV_NRD_NRD_1	245	247	PF00675	0.532
CLV_NRD_NRD_1	30	32	PF00675	0.720
CLV_PCSK_FUR_1	28	32	PF00082	0.565
CLV_PCSK_KEX2_1	133	135	PF00082	0.728
CLV_PCSK_KEX2_1	213	215	PF00082	0.566
CLV_PCSK_KEX2_1	226	228	PF00082	0.538
CLV_PCSK_KEX2_1	245	247	PF00082	0.532
CLV_PCSK_KEX2_1	30	32	PF00082	0.720
CLV_PCSK_PC7_1	222	228	PF00082	0.525
CLV_PCSK_SKI1_1	200	204	PF00082	0.494
DEG_APCC_DBOX_1	199	207	PF00400	0.496
DEG_Nend_Nbox_1	1	3	PF02207	0.737
DOC_PP2B_LxvP_1	342	345	PF13499	0.696
DOC_USP7_MATH_1	179	183	PF00917	0.487
DOC_USP7_MATH_1	288	292	PF00917	0.731
DOC_WW_Pin1_4	183	188	PF00397	0.562
DOC_WW_Pin1_4	2	7	PF00397	0.633
LIG_14-3-3_CanoR_1	178	184	PF00244	0.605
LIG_14-3-3_CanoR_1	213	218	PF00244	0.542
LIG_14-3-3_CanoR_1	228	237	PF00244	0.520
LIG_BRCT_BRCA1_1	181	185	PF00533	0.578
LIG_BRCT_BRCA1_1	327	331	PF00533	0.675
LIG_Clathr_ClatBox_1	161	165	PF01394	0.665
LIG_DCNL_PONY_1	1	4	PF03556	0.766
LIG_FHA_1	230	236	PF00498	0.501
LIG_FHA_2	272	278	PF00498	0.661
LIG_LIR_Gen_1	262	271	PF02991	0.669
LIG_NRBOX	193	199	PF00104	0.512
LIG_SH2_CRK	199	203	PF00017	0.488
LIG_SH2_CRK	209	213	PF00017	0.566
LIG_SH2_STAP1	138	142	PF00017	0.561
LIG_SH2_STAT5	160	163	PF00017	0.632
LIG_SH2_STAT5	249	252	PF00017	0.492
LIG_SH3_2	173	178	PF14604	0.748
LIG_SH3_3	110	116	PF00018	0.758
LIG_SH3_3	167	173	PF00018	0.572
LIG_SH3_3	282	288	PF00018	0.641
LIG_SH3_3	341	347	PF00018	0.698
LIG_SH3_3	56	62	PF00018	0.814
LIG_SUMO_SIM_anti_2	193	199	PF11976	0.614
LIG_SUMO_SIM_par_1	15	22	PF11976	0.508
LIG_TRAF2_1	156	159	PF00917	0.627
LIG_TRAF2_2	113	118	PF00917	0.654
LIG_TYR_ITIM	197	202	PF00017	0.495
MOD_CDK_SPxxK_3	185	192	PF00069	0.551
MOD_CK1_1	77	83	PF00069	0.809
MOD_CK2_1	277	283	PF00069	0.646
MOD_Cter_Amidation	28	31	PF01082	0.563
MOD_GlcNHglycan	316	319	PF01048	0.656
MOD_GlcNHglycan	32	35	PF01048	0.718
MOD_GSK3_1	179	186	PF00069	0.596
MOD_GSK3_1	255	262	PF00069	0.602
MOD_GSK3_1	30	37	PF00069	0.662
MOD_GSK3_1	71	78	PF00069	0.809
MOD_N-GLC_1	255	260	PF02516	0.588
MOD_N-GLC_1	296	301	PF02516	0.754
MOD_NEK2_1	12	17	PF00069	0.592
MOD_NEK2_1	19	24	PF00069	0.623
MOD_NEK2_1	257	262	PF00069	0.595
MOD_NEK2_1	71	76	PF00069	0.737
MOD_NEK2_1	86	91	PF00069	0.648
MOD_NEK2_2	244	249	PF00069	0.623
MOD_PIKK_1	154	160	PF00454	0.632
MOD_PKA_1	213	219	PF00069	0.543
MOD_PKA_1	30	36	PF00069	0.575
MOD_PKA_2	179	185	PF00069	0.595
MOD_PKA_2	213	219	PF00069	0.531
MOD_PKA_2	24	30	PF00069	0.730
MOD_PKA_2	244	250	PF00069	0.630
MOD_PKB_1	28	36	PF00069	0.569
MOD_Plk_1	288	294	PF00069	0.738
MOD_Plk_2-3	277	283	PF00069	0.646
MOD_Plk_4	190	196	PF00069	0.630
MOD_Plk_4	277	283	PF00069	0.646
MOD_Plk_4	42	48	PF00069	0.792
MOD_ProDKin_1	183	189	PF00069	0.563
MOD_ProDKin_1	2	8	PF00069	0.633
MOD_SUMO_for_1	331	334	PF00179	0.772
MOD_SUMO_rev_2	184	194	PF00179	0.546
MOD_SUMO_rev_2	273	280	PF00179	0.653
MOD_SUMO_rev_2	319	328	PF00179	0.732
TRG_DiLeu_BaEn_1	190	195	PF01217	0.527
TRG_DiLeu_BaLyEn_6	14	19	PF01217	0.612
TRG_ENDOCYTIC_2	199	202	PF00928	0.495
TRG_ENDOCYTIC_2	209	212	PF00928	0.518
TRG_ENDOCYTIC_2	220	223	PF00928	0.438
TRG_ER_diArg_1	133	135	PF00400	0.728
TRG_ER_diArg_1	212	215	PF00400	0.578
TRG_ER_diArg_1	225	228	PF00400	0.526
TRG_ER_diArg_1	28	31	PF00400	0.693
TRG_Pf-PMV_PEXEL_1	134	139	PF00026	0.667

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I921	Leptomonas seymouri	72%	97%
A0A3S7WQ84	Leishmania donovani	94%	100%
A4H5C2	Leishmania braziliensis	86%	100%
A4HTK2	Leishmania infantum	95%	100%
E9AMD3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%