Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QIB2_LEIMA

TriTrypDb:

LmjF.08.0570 , LMJLV39_080010900 , LMJSD75_080010900

Length:

179

Annotations

LeishMANIAdb annotations

This protein family is endemic to Kinetoplastids, might have emerged de novo and also expanded. . The family also contains Leishmaniid members lacking the signal peptide and only having an MTTPA- start sequence

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 9
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4QIB2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIB2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_SPOP_SBC_1	146	150	PF00917	0.643
DOC_CKS1_1	1	6	PF01111	0.438
DOC_CYCLIN_RxL_1	134	145	PF00134	0.645
DOC_PP2B_PxIxI_1	67	73	PF00149	0.245
DOC_USP7_MATH_1	11	15	PF00917	0.384
DOC_USP7_MATH_1	135	139	PF00917	0.700
DOC_USP7_MATH_1	167	171	PF00917	0.652
LIG_14-3-3_CanoR_1	139	144	PF00244	0.691
LIG_eIF4E_1	66	72	PF01652	0.315
LIG_EVH1_2	56	60	PF00568	0.381
LIG_FHA_1	125	131	PF00498	0.690
LIG_LIR_Nem_3	109	115	PF02991	0.661
LIG_Pex14_2	61	65	PF04695	0.396
LIG_SH2_GRB2like	112	115	PF00017	0.626
LIG_SH2_PTP2	66	69	PF00017	0.293
LIG_SH2_PTP2	80	83	PF00017	0.398
LIG_SH2_SRC	66	69	PF00017	0.229
LIG_SH2_STAP1	24	28	PF00017	0.339
LIG_SH2_STAT3	48	51	PF00017	0.450
LIG_SH2_STAT5	112	115	PF00017	0.678
LIG_SH2_STAT5	66	69	PF00017	0.416
LIG_SH2_STAT5	80	83	PF00017	0.359
LIG_SH3_3	37	43	PF00018	0.433
MOD_CK1_1	106	112	PF00069	0.625
MOD_CK1_1	142	148	PF00069	0.691
MOD_CK1_1	149	155	PF00069	0.692
MOD_CK1_1	16	22	PF00069	0.396
MOD_CK1_1	160	166	PF00069	0.706
MOD_CK2_1	160	166	PF00069	0.766
MOD_CK2_1	167	173	PF00069	0.683
MOD_GlcNHglycan	13	16	PF01048	0.574
MOD_GlcNHglycan	33	36	PF01048	0.651
MOD_GlcNHglycan	4	7	PF01048	0.625
MOD_GSK3_1	135	142	PF00069	0.674
MOD_GSK3_1	145	152	PF00069	0.630
MOD_GSK3_1	16	23	PF00069	0.414
MOD_GSK3_1	27	34	PF00069	0.378
MOD_N-GLC_1	51	56	PF02516	0.623
MOD_NEK2_1	141	146	PF00069	0.735
MOD_PKB_1	137	145	PF00069	0.700
MOD_Plk_1	152	158	PF00069	0.675
MOD_Plk_1	167	173	PF00069	0.761
MOD_Plk_1	51	57	PF00069	0.422
MOD_Plk_4	167	173	PF00069	0.626
TRG_ENDOCYTIC_2	112	115	PF00928	0.658
TRG_ENDOCYTIC_2	66	69	PF00928	0.293
TRG_ENDOCYTIC_2	80	83	PF00928	0.356

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P923	Leptomonas seymouri	40%	85%
A0A3S5H659	Leishmania donovani	35%	100%
A0A3S7WQ87	Leishmania donovani	84%	100%
A4H5C6	Leishmania braziliensis	58%	82%
A4H5C7	Leishmania braziliensis	37%	81%
A4HTK6	Leishmania infantum	84%	100%
A4HTK7	Leishmania infantum	36%	100%
E9AMD7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
E9AMD8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
Q4QIB1	Leishmania major	34%	100%