Movement protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Movement protein

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QIB1_LEIMA

TriTrypDb:

LmjF.08.0580 , LMJLV39_080011000 , LMJSD75_080011000

Length:

167

Annotations

LeishMANIAdb annotations

This protein family is endemic to Kinetoplastids, might have emerged de novo and also expanded. . The family also contains Leishmaniid members lacking the signal peptide and only having an MTTPA- start sequence

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 9
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4QIB1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIB1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.689
CLV_NRD_NRD_1	101	103	PF00675	0.527
CLV_NRD_NRD_1	110	112	PF00675	0.487
CLV_NRD_NRD_1	69	71	PF00675	0.403
CLV_PCSK_FUR_1	99	103	PF00082	0.495
CLV_PCSK_KEX2_1	101	103	PF00082	0.526
CLV_PCSK_KEX2_1	110	112	PF00082	0.485
CLV_PCSK_SKI1_1	31	35	PF00082	0.599
CLV_PCSK_SKI1_1	70	74	PF00082	0.398
DEG_MDM2_SWIB_1	34	42	PF02201	0.370
DOC_CKS1_1	1	6	PF01111	0.428
DOC_USP7_MATH_1	117	121	PF00917	0.729
DOC_USP7_MATH_1	15	19	PF00917	0.386
DOC_USP7_MATH_1	29	33	PF00917	0.431
LIG_14-3-3_CanoR_1	110	115	PF00244	0.690
LIG_14-3-3_CterR_2	163	167	PF00244	0.653
LIG_FHA_1	110	116	PF00498	0.649
LIG_FHA_1	38	44	PF00498	0.278
LIG_FHA_1	90	96	PF00498	0.648
LIG_FHA_2	138	144	PF00498	0.630
LIG_FHA_2	8	14	PF00498	0.407
LIG_LIR_Gen_1	144	155	PF02991	0.614
LIG_LIR_Gen_1	18	29	PF02991	0.411
LIG_LIR_Nem_3	144	150	PF02991	0.640
LIG_LIR_Nem_3	18	24	PF02991	0.418
LIG_LIR_Nem_3	36	42	PF02991	0.329
LIG_LIR_Nem_3	82	88	PF02991	0.647
LIG_Pex14_2	34	38	PF04695	0.405
LIG_PTB_Apo_2	80	87	PF02174	0.590
LIG_SH2_CRK	21	25	PF00017	0.401
LIG_SH2_CRK	39	43	PF00017	0.220
LIG_SH2_CRK	53	57	PF00017	0.264
LIG_SH2_PTP2	147	150	PF00017	0.627
LIG_SH2_STAT3	66	69	PF00017	0.620
LIG_SH2_STAT5	147	150	PF00017	0.627
LIG_SH2_STAT5	39	42	PF00017	0.407
LIG_SH2_STAT5	80	83	PF00017	0.666
LIG_SH3_3	151	157	PF00018	0.632
LIG_SH3_3	9	15	PF00018	0.444
LIG_SUMO_SIM_anti_2	40	46	PF11976	0.289
LIG_TYR_ITIM	19	24	PF00017	0.393
MOD_CK1_1	104	110	PF00069	0.701
MOD_CK1_1	136	142	PF00069	0.734
MOD_CK2_1	119	125	PF00069	0.607
MOD_CK2_1	137	143	PF00069	0.768
MOD_CK2_1	7	13	PF00069	0.410
MOD_Cter_Amidation	99	102	PF01082	0.419
MOD_GlcNHglycan	119	122	PF01048	0.468
MOD_GlcNHglycan	133	136	PF01048	0.450
MOD_GSK3_1	100	107	PF00069	0.711
MOD_GSK3_1	131	138	PF00069	0.735
MOD_GSK3_1	29	36	PF00069	0.456
MOD_N-GLC_1	105	110	PF02516	0.437
MOD_NEK2_1	33	38	PF00069	0.346
MOD_NEK2_2	29	34	PF00069	0.363
MOD_PKA_1	101	107	PF00069	0.682
MOD_PKA_1	110	116	PF00069	0.680
MOD_PKA_2	100	106	PF00069	0.684
MOD_PKA_2	109	115	PF00069	0.702
MOD_PKA_2	89	95	PF00069	0.662
MOD_PKB_1	99	107	PF00069	0.708
MOD_Plk_1	126	132	PF00069	0.668
MOD_Plk_4	110	116	PF00069	0.668
MOD_Plk_4	15	21	PF00069	0.432
MOD_Plk_4	29	35	PF00069	0.373
TRG_ENDOCYTIC_2	147	150	PF00928	0.627
TRG_ENDOCYTIC_2	21	24	PF00928	0.400
TRG_ENDOCYTIC_2	39	42	PF00928	0.288
TRG_ENDOCYTIC_2	53	56	PF00928	0.341
TRG_ER_diArg_1	162	165	PF00400	0.647
TRG_ER_diArg_1	99	102	PF00400	0.691
TRG_NLS_MonoExtC_3	69	74	PF00514	0.619

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P923	Leptomonas seymouri	42%	79%
A0A3S5H659	Leishmania donovani	86%	100%
A0A3S7WQ87	Leishmania donovani	29%	100%
A4H5C6	Leishmania braziliensis	36%	77%
A4H5C7	Leishmania braziliensis	59%	75%
A4HTK6	Leishmania infantum	29%	100%
A4HTK7	Leishmania infantum	85%	100%
E9AMD7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	93%
E9AMD8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4QIB2	Leishmania major	34%	100%