Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QIB0_LEIMA

TriTrypDb:

LmjF.08.0590 , LMJLV39_080011100 , LMJSD75_080011100

Length:

473

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4QIB0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIB0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	199	203	PF00656	0.724
CLV_NRD_NRD_1	238	240	PF00675	0.540
CLV_NRD_NRD_1	278	280	PF00675	0.538
CLV_NRD_NRD_1	284	286	PF00675	0.506
CLV_NRD_NRD_1	66	68	PF00675	0.451
CLV_NRD_NRD_1	70	72	PF00675	0.502
CLV_NRD_NRD_1	75	77	PF00675	0.525
CLV_PCSK_FUR_1	276	280	PF00082	0.480
CLV_PCSK_KEX2_1	276	278	PF00082	0.543
CLV_PCSK_KEX2_1	284	286	PF00082	0.501
CLV_PCSK_KEX2_1	66	68	PF00082	0.453
CLV_PCSK_KEX2_1	70	72	PF00082	0.504
CLV_PCSK_PC7_1	66	72	PF00082	0.471
CLV_PCSK_SKI1_1	133	137	PF00082	0.429
CLV_PCSK_SKI1_1	239	243	PF00082	0.542
DEG_SPOP_SBC_1	28	32	PF00917	0.430
DEG_SPOP_SBC_1	308	312	PF00917	0.655
DEG_SPOP_SBC_1	340	344	PF00917	0.665
DOC_CYCLIN_RxL_1	210	224	PF00134	0.734
DOC_CYCLIN_RxL_1	247	255	PF00134	0.729
DOC_MAPK_gen_1	21	29	PF00069	0.574
DOC_MAPK_gen_1	453	461	PF00069	0.713
DOC_MAPK_MEF2A_6	21	29	PF00069	0.532
DOC_PP2B_LxvP_1	209	212	PF13499	0.657
DOC_PP2B_LxvP_1	272	275	PF13499	0.671
DOC_PP2B_LxvP_1	79	82	PF13499	0.726
DOC_USP7_MATH_1	120	124	PF00917	0.724
DOC_USP7_MATH_1	248	252	PF00917	0.732
DOC_USP7_MATH_1	256	260	PF00917	0.664
DOC_USP7_MATH_1	340	344	PF00917	0.665
DOC_USP7_MATH_1	429	433	PF00917	0.708
DOC_USP7_MATH_1	444	448	PF00917	0.605
DOC_USP7_MATH_1	467	471	PF00917	0.715
DOC_USP7_MATH_1	88	92	PF00917	0.722
DOC_WW_Pin1_4	102	107	PF00397	0.746
DOC_WW_Pin1_4	113	118	PF00397	0.683
DOC_WW_Pin1_4	168	173	PF00397	0.825
DOC_WW_Pin1_4	252	257	PF00397	0.721
DOC_WW_Pin1_4	258	263	PF00397	0.674
DOC_WW_Pin1_4	30	35	PF00397	0.562
DOC_WW_Pin1_4	329	334	PF00397	0.670
DOC_WW_Pin1_4	353	358	PF00397	0.706
DOC_WW_Pin1_4	368	373	PF00397	0.626
DOC_WW_Pin1_4	412	417	PF00397	0.726
LIG_14-3-3_CanoR_1	250	255	PF00244	0.717
LIG_BIR_III_2	103	107	PF00653	0.683
LIG_BRCT_BRCA1_1	48	52	PF00533	0.367
LIG_FHA_1	30	36	PF00498	0.549
LIG_FHA_1	342	348	PF00498	0.730
LIG_FHA_1	353	359	PF00498	0.642
LIG_FHA_1	371	377	PF00498	0.607
LIG_FHA_1	404	410	PF00498	0.658
LIG_FHA_2	158	164	PF00498	0.675
LIG_FHA_2	389	395	PF00498	0.690
LIG_LIR_Apic_2	310	316	PF02991	0.722
LIG_LIR_Gen_1	399	409	PF02991	0.721
LIG_LIR_Gen_1	43	52	PF02991	0.367
LIG_LIR_Nem_3	43	47	PF02991	0.481
LIG_LIR_Nem_3	49	55	PF02991	0.461
LIG_MAD2	17	25	PF02301	0.491
LIG_MLH1_MIPbox_1	48	52	PF16413	0.367
LIG_MYND_1	357	361	PF01753	0.642
LIG_Pex14_2	48	52	PF04695	0.511
LIG_SH2_PTP2	362	365	PF00017	0.724
LIG_SH2_PTP2	44	47	PF00017	0.367
LIG_SH2_SRC	44	47	PF00017	0.367
LIG_SH2_STAP1	389	393	PF00017	0.709
LIG_SH2_STAT5	323	326	PF00017	0.668
LIG_SH2_STAT5	362	365	PF00017	0.724
LIG_SH2_STAT5	44	47	PF00017	0.450
LIG_SH2_STAT5	51	54	PF00017	0.338
LIG_SH2_STAT5	95	98	PF00017	0.661
LIG_SH3_1	457	463	PF00018	0.714
LIG_SH3_3	355	361	PF00018	0.654
LIG_SH3_3	371	377	PF00018	0.672
LIG_SH3_3	407	413	PF00018	0.724
LIG_SH3_3	457	463	PF00018	0.714
LIG_SH3_3	72	78	PF00018	0.656
LIG_SUMO_SIM_anti_2	163	169	PF11976	0.728
LIG_SUMO_SIM_anti_2	204	210	PF11976	0.656
LIG_SUMO_SIM_anti_2	36	43	PF11976	0.397
LIG_SUMO_SIM_par_1	25	33	PF11976	0.493
LIG_SUMO_SIM_par_1	435	443	PF11976	0.698
LIG_TYR_ITIM	360	365	PF00017	0.719
LIG_TYR_ITIM	42	47	PF00017	0.367
LIG_WRC_WIRS_1	462	467	PF05994	0.713
MOD_CDC14_SPxK_1	105	108	PF00782	0.749
MOD_CDK_SPxK_1	102	108	PF00069	0.748
MOD_CDK_SPxK_1	168	174	PF00069	0.718
MOD_CK1_1	102	108	PF00069	0.741
MOD_CK1_1	113	119	PF00069	0.676
MOD_CK1_1	127	133	PF00069	0.602
MOD_CK1_1	185	191	PF00069	0.741
MOD_CK1_1	233	239	PF00069	0.738
MOD_CK1_1	30	36	PF00069	0.457
MOD_CK1_1	317	323	PF00069	0.729
MOD_CK1_1	325	331	PF00069	0.688
MOD_CK1_1	370	376	PF00069	0.716
MOD_CK1_1	415	421	PF00069	0.725
MOD_CK1_1	432	438	PF00069	0.602
MOD_CK1_1	449	455	PF00069	0.606
MOD_CK2_1	157	163	PF00069	0.677
MOD_CK2_1	388	394	PF00069	0.693
MOD_GlcNHglycan	149	153	PF01048	0.531
MOD_GlcNHglycan	184	187	PF01048	0.539
MOD_GlcNHglycan	188	191	PF01048	0.519
MOD_GlcNHglycan	329	332	PF01048	0.492
MOD_GlcNHglycan	435	438	PF01048	0.443
MOD_GSK3_1	109	116	PF00069	0.687
MOD_GSK3_1	120	127	PF00069	0.647
MOD_GSK3_1	181	188	PF00069	0.739
MOD_GSK3_1	248	255	PF00069	0.728
MOD_GSK3_1	29	36	PF00069	0.541
MOD_GSK3_1	314	321	PF00069	0.724
MOD_GSK3_1	322	329	PF00069	0.685
MOD_GSK3_1	348	355	PF00069	0.719
MOD_GSK3_1	429	436	PF00069	0.706
MOD_GSK3_1	449	456	PF00069	0.588
MOD_GSK3_1	95	102	PF00069	0.772
MOD_N-GLC_1	340	345	PF02516	0.465
MOD_NEK2_1	1	6	PF00069	0.430
MOD_NEK2_1	27	32	PF00069	0.522
MOD_NEK2_1	35	40	PF00069	0.325
MOD_OFUCOSY	288	295	PF10250	0.532
MOD_PKA_2	120	126	PF00069	0.718
MOD_PKA_2	195	201	PF00069	0.730
MOD_PKA_2	286	292	PF00069	0.740
MOD_PKA_2	449	455	PF00069	0.708
MOD_Plk_1	127	133	PF00069	0.699
MOD_Plk_1	201	207	PF00069	0.721
MOD_Plk_1	233	239	PF00069	0.738
MOD_Plk_1	308	314	PF00069	0.682
MOD_Plk_1	318	324	PF00069	0.637
MOD_Plk_1	444	450	PF00069	0.632
MOD_Plk_2-3	388	394	PF00069	0.713
MOD_Plk_4	127	133	PF00069	0.686
MOD_Plk_4	163	169	PF00069	0.728
MOD_Plk_4	309	315	PF00069	0.723
MOD_Plk_4	319	325	PF00069	0.671
MOD_Plk_4	378	384	PF00069	0.658
MOD_Plk_4	40	46	PF00069	0.353
MOD_Plk_4	461	467	PF00069	0.715
MOD_Plk_4	82	88	PF00069	0.675
MOD_ProDKin_1	102	108	PF00069	0.748
MOD_ProDKin_1	113	119	PF00069	0.682
MOD_ProDKin_1	168	174	PF00069	0.718
MOD_ProDKin_1	252	258	PF00069	0.720
MOD_ProDKin_1	30	36	PF00069	0.555
MOD_ProDKin_1	329	335	PF00069	0.671
MOD_ProDKin_1	353	359	PF00069	0.707
MOD_ProDKin_1	368	374	PF00069	0.625
MOD_ProDKin_1	412	418	PF00069	0.724
TRG_DiLeu_BaLyEn_6	457	462	PF01217	0.714
TRG_ENDOCYTIC_2	132	135	PF00928	0.628
TRG_ENDOCYTIC_2	362	365	PF00928	0.724
TRG_ENDOCYTIC_2	44	47	PF00928	0.473
TRG_ER_diArg_1	15	18	PF00400	0.477
TRG_ER_diArg_1	275	278	PF00400	0.740
TRG_ER_diArg_1	69	71	PF00400	0.712
TRG_NLS_MonoExtC_3	238	244	PF00514	0.740

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WQA9	Leishmania donovani	79%	92%
A4HTK8	Leishmania infantum	80%	92%