Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QIA9_LEIMA

TriTrypDb:

LmjF.08.0600 , LMJLV39_080011300 , LMJSD75_080011300

Length:

143

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 3
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4QIA9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIA9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	12	14	PF00675	0.387
CLV_NRD_NRD_1	51	53	PF00675	0.634
CLV_NRD_NRD_1	99	101	PF00675	0.440
CLV_PCSK_KEX2_1	51	53	PF00082	0.634
CLV_PCSK_KEX2_1	98	100	PF00082	0.439
DEG_Nend_UBRbox_2	1	3	PF02207	0.760
DEG_SCF_FBW7_1	41	47	PF00400	0.521
DOC_CKS1_1	41	46	PF01111	0.525
DOC_MAPK_gen_1	11	21	PF00069	0.558
DOC_MAPK_MEF2A_6	13	21	PF00069	0.440
DOC_WW_Pin1_4	138	143	PF00397	0.704
DOC_WW_Pin1_4	40	45	PF00397	0.450
LIG_14-3-3_CanoR_1	129	139	PF00244	0.759
LIG_14-3-3_CanoR_1	51	55	PF00244	0.430
LIG_BRCT_BRCA1_1	17	21	PF00533	0.262
LIG_EH1_1	68	76	PF00400	0.389
LIG_FHA_1	45	51	PF00498	0.449
LIG_FHA_2	106	112	PF00498	0.617
LIG_GBD_Chelix_1	22	30	PF00786	0.294
LIG_LIR_Apic_2	133	138	PF02991	0.689
LIG_LIR_Nem_3	62	67	PF02991	0.381
LIG_NRBOX	73	79	PF00104	0.299
LIG_PDZ_Class_1	138	143	PF00595	0.682
LIG_Pex14_1	65	69	PF04695	0.292
LIG_Pex14_2	61	65	PF04695	0.386
LIG_SH2_CRK	135	139	PF00017	0.714
LIG_SH2_CRK	84	88	PF00017	0.431
LIG_SH2_GRB2like	135	138	PF00017	0.687
LIG_SH2_NCK_1	84	88	PF00017	0.389
LIG_SH2_STAP1	54	58	PF00017	0.479
LIG_SH2_STAT5	49	52	PF00017	0.457
LIG_SH3_3	38	44	PF00018	0.538
LIG_TYR_ITIM	82	87	PF00017	0.380
LIG_TYR_ITSM	60	67	PF00017	0.380
MOD_CDK_SPK_2	40	45	PF00069	0.413
MOD_CDK_SPxxK_3	44	51	PF00069	0.521
MOD_CK1_1	130	136	PF00069	0.799
MOD_CK2_1	105	111	PF00069	0.588
MOD_GSK3_1	105	112	PF00069	0.570
MOD_GSK3_1	127	134	PF00069	0.717
MOD_GSK3_1	40	47	PF00069	0.541
MOD_NEK2_1	105	110	PF00069	0.579
MOD_NEK2_1	26	31	PF00069	0.311
MOD_PIKK_1	118	124	PF00454	0.713
MOD_PIKK_1	59	65	PF00454	0.427
MOD_PKA_2	50	56	PF00069	0.429
MOD_PKB_1	107	115	PF00069	0.609
MOD_Plk_1	110	116	PF00069	0.650
MOD_Plk_2-3	111	117	PF00069	0.594
MOD_Plk_4	15	21	PF00069	0.296
MOD_ProDKin_1	40	46	PF00069	0.450
MOD_SUMO_rev_2	111	119	PF00179	0.648
TRG_ENDOCYTIC_2	64	67	PF00928	0.363
TRG_ENDOCYTIC_2	84	87	PF00928	0.494
TRG_ER_diArg_1	107	110	PF00400	0.630
TRG_ER_diArg_1	50	52	PF00400	0.440
TRG_ER_diArg_1	97	100	PF00400	0.703

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IC93	Leptomonas seymouri	54%	100%
A0A3S5H661	Leishmania donovani	83%	100%
A4H5E7	Leishmania braziliensis	56%	100%
A4HTK9	Leishmania infantum	84%	100%
E9AME0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%