Amastin surface glycofamily protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Amastin surface glycoprotein, putative

Species:

Leishmania major

UniProt:

Q4QIA5_LEIMA

TriTrypDb:

LmjF.08.0640 , LMJLV39_080011600 , LMJSD75_080011600

Length:

299

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4QIA5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIA5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	239	241	PF00675	0.596
CLV_NRD_NRD_1	276	278	PF00675	0.513
CLV_PCSK_KEX2_1	276	278	PF00082	0.513
CLV_PCSK_SKI1_1	153	157	PF00082	0.615
CLV_PCSK_SKI1_1	179	183	PF00082	0.680
CLV_PCSK_SKI1_1	190	194	PF00082	0.606
CLV_PCSK_SKI1_1	199	203	PF00082	0.639
DEG_SCF_FBW7_2	55	61	PF00400	0.390
DOC_CKS1_1	55	60	PF01111	0.390
DOC_CYCLIN_RxL_1	176	186	PF00134	0.483
DOC_MAPK_MEF2A_6	190	198	PF00069	0.453
DOC_MAPK_MEF2A_6	204	213	PF00069	0.400
DOC_MAPK_MEF2A_6	71	80	PF00069	0.394
DOC_PP2B_LxvP_1	175	178	PF13499	0.428
DOC_PP2B_LxvP_1	209	212	PF13499	0.434
DOC_USP7_MATH_1	188	192	PF00917	0.488
DOC_USP7_MATH_1	2	6	PF00917	0.599
DOC_USP7_MATH_1	218	222	PF00917	0.501
DOC_USP7_MATH_1	256	260	PF00917	0.335
DOC_USP7_MATH_1	83	87	PF00917	0.353
DOC_USP7_UBL2_3	67	71	PF12436	0.436
DOC_WW_Pin1_4	190	195	PF00397	0.500
DOC_WW_Pin1_4	54	59	PF00397	0.384
LIG_14-3-3_CanoR_1	111	115	PF00244	0.687
LIG_14-3-3_CanoR_1	276	283	PF00244	0.661
LIG_BIR_II_1	1	5	PF00653	0.609
LIG_deltaCOP1_diTrp_1	248	254	PF00928	0.425
LIG_EH_1	229	233	PF12763	0.389
LIG_FHA_1	127	133	PF00498	0.474
LIG_FHA_1	191	197	PF00498	0.539
LIG_FHA_1	220	226	PF00498	0.561
LIG_FHA_1	266	272	PF00498	0.477
LIG_FHA_1	27	33	PF00498	0.473
LIG_FHA_1	45	51	PF00498	0.273
LIG_FHA_2	243	249	PF00498	0.475
LIG_LIR_Gen_1	101	109	PF02991	0.464
LIG_LIR_Gen_1	252	262	PF02991	0.324
LIG_LIR_LC3C_4	267	271	PF02991	0.460
LIG_LIR_Nem_3	101	106	PF02991	0.450
LIG_LIR_Nem_3	252	257	PF02991	0.361
LIG_SH2_GRB2like	146	149	PF00017	0.399
LIG_SH2_NCK_1	56	60	PF00017	0.380
LIG_SH2_STAP1	146	150	PF00017	0.502
LIG_SH2_STAT5	140	143	PF00017	0.392
LIG_SH2_STAT5	56	59	PF00017	0.397
LIG_SH3_3	166	172	PF00018	0.458
LIG_SUMO_SIM_anti_2	267	275	PF11976	0.408
LIG_SUMO_SIM_anti_2	285	292	PF11976	0.592
LIG_SUMO_SIM_anti_2	5	13	PF11976	0.625
LIG_SUMO_SIM_par_1	267	275	PF11976	0.391
LIG_UBA3_1	208	215	PF00899	0.435
LIG_WRC_WIRS_1	106	111	PF05994	0.621
LIG_WRC_WIRS_1	236	241	PF05994	0.452
LIG_WRC_WIRS_1	66	71	PF05994	0.376
MOD_CK1_1	107	113	PF00069	0.674
MOD_CK1_1	275	281	PF00069	0.659
MOD_CK1_1	3	9	PF00069	0.694
MOD_CK1_1	44	50	PF00069	0.360
MOD_CK2_1	242	248	PF00069	0.447
MOD_DYRK1A_RPxSP_1	190	194	PF00069	0.430
MOD_GlcNHglycan	100	103	PF01048	0.278
MOD_GlcNHglycan	12	15	PF01048	0.317
MOD_GlcNHglycan	17	20	PF01048	0.394
MOD_GlcNHglycan	2	5	PF01048	0.440
MOD_GlcNHglycan	258	261	PF01048	0.278
MOD_GlcNHglycan	285	288	PF01048	0.550
MOD_GSK3_1	105	112	PF00069	0.657
MOD_GSK3_1	184	191	PF00069	0.443
MOD_GSK3_1	214	221	PF00069	0.453
MOD_GSK3_1	272	279	PF00069	0.550
MOD_GSK3_1	42	49	PF00069	0.394
MOD_GSK3_1	50	57	PF00069	0.412
MOD_N-GLC_1	153	158	PF02516	0.699
MOD_N-GLC_1	42	47	PF02516	0.629
MOD_N-GLC_2	149	151	PF02516	0.624
MOD_NEK2_1	10	15	PF00069	0.657
MOD_NEK2_1	105	110	PF00069	0.620
MOD_NEK2_1	126	131	PF00069	0.484
MOD_NEK2_1	242	247	PF00069	0.475
MOD_NEK2_1	26	31	PF00069	0.263
MOD_NEK2_1	265	270	PF00069	0.385
MOD_NEK2_1	283	288	PF00069	0.664
MOD_NEK2_1	42	47	PF00069	0.322
MOD_NEK2_1	98	103	PF00069	0.465
MOD_NEK2_2	235	240	PF00069	0.445
MOD_PIKK_1	44	50	PF00454	0.375
MOD_PKA_1	276	282	PF00069	0.678
MOD_PKA_2	110	116	PF00069	0.655
MOD_PKA_2	275	281	PF00069	0.676
MOD_Plk_1	153	159	PF00069	0.492
MOD_Plk_1	42	48	PF00069	0.424
MOD_Plk_4	170	176	PF00069	0.502
MOD_Plk_4	177	183	PF00069	0.462
MOD_Plk_4	265	271	PF00069	0.457
MOD_Plk_4	46	52	PF00069	0.340
MOD_Plk_4	65	71	PF00069	0.471
MOD_Plk_4	84	90	PF00069	0.429
MOD_ProDKin_1	190	196	PF00069	0.501
MOD_ProDKin_1	54	60	PF00069	0.384
TRG_DiLeu_BaEn_1	294	299	PF01217	0.692
TRG_DiLeu_LyEn_5	294	299	PF01217	0.718
TRG_ER_diArg_1	114	117	PF00400	0.698

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I287	Leptomonas seymouri	38%	100%
A0A3S7WQ88	Leishmania donovani	82%	100%
A4H5G2	Leishmania braziliensis	58%	100%
A4HTL2	Leishmania infantum	81%	100%
E9AME3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	98%