J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QIA4_LEIMA

TriTrypDb:

LmjF.08.0650 , LMJLV39_080011700 , LMJSD75_080011700

Length:

286

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QIA4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QIA4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	131	135	PF00656	0.583
CLV_NRD_NRD_1	24	26	PF00675	0.412
CLV_NRD_NRD_1	275	277	PF00675	0.540
CLV_NRD_NRD_1	70	72	PF00675	0.346
CLV_NRD_NRD_1	97	99	PF00675	0.662
CLV_PCSK_FUR_1	95	99	PF00082	0.525
CLV_PCSK_KEX2_1	24	26	PF00082	0.432
CLV_PCSK_KEX2_1	275	277	PF00082	0.540
CLV_PCSK_KEX2_1	70	72	PF00082	0.390
CLV_PCSK_KEX2_1	97	99	PF00082	0.662
CLV_PCSK_SKI1_1	219	223	PF00082	0.589
CLV_PCSK_SKI1_1	24	28	PF00082	0.369
DEG_Nend_UBRbox_3	1	3	PF02207	0.511
DOC_CYCLIN_yCln2_LP_2	8	14	PF00134	0.391
DOC_MAPK_gen_1	24	30	PF00069	0.256
DOC_PP2B_LxvP_1	8	11	PF13499	0.391
DOC_PP4_MxPP_1	163	166	PF00568	0.528
DOC_USP7_MATH_1	114	118	PF00917	0.620
DOC_USP7_MATH_1	263	267	PF00917	0.571
DOC_WW_Pin1_4	196	201	PF00397	0.675
DOC_WW_Pin1_4	245	250	PF00397	0.678
LIG_14-3-3_CanoR_1	83	93	PF00244	0.517
LIG_Actin_WH2_2	46	61	PF00022	0.256
LIG_FHA_1	170	176	PF00498	0.654
LIG_FHA_1	184	190	PF00498	0.543
LIG_FHA_1	211	217	PF00498	0.630
LIG_FHA_1	225	231	PF00498	0.584
LIG_FHA_1	45	51	PF00498	0.375
LIG_FHA_1	77	83	PF00498	0.512
LIG_FHA_2	1	7	PF00498	0.432
LIG_FHA_2	129	135	PF00498	0.582
LIG_FHA_2	186	192	PF00498	0.680
LIG_FHA_2	44	50	PF00498	0.323
LIG_Integrin_RGD_1	159	161	PF01839	0.583
LIG_LIR_Apic_2	86	92	PF02991	0.557
LIG_LIR_Gen_1	3	12	PF02991	0.391
LIG_LIR_LC3C_4	227	232	PF02991	0.567
LIG_LIR_Nem_3	17	23	PF02991	0.323
LIG_LIR_Nem_3	3	8	PF02991	0.391
LIG_LIR_Nem_3	73	77	PF02991	0.342
LIG_PDZ_Class_2	281	286	PF00595	0.563
LIG_PTB_Apo_2	56	63	PF02174	0.278
LIG_PTB_Phospho_1	56	62	PF10480	0.278
LIG_SH2_CRK	167	171	PF00017	0.655
LIG_SH2_CRK	23	27	PF00017	0.391
LIG_SH2_CRK	5	9	PF00017	0.391
LIG_SH2_CRK	62	66	PF00017	0.391
LIG_SH2_CRK	89	93	PF00017	0.576
LIG_SH2_GRB2like	167	170	PF00017	0.653
LIG_SH2_SRC	167	170	PF00017	0.653
LIG_SH2_STAP1	74	78	PF00017	0.485
LIG_SH2_STAT5	77	80	PF00017	0.506
LIG_SH3_3	140	146	PF00018	0.550
LIG_SH3_3	246	252	PF00018	0.623
LIG_SH3_3	268	274	PF00018	0.600
LIG_SH3_3	93	99	PF00018	0.544
LIG_SUMO_SIM_anti_2	206	215	PF11976	0.596
LIG_SUMO_SIM_par_1	229	235	PF11976	0.574
LIG_TRAF2_1	153	156	PF00917	0.679
LIG_WRC_WIRS_1	1	6	PF05994	0.323
MOD_CK1_1	199	205	PF00069	0.626
MOD_CK1_1	206	212	PF00069	0.586
MOD_CK1_1	242	248	PF00069	0.653
MOD_CK1_1	84	90	PF00069	0.546
MOD_CK2_1	150	156	PF00069	0.698
MOD_CK2_1	185	191	PF00069	0.678
MOD_CK2_1	43	49	PF00069	0.323
MOD_GlcNHglycan	118	121	PF01048	0.560
MOD_GlcNHglycan	12	15	PF01048	0.366
MOD_GlcNHglycan	147	150	PF01048	0.678
MOD_GlcNHglycan	152	155	PF01048	0.632
MOD_GlcNHglycan	241	244	PF01048	0.701
MOD_GlcNHglycan	256	259	PF01048	0.690
MOD_GlcNHglycan	265	268	PF01048	0.539
MOD_GlcNHglycan	86	89	PF01048	0.544
MOD_GSK3_1	183	190	PF00069	0.616
MOD_GSK3_1	199	206	PF00069	0.558
MOD_GSK3_1	210	217	PF00069	0.534
MOD_GSK3_1	239	246	PF00069	0.694
MOD_GSK3_1	6	13	PF00069	0.338
MOD_N-GLC_1	114	119	PF02516	0.597
MOD_N-GLC_1	38	43	PF02516	0.391
MOD_N-GLC_1	44	49	PF02516	0.334
MOD_N-GLC_1	84	89	PF02516	0.566
MOD_NEK2_1	175	180	PF00069	0.621
MOD_PIKK_1	12	18	PF00454	0.391
MOD_Plk_1	114	120	PF00069	0.603
MOD_Plk_1	38	44	PF00069	0.391
MOD_Plk_1	84	90	PF00069	0.575
MOD_Plk_4	206	212	PF00069	0.602
MOD_ProDKin_1	196	202	PF00069	0.672
MOD_ProDKin_1	245	251	PF00069	0.674
TRG_DiLeu_BaLyEn_6	22	27	PF01217	0.391
TRG_ENDOCYTIC_2	23	26	PF00928	0.391
TRG_ENDOCYTIC_2	5	8	PF00928	0.455
TRG_ENDOCYTIC_2	62	65	PF00928	0.391
TRG_ER_diArg_1	23	25	PF00400	0.450
TRG_ER_diArg_1	274	276	PF00400	0.602
TRG_ER_diArg_1	95	98	PF00400	0.654
TRG_Pf-PMV_PEXEL_1	278	282	PF00026	0.601
TRG_Pf-PMV_PEXEL_1	48	52	PF00026	0.369

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WQB1	Leishmania donovani	82%	97%
A4H5G3	Leishmania braziliensis	55%	94%
A4HTL3	Leishmania infantum	82%	97%
E9AME4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	99%