Putative tuzin

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Putative tuzin

Gene product:

tuzin, putative

Species:

Leishmania major

UniProt:

Q4QI91_LEIMA

TriTrypDb:

LmjF.08.0780 , LMJLV39_080012400 , LMJSD75_080012100

Length:

509

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 33
NetGPI	no	yes: 0, no: 33

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	15
GO:0110165	cellular anatomical entity	1	15

Expansion

Sequence features

Q4QI91

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QI91

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	471	475	PF00656	0.422
CLV_MEL_PAP_1	16	22	PF00089	0.404
CLV_NRD_NRD_1	126	128	PF00675	0.282
CLV_NRD_NRD_1	131	133	PF00675	0.411
CLV_NRD_NRD_1	193	195	PF00675	0.629
CLV_NRD_NRD_1	240	242	PF00675	0.600
CLV_NRD_NRD_1	268	270	PF00675	0.556
CLV_NRD_NRD_1	350	352	PF00675	0.514
CLV_NRD_NRD_1	423	425	PF00675	0.609
CLV_NRD_NRD_1	453	455	PF00675	0.664
CLV_NRD_NRD_1	91	93	PF00675	0.336
CLV_PCSK_FUR_1	191	195	PF00082	0.469
CLV_PCSK_KEX2_1	131	133	PF00082	0.365
CLV_PCSK_KEX2_1	190	192	PF00082	0.653
CLV_PCSK_KEX2_1	193	195	PF00082	0.655
CLV_PCSK_KEX2_1	240	242	PF00082	0.600
CLV_PCSK_KEX2_1	350	352	PF00082	0.514
CLV_PCSK_KEX2_1	452	454	PF00082	0.636
CLV_PCSK_KEX2_1	91	93	PF00082	0.326
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.479
CLV_PCSK_PC1ET2_1	452	454	PF00082	0.626
CLV_PCSK_PC7_1	127	133	PF00082	0.257
CLV_PCSK_PC7_1	236	242	PF00082	0.605
CLV_PCSK_SKI1_1	132	136	PF00082	0.385
CLV_PCSK_SKI1_1	149	153	PF00082	0.381
CLV_PCSK_SKI1_1	22	26	PF00082	0.375
CLV_PCSK_SKI1_1	236	240	PF00082	0.606
CLV_PCSK_SKI1_1	273	277	PF00082	0.496
CLV_PCSK_SKI1_1	292	296	PF00082	0.567
CLV_PCSK_SKI1_1	315	319	PF00082	0.635
CLV_PCSK_SKI1_1	385	389	PF00082	0.647
CLV_PCSK_SKI1_1	454	458	PF00082	0.469
CLV_PCSK_SKI1_1	493	497	PF00082	0.590
DEG_APCC_DBOX_1	235	243	PF00400	0.431
DEG_APCC_DBOX_1	453	461	PF00400	0.384
DEG_APCC_DBOX_1	94	102	PF00400	0.542
DEG_MDM2_SWIB_1	172	179	PF02201	0.192
DEG_Nend_UBRbox_2	1	3	PF02207	0.604
DOC_MAPK_DCC_7	318	328	PF00069	0.350
DOC_MAPK_gen_1	105	114	PF00069	0.557
DOC_MAPK_gen_1	127	135	PF00069	0.575
DOC_MAPK_gen_1	269	280	PF00069	0.337
DOC_MAPK_MEF2A_6	269	278	PF00069	0.304
DOC_MAPK_MEF2A_6	318	327	PF00069	0.358
DOC_PP1_RVXF_1	371	377	PF00149	0.326
DOC_PP2B_PxIxI_1	246	252	PF00149	0.320
DOC_USP7_MATH_1	10	14	PF00917	0.666
DOC_USP7_MATH_1	360	364	PF00917	0.287
DOC_USP7_MATH_1	55	59	PF00917	0.510
DOC_WW_Pin1_4	215	220	PF00397	0.530
DOC_WW_Pin1_4	4	9	PF00397	0.609
LIG_14-3-3_CanoR_1	127	131	PF00244	0.531
LIG_14-3-3_CanoR_1	194	200	PF00244	0.429
LIG_14-3-3_CanoR_1	214	219	PF00244	0.584
LIG_14-3-3_CanoR_1	241	247	PF00244	0.412
LIG_14-3-3_CanoR_1	248	252	PF00244	0.406
LIG_14-3-3_CanoR_1	493	501	PF00244	0.366
LIG_APCC_ABBAyCdc20_2	273	279	PF00400	0.360
LIG_BRCT_BRCA1_1	168	172	PF00533	0.249
LIG_deltaCOP1_diTrp_1	158	164	PF00928	0.572
LIG_deltaCOP1_diTrp_1	492	496	PF00928	0.333
LIG_FHA_1	286	292	PF00498	0.393
LIG_FHA_1	41	47	PF00498	0.579
LIG_FHA_1	471	477	PF00498	0.411
LIG_FHA_1	495	501	PF00498	0.352
LIG_FHA_2	207	213	PF00498	0.453
LIG_FHA_2	23	29	PF00498	0.727
LIG_IRF3_LxIS_1	361	367	PF10401	0.242
LIG_LIR_Gen_1	14	24	PF02991	0.520
LIG_LIR_Gen_1	304	313	PF02991	0.336
LIG_LIR_Gen_1	74	84	PF02991	0.479
LIG_LIR_Nem_3	14	20	PF02991	0.582
LIG_LIR_Nem_3	158	164	PF02991	0.549
LIG_LIR_Nem_3	173	179	PF02991	0.294
LIG_LIR_Nem_3	304	308	PF02991	0.346
LIG_LIR_Nem_3	375	379	PF02991	0.327
LIG_MLH1_MIPbox_1	168	172	PF16413	0.192
LIG_MYND_3	296	300	PF01753	0.282
LIG_NRBOX	97	103	PF00104	0.533
LIG_Pex14_2	172	176	PF04695	0.332
LIG_PTB_Apo_2	47	54	PF02174	0.571
LIG_SH2_CRK	487	491	PF00017	0.367
LIG_SH2_NCK_1	487	491	PF00017	0.362
LIG_SH2_PTP2	17	20	PF00017	0.594
LIG_SH2_SRC	487	490	PF00017	0.383
LIG_SH2_STAP1	357	361	PF00017	0.332
LIG_SH2_STAT3	163	166	PF00017	0.590
LIG_SH2_STAT3	431	434	PF00017	0.288
LIG_SH2_STAT3	466	469	PF00017	0.382
LIG_SH2_STAT5	113	116	PF00017	0.553
LIG_SH2_STAT5	125	128	PF00017	0.564
LIG_SH2_STAT5	163	166	PF00017	0.515
LIG_SH2_STAT5	17	20	PF00017	0.566
LIG_SH2_STAT5	305	308	PF00017	0.340
LIG_SH2_STAT5	390	393	PF00017	0.361
LIG_SH2_STAT5	431	434	PF00017	0.351
LIG_SH2_STAT5	466	469	PF00017	0.403
LIG_SH3_3	216	222	PF00018	0.510
LIG_SH3_3	366	372	PF00018	0.328
LIG_SUMO_SIM_anti_2	60	66	PF11976	0.648
LIG_SUMO_SIM_par_1	322	329	PF11976	0.353
LIG_SUMO_SIM_par_1	60	66	PF11976	0.586
LIG_TRAF2_1	229	232	PF00917	0.389
LIG_TRFH_1	113	117	PF08558	0.468
LIG_TYR_ITIM	485	490	PF00017	0.340
LIG_UBA3_1	286	295	PF00899	0.228
LIG_UBA3_1	417	425	PF00899	0.265
MOD_CK1_1	215	221	PF00069	0.488
MOD_CK1_1	334	340	PF00069	0.366
MOD_CK1_1	40	46	PF00069	0.597
MOD_CK1_1	69	75	PF00069	0.643
MOD_CK2_1	424	430	PF00069	0.373
MOD_GlcNHglycan	168	171	PF01048	0.293
MOD_GlcNHglycan	172	175	PF01048	0.286
MOD_GlcNHglycan	265	268	PF01048	0.574
MOD_GlcNHglycan	470	473	PF01048	0.583
MOD_GlcNHglycan	85	88	PF01048	0.355
MOD_GSK3_1	166	173	PF00069	0.451
MOD_GSK3_1	204	211	PF00069	0.432
MOD_GSK3_1	259	266	PF00069	0.346
MOD_GSK3_1	307	314	PF00069	0.425
MOD_GSK3_1	360	367	PF00069	0.285
MOD_N-GLC_1	340	345	PF02516	0.525
MOD_N-GLC_1	40	45	PF02516	0.383
MOD_N-GLC_1	49	54	PF02516	0.398
MOD_NEK2_1	126	131	PF00069	0.498
MOD_NEK2_1	242	247	PF00069	0.420
MOD_NEK2_1	263	268	PF00069	0.312
MOD_NEK2_1	326	331	PF00069	0.324
MOD_NEK2_1	364	369	PF00069	0.358
MOD_NEK2_1	403	408	PF00069	0.335
MOD_NEK2_2	180	185	PF00069	0.292
MOD_PIKK_1	55	61	PF00454	0.616
MOD_PK_1	424	430	PF00069	0.381
MOD_PKA_1	240	246	PF00069	0.277
MOD_PKA_1	424	430	PF00069	0.421
MOD_PKA_2	126	132	PF00069	0.528
MOD_PKA_2	213	219	PF00069	0.594
MOD_PKA_2	232	238	PF00069	0.314
MOD_PKA_2	240	246	PF00069	0.327
MOD_PKA_2	247	253	PF00069	0.311
MOD_PKA_2	69	75	PF00069	0.600
MOD_Plk_1	334	340	PF00069	0.312
MOD_Plk_1	391	397	PF00069	0.425
MOD_Plk_1	49	55	PF00069	0.629
MOD_Plk_2-3	49	55	PF00069	0.582
MOD_Plk_4	180	186	PF00069	0.242
MOD_Plk_4	259	265	PF00069	0.287
MOD_Plk_4	340	346	PF00069	0.344
MOD_ProDKin_1	215	221	PF00069	0.529
MOD_ProDKin_1	4	10	PF00069	0.596
MOD_SUMO_rev_2	266	275	PF00179	0.351
MOD_SUMO_rev_2	427	436	PF00179	0.265
TRG_DiLeu_BaEn_1	147	152	PF01217	0.585
TRG_DiLeu_BaEn_1	322	327	PF01217	0.319
TRG_ENDOCYTIC_2	168	171	PF00928	0.304
TRG_ENDOCYTIC_2	17	20	PF00928	0.594
TRG_ENDOCYTIC_2	189	192	PF00928	0.350
TRG_ENDOCYTIC_2	305	308	PF00928	0.340
TRG_ENDOCYTIC_2	487	490	PF00928	0.363
TRG_ENDOCYTIC_2	77	80	PF00928	0.541
TRG_ER_diArg_1	130	132	PF00400	0.628
TRG_ER_diArg_1	192	194	PF00400	0.456
TRG_ER_diArg_1	239	241	PF00400	0.405
TRG_ER_diArg_1	350	352	PF00400	0.297
TRG_ER_diArg_1	68	71	PF00400	0.636
TRG_NES_CRM1_1	284	300	PF08389	0.355
TRG_NES_CRM1_1	416	430	PF08389	0.267
TRG_NLS_MonoExtC_3	189	194	PF00514	0.266
TRG_Pf-PMV_PEXEL_1	149	154	PF00026	0.375
TRG_Pf-PMV_PEXEL_1	458	462	PF00026	0.575

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAN2	Leptomonas seymouri	41%	77%
A0A0N1PB02	Leptomonas seymouri	50%	78%
A0A0S4J6C6	Bodo saltans	42%	79%
A0A1X0P9A6	Trypanosomatidae	50%	75%
A0A3Q8IHH1	Leishmania donovani	39%	70%
A0A3R7K2Y9	Trypanosoma rangeli	49%	74%
A0A3S5H668	Leishmania donovani	95%	100%
A0A3S5H669	Leishmania donovani	47%	80%
A0A3S7X835	Leishmania donovani	49%	91%
A4H5C9	Leishmania braziliensis	75%	100%
A4H5D0	Leishmania braziliensis	44%	85%
A4HAZ7	Leishmania braziliensis	45%	100%
A4HAZ9	Leishmania braziliensis	46%	82%
A4HB01	Leishmania braziliensis	46%	87%
A4HTM0	Leishmania infantum	95%	100%
A4HTM1	Leishmania infantum	45%	80%
A4IA57	Leishmania infantum	49%	91%
C6K3V8	Leptomonas seymouri	77%	84%
C6K3V9	Leptomonas seymouri	42%	78%
C9ZMY5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	75%
E8NHE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	81%
E8NHF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	84%
E9AME6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9AME7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	80%
E9B571	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	92%
Q4Q1U8	Leishmania major	38%	100%
Q4Q2R4	Leishmania major	50%	100%
Q4Q310	Leishmania major	37%	100%
Q4Q312	Leishmania major	37%	100%
Q4Q340	Leishmania major	38%	100%
Q4Q342	Leishmania major	38%	100%
Q4QI90	Leishmania major	47%	100%