Putative tuzin

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Putative tuzin

Gene product:

tuzin, putative

Species:

Leishmania major

UniProt:

Q4QI90_LEIMA

TriTrypDb:

LmjF.08.0790 , LMJLV39_080012500 , LMJSD75_080012200

Length:

635

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 33
NetGPI	no	yes: 0, no: 33

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	16
GO:0110165	cellular anatomical entity	1	16

Expansion

Sequence features

Q4QI90

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QI90

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	265	267	PF00675	0.455
CLV_NRD_NRD_1	39	41	PF00675	0.390
CLV_NRD_NRD_1	474	476	PF00675	0.508
CLV_NRD_NRD_1	68	70	PF00675	0.373
CLV_NRD_NRD_1	7	9	PF00675	0.487
CLV_PCSK_FUR_1	263	267	PF00082	0.380
CLV_PCSK_FUR_1	5	9	PF00082	0.368
CLV_PCSK_KEX2_1	265	267	PF00082	0.435
CLV_PCSK_KEX2_1	39	41	PF00082	0.389
CLV_PCSK_KEX2_1	474	476	PF00082	0.508
CLV_PCSK_KEX2_1	582	584	PF00082	0.568
CLV_PCSK_KEX2_1	68	70	PF00082	0.372
CLV_PCSK_KEX2_1	7	9	PF00082	0.494
CLV_PCSK_PC1ET2_1	582	584	PF00082	0.591
CLV_PCSK_SKI1_1	131	135	PF00082	0.312
CLV_PCSK_SKI1_1	225	229	PF00082	0.384
CLV_PCSK_SKI1_1	359	363	PF00082	0.589
CLV_PCSK_SKI1_1	440	444	PF00082	0.636
CLV_PCSK_SKI1_1	559	563	PF00082	0.495
CLV_PCSK_SKI1_1	8	12	PF00082	0.427
DEG_Kelch_actinfilin_1	447	451	PF01344	0.227
DEG_Nend_Nbox_1	1	3	PF02207	0.616
DEG_SCF_FBW7_1	488	493	PF00400	0.251
DEG_SPOP_SBC_1	333	337	PF00917	0.498
DOC_CYCLIN_RxL_1	5	15	PF00134	0.593
DOC_MAPK_gen_1	209	218	PF00069	0.550
DOC_MAPK_gen_1	474	481	PF00069	0.277
DOC_MAPK_gen_1	68	74	PF00069	0.539
DOC_MAPK_MEF2A_6	446	454	PF00069	0.328
DOC_MAPK_MEF2A_6	474	483	PF00069	0.303
DOC_PP1_RVXF_1	181	188	PF00149	0.449
DOC_PP1_RVXF_1	495	501	PF00149	0.341
DOC_PP1_RVXF_1	606	613	PF00149	0.315
DOC_PP2B_LxvP_1	159	162	PF13499	0.512
DOC_PP2B_LxvP_1	417	420	PF13499	0.370
DOC_PP2B_PxIxI_1	369	375	PF00149	0.296
DOC_PP4_FxxP_1	43	46	PF00568	0.659
DOC_SPAK_OSR1_1	306	310	PF12202	0.374
DOC_USP7_MATH_1	13	17	PF00917	0.628
DOC_USP7_MATH_1	22	26	PF00917	0.700
DOC_USP7_MATH_1	234	238	PF00917	0.564
DOC_USP7_MATH_1	484	488	PF00917	0.294
DOC_USP7_MATH_2	552	558	PF00917	0.263
DOC_USP7_UBL2_3	310	314	PF12436	0.365
DOC_USP7_UBL2_3	578	582	PF12436	0.360
DOC_WW_Pin1_4	486	491	PF00397	0.363
DOC_WW_Pin1_4	548	553	PF00397	0.364
LIG_14-3-3_CanoR_1	235	239	PF00244	0.515
LIG_14-3-3_CanoR_1	265	275	PF00244	0.613
LIG_14-3-3_CanoR_1	294	303	PF00244	0.436
LIG_14-3-3_CanoR_1	344	353	PF00244	0.381
LIG_14-3-3_CanoR_1	39	44	PF00244	0.672
LIG_14-3-3_CanoR_1	565	575	PF00244	0.408
LIG_14-3-3_CanoR_1	8	18	PF00244	0.640
LIG_Actin_WH2_2	169	185	PF00022	0.474
LIG_Actin_WH2_2	396	413	PF00022	0.359
LIG_APCC_ABBA_1	524	529	PF00400	0.339
LIG_BIR_III_4	520	524	PF00653	0.275
LIG_BRCT_BRCA1_1	278	282	PF00533	0.270
LIG_BRCT_BRCA1_1	82	86	PF00533	0.603
LIG_deltaCOP1_diTrp_1	355	362	PF00928	0.358
LIG_deltaCOP1_diTrp_1	618	622	PF00928	0.315
LIG_EH1_1	132	140	PF00400	0.474
LIG_eIF4E_1	555	561	PF01652	0.317
LIG_FHA_1	130	136	PF00498	0.585
LIG_FHA_1	145	151	PF00498	0.560
LIG_FHA_1	167	173	PF00498	0.568
LIG_FHA_1	194	200	PF00498	0.509
LIG_FHA_1	489	495	PF00498	0.426
LIG_FHA_2	329	335	PF00498	0.609
LIG_LIR_Apic_2	41	46	PF02991	0.665
LIG_LIR_Apic_2	499	504	PF02991	0.356
LIG_LIR_Gen_1	509	519	PF02991	0.362
LIG_LIR_Nem_3	103	109	PF02991	0.549
LIG_LIR_Nem_3	269	275	PF02991	0.456
LIG_LIR_Nem_3	499	503	PF02991	0.334
LIG_LIR_Nem_3	509	515	PF02991	0.340
LIG_NRBOX	147	153	PF00104	0.460
LIG_NRBOX	537	543	PF00104	0.331
LIG_Pex14_2	282	286	PF04695	0.317
LIG_Pex14_2	86	90	PF04695	0.595
LIG_SH2_CRK	272	276	PF00017	0.277
LIG_SH2_CRK	501	505	PF00017	0.363
LIG_SH2_CRK	613	617	PF00017	0.353
LIG_SH2_NCK_1	501	505	PF00017	0.315
LIG_SH2_NCK_1	613	617	PF00017	0.348
LIG_SH2_SRC	512	515	PF00017	0.410
LIG_SH2_SRC	589	592	PF00017	0.323
LIG_SH2_STAT3	555	558	PF00017	0.303
LIG_SH2_STAT5	106	109	PF00017	0.533
LIG_SH2_STAT5	181	184	PF00017	0.532
LIG_SH2_STAT5	217	220	PF00017	0.553
LIG_SH2_STAT5	296	299	PF00017	0.380
LIG_SH2_STAT5	378	381	PF00017	0.340
LIG_SH2_STAT5	501	504	PF00017	0.364
LIG_SH2_STAT5	514	517	PF00017	0.338
LIG_SH2_STAT5	555	558	PF00017	0.365
LIG_SH3_3	478	484	PF00018	0.333
LIG_SH3_3	55	61	PF00018	0.653
LIG_SUMO_SIM_par_1	371	376	PF11976	0.290
LIG_TYR_ITIM	611	616	PF00017	0.324
MOD_CK1_1	3	9	PF00069	0.596
MOD_CK1_1	336	342	PF00069	0.532
MOD_CK1_1	97	103	PF00069	0.703
MOD_CK2_1	234	240	PF00069	0.545
MOD_CK2_1	328	334	PF00069	0.626
MOD_CK2_1	548	554	PF00069	0.386
MOD_GlcNHglycan	125	128	PF01048	0.564
MOD_GlcNHglycan	189	192	PF01048	0.354
MOD_GlcNHglycan	193	196	PF01048	0.352
MOD_GlcNHglycan	232	235	PF01048	0.325
MOD_GlcNHglycan	268	271	PF01048	0.348
MOD_GlcNHglycan	276	279	PF01048	0.280
MOD_GlcNHglycan	324	327	PF01048	0.703
MOD_GlcNHglycan	339	342	PF01048	0.668
MOD_GlcNHglycan	35	38	PF01048	0.510
MOD_GlcNHglycan	96	99	PF01048	0.321
MOD_GSK3_1	17	24	PF00069	0.673
MOD_GSK3_1	187	194	PF00069	0.499
MOD_GSK3_1	219	226	PF00069	0.513
MOD_GSK3_1	230	237	PF00069	0.474
MOD_GSK3_1	295	302	PF00069	0.411
MOD_GSK3_1	328	335	PF00069	0.548
MOD_GSK3_1	339	346	PF00069	0.511
MOD_GSK3_1	382	389	PF00069	0.322
MOD_GSK3_1	484	491	PF00069	0.302
MOD_GSK3_1	550	557	PF00069	0.462
MOD_GSK3_1	9	16	PF00069	0.649
MOD_GSK3_1	90	97	PF00069	0.558
MOD_N-GLC_1	129	134	PF02516	0.418
MOD_N-GLC_1	144	149	PF02516	0.366
MOD_N-GLC_1	18	23	PF02516	0.440
MOD_N-GLC_1	504	509	PF02516	0.541
MOD_NEK2_1	129	134	PF00069	0.703
MOD_NEK2_1	230	235	PF00069	0.509
MOD_NEK2_1	276	281	PF00069	0.337
MOD_NEK2_1	386	391	PF00069	0.284
MOD_NEK2_1	506	511	PF00069	0.363
MOD_NEK2_1	527	532	PF00069	0.323
MOD_NEK2_1	597	602	PF00069	0.329
MOD_NEK2_1	612	617	PF00069	0.350
MOD_NEK2_1	90	95	PF00069	0.613
MOD_NEK2_2	284	289	PF00069	0.286
MOD_PIKK_1	115	121	PF00454	0.691
MOD_PIKK_1	228	234	PF00454	0.496
MOD_PIKK_1	506	512	PF00454	0.351
MOD_PIKK_1	554	560	PF00454	0.252
MOD_PIKK_1	63	69	PF00454	0.574
MOD_PK_1	438	444	PF00069	0.265
MOD_PKA_1	39	45	PF00069	0.548
MOD_PKA_2	234	240	PF00069	0.519
MOD_PKA_2	343	349	PF00069	0.404
MOD_PKA_2	38	44	PF00069	0.574
MOD_Plk_1	129	135	PF00069	0.700
MOD_Plk_1	406	412	PF00069	0.415
MOD_Plk_1	597	603	PF00069	0.320
MOD_Plk_4	234	240	PF00069	0.507
MOD_Plk_4	490	496	PF00069	0.286
MOD_Plk_4	80	86	PF00069	0.537
MOD_ProDKin_1	486	492	PF00069	0.359
MOD_ProDKin_1	548	554	PF00069	0.365
TRG_DiLeu_BaEn_1	214	219	PF01217	0.534
TRG_ENDOCYTIC_2	181	184	PF00928	0.523
TRG_ENDOCYTIC_2	272	275	PF00928	0.298
TRG_ENDOCYTIC_2	512	515	PF00928	0.354
TRG_ENDOCYTIC_2	613	616	PF00928	0.347
TRG_ER_diArg_1	265	267	PF00400	0.659
TRG_ER_diArg_1	38	40	PF00400	0.633
TRG_ER_diArg_1	5	8	PF00400	0.716
TRG_ER_diArg_1	68	70	PF00400	0.676
TRG_NES_CRM1_1	408	423	PF08389	0.358
TRG_NES_CRM1_1	513	525	PF08389	0.363
TRG_Pf-PMV_PEXEL_1	356	360	PF00026	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAN2	Leptomonas seymouri	42%	97%
A0A0N1PB02	Leptomonas seymouri	49%	97%
A0A0S4J6C6	Bodo saltans	44%	98%
A0A1X0P9A6	Trypanosomatidae	43%	93%
A0A3Q8IHH1	Leishmania donovani	36%	87%
A0A3R7K2Y9	Trypanosoma rangeli	49%	93%
A0A3S5H668	Leishmania donovani	47%	100%
A0A3S5H669	Leishmania donovani	94%	100%
A0A3S7X835	Leishmania donovani	46%	100%
A4H5C9	Leishmania braziliensis	44%	100%
A4H5D0	Leishmania braziliensis	73%	100%
A4HAZ7	Leishmania braziliensis	42%	100%
A4HAZ9	Leishmania braziliensis	43%	100%
A4HB01	Leishmania braziliensis	43%	100%
A4HTM0	Leishmania infantum	47%	100%
A4HTM1	Leishmania infantum	94%	100%
A4IA57	Leishmania infantum	46%	100%
C6K3V8	Leptomonas seymouri	44%	100%
C6K3V9	Leptomonas seymouri	71%	97%
C9ZMY5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	94%
E8NHE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E8NHF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9AME6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9AME7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9B571	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
Q4Q1U8	Leishmania major	38%	100%
Q4Q2R4	Leishmania major	46%	99%
Q4Q310	Leishmania major	38%	100%
Q4Q312	Leishmania major	37%	100%
Q4Q340	Leishmania major	38%	100%
Q4Q342	Leishmania major	38%	100%
Q4QI91	Leishmania major	47%	100%