Bridging integrator 2

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QI82_LEIMA

TriTrypDb:

LmjF.08.0870 , LMJLV39_080013000 , LMJSD75_080013100

Length:

399

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QI82

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QI82

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	324	328	PF00656	0.545
CLV_C14_Caspase3-7	339	343	PF00656	0.539
CLV_NRD_NRD_1	131	133	PF00675	0.459
CLV_NRD_NRD_1	142	144	PF00675	0.446
CLV_NRD_NRD_1	233	235	PF00675	0.408
CLV_NRD_NRD_1	29	31	PF00675	0.403
CLV_NRD_NRD_1	35	37	PF00675	0.434
CLV_PCSK_KEX2_1	131	133	PF00082	0.443
CLV_PCSK_KEX2_1	142	144	PF00082	0.422
CLV_PCSK_KEX2_1	222	224	PF00082	0.416
CLV_PCSK_KEX2_1	233	235	PF00082	0.400
CLV_PCSK_KEX2_1	29	31	PF00082	0.403
CLV_PCSK_KEX2_1	35	37	PF00082	0.434
CLV_PCSK_PC1ET2_1	222	224	PF00082	0.416
CLV_PCSK_SKI1_1	132	136	PF00082	0.441
DEG_Nend_UBRbox_3	1	3	PF02207	0.549
DOC_AGCK_PIF_2	22	27	PF00069	0.327
DOC_CYCLIN_RxL_1	255	265	PF00134	0.416
DOC_USP7_MATH_1	149	153	PF00917	0.392
DOC_USP7_MATH_1	311	315	PF00917	0.614
DOC_USP7_MATH_1	347	351	PF00917	0.620
DOC_USP7_MATH_1	364	368	PF00917	0.576
DOC_USP7_MATH_1	384	388	PF00917	0.601
DOC_USP7_MATH_2	123	129	PF00917	0.468
DOC_USP7_UBL2_3	201	205	PF12436	0.415
DOC_USP7_UBL2_3	214	218	PF12436	0.443
DOC_USP7_UBL2_3	315	319	PF12436	0.535
DOC_WW_Pin1_4	305	310	PF00397	0.439
LIG_14-3-3_CanoR_1	132	138	PF00244	0.434
LIG_Actin_WH2_2	158	175	PF00022	0.426
LIG_deltaCOP1_diTrp_1	7	12	PF00928	0.462
LIG_FHA_1	295	301	PF00498	0.485
LIG_FHA_2	134	140	PF00498	0.383
LIG_FHA_2	230	236	PF00498	0.311
LIG_FHA_2	381	387	PF00498	0.635
LIG_FHA_2	92	98	PF00498	0.575
LIG_IBAR_NPY_1	90	92	PF08397	0.536
LIG_LIR_Gen_1	290	299	PF02991	0.491
LIG_LIR_Gen_1	60	69	PF02991	0.437
LIG_LIR_Nem_3	187	192	PF02991	0.483
LIG_LIR_Nem_3	20	25	PF02991	0.440
LIG_LIR_Nem_3	224	230	PF02991	0.412
LIG_LIR_Nem_3	240	244	PF02991	0.410
LIG_LIR_Nem_3	290	294	PF02991	0.540
LIG_LIR_Nem_3	60	65	PF02991	0.431
LIG_MYND_3	166	170	PF01753	0.370
LIG_PCNA_PIPBox_1	338	347	PF02747	0.574
LIG_PDZ_Class_3	394	399	PF00595	0.523
LIG_Pex14_1	8	12	PF04695	0.461
LIG_Pex14_2	237	241	PF04695	0.405
LIG_PTB_Apo_2	260	267	PF02174	0.336
LIG_PTB_Phospho_1	260	266	PF10480	0.333
LIG_SH2_CRK	291	295	PF00017	0.482
LIG_SH2_NCK_1	62	66	PF00017	0.408
LIG_SH2_STAP1	113	117	PF00017	0.513
LIG_SH2_STAP1	375	379	PF00017	0.569
LIG_SH2_STAT3	100	103	PF00017	0.565
LIG_SH2_STAT3	266	269	PF00017	0.390
LIG_SH2_STAT3	345	348	PF00017	0.570
LIG_SH2_STAT5	203	206	PF00017	0.433
LIG_SH2_STAT5	219	222	PF00017	0.400
LIG_SH2_STAT5	230	233	PF00017	0.394
LIG_SH2_STAT5	259	262	PF00017	0.416
LIG_SH2_STAT5	266	269	PF00017	0.440
LIG_SH3_3	388	394	PF00018	0.622
LIG_SH3_3	77	83	PF00018	0.577
LIG_SUMO_SIM_par_1	296	301	PF11976	0.484
LIG_UBA3_1	165	173	PF00899	0.363
LIG_UBA3_1	52	56	PF00899	0.479
MOD_CK1_1	116	122	PF00069	0.522
MOD_CK1_1	323	329	PF00069	0.652
MOD_CK1_1	350	356	PF00069	0.599
MOD_CK2_1	133	139	PF00069	0.448
MOD_CK2_1	171	177	PF00069	0.517
MOD_CK2_1	364	370	PF00069	0.580
MOD_CK2_1	380	386	PF00069	0.575
MOD_CK2_1	57	63	PF00069	0.417
MOD_GlcNHglycan	364	367	PF01048	0.579
MOD_GlcNHglycan	59	62	PF01048	0.425
MOD_GSK3_1	11	18	PF00069	0.509
MOD_GSK3_1	113	120	PF00069	0.537
MOD_GSK3_1	290	297	PF00069	0.508
MOD_GSK3_1	311	318	PF00069	0.626
MOD_GSK3_1	347	354	PF00069	0.625
MOD_GSK3_1	358	365	PF00069	0.703
MOD_GSK3_1	380	387	PF00069	0.653
MOD_LATS_1	313	319	PF00433	0.548
MOD_N-GLC_1	237	242	PF02516	0.398
MOD_NEK2_1	133	138	PF00069	0.499
MOD_NEK2_1	210	215	PF00069	0.450
MOD_NEK2_1	237	242	PF00069	0.395
MOD_NEK2_1	294	299	PF00069	0.420
MOD_NEK2_1	369	374	PF00069	0.577
MOD_NEK2_1	72	77	PF00069	0.515
MOD_PIKK_1	125	131	PF00454	0.436
MOD_PIKK_1	99	105	PF00454	0.530
MOD_PKA_1	217	223	PF00069	0.409
MOD_Plk_1	237	243	PF00069	0.386
MOD_Plk_1	369	375	PF00069	0.574
MOD_Plk_1	70	76	PF00069	0.486
MOD_Plk_2-3	371	377	PF00069	0.643
MOD_Plk_4	294	300	PF00069	0.539
MOD_ProDKin_1	305	311	PF00069	0.441
TRG_DiLeu_BaLyEn_6	161	166	PF01217	0.372
TRG_ENDOCYTIC_2	259	262	PF00928	0.404
TRG_ENDOCYTIC_2	291	294	PF00928	0.492
TRG_ENDOCYTIC_2	62	65	PF00928	0.416
TRG_ER_diArg_1	130	132	PF00400	0.446
TRG_ER_diArg_1	142	144	PF00400	0.420
TRG_ER_diArg_1	29	31	PF00400	0.374
TRG_ER_diArg_1	34	36	PF00400	0.429
TRG_NLS_MonoExtC_3	204	209	PF00514	0.446
TRG_Pf-PMV_PEXEL_1	142	146	PF00026	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P348	Leptomonas seymouri	69%	91%
A0A0N0P3S1	Leptomonas seymouri	24%	87%
A0A3Q8IG21	Leishmania donovani	25%	95%
A0A3Q8IIE7	Leishmania donovani	24%	100%
A0A3S7WQB3	Leishmania donovani	93%	95%
A4H6C6	Leishmania braziliensis	76%	100%
A4HJ56	Leishmania braziliensis	24%	92%
A4HTM7	Leishmania infantum	94%	95%
A4I6H9	Leishmania infantum	24%	95%
E9AHL0	Leishmania infantum	24%	100%
E9AMG1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	95%
E9B1M8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
E9B1N5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9B1N6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	95%
Q4Q6H8	Leishmania major	24%	92%
Q4Q6I6	Leishmania major	23%	100%