SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QI81_LEIMA

TriTrypDb:

LmjF.08.0880 , LMJLV39_080013100 , LMJSD75_080013200

Length:

514

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005654	nucleoplasm	2	2
GO:0005730	nucleolus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QI81

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QI81

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	3
GO:0008213	protein alkylation	5	2
GO:0009987	cellular process	1	2
GO:0016570	histone modification	5	2
GO:0016571	histone methylation	5	2
GO:0018022	peptidyl-lysine methylation	5	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018205	peptidyl-lysine modification	6	2
GO:0019538	protein metabolic process	3	2
GO:0032259	methylation	2	3
GO:0034968	histone lysine methylation	6	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043414	macromolecule methylation	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0008168	methyltransferase activity	4	3
GO:0008170	N-methyltransferase activity	5	2
GO:0008276	protein methyltransferase activity	3	2
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	2
GO:0016278	lysine N-methyltransferase activity	6	2
GO:0016279	protein-lysine N-methyltransferase activity	4	2
GO:0016740	transferase activity	2	3
GO:0016741	transferase activity, transferring one-carbon groups	3	3
GO:0018024	obsolete histone lysine N-methyltransferase activity	5	2
GO:0042054	histone methyltransferase activity	4	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	393	397	PF00656	0.598
CLV_NRD_NRD_1	177	179	PF00675	0.791
CLV_NRD_NRD_1	34	36	PF00675	0.645
CLV_NRD_NRD_1	38	40	PF00675	0.502
CLV_NRD_NRD_1	425	427	PF00675	0.360
CLV_PCSK_KEX2_1	177	179	PF00082	0.780
CLV_PCSK_KEX2_1	182	184	PF00082	0.675
CLV_PCSK_KEX2_1	34	36	PF00082	0.674
CLV_PCSK_KEX2_1	38	40	PF00082	0.542
CLV_PCSK_KEX2_1	425	427	PF00082	0.398
CLV_PCSK_PC1ET2_1	182	184	PF00082	0.757
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.720
CLV_PCSK_PC7_1	178	184	PF00082	0.766
CLV_PCSK_SKI1_1	281	285	PF00082	0.503
CLV_PCSK_SKI1_1	491	495	PF00082	0.452
CLV_PCSK_SKI1_1	510	514	PF00082	0.526
DEG_APCC_DBOX_1	190	198	PF00400	0.582
DEG_SCF_TRCP1_1	154	160	PF00400	0.556
DEG_SPOP_SBC_1	438	442	PF00917	0.580
DEG_SPOP_SBC_1	445	449	PF00917	0.531
DOC_CYCLIN_RxL_1	488	495	PF00134	0.444
DOC_MAPK_gen_1	34	46	PF00069	0.662
DOC_MAPK_gen_1	351	359	PF00069	0.511
DOC_PP2B_LxvP_1	143	146	PF13499	0.548
DOC_PP2B_PxIxI_1	56	62	PF00149	0.495
DOC_PP4_FxxP_1	53	56	PF00568	0.477
DOC_USP7_MATH_1	439	443	PF00917	0.575
DOC_USP7_MATH_1	6	10	PF00917	0.573
DOC_WW_Pin1_4	104	109	PF00397	0.774
DOC_WW_Pin1_4	111	116	PF00397	0.700
DOC_WW_Pin1_4	329	334	PF00397	0.259
DOC_WW_Pin1_4	441	446	PF00397	0.564
DOC_WW_Pin1_4	448	453	PF00397	0.566
DOC_WW_Pin1_4	61	66	PF00397	0.438
LIG_14-3-3_CanoR_1	183	188	PF00244	0.594
LIG_14-3-3_CanoR_1	244	250	PF00244	0.598
LIG_14-3-3_CanoR_1	271	277	PF00244	0.492
LIG_14-3-3_CanoR_1	337	343	PF00244	0.566
LIG_14-3-3_CanoR_1	39	45	PF00244	0.520
LIG_14-3-3_CanoR_1	407	416	PF00244	0.542
LIG_14-3-3_CanoR_1	425	435	PF00244	0.596
LIG_14-3-3_CanoR_1	436	446	PF00244	0.468
LIG_14-3-3_CanoR_1	498	507	PF00244	0.565
LIG_14-3-3_CanoR_1	508	513	PF00244	0.426
LIG_BRCT_BRCA1_1	355	359	PF00533	0.542
LIG_FHA_1	163	169	PF00498	0.721
LIG_FHA_1	220	226	PF00498	0.424
LIG_FHA_1	41	47	PF00498	0.544
LIG_FHA_1	461	467	PF00498	0.588
LIG_FHA_1	500	506	PF00498	0.503
LIG_FHA_2	438	444	PF00498	0.598
LIG_LIR_Apic_2	8	13	PF02991	0.689
LIG_LIR_Gen_1	221	231	PF02991	0.423
LIG_LIR_Gen_1	341	350	PF02991	0.582
LIG_LIR_Gen_1	473	482	PF02991	0.572
LIG_LIR_Nem_3	221	227	PF02991	0.434
LIG_LIR_Nem_3	341	345	PF02991	0.582
LIG_LIR_Nem_3	473	479	PF02991	0.501
LIG_LIR_Nem_3	495	500	PF02991	0.434
LIG_NRP_CendR_1	513	514	PF00754	0.602
LIG_Rb_pABgroove_1	386	394	PF01858	0.554
LIG_SH2_CRK	133	137	PF00017	0.559
LIG_SH2_CRK	208	212	PF00017	0.506
LIG_SH2_CRK	497	501	PF00017	0.471
LIG_SH2_NCK_1	392	396	PF00017	0.570
LIG_SH2_PTP2	10	13	PF00017	0.692
LIG_SH2_PTP2	476	479	PF00017	0.454
LIG_SH2_SRC	10	13	PF00017	0.692
LIG_SH2_STAP1	446	450	PF00017	0.542
LIG_SH2_STAT5	10	13	PF00017	0.692
LIG_SH2_STAT5	133	136	PF00017	0.552
LIG_SH2_STAT5	208	211	PF00017	0.477
LIG_SH2_STAT5	236	239	PF00017	0.437
LIG_SH2_STAT5	476	479	PF00017	0.443
LIG_SH3_3	126	132	PF00018	0.451
LIG_SH3_3	330	336	PF00018	0.591
LIG_SUMO_SIM_anti_2	58	64	PF11976	0.393
LIG_SUMO_SIM_par_1	387	394	PF11976	0.530
LIG_TRAF2_1	25	28	PF00917	0.612
LIG_TRAF2_1	468	471	PF00917	0.501
LIG_TYR_ITIM	474	479	PF00017	0.586
LIG_WRC_WIRS_1	273	278	PF05994	0.503
LIG_WW_1	335	338	PF00397	0.560
LIG_WW_3	334	338	PF00397	0.598
MOD_CDK_SPxxK_3	61	68	PF00069	0.470
MOD_CK1_1	113	119	PF00069	0.733
MOD_CK1_1	254	260	PF00069	0.598
MOD_CK1_1	441	447	PF00069	0.536
MOD_CK2_1	437	443	PF00069	0.585
MOD_Cter_Amidation	180	183	PF01082	0.650
MOD_Cter_Amidation	36	39	PF01082	0.612
MOD_GlcNHglycan	154	157	PF01048	0.562
MOD_GlcNHglycan	160	163	PF01048	0.648
MOD_GlcNHglycan	292	295	PF01048	0.769
MOD_GlcNHglycan	310	313	PF01048	0.788
MOD_GlcNHglycan	327	330	PF01048	0.497
MOD_GlcNHglycan	393	396	PF01048	0.341
MOD_GSK3_1	100	107	PF00069	0.803
MOD_GSK3_1	109	116	PF00069	0.659
MOD_GSK3_1	158	165	PF00069	0.575
MOD_GSK3_1	207	214	PF00069	0.463
MOD_GSK3_1	283	290	PF00069	0.706
MOD_GSK3_1	325	332	PF00069	0.494
MOD_GSK3_1	345	352	PF00069	0.470
MOD_GSK3_1	360	367	PF00069	0.457
MOD_GSK3_1	437	444	PF00069	0.558
MOD_GSK3_1	446	453	PF00069	0.489
MOD_N-GLC_1	219	224	PF02516	0.526
MOD_N-GLC_1	251	256	PF02516	0.528
MOD_N-GLC_1	378	383	PF02516	0.301
MOD_NEK2_1	118	123	PF00069	0.721
MOD_NEK2_1	152	157	PF00069	0.554
MOD_NEK2_1	237	242	PF00069	0.418
MOD_NEK2_1	345	350	PF00069	0.493
MOD_NEK2_1	371	376	PF00069	0.560
MOD_NEK2_1	378	383	PF00069	0.560
MOD_OFUCOSY	376	382	PF10250	0.301
MOD_PIKK_1	11	17	PF00454	0.766
MOD_PIKK_1	417	423	PF00454	0.542
MOD_PK_1	183	189	PF00069	0.700
MOD_PK_1	353	359	PF00069	0.510
MOD_PKA_1	426	432	PF00069	0.562
MOD_PKA_2	325	331	PF00069	0.738
MOD_PKA_2	345	351	PF00069	0.362
MOD_PKB_1	351	359	PF00069	0.560
MOD_Plk_1	251	257	PF00069	0.617
MOD_Plk_1	378	384	PF00069	0.525
MOD_Plk_1	470	476	PF00069	0.501
MOD_Plk_2-3	478	484	PF00069	0.627
MOD_Plk_4	183	189	PF00069	0.644
MOD_Plk_4	345	351	PF00069	0.542
MOD_Plk_4	6	12	PF00069	0.537
MOD_ProDKin_1	104	110	PF00069	0.773
MOD_ProDKin_1	111	117	PF00069	0.699
MOD_ProDKin_1	329	335	PF00069	0.259
MOD_ProDKin_1	441	447	PF00069	0.564
MOD_ProDKin_1	448	454	PF00069	0.566
MOD_ProDKin_1	61	67	PF00069	0.434
TRG_DiLeu_BaEn_2	494	500	PF01217	0.459
TRG_DiLeu_BaLyEn_6	170	175	PF01217	0.593
TRG_DiLeu_BaLyEn_6	193	198	PF01217	0.461
TRG_ENDOCYTIC_2	208	211	PF00928	0.477
TRG_ENDOCYTIC_2	476	479	PF00928	0.454
TRG_ENDOCYTIC_2	497	500	PF00928	0.425
TRG_ENDOCYTIC_2	63	66	PF00928	0.425
TRG_ER_diArg_1	323	326	PF00400	0.633
TRG_ER_diArg_1	350	353	PF00400	0.560
TRG_ER_diArg_1	38	40	PF00400	0.557
TRG_ER_diArg_1	507	510	PF00400	0.569
TRG_NLS_MonoExtC_3	33	38	PF00514	0.694
TRG_NLS_MonoExtN_4	31	38	PF00514	0.746
TRG_Pf-PMV_PEXEL_1	491	495	PF00026	0.485
TRG_Pf-PMV_PEXEL_1	73	78	PF00026	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3I8	Leptomonas seymouri	49%	93%
A0A1X0NPE5	Trypanosomatidae	26%	100%
A0A3S5H671	Leishmania donovani	94%	79%
A4H6C5	Leishmania braziliensis	86%	100%
A4HTM8	Leishmania infantum	94%	100%
C9ZPC4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AMG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%