DNA polymerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

DNA polymerase

Gene product:

mitochondrial DNA polymerase beta-PAK, putative

Species:

Leishmania major

UniProt:

Q4QI79_LEIMA

TriTrypDb:

LmjF.08.0900 , LMJLV39_080013300 , LMJSD75_080013400

Length:

673

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	4
GO:0005737	cytoplasm	2	5
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

Q4QI79

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QI79

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	5
GO:0006259	DNA metabolic process	4	5
GO:0006281	DNA repair	5	5
GO:0006302	double-strand break repair	6	2
GO:0006303	double-strand break repair via nonhomologous end joining	7	2
GO:0006396	RNA processing	6	5
GO:0006725	cellular aromatic compound metabolic process	3	5
GO:0006807	nitrogen compound metabolic process	2	5
GO:0006950	response to stress	2	5
GO:0006974	DNA damage response	4	5
GO:0008152	metabolic process	1	5
GO:0009987	cellular process	1	5
GO:0016070	RNA metabolic process	5	5
GO:0031123	RNA 3'-end processing	7	5
GO:0033554	cellular response to stress	3	5
GO:0034641	cellular nitrogen compound metabolic process	3	5
GO:0043170	macromolecule metabolic process	3	5
GO:0044237	cellular metabolic process	2	5
GO:0044238	primary metabolic process	2	5
GO:0044260	obsolete cellular macromolecule metabolic process	3	5
GO:0046483	heterocycle metabolic process	3	5
GO:0050896	response to stimulus	1	5
GO:0051716	cellular response to stimulus	2	5
GO:0071076	RNA 3' uridylation	8	5
GO:0071704	organic substance metabolic process	2	5
GO:0090304	nucleic acid metabolic process	4	5
GO:1901360	organic cyclic compound metabolic process	3	5

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	5
GO:0003677	DNA binding	4	5
GO:0003824	catalytic activity	1	5
GO:0003887	DNA-directed DNA polymerase activity	5	5
GO:0005488	binding	1	5
GO:0016740	transferase activity	2	5
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	5
GO:0016779	nucleotidyltransferase activity	4	5
GO:0034061	DNA polymerase activity	4	5
GO:0043167	ion binding	2	4
GO:0043169	cation binding	3	4
GO:0046872	metal ion binding	4	4
GO:0050265	RNA uridylyltransferase activity	4	5
GO:0070569	uridylyltransferase activity	5	5
GO:0097159	organic cyclic compound binding	2	5
GO:0140097	catalytic activity, acting on DNA	3	5
GO:0140098	catalytic activity, acting on RNA	3	5
GO:0140640	catalytic activity, acting on a nucleic acid	2	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	316	320	PF00656	0.477
CLV_NRD_NRD_1	371	373	PF00675	0.221
CLV_NRD_NRD_1	388	390	PF00675	0.224
CLV_NRD_NRD_1	404	406	PF00675	0.208
CLV_NRD_NRD_1	491	493	PF00675	0.252
CLV_NRD_NRD_1	537	539	PF00675	0.352
CLV_NRD_NRD_1	541	543	PF00675	0.342
CLV_PCSK_FUR_1	226	230	PF00082	0.473
CLV_PCSK_FUR_1	489	493	PF00082	0.277
CLV_PCSK_KEX2_1	177	179	PF00082	0.394
CLV_PCSK_KEX2_1	217	219	PF00082	0.574
CLV_PCSK_KEX2_1	228	230	PF00082	0.344
CLV_PCSK_KEX2_1	388	390	PF00082	0.221
CLV_PCSK_KEX2_1	404	406	PF00082	0.221
CLV_PCSK_KEX2_1	491	493	PF00082	0.252
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.394
CLV_PCSK_PC1ET2_1	217	219	PF00082	0.574
CLV_PCSK_PC1ET2_1	228	230	PF00082	0.344
CLV_PCSK_PC7_1	224	230	PF00082	0.472
CLV_PCSK_SKI1_1	275	279	PF00082	0.318
CLV_PCSK_SKI1_1	421	425	PF00082	0.277
CLV_PCSK_SKI1_1	476	480	PF00082	0.302
CLV_PCSK_SKI1_1	613	617	PF00082	0.281
CLV_PCSK_SKI1_1	655	659	PF00082	0.252
DEG_APCC_DBOX_1	567	575	PF00400	0.477
DEG_SCF_TRCP1_1	319	324	PF00400	0.477
DOC_ANK_TNKS_1	404	411	PF00023	0.377
DOC_CYCLIN_RxL_1	224	236	PF00134	0.475
DOC_CYCLIN_yClb5_NLxxxL_5	233	242	PF00134	0.487
DOC_CYCLIN_yCln2_LP_2	185	188	PF00134	0.444
DOC_CYCLIN_yCln2_LP_2	423	426	PF00134	0.477
DOC_MAPK_gen_1	224	233	PF00069	0.469
DOC_MAPK_gen_1	245	253	PF00069	0.334
DOC_MAPK_gen_1	487	495	PF00069	0.434
DOC_MAPK_JIP1_4	322	328	PF00069	0.477
DOC_MAPK_MEF2A_6	247	255	PF00069	0.412
DOC_PP2B_LxvP_1	185	188	PF13499	0.444
DOC_PP2B_LxvP_1	191	194	PF13499	0.443
DOC_PP2B_LxvP_1	423	426	PF13499	0.477
DOC_PP4_FxxP_1	537	540	PF00568	0.477
DOC_USP7_MATH_1	109	113	PF00917	0.548
DOC_USP7_MATH_1	116	120	PF00917	0.621
DOC_USP7_MATH_1	227	231	PF00917	0.468
DOC_USP7_MATH_1	3	7	PF00917	0.671
DOC_USP7_MATH_1	330	334	PF00917	0.477
DOC_USP7_MATH_1	555	559	PF00917	0.477
DOC_USP7_MATH_1	582	586	PF00917	0.437
DOC_USP7_MATH_1	598	602	PF00917	0.397
DOC_USP7_MATH_1	94	98	PF00917	0.638
DOC_USP7_UBL2_3	177	181	PF12436	0.474
DOC_USP7_UBL2_3	245	249	PF12436	0.342
DOC_USP7_UBL2_3	318	322	PF12436	0.485
DOC_USP7_UBL2_3	373	377	PF12436	0.421
DOC_USP7_UBL2_3	479	483	PF12436	0.427
DOC_USP7_UBL2_3	539	543	PF12436	0.477
DOC_USP7_UBL2_3	621	625	PF12436	0.468
DOC_WW_Pin1_4	70	75	PF00397	0.738
LIG_14-3-3_CanoR_1	226	232	PF00244	0.550
LIG_14-3-3_CanoR_1	459	465	PF00244	0.369
LIG_BIR_II_1	1	5	PF00653	0.782
LIG_BIR_III_3	1	5	PF00653	0.642
LIG_BIR_III_4	606	610	PF00653	0.477
LIG_BRCT_BRCA1_1	499	503	PF00533	0.421
LIG_BRCT_BRCA1_1	512	516	PF00533	0.371
LIG_EH1_1	637	645	PF00400	0.377
LIG_FHA_1	254	260	PF00498	0.398
LIG_FHA_1	463	469	PF00498	0.477
LIG_FHA_1	614	620	PF00498	0.377
LIG_FHA_2	285	291	PF00498	0.568
LIG_FHA_2	36	42	PF00498	0.353
LIG_FHA_2	461	467	PF00498	0.377
LIG_FHA_2	628	634	PF00498	0.477
LIG_FHA_2	651	657	PF00498	0.477
LIG_Integrin_RGD_1	178	180	PF01839	0.491
LIG_LIR_Apic_2	664	668	PF02991	0.464
LIG_LIR_Gen_1	180	191	PF02991	0.387
LIG_LIR_Gen_1	364	374	PF02991	0.421
LIG_LIR_Gen_1	378	387	PF02991	0.421
LIG_LIR_Gen_1	513	524	PF02991	0.423
LIG_LIR_Gen_1	556	567	PF02991	0.477
LIG_LIR_Gen_1	656	666	PF02991	0.421
LIG_LIR_LC3C_4	324	328	PF02991	0.477
LIG_LIR_LC3C_4	378	383	PF02991	0.477
LIG_LIR_Nem_3	136	142	PF02991	0.521
LIG_LIR_Nem_3	180	186	PF02991	0.379
LIG_LIR_Nem_3	290	295	PF02991	0.464
LIG_LIR_Nem_3	364	369	PF02991	0.421
LIG_LIR_Nem_3	378	382	PF02991	0.421
LIG_LIR_Nem_3	452	457	PF02991	0.421
LIG_LIR_Nem_3	513	519	PF02991	0.423
LIG_LIR_Nem_3	533	537	PF02991	0.422
LIG_LIR_Nem_3	656	661	PF02991	0.421
LIG_MYND_1	188	192	PF01753	0.498
LIG_MYND_1	422	426	PF01753	0.477
LIG_SH2_CRK	548	552	PF00017	0.477
LIG_SH2_PTP2	665	668	PF00017	0.421
LIG_SH2_SRC	442	445	PF00017	0.421
LIG_SH2_SRC	497	500	PF00017	0.477
LIG_SH2_SRC	665	668	PF00017	0.464
LIG_SH2_STAP1	306	310	PF00017	0.477
LIG_SH2_STAP1	379	383	PF00017	0.421
LIG_SH2_STAT3	387	390	PF00017	0.477
LIG_SH2_STAT5	291	294	PF00017	0.477
LIG_SH2_STAT5	374	377	PF00017	0.421
LIG_SH2_STAT5	442	445	PF00017	0.452
LIG_SH2_STAT5	497	500	PF00017	0.477
LIG_SH2_STAT5	509	512	PF00017	0.327
LIG_SH2_STAT5	665	668	PF00017	0.421
LIG_SH3_3	16	22	PF00018	0.575
LIG_SH3_3	40	46	PF00018	0.658
LIG_SH3_3	419	425	PF00018	0.496
LIG_SH3_3	7	13	PF00018	0.622
LIG_SH3_4	539	546	PF00018	0.477
LIG_SUMO_SIM_anti_2	38	44	PF11976	0.375
LIG_SUMO_SIM_anti_2	396	402	PF11976	0.421
LIG_TRAF2_1	356	359	PF00917	0.464
LIG_TRAF2_1	630	633	PF00917	0.477
LIG_TRFH_1	183	187	PF08558	0.449
LIG_TRFH_1	53	57	PF08558	0.633
LIG_UBA3_1	203	209	PF00899	0.423
LIG_UBA3_1	238	245	PF00899	0.471
MOD_CK1_1	101	107	PF00069	0.641
MOD_CK1_1	119	125	PF00069	0.568
MOD_CK1_1	133	139	PF00069	0.450
MOD_CK1_1	414	420	PF00069	0.297
MOD_CK1_1	469	475	PF00069	0.267
MOD_CK1_1	594	600	PF00069	0.320
MOD_CK1_1	601	607	PF00069	0.424
MOD_CK2_1	21	27	PF00069	0.407
MOD_CK2_1	35	41	PF00069	0.384
MOD_CK2_1	403	409	PF00069	0.407
MOD_CK2_1	460	466	PF00069	0.197
MOD_CK2_1	582	588	PF00069	0.337
MOD_CK2_1	627	633	PF00069	0.337
MOD_CK2_1	650	656	PF00069	0.337
MOD_GlcNHglycan	101	104	PF01048	0.630
MOD_GlcNHglycan	107	110	PF01048	0.693
MOD_GlcNHglycan	111	114	PF01048	0.741
MOD_GlcNHglycan	118	121	PF01048	0.621
MOD_GlcNHglycan	122	125	PF01048	0.597
MOD_GlcNHglycan	157	160	PF01048	0.528
MOD_GlcNHglycan	319	322	PF01048	0.296
MOD_GlcNHglycan	392	395	PF01048	0.263
MOD_GlcNHglycan	405	408	PF01048	0.248
MOD_GlcNHglycan	417	420	PF01048	0.421
MOD_GlcNHglycan	468	471	PF01048	0.267
MOD_GlcNHglycan	570	574	PF01048	0.295
MOD_GlcNHglycan	585	588	PF01048	0.185
MOD_GlcNHglycan	593	596	PF01048	0.277
MOD_GlcNHglycan	600	603	PF01048	0.352
MOD_GlcNHglycan	68	71	PF01048	0.762
MOD_GlcNHglycan	74	77	PF01048	0.686
MOD_GlcNHglycan	92	95	PF01048	0.453
MOD_GSK3_1	101	108	PF00069	0.598
MOD_GSK3_1	115	122	PF00069	0.642
MOD_GSK3_1	151	158	PF00069	0.434
MOD_GSK3_1	227	234	PF00069	0.464
MOD_GSK3_1	313	320	PF00069	0.318
MOD_GSK3_1	399	406	PF00069	0.417
MOD_GSK3_1	411	418	PF00069	0.253
MOD_GSK3_1	460	467	PF00069	0.277
MOD_GSK3_1	594	601	PF00069	0.337
MOD_GSK3_1	609	616	PF00069	0.267
MOD_GSK3_1	66	73	PF00069	0.752
MOD_GSK3_1	90	97	PF00069	0.610
MOD_N-GLC_1	582	587	PF02516	0.197
MOD_N-GLC_1	65	70	PF02516	0.519
MOD_NEK2_1	313	318	PF00069	0.337
MOD_NEK2_1	460	465	PF00069	0.201
MOD_NEK2_1	508	513	PF00069	0.258
MOD_NEK2_1	569	574	PF00069	0.337
MOD_NEK2_1	90	95	PF00069	0.620
MOD_NEK2_2	555	560	PF00069	0.337
MOD_PIKK_1	151	157	PF00454	0.428
MOD_PIKK_1	163	169	PF00454	0.331
MOD_PIKK_1	275	281	PF00454	0.258
MOD_PIKK_1	80	86	PF00454	0.754
MOD_PKA_1	538	544	PF00069	0.337
MOD_PKA_1	613	619	PF00069	0.407
MOD_PKA_2	403	409	PF00069	0.332
MOD_PKA_2	460	466	PF00069	0.197
MOD_PKA_2	80	86	PF00069	0.641
MOD_Plk_1	275	281	PF00069	0.258
MOD_Plk_1	443	449	PF00069	0.258
MOD_Plk_1	51	57	PF00069	0.614
MOD_Plk_1	555	561	PF00069	0.337
MOD_Plk_1	569	575	PF00069	0.148
MOD_Plk_2-3	21	27	PF00069	0.477
MOD_Plk_4	133	139	PF00069	0.597
MOD_ProDKin_1	70	76	PF00069	0.738
MOD_SUMO_for_1	574	577	PF00179	0.337
MOD_SUMO_rev_2	260	270	PF00179	0.449
TRG_DiLeu_BaLyEn_6	419	424	PF01217	0.337
TRG_ENDOCYTIC_2	348	351	PF00928	0.310
TRG_ENDOCYTIC_2	379	382	PF00928	0.337
TRG_ENDOCYTIC_2	534	537	PF00928	0.258
TRG_ENDOCYTIC_2	548	551	PF00928	0.258
TRG_ER_diArg_1	369	372	PF00400	0.258
TRG_ER_diArg_1	387	389	PF00400	0.258
TRG_ER_diArg_1	488	491	PF00400	0.311
TRG_ER_diArg_1	646	649	PF00400	0.263
TRG_NLS_Bipartite_1	613	628	PF00514	0.337
TRG_NLS_MonoExtC_3	622	627	PF00514	0.316
TRG_NLS_MonoExtN_4	198	203	PF00514	0.504
TRG_NLS_MonoExtN_4	621	628	PF00514	0.330
TRG_Pf-PMV_PEXEL_1	272	276	PF00026	0.365
TRG_Pf-PMV_PEXEL_1	655	659	PF00026	0.318

Homologs


Protein	Taxonomy	Sequence identity	Coverage
C9ZPC9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	83%
E9AMG4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q67VC8	Oryza sativa subsp. japonica	22%	100%
V5B1F6	Trypanosoma cruzi	46%	100%