Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QI77_LEIMA

TriTrypDb:

LmjF.08.0920 , LMJLV39_080013500 , LMJSD75_080013600

Length:

204

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QI77

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QI77

PDB structure(s): 7aih_D , 7ane_D

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	32	34	PF00675	0.462
CLV_NRD_NRD_1	83	85	PF00675	0.438
CLV_PCSK_KEX2_1	32	34	PF00082	0.475
CLV_PCSK_KEX2_1	83	85	PF00082	0.423
CLV_PCSK_SKI1_1	123	127	PF00082	0.462
CLV_PCSK_SKI1_1	130	134	PF00082	0.405
CLV_Separin_Metazoa	112	116	PF03568	0.548
DEG_Nend_Nbox_1	1	3	PF02207	0.452
DOC_CDC14_PxL_1	131	139	PF14671	0.397
DOC_MAPK_MEF2A_6	123	131	PF00069	0.393
DOC_MAPK_MEF2A_6	136	145	PF00069	0.413
DOC_MAPK_MEF2A_6	16	24	PF00069	0.549
DOC_PP2B_LxvP_1	143	146	PF13499	0.434
DOC_USP7_MATH_1	12	16	PF00917	0.617
DOC_USP7_MATH_1	183	187	PF00917	0.762
DOC_USP7_MATH_1	91	95	PF00917	0.573
DOC_WW_Pin1_4	16	21	PF00397	0.515
DOC_WW_Pin1_4	46	51	PF00397	0.510
LIG_14-3-3_CanoR_1	123	128	PF00244	0.470
LIG_14-3-3_CanoR_1	40	48	PF00244	0.508
LIG_Actin_WH2_2	7	25	PF00022	0.600
LIG_FHA_1	108	114	PF00498	0.414
LIG_FHA_1	124	130	PF00498	0.435
LIG_LIR_Gen_1	147	156	PF02991	0.571
LIG_LIR_Nem_3	119	125	PF02991	0.477
LIG_LIR_Nem_3	51	56	PF02991	0.493
LIG_NRP_CendR_1	203	204	PF00754	0.672
LIG_SH2_STAT5	29	32	PF00017	0.552
LIG_SH2_STAT5	48	51	PF00017	0.505
LIG_SH2_STAT5	52	55	PF00017	0.507
LIG_SH3_1	111	117	PF00018	0.420
LIG_SH3_3	111	117	PF00018	0.420
LIG_SUMO_SIM_par_1	105	110	PF11976	0.382
LIG_UBA3_1	124	130	PF00899	0.464
MOD_CDK_SPK_2	16	21	PF00069	0.574
MOD_CDK_SPxxK_3	16	23	PF00069	0.554
MOD_CK1_1	147	153	PF00069	0.570
MOD_CK1_1	186	192	PF00069	0.758
MOD_GlcNHglycan	185	188	PF01048	0.761
MOD_GlcNHglycan	194	198	PF01048	0.565
MOD_GlcNHglycan	41	44	PF01048	0.438
MOD_GlcNHglycan	80	83	PF01048	0.522
MOD_GSK3_1	12	19	PF00069	0.528
MOD_GSK3_1	48	55	PF00069	0.512
MOD_PKA_2	39	45	PF00069	0.530
MOD_Plk_4	144	150	PF00069	0.474
MOD_Plk_4	152	158	PF00069	0.542
MOD_Plk_4	48	54	PF00069	0.442
MOD_ProDKin_1	16	22	PF00069	0.505
MOD_ProDKin_1	46	52	PF00069	0.505
MOD_SUMO_rev_2	159	166	PF00179	0.696
MOD_SUMO_rev_2	167	175	PF00179	0.611
TRG_DiLeu_BaLyEn_6	62	67	PF01217	0.494
TRG_ER_diArg_1	20	23	PF00400	0.391

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZU7	Leptomonas seymouri	68%	100%
A0A0S4J9I7	Bodo saltans	41%	100%
A0A1X0NP61	Trypanosomatidae	57%	100%
A0A3R7NPP0	Trypanosoma rangeli	53%	100%
A0A3S5H674	Leishmania donovani	96%	100%
A4H5D7	Leishmania braziliensis	76%	100%
A4HTN2	Leishmania infantum	96%	100%
C9ZPD1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9AMG6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BGW6	Trypanosoma cruzi	53%	97%