Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Serine/threonine-protein kinase NEK6, putative

Species:

Leishmania major

UniProt:

Q4QI76_LEIMA

TriTrypDb:

LmjF.08.0930 , LMJLV39_080013800 , LMJSD75_080013900

Length:

1151

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QI76

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QI76

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	5
GO:0006793	phosphorus metabolic process	3	5
GO:0006796	phosphate-containing compound metabolic process	4	5
GO:0006807	nitrogen compound metabolic process	2	5
GO:0008152	metabolic process	1	5
GO:0009987	cellular process	1	5
GO:0016310	phosphorylation	5	5
GO:0019538	protein metabolic process	3	5
GO:0036211	protein modification process	4	5
GO:0043170	macromolecule metabolic process	3	5
GO:0043412	macromolecule modification	4	5
GO:0044237	cellular metabolic process	2	5
GO:0044238	primary metabolic process	2	5
GO:0071704	organic substance metabolic process	2	5
GO:1901564	organonitrogen compound metabolic process	3	5

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	5
GO:0003824	catalytic activity	1	5
GO:0004672	protein kinase activity	3	5
GO:0004674	protein serine/threonine kinase activity	4	2
GO:0005488	binding	1	5
GO:0005524	ATP binding	5	5
GO:0016301	kinase activity	4	5
GO:0016740	transferase activity	2	5
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	5
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	5
GO:0017076	purine nucleotide binding	4	5
GO:0030554	adenyl nucleotide binding	5	5
GO:0032553	ribonucleotide binding	3	5
GO:0032555	purine ribonucleotide binding	4	5
GO:0032559	adenyl ribonucleotide binding	5	5
GO:0035639	purine ribonucleoside triphosphate binding	4	5
GO:0036094	small molecule binding	2	5
GO:0043167	ion binding	2	5
GO:0043168	anion binding	3	5
GO:0097159	organic cyclic compound binding	2	5
GO:0097367	carbohydrate derivative binding	2	5
GO:0140096	catalytic activity, acting on a protein	2	5
GO:1901265	nucleoside phosphate binding	3	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.368
CLV_C14_Caspase3-7	575	579	PF00656	0.602
CLV_C14_Caspase3-7	777	781	PF00656	0.666
CLV_C14_Caspase3-7	788	792	PF00656	0.584
CLV_C14_Caspase3-7	852	856	PF00656	0.642
CLV_NRD_NRD_1	1004	1006	PF00675	0.656
CLV_NRD_NRD_1	124	126	PF00675	0.365
CLV_NRD_NRD_1	178	180	PF00675	0.470
CLV_NRD_NRD_1	24	26	PF00675	0.480
CLV_NRD_NRD_1	301	303	PF00675	0.368
CLV_NRD_NRD_1	456	458	PF00675	0.656
CLV_NRD_NRD_1	495	497	PF00675	0.592
CLV_NRD_NRD_1	549	551	PF00675	0.624
CLV_NRD_NRD_1	606	608	PF00675	0.712
CLV_NRD_NRD_1	665	667	PF00675	0.579
CLV_NRD_NRD_1	771	773	PF00675	0.658
CLV_NRD_NRD_1	843	845	PF00675	0.546
CLV_PCSK_KEX2_1	124	126	PF00082	0.296
CLV_PCSK_KEX2_1	178	180	PF00082	0.470
CLV_PCSK_KEX2_1	300	302	PF00082	0.368
CLV_PCSK_KEX2_1	422	424	PF00082	0.678
CLV_PCSK_KEX2_1	455	457	PF00082	0.649
CLV_PCSK_KEX2_1	549	551	PF00082	0.624
CLV_PCSK_KEX2_1	606	608	PF00082	0.712
CLV_PCSK_KEX2_1	771	773	PF00082	0.658
CLV_PCSK_PC1ET2_1	422	424	PF00082	0.678
CLV_PCSK_PC1ET2_1	455	457	PF00082	0.649
CLV_PCSK_PC7_1	418	424	PF00082	0.606
CLV_PCSK_SKI1_1	178	182	PF00082	0.478
CLV_PCSK_SKI1_1	183	187	PF00082	0.397
CLV_PCSK_SKI1_1	528	532	PF00082	0.640
CLV_PCSK_SKI1_1	646	650	PF00082	0.541
CLV_PCSK_SKI1_1	743	747	PF00082	0.602
CLV_PCSK_SKI1_1	761	765	PF00082	0.586
CLV_PCSK_SKI1_1	908	912	PF00082	0.567
DEG_APCC_DBOX_1	912	920	PF00400	0.561
DEG_Nend_UBRbox_3	1	3	PF02207	0.544
DEG_SCF_FBW7_1	1075	1081	PF00400	0.581
DEG_SPOP_SBC_1	1026	1030	PF00917	0.555
DEG_SPOP_SBC_1	394	398	PF00917	0.603
DOC_CDC14_PxL_1	315	323	PF14671	0.517
DOC_CKS1_1	1075	1080	PF01111	0.602
DOC_CKS1_1	958	963	PF01111	0.533
DOC_CYCLIN_RxL_1	55	66	PF00134	0.320
DOC_CYCLIN_yCln2_LP_2	1070	1076	PF00134	0.686
DOC_CYCLIN_yCln2_LP_2	309	315	PF00134	0.368
DOC_MAPK_gen_1	183	192	PF00069	0.470
DOC_MAPK_gen_1	25	32	PF00069	0.453
DOC_MAPK_gen_1	549	556	PF00069	0.573
DOC_MAPK_JIP1_4	550	556	PF00069	0.573
DOC_MAPK_MEF2A_6	17	24	PF00069	0.484
DOC_MAPK_MEF2A_6	549	556	PF00069	0.573
DOC_MAPK_RevD_3	11	26	PF00069	0.511
DOC_PP2B_LxvP_1	1118	1121	PF13499	0.587
DOC_PP2B_LxvP_1	368	371	PF13499	0.643
DOC_PP2B_LxvP_1	417	420	PF13499	0.606
DOC_PP2B_LxvP_1	590	593	PF13499	0.681
DOC_PP2B_LxvP_1	817	820	PF13499	0.687
DOC_PP2B_LxvP_1	943	946	PF13499	0.632
DOC_PP2B_LxvP_1	956	959	PF13499	0.533
DOC_PP4_FxxP_1	47	50	PF00568	0.368
DOC_PP4_FxxP_1	531	534	PF00568	0.662
DOC_PP4_FxxP_1	764	767	PF00568	0.637
DOC_PP4_FxxP_1	867	870	PF00568	0.560
DOC_PP4_MxPP_1	532	535	PF00568	0.651
DOC_USP7_MATH_1	1027	1031	PF00917	0.601
DOC_USP7_MATH_1	1078	1082	PF00917	0.589
DOC_USP7_MATH_1	1103	1107	PF00917	0.469
DOC_USP7_MATH_1	214	218	PF00917	0.368
DOC_USP7_MATH_1	235	239	PF00917	0.368
DOC_USP7_MATH_1	258	262	PF00917	0.368
DOC_USP7_MATH_1	31	35	PF00917	0.384
DOC_USP7_MATH_1	394	398	PF00917	0.628
DOC_USP7_MATH_1	400	404	PF00917	0.620
DOC_USP7_MATH_1	472	476	PF00917	0.703
DOC_USP7_MATH_1	524	528	PF00917	0.681
DOC_USP7_MATH_1	63	67	PF00917	0.320
DOC_USP7_MATH_1	909	913	PF00917	0.601
DOC_USP7_MATH_1	959	963	PF00917	0.625
DOC_USP7_MATH_1	972	976	PF00917	0.578
DOC_WW_Pin1_4	1018	1023	PF00397	0.643
DOC_WW_Pin1_4	1074	1079	PF00397	0.603
DOC_WW_Pin1_4	143	148	PF00397	0.327
DOC_WW_Pin1_4	219	224	PF00397	0.368
DOC_WW_Pin1_4	308	313	PF00397	0.368
DOC_WW_Pin1_4	395	400	PF00397	0.651
DOC_WW_Pin1_4	409	414	PF00397	0.628
DOC_WW_Pin1_4	481	486	PF00397	0.680
DOC_WW_Pin1_4	515	520	PF00397	0.684
DOC_WW_Pin1_4	556	561	PF00397	0.676
DOC_WW_Pin1_4	684	689	PF00397	0.702
DOC_WW_Pin1_4	690	695	PF00397	0.632
DOC_WW_Pin1_4	696	701	PF00397	0.582
DOC_WW_Pin1_4	763	768	PF00397	0.636
DOC_WW_Pin1_4	815	820	PF00397	0.642
DOC_WW_Pin1_4	957	962	PF00397	0.632
LIG_14-3-3_CanoR_1	844	848	PF00244	0.575
LIG_14-3-3_CanoR_1	908	916	PF00244	0.548
LIG_APCC_ABBA_1	44	49	PF00400	0.368
LIG_APCC_ABBAyCdc20_2	178	184	PF00400	0.368
LIG_BIR_III_4	791	795	PF00653	0.630
LIG_BIR_III_4	963	967	PF00653	0.582
LIG_BRCT_BRCA1_1	187	191	PF00533	0.385
LIG_BRCT_BRCA1_1	863	867	PF00533	0.542
LIG_CSL_BTD_1	1024	1027	PF09270	0.622
LIG_EH1_1	434	442	PF00400	0.590
LIG_eIF4E_1	950	956	PF01652	0.555
LIG_FHA_1	1040	1046	PF00498	0.665
LIG_FHA_1	150	156	PF00498	0.368
LIG_FHA_1	167	173	PF00498	0.208
LIG_FHA_1	466	472	PF00498	0.698
LIG_FHA_1	515	521	PF00498	0.592
LIG_FHA_1	844	850	PF00498	0.607
LIG_FHA_1	871	877	PF00498	0.601
LIG_FHA_1	900	906	PF00498	0.615
LIG_FHA_1	932	938	PF00498	0.527
LIG_FHA_2	573	579	PF00498	0.596
LIG_FHA_2	640	646	PF00498	0.478
LIG_FHA_2	777	783	PF00498	0.659
LIG_FHA_2	793	799	PF00498	0.525
LIG_FHA_2	892	898	PF00498	0.521
LIG_FHA_2	958	964	PF00498	0.679
LIG_GSK3_LRP6_1	690	695	PF00069	0.658
LIG_Integrin_RGD_1	775	777	PF01839	0.607
LIG_LIR_Apic_2	222	228	PF02991	0.368
LIG_LIR_Apic_2	864	870	PF02991	0.562
LIG_LIR_Apic_2	947	953	PF02991	0.549
LIG_LIR_Gen_1	112	120	PF02991	0.368
LIG_LIR_Gen_1	286	295	PF02991	0.366
LIG_LIR_Gen_1	941	950	PF02991	0.634
LIG_LIR_Nem_3	112	117	PF02991	0.368
LIG_LIR_Nem_3	27	32	PF02991	0.538
LIG_LIR_Nem_3	286	291	PF02991	0.366
LIG_LIR_Nem_3	917	923	PF02991	0.616
LIG_LIR_Nem_3	941	945	PF02991	0.638
LIG_MYND_1	481	485	PF01753	0.630
LIG_NBox_RRM_1	789	799	PF00076	0.627
LIG_NRBOX	244	250	PF00104	0.368
LIG_NRBOX	6	12	PF00104	0.539
LIG_OCRL_FandH_1	54	66	PF00620	0.368
LIG_SH2_CRK	1099	1103	PF00017	0.703
LIG_SH2_CRK	114	118	PF00017	0.368
LIG_SH2_CRK	600	604	PF00017	0.635
LIG_SH2_CRK	950	954	PF00017	0.552
LIG_SH2_PTP2	29	32	PF00017	0.320
LIG_SH2_SRC	107	110	PF00017	0.258
LIG_SH2_SRC	29	32	PF00017	0.368
LIG_SH2_SRC	95	98	PF00017	0.368
LIG_SH2_STAP1	1099	1103	PF00017	0.461
LIG_SH2_STAP1	250	254	PF00017	0.368
LIG_SH2_STAP1	283	287	PF00017	0.320
LIG_SH2_STAP1	95	99	PF00017	0.293
LIG_SH2_STAT5	102	105	PF00017	0.284
LIG_SH2_STAT5	1096	1099	PF00017	0.549
LIG_SH2_STAT5	225	228	PF00017	0.368
LIG_SH2_STAT5	29	32	PF00017	0.462
LIG_SH2_STAT5	54	57	PF00017	0.388
LIG_SH2_STAT5	91	94	PF00017	0.335
LIG_SH3_1	274	280	PF00018	0.368
LIG_SH3_1	410	416	PF00018	0.657
LIG_SH3_1	506	512	PF00018	0.632
LIG_SH3_2	357	362	PF14604	0.692
LIG_SH3_2	413	418	PF14604	0.594
LIG_SH3_3	1012	1018	PF00018	0.636
LIG_SH3_3	1021	1027	PF00018	0.592
LIG_SH3_3	1056	1062	PF00018	0.600
LIG_SH3_3	1072	1078	PF00018	0.525
LIG_SH3_3	12	18	PF00018	0.701
LIG_SH3_3	274	280	PF00018	0.368
LIG_SH3_3	353	359	PF00018	0.686
LIG_SH3_3	410	416	PF00018	0.611
LIG_SH3_3	506	512	PF00018	0.680
LIG_SH3_3	531	537	PF00018	0.661
LIG_SH3_3	549	555	PF00018	0.525
LIG_SH3_3	682	688	PF00018	0.643
LIG_SH3_3	710	716	PF00018	0.609
LIG_SH3_CIN85_PxpxPR_1	357	362	PF14604	0.704
LIG_SUMO_SIM_anti_2	1129	1134	PF11976	0.552
LIG_SUMO_SIM_par_1	954	960	PF11976	0.536
LIG_TRAF2_1	436	439	PF00917	0.591
LIG_TYR_ITIM	1097	1102	PF00017	0.693
LIG_UBA3_1	267	274	PF00899	0.368
LIG_UBA3_1	290	297	PF00899	0.368
LIG_WRC_WIRS_1	920	925	PF05994	0.597
LIG_WW_2	534	537	PF00397	0.653
LIG_WW_3	275	279	PF00397	0.320
LIG_WW_3	359	363	PF00397	0.697
MOD_CDK_SPxxK_3	411	418	PF00069	0.599
MOD_CK1_1	1030	1036	PF00069	0.635
MOD_CK1_1	1081	1087	PF00069	0.629
MOD_CK1_1	115	121	PF00069	0.368
MOD_CK1_1	136	142	PF00069	0.368
MOD_CK1_1	145	151	PF00069	0.292
MOD_CK1_1	559	565	PF00069	0.689
MOD_CK1_1	638	644	PF00069	0.579
MOD_CK1_1	64	70	PF00069	0.320
MOD_CK1_1	695	701	PF00069	0.625
MOD_CK1_1	830	836	PF00069	0.629
MOD_CK1_1	957	963	PF00069	0.629
MOD_CK2_1	433	439	PF00069	0.649
MOD_CK2_1	639	645	PF00069	0.583
MOD_CK2_1	819	825	PF00069	0.680
MOD_Cter_Amidation	494	497	PF01082	0.590
MOD_GlcNHglycan	1029	1032	PF01048	0.634
MOD_GlcNHglycan	118	121	PF01048	0.368
MOD_GlcNHglycan	133	136	PF01048	0.311
MOD_GlcNHglycan	138	141	PF01048	0.460
MOD_GlcNHglycan	148	151	PF01048	0.360
MOD_GlcNHglycan	26	29	PF01048	0.454
MOD_GlcNHglycan	340	343	PF01048	0.669
MOD_GlcNHglycan	351	354	PF01048	0.590
MOD_GlcNHglycan	458	461	PF01048	0.674
MOD_GlcNHglycan	474	477	PF01048	0.548
MOD_GlcNHglycan	512	515	PF01048	0.694
MOD_GlcNHglycan	566	569	PF01048	0.658
MOD_GlcNHglycan	590	593	PF01048	0.622
MOD_GlcNHglycan	614	619	PF01048	0.715
MOD_GlcNHglycan	620	623	PF01048	0.656
MOD_GlcNHglycan	631	636	PF01048	0.453
MOD_GlcNHglycan	694	697	PF01048	0.694
MOD_GlcNHglycan	805	808	PF01048	0.579
MOD_GlcNHglycan	822	825	PF01048	0.564
MOD_GlcNHglycan	827	830	PF01048	0.649
MOD_GlcNHglycan	832	835	PF01048	0.595
MOD_GlcNHglycan	974	977	PF01048	0.709
MOD_GSK3_1	1026	1033	PF00069	0.584
MOD_GSK3_1	1074	1081	PF00069	0.623
MOD_GSK3_1	112	119	PF00069	0.368
MOD_GSK3_1	131	138	PF00069	0.399
MOD_GSK3_1	142	149	PF00069	0.391
MOD_GSK3_1	20	27	PF00069	0.542
MOD_GSK3_1	204	211	PF00069	0.368
MOD_GSK3_1	215	222	PF00069	0.275
MOD_GSK3_1	378	385	PF00069	0.630
MOD_GSK3_1	395	402	PF00069	0.678
MOD_GSK3_1	510	517	PF00069	0.597
MOD_GSK3_1	614	621	PF00069	0.645
MOD_GSK3_1	631	638	PF00069	0.497
MOD_GSK3_1	692	699	PF00069	0.670
MOD_GSK3_1	781	788	PF00069	0.671
MOD_GSK3_1	815	822	PF00069	0.641
MOD_GSK3_1	839	846	PF00069	0.644
MOD_GSK3_1	857	864	PF00069	0.490
MOD_GSK3_1	919	926	PF00069	0.656
MOD_N-GLC_1	327	332	PF02516	0.509
MOD_NEK2_1	116	121	PF00069	0.368
MOD_NEK2_1	126	131	PF00069	0.267
MOD_NEK2_1	142	147	PF00069	0.219
MOD_NEK2_1	165	170	PF00069	0.406
MOD_NEK2_1	203	208	PF00069	0.368
MOD_NEK2_1	209	214	PF00069	0.317
MOD_NEK2_1	215	220	PF00069	0.267
MOD_NEK2_1	24	29	PF00069	0.457
MOD_NEK2_1	259	264	PF00069	0.368
MOD_NEK2_1	839	844	PF00069	0.631
MOD_NEK2_1	861	866	PF00069	0.605
MOD_NEK2_1	876	881	PF00069	0.520
MOD_NEK2_1	900	905	PF00069	0.622
MOD_NEK2_1	933	938	PF00069	0.621
MOD_PIKK_1	1078	1084	PF00454	0.615
MOD_PIKK_1	281	287	PF00454	0.320
MOD_PIKK_1	400	406	PF00454	0.673
MOD_PIKK_1	559	565	PF00454	0.580
MOD_PIKK_1	730	736	PF00454	0.636
MOD_PIKK_1	783	789	PF00454	0.613
MOD_PK_1	644	650	PF00069	0.612
MOD_PKA_1	456	462	PF00069	0.674
MOD_PKA_1	496	502	PF00069	0.596
MOD_PKA_1	771	777	PF00069	0.663
MOD_PKA_2	24	30	PF00069	0.456
MOD_PKA_2	456	462	PF00069	0.674
MOD_PKA_2	510	516	PF00069	0.690
MOD_PKA_2	564	570	PF00069	0.706
MOD_PKA_2	771	777	PF00069	0.663
MOD_PKA_2	843	849	PF00069	0.546
MOD_PKA_2	931	937	PF00069	0.604
MOD_PKA_2	972	978	PF00069	0.609
MOD_Plk_1	259	265	PF00069	0.368
MOD_Plk_1	631	637	PF00069	0.573
MOD_Plk_1	638	644	PF00069	0.537
MOD_Plk_1	781	787	PF00069	0.602
MOD_Plk_2-3	1126	1132	PF00069	0.554
MOD_Plk_2-3	639	645	PF00069	0.583
MOD_Plk_2-3	891	897	PF00069	0.523
MOD_Plk_4	1103	1109	PF00069	0.554
MOD_Plk_4	112	118	PF00069	0.368
MOD_Plk_4	204	210	PF00069	0.368
MOD_Plk_4	785	791	PF00069	0.651
MOD_Plk_4	857	863	PF00069	0.640
MOD_Plk_4	914	920	PF00069	0.610
MOD_ProDKin_1	1018	1024	PF00069	0.650
MOD_ProDKin_1	1074	1080	PF00069	0.604
MOD_ProDKin_1	143	149	PF00069	0.327
MOD_ProDKin_1	219	225	PF00069	0.368
MOD_ProDKin_1	308	314	PF00069	0.368
MOD_ProDKin_1	395	401	PF00069	0.654
MOD_ProDKin_1	409	415	PF00069	0.622
MOD_ProDKin_1	481	487	PF00069	0.683
MOD_ProDKin_1	515	521	PF00069	0.684
MOD_ProDKin_1	556	562	PF00069	0.677
MOD_ProDKin_1	684	690	PF00069	0.696
MOD_ProDKin_1	696	702	PF00069	0.583
MOD_ProDKin_1	763	769	PF00069	0.636
MOD_ProDKin_1	815	821	PF00069	0.641
MOD_ProDKin_1	957	963	PF00069	0.636
MOD_SUMO_for_1	988	991	PF00179	0.596
MOD_SUMO_rev_2	665	674	PF00179	0.582
TRG_DiLeu_BaEn_1	1143	1148	PF01217	0.523
TRG_DiLeu_BaEn_1	286	291	PF01217	0.320
TRG_DiLeu_BaEn_1	6	11	PF01217	0.535
TRG_DiLeu_BaEn_4	96	102	PF01217	0.368
TRG_DiLeu_BaLyEn_6	138	143	PF01217	0.260
TRG_DiLeu_BaLyEn_6	176	181	PF01217	0.368
TRG_ENDOCYTIC_2	102	105	PF00928	0.368
TRG_ENDOCYTIC_2	1099	1102	PF00928	0.695
TRG_ENDOCYTIC_2	114	117	PF00928	0.267
TRG_ENDOCYTIC_2	29	32	PF00928	0.462
TRG_ENDOCYTIC_2	54	57	PF00928	0.368
TRG_ENDOCYTIC_2	920	923	PF00928	0.746
TRG_ER_diArg_1	124	126	PF00400	0.296
TRG_ER_diArg_1	178	180	PF00400	0.368
TRG_ER_diArg_1	300	302	PF00400	0.368
TRG_ER_diArg_1	480	483	PF00400	0.641
TRG_ER_diArg_1	549	551	PF00400	0.624
TRG_NLS_MonoCore_2	454	459	PF00514	0.650
TRG_Pf-PMV_PEXEL_1	179	184	PF00026	0.368

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H675	Leishmania donovani	89%	100%
A4H5D8	Leishmania braziliensis	68%	100%
E9AMG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%