Dpy-30 motif containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Dpy-30 motif containing protein, putative

Species:

Leishmania major

UniProt:

Q4QI73_LEIMA

TriTrypDb:

LmjF.08.0960 , LMJLV39_080014100 , LMJSD75_080014200

Length:

565

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	2
GO:0032991	protein-containing complex	1	10
GO:0034708	methyltransferase complex	4	10
GO:0035097	histone methyltransferase complex	3	10
GO:0044666	MLL3/4 complex	4	10
GO:0048188	Set1C/COMPASS complex	4	10
GO:0110165	cellular anatomical entity	1	2
GO:0140513	nuclear protein-containing complex	2	10
GO:1902494	catalytic complex	2	10
GO:1990234	transferase complex	3	10

Expansion

Sequence features

Q4QI73

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QI73

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0008213	protein alkylation	5	2
GO:0009987	cellular process	1	2
GO:0016570	histone modification	5	2
GO:0016571	histone methylation	5	2
GO:0018022	peptidyl-lysine methylation	5	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018205	peptidyl-lysine modification	6	2
GO:0019538	protein metabolic process	3	2
GO:0032259	methylation	2	2
GO:0034968	histone lysine methylation	6	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043414	macromolecule methylation	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0051568	histone H3-K4 methylation	7	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	329	333	PF00656	0.674
CLV_NRD_NRD_1	161	163	PF00675	0.401
CLV_NRD_NRD_1	362	364	PF00675	0.344
CLV_NRD_NRD_1	45	47	PF00675	0.462
CLV_NRD_NRD_1	537	539	PF00675	0.478
CLV_NRD_NRD_1	54	56	PF00675	0.439
CLV_NRD_NRD_1	91	93	PF00675	0.409
CLV_PCSK_FUR_1	52	56	PF00082	0.600
CLV_PCSK_FUR_1	535	539	PF00082	0.467
CLV_PCSK_FUR_1	89	93	PF00082	0.581
CLV_PCSK_KEX2_1	161	163	PF00082	0.415
CLV_PCSK_KEX2_1	362	364	PF00082	0.344
CLV_PCSK_KEX2_1	52	54	PF00082	0.490
CLV_PCSK_KEX2_1	537	539	PF00082	0.585
CLV_PCSK_KEX2_1	91	93	PF00082	0.520
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.521
CLV_PCSK_PC7_1	89	95	PF00082	0.532
CLV_PCSK_SKI1_1	162	166	PF00082	0.373
CLV_PCSK_SKI1_1	169	173	PF00082	0.305
CLV_PCSK_SKI1_1	411	415	PF00082	0.439
DEG_Nend_UBRbox_2	1	3	PF02207	0.530
DEG_SCF_FBW7_1	268	275	PF00400	0.462
DOC_CYCLIN_RxL_1	166	175	PF00134	0.512
DOC_MAPK_gen_1	166	174	PF00069	0.330
DOC_MAPK_gen_1	409	416	PF00069	0.444
DOC_MAPK_MEF2A_6	409	416	PF00069	0.434
DOC_MAPK_MEF2A_6	473	480	PF00069	0.636
DOC_MAPK_NFAT4_5	409	417	PF00069	0.425
DOC_MAPK_NFAT4_5	473	481	PF00069	0.642
DOC_PP1_RVXF_1	254	261	PF00149	0.322
DOC_PP4_FxxP_1	353	356	PF00568	0.543
DOC_USP7_MATH_1	24	28	PF00917	0.447
DOC_USP7_MATH_1	274	278	PF00917	0.474
DOC_USP7_MATH_1	299	303	PF00917	0.362
DOC_WW_Pin1_4	228	233	PF00397	0.633
DOC_WW_Pin1_4	268	273	PF00397	0.388
LIG_14-3-3_CanoR_1	169	175	PF00244	0.417
LIG_14-3-3_CanoR_1	454	462	PF00244	0.320
LIG_BIR_III_4	509	513	PF00653	0.445
LIG_BRCT_BRCA1_1	349	353	PF00533	0.634
LIG_CaM_IQ_9	38	54	PF13499	0.495
LIG_eIF4E_1	32	38	PF01652	0.447
LIG_FHA_1	356	362	PF00498	0.481
LIG_FHA_1	368	374	PF00498	0.473
LIG_FHA_1	503	509	PF00498	0.644
LIG_FHA_2	413	419	PF00498	0.609
LIG_FHA_2	480	486	PF00498	0.639
LIG_GBD_Chelix_1	33	41	PF00786	0.247
LIG_LIR_Apic_2	350	356	PF02991	0.585
LIG_LIR_Gen_1	31	38	PF02991	0.447
LIG_LIR_Gen_1	447	458	PF02991	0.341
LIG_LIR_Gen_1	481	491	PF02991	0.581
LIG_LIR_Nem_3	31	35	PF02991	0.447
LIG_LIR_Nem_3	447	453	PF02991	0.338
LIG_LIR_Nem_3	481	486	PF02991	0.597
LIG_MYND_1	228	232	PF01753	0.632
LIG_NRBOX	262	268	PF00104	0.403
LIG_REV1ctd_RIR_1	162	170	PF16727	0.444
LIG_RPA_C_Fungi	49	61	PF08784	0.457
LIG_SH2_CRK	450	454	PF00017	0.312
LIG_SH2_NCK_1	104	108	PF00017	0.398
LIG_SH2_STAP1	387	391	PF00017	0.551
LIG_SH2_STAP1	543	547	PF00017	0.522
LIG_SH2_STAT5	254	257	PF00017	0.342
LIG_SH2_STAT5	265	268	PF00017	0.272
LIG_SH2_STAT5	32	35	PF00017	0.284
LIG_SH2_STAT5	387	390	PF00017	0.484
LIG_SH2_STAT5	5	8	PF00017	0.284
LIG_SH3_3	23	29	PF00018	0.284
LIG_SUMO_SIM_par_1	170	175	PF11976	0.346
LIG_SUMO_SIM_par_1	412	419	PF11976	0.378
LIG_TRAF2_1	149	152	PF00917	0.543
LIG_TRAF2_1	208	211	PF00917	0.457
LIG_TRAF2_1	343	346	PF00917	0.616
LIG_TRAF2_1	557	560	PF00917	0.628
LIG_TYR_ITIM	263	268	PF00017	0.390
LIG_TYR_ITIM	448	453	PF00017	0.370
LIG_UBA3_1	171	176	PF00899	0.357
LIG_WRC_WIRS_1	480	485	PF05994	0.547
MOD_CDK_SPK_2	268	273	PF00069	0.348
MOD_CK1_1	222	228	PF00069	0.547
MOD_CK2_1	136	142	PF00069	0.674
MOD_CK2_1	340	346	PF00069	0.711
MOD_CK2_1	398	404	PF00069	0.508
MOD_CK2_1	479	485	PF00069	0.547
MOD_CK2_1	554	560	PF00069	0.626
MOD_GlcNHglycan	142	145	PF01048	0.632
MOD_GlcNHglycan	176	179	PF01048	0.443
MOD_GlcNHglycan	2	5	PF01048	0.284
MOD_GlcNHglycan	224	227	PF01048	0.587
MOD_GlcNHglycan	276	279	PF01048	0.512
MOD_GlcNHglycan	320	323	PF01048	0.607
MOD_GlcNHglycan	342	345	PF01048	0.740
MOD_GlcNHglycan	456	459	PF01048	0.323
MOD_GlcNHglycan	555	559	PF01048	0.651
MOD_GSK3_1	136	143	PF00069	0.631
MOD_GSK3_1	170	177	PF00069	0.431
MOD_GSK3_1	20	27	PF00069	0.400
MOD_GSK3_1	215	222	PF00069	0.546
MOD_GSK3_1	268	275	PF00069	0.370
MOD_GSK3_1	347	354	PF00069	0.629
MOD_N-GLC_1	268	273	PF02516	0.464
MOD_NEK2_1	170	175	PF00069	0.432
MOD_NEK2_1	318	323	PF00069	0.516
MOD_NEK2_1	412	417	PF00069	0.395
MOD_PIKK_1	351	357	PF00454	0.447
MOD_PIKK_1	436	442	PF00454	0.400
MOD_PKA_2	140	146	PF00069	0.607
MOD_PKB_1	442	450	PF00069	0.280
MOD_Plk_1	197	203	PF00069	0.497
MOD_Plk_2-3	385	391	PF00069	0.550
MOD_Plk_2-3	400	406	PF00069	0.656
MOD_Plk_4	285	291	PF00069	0.468
MOD_Plk_4	444	450	PF00069	0.346
MOD_ProDKin_1	228	234	PF00069	0.627
MOD_ProDKin_1	268	274	PF00069	0.390
MOD_SUMO_for_1	121	124	PF00179	0.473
MOD_SUMO_for_1	182	185	PF00179	0.362
MOD_SUMO_for_1	309	312	PF00179	0.487
MOD_SUMO_rev_2	43	48	PF00179	0.496
TRG_DiLeu_BaEn_1	110	115	PF01217	0.393
TRG_DiLeu_BaEn_4	503	509	PF01217	0.663
TRG_ENDOCYTIC_2	257	260	PF00928	0.304
TRG_ENDOCYTIC_2	265	268	PF00928	0.315
TRG_ENDOCYTIC_2	32	35	PF00928	0.284
TRG_ENDOCYTIC_2	450	453	PF00928	0.325
TRG_ER_diArg_1	192	195	PF00400	0.513
TRG_ER_diArg_1	361	363	PF00400	0.351
TRG_ER_diArg_1	441	444	PF00400	0.312
TRG_ER_diArg_1	52	55	PF00400	0.566
TRG_ER_diArg_1	537	540	PF00400	0.485
TRG_ER_diArg_1	89	92	PF00400	0.356
TRG_NLS_MonoExtC_3	91	97	PF00514	0.419
TRG_NLS_MonoExtN_4	89	96	PF00514	0.418
TRG_Pf-PMV_PEXEL_1	68	72	PF00026	0.421

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3H1	Leptomonas seymouri	63%	97%
A0A3S7WQC3	Leishmania donovani	94%	100%
A0A422NJV4	Trypanosoma rangeli	39%	100%
A4H5E1	Leishmania braziliensis	82%	99%
A4HTN6	Leishmania infantum	94%	100%
C9ZPD6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AMH0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BR17	Trypanosoma cruzi	40%	100%