EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2453), putative

Species:

Leishmania major

UniProt:

Q4QI72_LEIMA

TriTrypDb:

LmjF.08.0970 , LMJLV39_080014200 , LMJSD75_080014300

Length:

610

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0016020	membrane	2	6
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4QI72

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QI72

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0005509	calcium ion binding	5	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	225	229	PF00656	0.535
CLV_NRD_NRD_1	196	198	PF00675	0.671
CLV_NRD_NRD_1	241	243	PF00675	0.729
CLV_NRD_NRD_1	251	253	PF00675	0.687
CLV_NRD_NRD_1	567	569	PF00675	0.391
CLV_PCSK_FUR_1	164	168	PF00082	0.713
CLV_PCSK_KEX2_1	166	168	PF00082	0.708
CLV_PCSK_KEX2_1	196	198	PF00082	0.671
CLV_PCSK_KEX2_1	241	243	PF00082	0.729
CLV_PCSK_KEX2_1	250	252	PF00082	0.694
CLV_PCSK_KEX2_1	567	569	PF00082	0.391
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.708
CLV_PCSK_PC1ET2_1	250	252	PF00082	0.768
CLV_PCSK_PC7_1	162	168	PF00082	0.717
CLV_PCSK_PC7_1	563	569	PF00082	0.391
CLV_PCSK_SKI1_1	145	149	PF00082	0.740
CLV_PCSK_SKI1_1	196	200	PF00082	0.667
CLV_PCSK_SKI1_1	252	256	PF00082	0.765
CLV_PCSK_SKI1_1	40	44	PF00082	0.777
CLV_PCSK_SKI1_1	600	604	PF00082	0.479
DEG_APCC_DBOX_1	195	203	PF00400	0.477
DEG_Nend_UBRbox_3	1	3	PF02207	0.451
DEG_SCF_FBW7_1	411	418	PF00400	0.453
DEG_SCF_SKP2-CKS1_1	243	250	PF00560	0.545
DEG_SPOP_SBC_1	134	138	PF00917	0.558
DEG_SPOP_SBC_1	294	298	PF00917	0.522
DEG_SPOP_SBC_1	65	69	PF00917	0.539
DOC_CKS1_1	412	417	PF01111	0.450
DOC_MAPK_DCC_7	507	515	PF00069	0.324
DOC_MAPK_gen_1	330	337	PF00069	0.570
DOC_MAPK_MEF2A_6	507	515	PF00069	0.324
DOC_USP7_MATH_1	110	114	PF00917	0.588
DOC_USP7_MATH_1	134	138	PF00917	0.547
DOC_USP7_MATH_1	269	273	PF00917	0.529
DOC_USP7_MATH_1	294	298	PF00917	0.580
DOC_USP7_MATH_1	322	326	PF00917	0.541
DOC_USP7_MATH_1	34	38	PF00917	0.567
DOC_USP7_MATH_1	385	389	PF00917	0.512
DOC_USP7_MATH_1	390	394	PF00917	0.465
DOC_USP7_MATH_1	423	427	PF00917	0.528
DOC_USP7_MATH_1	45	49	PF00917	0.538
DOC_USP7_MATH_1	50	54	PF00917	0.525
DOC_USP7_MATH_1	57	61	PF00917	0.556
DOC_USP7_MATH_1	570	574	PF00917	0.698
DOC_USP7_MATH_1	65	69	PF00917	0.489
DOC_USP7_MATH_1	86	90	PF00917	0.555
DOC_WW_Pin1_4	111	116	PF00397	0.633
DOC_WW_Pin1_4	156	161	PF00397	0.601
DOC_WW_Pin1_4	244	249	PF00397	0.605
DOC_WW_Pin1_4	302	307	PF00397	0.576
DOC_WW_Pin1_4	324	329	PF00397	0.481
DOC_WW_Pin1_4	376	381	PF00397	0.567
DOC_WW_Pin1_4	405	410	PF00397	0.555
DOC_WW_Pin1_4	411	416	PF00397	0.499
DOC_WW_Pin1_4	541	546	PF00397	0.447
DOC_WW_Pin1_4	55	60	PF00397	0.587
DOC_WW_Pin1_4	61	66	PF00397	0.539
DOC_WW_Pin1_4	84	89	PF00397	0.578
LIG_14-3-3_CanoR_1	145	154	PF00244	0.587
LIG_14-3-3_CanoR_1	512	516	PF00244	0.398
LIG_14-3-3_CanoR_1	525	533	PF00244	0.314
LIG_14-3-3_CanoR_1	576	582	PF00244	0.657
LIG_BIR_III_4	399	403	PF00653	0.531
LIG_BRCT_BRCA1_1	205	209	PF00533	0.475
LIG_FHA_1	123	129	PF00498	0.548
LIG_FHA_1	457	463	PF00498	0.560
LIG_FHA_1	542	548	PF00498	0.348
LIG_FHA_2	223	229	PF00498	0.524
LIG_FHA_2	425	431	PF00498	0.418
LIG_GBD_Chelix_1	169	177	PF00786	0.699
LIG_Integrin_RGD_1	605	607	PF01839	0.409
LIG_LIR_Gen_1	212	220	PF02991	0.512
LIG_LIR_Gen_1	262	271	PF02991	0.450
LIG_LIR_Gen_1	438	447	PF02991	0.361
LIG_LIR_Nem_3	206	211	PF02991	0.495
LIG_LIR_Nem_3	212	216	PF02991	0.467
LIG_LIR_Nem_3	262	267	PF02991	0.451
LIG_LIR_Nem_3	408	413	PF02991	0.510
LIG_LIR_Nem_3	438	442	PF02991	0.422
LIG_MAD2	441	449	PF02301	0.428
LIG_MLH1_MIPbox_1	205	209	PF16413	0.475
LIG_MYND_1	181	185	PF01753	0.488
LIG_NRBOX	172	178	PF00104	0.503
LIG_RPA_C_Fungi	389	401	PF08784	0.672
LIG_SH2_NCK_1	213	217	PF00017	0.636
LIG_SH2_NCK_1	505	509	PF00017	0.428
LIG_SH2_NCK_1	523	527	PF00017	0.211
LIG_SH2_SRC	213	216	PF00017	0.641
LIG_SH2_SRC	319	322	PF00017	0.557
LIG_SH2_STAP1	213	217	PF00017	0.636
LIG_SH2_STAP1	236	240	PF00017	0.635
LIG_SH2_STAP1	505	509	PF00017	0.375
LIG_SH2_STAT5	208	211	PF00017	0.614
LIG_SH2_STAT5	319	322	PF00017	0.557
LIG_SH2_STAT5	433	436	PF00017	0.545
LIG_SH2_STAT5	439	442	PF00017	0.445
LIG_SH2_STAT5	505	508	PF00017	0.428
LIG_SH3_3	284	290	PF00018	0.660
LIG_SH3_3	406	412	PF00018	0.691
LIG_SH3_3	53	59	PF00018	0.680
LIG_SH3_3	68	74	PF00018	0.748
LIG_Sin3_3	20	27	PF02671	0.697
LIG_TRAF2_1	556	559	PF00917	0.625
LIG_TYR_ITIM	211	216	PF00017	0.646
LIG_WW_3	509	513	PF00397	0.428
MOD_CDC14_SPxK_1	159	162	PF00782	0.668
MOD_CDC14_SPxK_1	379	382	PF00782	0.681
MOD_CDK_SPK_2	381	386	PF00069	0.582
MOD_CDK_SPxK_1	156	162	PF00069	0.679
MOD_CDK_SPxK_1	244	250	PF00069	0.687
MOD_CDK_SPxK_1	324	330	PF00069	0.574
MOD_CDK_SPxK_1	376	382	PF00069	0.685
MOD_CDK_SPxxK_3	244	251	PF00069	0.701
MOD_CDK_SPxxK_3	302	309	PF00069	0.609
MOD_CDK_SPxxK_3	55	62	PF00069	0.656
MOD_CDK_SPxxK_3	84	91	PF00069	0.704
MOD_CK1_1	113	119	PF00069	0.745
MOD_CK1_1	121	127	PF00069	0.632
MOD_CK1_1	136	142	PF00069	0.838
MOD_CK1_1	179	185	PF00069	0.579
MOD_CK1_1	192	198	PF00069	0.477
MOD_CK1_1	230	236	PF00069	0.757
MOD_CK1_1	260	266	PF00069	0.756
MOD_CK1_1	288	294	PF00069	0.753
MOD_CK1_1	3	9	PF00069	0.788
MOD_CK1_1	302	308	PF00069	0.576
MOD_CK1_1	312	318	PF00069	0.586
MOD_CK1_1	354	360	PF00069	0.740
MOD_CK1_1	384	390	PF00069	0.696
MOD_CK1_1	421	427	PF00069	0.726
MOD_CK1_1	524	530	PF00069	0.443
MOD_CK1_1	550	556	PF00069	0.677
MOD_CK1_1	60	66	PF00069	0.733
MOD_CK2_1	135	141	PF00069	0.573
MOD_CK2_1	229	235	PF00069	0.654
MOD_CK2_1	86	92	PF00069	0.670
MOD_GlcNHglycan	120	123	PF01048	0.702
MOD_GlcNHglycan	191	194	PF01048	0.618
MOD_GlcNHglycan	2	5	PF01048	0.543
MOD_GlcNHglycan	259	262	PF01048	0.654
MOD_GlcNHglycan	271	274	PF01048	0.687
MOD_GlcNHglycan	301	304	PF01048	0.738
MOD_GlcNHglycan	306	309	PF01048	0.688
MOD_GlcNHglycan	311	314	PF01048	0.603
MOD_GlcNHglycan	316	319	PF01048	0.728
MOD_GlcNHglycan	324	327	PF01048	0.707
MOD_GlcNHglycan	343	346	PF01048	0.553
MOD_GlcNHglycan	356	359	PF01048	0.735
MOD_GlcNHglycan	36	39	PF01048	0.811
MOD_GlcNHglycan	387	390	PF01048	0.720
MOD_GlcNHglycan	420	423	PF01048	0.748
MOD_GlcNHglycan	472	475	PF01048	0.428
MOD_GlcNHglycan	490	493	PF01048	0.222
MOD_GlcNHglycan	52	55	PF01048	0.597
MOD_GlcNHglycan	549	552	PF01048	0.629
MOD_GlcNHglycan	59	62	PF01048	0.660
MOD_GlcNHglycan	71	74	PF01048	0.545
MOD_GlcNHglycan	88	91	PF01048	0.603
MOD_GSK3_1	104	111	PF00069	0.825
MOD_GSK3_1	114	121	PF00069	0.671
MOD_GSK3_1	136	143	PF00069	0.742
MOD_GSK3_1	148	155	PF00069	0.793
MOD_GSK3_1	2	9	PF00069	0.633
MOD_GSK3_1	285	292	PF00069	0.742
MOD_GSK3_1	295	302	PF00069	0.680
MOD_GSK3_1	322	329	PF00069	0.730
MOD_GSK3_1	371	378	PF00069	0.688
MOD_GSK3_1	381	388	PF00069	0.608
MOD_GSK3_1	41	48	PF00069	0.746
MOD_GSK3_1	411	418	PF00069	0.797
MOD_GSK3_1	472	479	PF00069	0.473
MOD_GSK3_1	517	524	PF00069	0.385
MOD_GSK3_1	57	64	PF00069	0.676
MOD_GSK3_1	65	72	PF00069	0.667
MOD_N-GLC_1	390	395	PF02516	0.719
MOD_N-GLC_1	457	462	PF02516	0.428
MOD_NEK2_1	140	145	PF00069	0.667
MOD_NEK2_1	243	248	PF00069	0.679
MOD_NEK2_1	333	338	PF00069	0.648
MOD_NEK2_1	351	356	PF00069	0.581
MOD_NEK2_1	41	46	PF00069	0.596
MOD_NEK2_1	456	461	PF00069	0.428
MOD_NEK2_1	472	477	PF00069	0.260
MOD_NEK2_1	547	552	PF00069	0.648
MOD_NEK2_1	7	12	PF00069	0.622
MOD_PIKK_1	476	482	PF00454	0.428
MOD_PIKK_1	524	530	PF00454	0.428
MOD_PIKK_1	550	556	PF00454	0.616
MOD_PIKK_1	91	97	PF00454	0.729
MOD_PK_1	227	233	PF00069	0.655
MOD_PKA_2	152	158	PF00069	0.748
MOD_PKA_2	503	509	PF00069	0.444
MOD_PKA_2	511	517	PF00069	0.396
MOD_PKA_2	524	530	PF00069	0.386
MOD_PKA_2	577	583	PF00069	0.465
MOD_Plk_1	227	233	PF00069	0.655
MOD_Plk_1	333	339	PF00069	0.590
MOD_Plk_1	456	462	PF00069	0.428
MOD_Plk_1	584	590	PF00069	0.526
MOD_Plk_4	263	269	PF00069	0.577
MOD_Plk_4	435	441	PF00069	0.619
MOD_Plk_4	457	463	PF00069	0.488
MOD_Plk_4	8	14	PF00069	0.725
MOD_ProDKin_1	111	117	PF00069	0.803
MOD_ProDKin_1	156	162	PF00069	0.760
MOD_ProDKin_1	244	250	PF00069	0.769
MOD_ProDKin_1	302	308	PF00069	0.725
MOD_ProDKin_1	324	330	PF00069	0.596
MOD_ProDKin_1	376	382	PF00069	0.717
MOD_ProDKin_1	405	411	PF00069	0.698
MOD_ProDKin_1	541	547	PF00069	0.447
MOD_ProDKin_1	55	61	PF00069	0.741
MOD_ProDKin_1	84	90	PF00069	0.727
MOD_SUMO_rev_2	601	610	PF00179	0.507
TRG_DiLeu_BaEn_1	194	199	PF01217	0.591
TRG_DiLeu_BaLyEn_6	542	547	PF01217	0.428
TRG_DiLeu_LyEn_5	194	199	PF01217	0.591
TRG_ENDOCYTIC_2	208	211	PF00928	0.614
TRG_ENDOCYTIC_2	213	216	PF00928	0.584
TRG_ENDOCYTIC_2	439	442	PF00928	0.513
TRG_ER_diArg_1	161	164	PF00400	0.660
TRG_ER_diArg_1	196	198	PF00400	0.579
TRG_ER_diArg_1	240	242	PF00400	0.652
TRG_ER_diArg_1	330	333	PF00400	0.591
TRG_ER_diArg_1	566	568	PF00400	0.596
TRG_ER_diArg_1	588	591	PF00400	0.548
TRG_NLS_MonoCore_2	15	20	PF00514	0.699
TRG_NLS_MonoExtN_4	14	20	PF00514	0.702
TRG_NLS_MonoExtN_4	248	254	PF00514	0.708

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H678	Leishmania donovani	88%	73%
A4H5E2	Leishmania braziliensis	70%	73%
A4HTN7	Leishmania infantum	88%	73%
E9AMH1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	87%