Cathepsin L-like protease

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cathepsin L-like protease

Species:

Leishmania major

UniProt:

Q4QI65_LEIMA

TriTrypDb:

LmjF.08.1040 , LMJLV39_080014800 , LMJSD75_080014900

Length:

348

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 125

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 21

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 37, no: 4
NetGPI	no	yes: 0, no: 41

Cellular components
Term	Name	Level	Count
GO:0000323	lytic vacuole	6	9
GO:0005615	extracellular space	2	9
GO:0005764	lysosome	7	9
GO:0005773	vacuole	5	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4QI65

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QI65

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	42
GO:0006807	nitrogen compound metabolic process	2	42
GO:0008152	metabolic process	1	42
GO:0019538	protein metabolic process	3	42
GO:0043170	macromolecule metabolic process	3	42
GO:0044238	primary metabolic process	2	42
GO:0051603	proteolysis involved in protein catabolic process	5	9
GO:0071704	organic substance metabolic process	2	42
GO:1901564	organonitrogen compound metabolic process	3	42

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	42
GO:0004175	endopeptidase activity	4	25
GO:0004197	cysteine-type endopeptidase activity	5	25
GO:0008233	peptidase activity	3	42
GO:0008234	cysteine-type peptidase activity	4	42
GO:0016787	hydrolase activity	2	42
GO:0140096	catalytic activity, acting on a protein	2	42

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	182	186	PF00656	0.458
CLV_NRD_NRD_1	116	118	PF00675	0.577
CLV_PCSK_KEX2_1	42	44	PF00082	0.510
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.510
CLV_PCSK_SKI1_1	5	9	PF00082	0.660
CLV_Separin_Metazoa	67	71	PF03568	0.444
DEG_APCC_DBOX_1	119	127	PF00400	0.571
DEG_APCC_DBOX_1	4	12	PF00400	0.681
DEG_ODPH_VHL_1	232	244	PF01847	0.271
DOC_CKS1_1	30	35	PF01111	0.639
DOC_CYCLIN_RxL_1	58	71	PF00134	0.444
DOC_MAPK_MEF2A_6	257	265	PF00069	0.424
DOC_MAPK_MEF2A_6	317	324	PF00069	0.403
DOC_SPAK_OSR1_1	80	84	PF12202	0.389
DOC_USP7_MATH_1	146	150	PF00917	0.530
DOC_USP7_MATH_1	215	219	PF00917	0.349
DOC_USP7_MATH_1	224	228	PF00917	0.349
DOC_WW_Pin1_4	136	141	PF00397	0.401
DOC_WW_Pin1_4	29	34	PF00397	0.602
DOC_WW_Pin1_4	340	345	PF00397	0.502
LIG_14-3-3_CanoR_1	172	179	PF00244	0.440
LIG_14-3-3_CanoR_1	321	325	PF00244	0.271
LIG_BIR_II_1	1	5	PF00653	0.667
LIG_FHA_1	277	283	PF00498	0.389
LIG_FHA_1	296	302	PF00498	0.454
LIG_FHA_1	321	327	PF00498	0.502
LIG_FHA_2	49	55	PF00498	0.446
LIG_LIR_Gen_1	239	248	PF02991	0.484
LIG_LIR_Gen_1	316	326	PF02991	0.380
LIG_LIR_Nem_3	211	217	PF02991	0.405
LIG_LIR_Nem_3	268	273	PF02991	0.349
LIG_LIR_Nem_3	300	306	PF02991	0.375
LIG_LIR_Nem_3	316	322	PF02991	0.340
LIG_LIR_Nem_3	84	89	PF02991	0.462
LIG_LYPXL_yS_3	214	217	PF13949	0.309
LIG_SH2_CRK	49	53	PF00017	0.392
LIG_SH2_GRB2like	98	101	PF00017	0.493
LIG_SH2_PTP2	319	322	PF00017	0.357
LIG_SH2_SRC	98	101	PF00017	0.506
LIG_SH2_STAT5	104	107	PF00017	0.464
LIG_SH2_STAT5	216	219	PF00017	0.363
LIG_SH2_STAT5	241	244	PF00017	0.468
LIG_SH2_STAT5	29	32	PF00017	0.529
LIG_SH2_STAT5	319	322	PF00017	0.357
LIG_SH2_STAT5	98	101	PF00017	0.466
LIG_SH3_3	27	33	PF00018	0.583
LIG_TYR_ITIM	301	306	PF00017	0.481
MOD_CDK_SPxK_1	136	142	PF00069	0.401
MOD_CK1_1	227	233	PF00069	0.426
MOD_CK1_1	243	249	PF00069	0.487
MOD_CK1_1	269	275	PF00069	0.365
MOD_CK2_1	48	54	PF00069	0.447
MOD_CK2_1	87	93	PF00069	0.351
MOD_GlcNHglycan	122	126	PF01048	0.598
MOD_GlcNHglycan	153	156	PF01048	0.468
MOD_GlcNHglycan	217	220	PF01048	0.358
MOD_GlcNHglycan	274	277	PF01048	0.457
MOD_GSK3_1	240	247	PF00069	0.460
MOD_GSK3_1	265	272	PF00069	0.383
MOD_GSK3_1	334	341	PF00069	0.438
MOD_N-GLC_1	204	209	PF02516	0.472
MOD_N-GLC_1	227	232	PF02516	0.509
MOD_N-GLC_1	295	300	PF02516	0.460
MOD_N-GLC_2	186	188	PF02516	0.359
MOD_N-GLC_2	327	329	PF02516	0.376
MOD_NEK2_1	1	6	PF00069	0.629
MOD_NEK2_1	204	209	PF00069	0.479
MOD_NEK2_1	41	46	PF00069	0.482
MOD_NEK2_1	81	86	PF00069	0.430
MOD_PIKK_1	158	164	PF00454	0.486
MOD_PIKK_1	338	344	PF00454	0.607
MOD_PKA_2	171	177	PF00069	0.440
MOD_PKA_2	320	326	PF00069	0.271
MOD_Plk_1	121	127	PF00069	0.654
MOD_Plk_1	210	216	PF00069	0.342
MOD_Plk_1	265	271	PF00069	0.321
MOD_Plk_4	204	210	PF00069	0.382
MOD_Plk_4	266	272	PF00069	0.329
MOD_ProDKin_1	136	142	PF00069	0.401
MOD_ProDKin_1	29	35	PF00069	0.597
MOD_ProDKin_1	340	346	PF00069	0.514
MOD_SUMO_rev_2	39	44	PF00179	0.514
TRG_DiLeu_BaEn_4	54	60	PF01217	0.464
TRG_ENDOCYTIC_2	214	217	PF00928	0.343
TRG_ENDOCYTIC_2	241	244	PF00928	0.525
TRG_ENDOCYTIC_2	303	306	PF00928	0.354
TRG_ENDOCYTIC_2	319	322	PF00928	0.322
TRG_ENDOCYTIC_2	49	52	PF00928	0.422
TRG_NES_CRM1_1	57	71	PF08389	0.444
TRG_NLS_MonoExtC_3	116	122	PF00514	0.623

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A072UTP9	Medicago truncatula	37%	99%
A0A0N0P293	Leptomonas seymouri	33%	94%
A0A0N0P8D1	Leptomonas seymouri	25%	100%
A0A0N1PA65	Leptomonas seymouri	51%	75%
A0A0S4III3	Bodo saltans	46%	100%
A0A0S4IMD3	Bodo saltans	46%	93%
A0A0S4IWQ5	Bodo saltans	36%	100%
A0A0S4IY45	Bodo saltans	35%	100%
A0A0S4J328	Bodo saltans	49%	100%
A0A0S4J3Q7	Bodo saltans	30%	95%
A0A0S4J918	Bodo saltans	40%	100%
A0A0S4J9K9	Bodo saltans	47%	100%
A0A0S4JIQ4	Bodo saltans	26%	100%
A0A0S4JPQ2	Bodo saltans	31%	94%
A0A0S4JSZ3	Bodo saltans	32%	94%
A0A0S4JV57	Bodo saltans	32%	95%
A0A0S4JXJ3	Bodo saltans	31%	91%
A0A0S4KGP4	Bodo saltans	44%	100%
A0A0S4KI32	Bodo saltans	31%	100%
A0A0S4KJA5	Bodo saltans	46%	75%
A0A1X0NIG8	Trypanosomatidae	32%	80%
A0A1X0NM52	Trypanosomatidae	54%	100%
A0A1X0NTV4	Trypanosomatidae	30%	100%
A0A1X0NXC8	Trypanosomatidae	31%	92%
A0A3R7N5T7	Trypanosoma rangeli	27%	100%
A0A3S5H682	Leishmania donovani	89%	88%
A0A3S5H683	Leishmania donovani	88%	79%
A0A3S5H684	Leishmania donovani	87%	79%
A0A3S5H685	Leishmania donovani	88%	79%
A0A3S7WQD0	Leishmania donovani	88%	79%
A0A6L0WJ22	Leishmania infantum	88%	79%
A0E358	Paramecium tetraurelia	35%	100%
A1E295	Sus scrofa	28%	100%
A1KXI0	Blomia tropicalis	30%	100%
A2XQE8	Oryza sativa subsp. indica	36%	100%
A4H5E4	Leishmania braziliensis	75%	79%
A4H5E5	Leishmania braziliensis	76%	79%
A4H5E6	Leishmania braziliensis	76%	79%
A4HA92	Leishmania braziliensis	48%	73%
A4HTP0	Leishmania infantum	86%	91%
A4HYH2	Leishmania infantum	46%	98%
A4I4D6	Leishmania infantum	32%	100%
A5HII1	Actinidia deliciosa	32%	92%
A8DS38	Tabernaemontana divaricata	37%	95%
B2LSD2	Mucuna pruriens	37%	81%
C9ZQ62	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
C9ZQB3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	77%
C9ZQB5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	77%
C9ZQB6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	86%
D3ZZ07	Rattus norvegicus	33%	100%
E8NHD8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	97%
E8NHH6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
E8NHJ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
E8NHJ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	69%
E8NHS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	93%
E9ADT5	Leishmania major	31%	100%
E9ALZ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AMH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	95%
E9AMH6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	79%
E9AMH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	97%
E9AS96	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	98%
F4JNL3	Arabidopsis thaliana	30%	98%
O10364	Orgyia pseudotsugata multicapsid polyhedrosis virus	37%	100%
O17473	Brugia pahangi	35%	88%
O23791	Ananas comosus	33%	99%
O35186	Rattus norvegicus	36%	100%
O45734	Caenorhabditis elegans	40%	100%
O46427	Sus scrofa	35%	100%
O60911	Homo sapiens	39%	100%
O65039	Ricinus communis	38%	97%
O65493	Arabidopsis thaliana	35%	98%
O70370	Mus musculus	35%	100%
O91466	Cydia pomonella granulosis virus (isolate Mexico/1963)	37%	100%
O97397	Phaedon cochleariae	33%	100%
O97578	Canis lupus familiaris	29%	80%
P00784	Carica papaya	34%	100%
P00785	Actinidia chinensis var. chinensis	32%	92%
P00786	Rattus norvegicus	36%	100%
P00787	Rattus norvegicus	30%	100%
P04988	Dictyostelium discoideum	36%	100%
P04989	Dictyostelium discoideum	34%	93%
P05167	Hordeum vulgare	40%	96%
P05994	Carica papaya	32%	100%
P06797	Mus musculus	39%	100%
P07154	Rattus norvegicus	40%	100%
P07688	Bos taurus	28%	100%
P07711	Homo sapiens	36%	100%
P07858	Homo sapiens	30%	100%
P08176	Dermatophagoides pteronyssinus	28%	100%
P09668	Homo sapiens	36%	100%
P10056	Carica papaya	35%	100%
P10605	Mus musculus	31%	100%
P12412	Vigna mungo	36%	96%
P13277	Homarus americanus	39%	100%
P14080	Carica papaya	36%	99%
P14658	Trypanosoma brucei brucei	52%	77%
P15242	Rattus norvegicus	36%	100%
P16311	Dermatophagoides farinae	30%	100%
P22497	Theileria parva	35%	79%
P22895	Glycine max	36%	92%
P25249	Hordeum vulgare	37%	94%
P25250	Hordeum vulgare	37%	93%
P25251	Brassica napus	35%	100%
P25326	Bos taurus	36%	100%
P25773	Felis catus	37%	100%
P25774	Homo sapiens	33%	100%
P25775	Leishmania mexicana	47%	98%
P25776	Oryza sativa subsp. japonica	38%	76%
P25777	Oryza sativa subsp. japonica	40%	75%
P25778	Oryza sativa subsp. japonica	40%	96%
P25779	Trypanosoma cruzi	56%	75%
P25780	Euroglyphus maynei	29%	100%
P25781	Theileria annulata	32%	79%
P25782	Homarus americanus	37%	100%
P25783	Autographa californica nuclear polyhedrosis virus	38%	100%
P25784	Homarus americanus	37%	100%
P25792	Schistosoma mansoni	25%	100%
P25802	Ostertagia ostertagi	27%	100%
P25803	Phaseolus vulgaris	36%	96%
P25804	Pisum sativum	41%	96%
P25807	Caenorhabditis elegans	28%	100%
P25975	Bos taurus	37%	100%
P35591	Leishmania pifanoi	47%	98%
P36184	Entamoeba histolytica	31%	100%
P36185	Entamoeba histolytica	28%	100%
P36400	Leishmania mexicana	85%	79%
P41715	Choristoneura fumiferana nuclear polyhedrosis virus	38%	100%
P41721	Bombyx mori nuclear polyhedrosis virus	37%	100%
P43156	Hemerocallis sp.	37%	97%
P43157	Schistosoma japonicum	26%	100%
P43233	Gallus gallus	29%	100%
P43234	Homo sapiens	36%	100%
P43235	Homo sapiens	36%	100%
P43236	Oryctolagus cuniculus	36%	100%
P43295	Arabidopsis thaliana	41%	96%
P43296	Arabidopsis thaliana	39%	95%
P43297	Arabidopsis thaliana	40%	75%
P43507	Caenorhabditis elegans	26%	94%
P43508	Caenorhabditis elegans	24%	100%
P43509	Caenorhabditis elegans	30%	100%
P43510	Caenorhabditis elegans	28%	92%
P46102	Plasmodium vinckei	30%	69%
P49935	Mus musculus	36%	100%
P53634	Homo sapiens	30%	75%
P54639	Dictyostelium discoideum	33%	79%
P54640	Dictyostelium discoideum	34%	100%
P55097	Mus musculus	36%	100%
P56202	Homo sapiens	32%	93%
P56203	Mus musculus	33%	94%
P61276	Macaca fascicularis	37%	100%
P61277	Macaca mulatta	37%	100%
P80067	Rattus norvegicus	31%	75%
P80884	Ananas comosus	32%	100%
P83205	Ovis aries	30%	100%
P90850	Caenorhabditis elegans	29%	77%
P92131	Giardia intestinalis	30%	100%
P92132	Giardia intestinalis	35%	100%
P92133	Giardia intestinalis	34%	100%
P97821	Mus musculus	33%	75%
Q01957	Entamoeba histolytica	29%	100%
Q01958	Entamoeba histolytica	30%	100%
Q02765	Rattus norvegicus	33%	100%
Q05094	Leishmania pifanoi	85%	78%
Q06964	Entamoeba histolytica	31%	100%
Q10716	Zea mays	39%	94%
Q10717	Zea mays	39%	97%
Q1EIQ3	Psoroptes ovis	31%	100%
Q23894	Dictyostelium discoideum	34%	100%
Q24940	Fasciola hepatica	38%	100%
Q26534	Schistosoma mansoni	38%	100%
Q26636	Sarcophaga peregrina	36%	100%
Q28944	Sus scrofa	38%	100%
Q3T0I2	Bos taurus	37%	100%
Q3ZCJ8	Bos taurus	30%	75%
Q3ZKN1	Canis lupus familiaris	36%	100%
Q40143	Solanum lycopersicum	38%	98%
Q4QD68	Leishmania major	49%	98%
Q4QI61	Leishmania major	100%	79%
Q4QI62	Leishmania major	99%	100%
Q4QI64	Leishmania major	100%	100%
Q4QI66	Leishmania major	99%	79%
Q4QI67	Leishmania major	99%	100%
Q4QI68	Leishmania major	99%	100%
Q4R5M2	Macaca fascicularis	30%	100%
Q5E968	Bos taurus	36%	100%
Q5E998	Bos taurus	37%	100%
Q5R6D1	Pongo abelii	31%	100%
Q5RB02	Pongo abelii	30%	75%
Q60HG6	Macaca fascicularis	31%	75%
Q63088	Rattus norvegicus	37%	100%
Q6VTL7	Choristoneura fumiferana defective polyhedrosis virus	39%	100%
Q6YD92	Petrosia ficiformis	34%	100%
Q7F3A8	Oryza sativa subsp. japonica	39%	94%
Q7GDU7	Oryza sativa subsp. japonica	39%	92%
Q7XR52	Oryza sativa subsp. japonica	38%	71%
Q7XWK5	Oryza sativa subsp. japonica	36%	100%
Q80LP4	Adoxophyes honmai nucleopolyhedrovirus	37%	100%
Q80UB0	Mus musculus	35%	100%
Q86GF7	Pandalus borealis	35%	100%
Q8B9D5	Rachiplusia ou multiple nucleopolyhedrovirus (strain R1)	37%	100%
Q8BM88	Mus musculus	36%	100%
Q8H166	Arabidopsis thaliana	39%	97%
Q8HY81	Canis lupus familiaris	37%	100%
Q8HY82	Saimiri boliviensis boliviensis	33%	100%
Q8QLK1	Mamestra configurata nucleopolyhedrovirus	38%	100%
Q8RWQ9	Arabidopsis thaliana	38%	97%
Q8V5U0	Heliothis zea nuclear polyhedrosis virus	38%	95%
Q8VYS0	Arabidopsis thaliana	39%	95%
Q91BH1	Spodoptera litura multicapsid nucleopolyhedrovirus	38%	100%
Q91CL9	Antheraea pernyi nuclear polyhedrosis virus	38%	100%
Q91GE3	Epiphyas postvittana nucleopolyhedrovirus	38%	100%
Q91ZF2	Mus musculus	33%	100%
Q93VC9	Arabidopsis thaliana	28%	96%
Q94503	Dictyostelium discoideum	36%	80%
Q94504	Dictyostelium discoideum	36%	76%
Q94714	Paramecium tetraurelia	35%	100%
Q94715	Paramecium tetraurelia	32%	100%
Q94B08	Arabidopsis thaliana	35%	93%
Q94K85	Arabidopsis thaliana	28%	97%
Q95029	Drosophila melanogaster	38%	94%
Q99JR5	Mus musculus	27%	75%
Q9BIE1	Leishmania donovani	46%	98%
Q9EQT5	Rattus norvegicus	27%	75%
Q9FGR9	Arabidopsis thaliana	39%	96%
Q9FJ47	Arabidopsis thaliana	39%	100%
Q9FMH8	Arabidopsis thaliana	39%	75%
Q9GKL8	Chlorocebus aethiops	36%	100%
Q9GL24	Canis lupus familiaris	37%	100%
Q9GLE3	Sus scrofa	35%	100%
Q9GQM5	Leishmania donovani	32%	100%
Q9GZM7	Homo sapiens	29%	75%
Q9J8B9	Spodoptera exigua nuclear polyhedrosis virus (strain US)	37%	100%
Q9JI81	Mus musculus	34%	100%
Q9JIA9	Mus musculus	36%	100%
Q9JL96	Mus musculus	33%	100%
Q9LM66	Arabidopsis thaliana	38%	98%
Q9LT77	Arabidopsis thaliana	37%	96%
Q9LT78	Arabidopsis thaliana	40%	77%
Q9LXW3	Arabidopsis thaliana	35%	93%
Q9PYY5	Xestia c-nigrum granulosis virus	39%	100%
Q9QZE3	Rattus norvegicus	33%	100%
Q9R013	Mus musculus	43%	75%
Q9R014	Mus musculus	37%	100%
Q9STL4	Arabidopsis thaliana	35%	96%
Q9STL5	Arabidopsis thaliana	39%	96%
Q9SUL1	Arabidopsis thaliana	39%	93%
Q9SUS9	Arabidopsis thaliana	36%	94%
Q9SUT0	Arabidopsis thaliana	34%	96%
Q9TST1	Felis catus	32%	93%
Q9UBX1	Homo sapiens	41%	72%
Q9WGE0	Hyphantria cunea nuclear polyhedrosis virus	36%	100%
Q9YMP9	Lymantria dispar multicapsid nuclear polyhedrosis virus	40%	98%
Q9YWK4	Buzura suppressaria nuclear polyhedrosis virus	36%	100%
V5B261	Trypanosoma cruzi	35%	89%
V5BNL4	Trypanosoma cruzi	31%	100%
V5LU01	Ambrosia artemisiifolia	35%	90%