Cathepsin L-like protease

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cathepsin L-like protease

Species:

Leishmania major

UniProt:

Q4QI61_LEIMA

TriTrypDb:

LmjF.08.1060 , LMJLV39_080014800 , LMJSD75_080014900

Length:

443

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 125

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 21

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 36, no: 5
NetGPI	no	yes: 0, no: 41

Cellular components
Term	Name	Level	Count
GO:0000323	lytic vacuole	6	9
GO:0005615	extracellular space	2	9
GO:0005764	lysosome	7	9
GO:0005773	vacuole	5	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	10
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4QI61

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QI61

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	42
GO:0006807	nitrogen compound metabolic process	2	42
GO:0008152	metabolic process	1	42
GO:0019538	protein metabolic process	3	42
GO:0043170	macromolecule metabolic process	3	42
GO:0044238	primary metabolic process	2	42
GO:0051603	proteolysis involved in protein catabolic process	5	9
GO:0071704	organic substance metabolic process	2	42
GO:1901564	organonitrogen compound metabolic process	3	42

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	42
GO:0004175	endopeptidase activity	4	29
GO:0004197	cysteine-type endopeptidase activity	5	29
GO:0008233	peptidase activity	3	42
GO:0008234	cysteine-type peptidase activity	4	42
GO:0016787	hydrolase activity	2	42
GO:0140096	catalytic activity, acting on a protein	2	42

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	182	186	PF00656	0.462
CLV_NRD_NRD_1	116	118	PF00675	0.547
CLV_NRD_NRD_1	372	374	PF00675	0.273
CLV_PCSK_KEX2_1	358	360	PF00082	0.281
CLV_PCSK_KEX2_1	42	44	PF00082	0.494
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.280
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.503
CLV_PCSK_SKI1_1	358	362	PF00082	0.464
CLV_PCSK_SKI1_1	363	367	PF00082	0.448
CLV_PCSK_SKI1_1	5	9	PF00082	0.669
CLV_Separin_Metazoa	67	71	PF03568	0.441
DEG_APCC_DBOX_1	119	127	PF00400	0.563
DEG_APCC_DBOX_1	4	12	PF00400	0.693
DEG_ODPH_VHL_1	232	244	PF01847	0.272
DEG_SPOP_SBC_1	348	352	PF00917	0.451
DOC_CKS1_1	30	35	PF01111	0.613
DOC_CYCLIN_RxL_1	58	71	PF00134	0.441
DOC_MAPK_MEF2A_6	257	265	PF00069	0.459
DOC_MAPK_MEF2A_6	317	324	PF00069	0.408
DOC_SPAK_OSR1_1	80	84	PF12202	0.389
DOC_USP7_MATH_1	146	150	PF00917	0.529
DOC_USP7_MATH_1	215	219	PF00917	0.360
DOC_USP7_MATH_1	224	228	PF00917	0.362
DOC_USP7_MATH_1	391	395	PF00917	0.453
DOC_WW_Pin1_4	136	141	PF00397	0.415
DOC_WW_Pin1_4	29	34	PF00397	0.574
DOC_WW_Pin1_4	340	345	PF00397	0.354
LIG_14-3-3_CanoR_1	172	179	PF00244	0.446
LIG_14-3-3_CanoR_1	321	325	PF00244	0.272
LIG_14-3-3_CanoR_1	359	363	PF00244	0.295
LIG_BIR_II_1	1	5	PF00653	0.686
LIG_FHA_1	277	283	PF00498	0.377
LIG_FHA_1	296	302	PF00498	0.298
LIG_FHA_1	321	327	PF00498	0.284
LIG_FHA_1	376	382	PF00498	0.351
LIG_FHA_2	364	370	PF00498	0.262
LIG_FHA_2	49	55	PF00498	0.471
LIG_LIR_Gen_1	239	248	PF02991	0.466
LIG_LIR_Gen_1	316	326	PF02991	0.434
LIG_LIR_Nem_3	211	217	PF02991	0.460
LIG_LIR_Nem_3	268	273	PF02991	0.359
LIG_LIR_Nem_3	300	306	PF02991	0.385
LIG_LIR_Nem_3	316	322	PF02991	0.350
LIG_LIR_Nem_3	84	89	PF02991	0.454
LIG_LYPXL_yS_3	214	217	PF13949	0.329
LIG_SH2_CRK	49	53	PF00017	0.421
LIG_SH2_GRB2like	98	101	PF00017	0.500
LIG_SH2_PTP2	319	322	PF00017	0.367
LIG_SH2_SRC	98	101	PF00017	0.522
LIG_SH2_STAT5	104	107	PF00017	0.496
LIG_SH2_STAT5	216	219	PF00017	0.356
LIG_SH2_STAT5	241	244	PF00017	0.487
LIG_SH2_STAT5	29	32	PF00017	0.535
LIG_SH2_STAT5	319	322	PF00017	0.367
LIG_SH2_STAT5	370	373	PF00017	0.455
LIG_SH2_STAT5	409	412	PF00017	0.359
LIG_SH2_STAT5	420	423	PF00017	0.479
LIG_SH2_STAT5	98	101	PF00017	0.486
LIG_SH3_3	27	33	PF00018	0.656
LIG_SxIP_EBH_1	374	384	PF03271	0.212
LIG_TYR_ITIM	301	306	PF00017	0.449
MOD_CDK_SPxK_1	136	142	PF00069	0.421
MOD_CK1_1	227	233	PF00069	0.405
MOD_CK1_1	243	249	PF00069	0.477
MOD_CK1_1	269	275	PF00069	0.352
MOD_CK1_1	433	439	PF00069	0.298
MOD_CK2_1	306	312	PF00069	0.380
MOD_CK2_1	48	54	PF00069	0.452
MOD_CK2_1	87	93	PF00069	0.352
MOD_GlcNHglycan	122	126	PF01048	0.601
MOD_GlcNHglycan	153	156	PF01048	0.472
MOD_GlcNHglycan	217	220	PF01048	0.378
MOD_GlcNHglycan	274	277	PF01048	0.454
MOD_GlcNHglycan	432	435	PF01048	0.345
MOD_GSK3_1	240	247	PF00069	0.456
MOD_GSK3_1	265	272	PF00069	0.381
MOD_GSK3_1	334	341	PF00069	0.474
MOD_GSK3_1	347	354	PF00069	0.265
MOD_GSK3_1	376	383	PF00069	0.288
MOD_GSK3_1	408	415	PF00069	0.364
MOD_GSK3_1	428	435	PF00069	0.611
MOD_N-GLC_1	204	209	PF02516	0.476
MOD_N-GLC_1	227	232	PF02516	0.458
MOD_N-GLC_1	295	300	PF02516	0.458
MOD_N-GLC_1	348	353	PF02516	0.212
MOD_N-GLC_1	412	417	PF02516	0.316
MOD_N-GLC_2	186	188	PF02516	0.482
MOD_N-GLC_2	327	329	PF02516	0.390
MOD_NEK2_1	1	6	PF00069	0.652
MOD_NEK2_1	204	209	PF00069	0.458
MOD_NEK2_1	405	410	PF00069	0.419
MOD_NEK2_1	41	46	PF00069	0.483
MOD_NEK2_1	81	86	PF00069	0.470
MOD_PIKK_1	158	164	PF00454	0.478
MOD_PIKK_1	338	344	PF00454	0.272
MOD_PKA_1	358	364	PF00069	0.280
MOD_PKA_2	171	177	PF00069	0.446
MOD_PKA_2	320	326	PF00069	0.272
MOD_PKA_2	358	364	PF00069	0.280
MOD_Plk_1	121	127	PF00069	0.588
MOD_Plk_1	210	216	PF00069	0.350
MOD_Plk_1	265	271	PF00069	0.331
MOD_Plk_4	204	210	PF00069	0.370
MOD_Plk_4	266	272	PF00069	0.340
MOD_Plk_4	376	382	PF00069	0.455
MOD_ProDKin_1	136	142	PF00069	0.415
MOD_ProDKin_1	29	35	PF00069	0.569
MOD_ProDKin_1	340	346	PF00069	0.354
MOD_SUMO_rev_2	39	44	PF00179	0.499
MOD_SUMO_rev_2	411	421	PF00179	0.479
TRG_DiLeu_BaEn_4	54	60	PF01217	0.423
TRG_ENDOCYTIC_2	214	217	PF00928	0.335
TRG_ENDOCYTIC_2	241	244	PF00928	0.525
TRG_ENDOCYTIC_2	303	306	PF00928	0.359
TRG_ENDOCYTIC_2	319	322	PF00928	0.359
TRG_ENDOCYTIC_2	409	412	PF00928	0.224
TRG_ENDOCYTIC_2	49	52	PF00928	0.423
TRG_NES_CRM1_1	57	71	PF08389	0.441
TRG_NLS_MonoExtC_3	116	122	PF00514	0.610

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A072UTP9	Medicago truncatula	37%	100%
A0A0N0P293	Leptomonas seymouri	33%	100%
A0A0N0P8D1	Leptomonas seymouri	25%	100%
A0A0N1PA65	Leptomonas seymouri	46%	95%
A0A0S4IMD3	Bodo saltans	46%	100%
A0A0S4ISD8	Bodo saltans	43%	83%
A0A0S4IWQ5	Bodo saltans	36%	100%
A0A0S4IY45	Bodo saltans	35%	100%
A0A0S4J328	Bodo saltans	49%	100%
A0A0S4J3Q7	Bodo saltans	30%	100%
A0A0S4J628	Bodo saltans	43%	81%
A0A0S4J9K9	Bodo saltans	47%	100%
A0A0S4JPQ2	Bodo saltans	31%	100%
A0A0S4JSZ3	Bodo saltans	32%	100%
A0A0S4JV57	Bodo saltans	32%	100%
A0A0S4JXJ3	Bodo saltans	31%	100%
A0A0S4KI32	Bodo saltans	31%	100%
A0A0S4KJA5	Bodo saltans	41%	95%
A0A1X0NIG8	Trypanosomatidae	31%	100%
A0A1X0NM52	Trypanosomatidae	54%	100%
A0A1X0NXC8	Trypanosomatidae	31%	100%
A0A3R7L7E7	Trypanosoma rangeli	48%	84%
A0A3S5H682	Leishmania donovani	89%	100%
A0A3S5H683	Leishmania donovani	78%	100%
A0A3S5H684	Leishmania donovani	78%	100%
A0A3S5H685	Leishmania donovani	78%	100%
A0A3S7WQD0	Leishmania donovani	79%	100%
A0A6L0WJ22	Leishmania infantum	79%	100%
A0E358	Paramecium tetraurelia	35%	100%
A1KXI0	Blomia tropicalis	30%	100%
A2XQE8	Oryza sativa subsp. indica	36%	100%
A4H5E4	Leishmania braziliensis	70%	100%
A4H5E5	Leishmania braziliensis	70%	100%
A4H5E6	Leishmania braziliensis	71%	100%
A4HA92	Leishmania braziliensis	44%	92%
A4HTP0	Leishmania infantum	86%	100%
A4HYH2	Leishmania infantum	46%	100%
A4I4D6	Leishmania infantum	32%	100%
A5HII1	Actinidia deliciosa	30%	100%
A8DS38	Tabernaemontana divaricata	37%	100%
C9ZQB3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	98%
C9ZQB5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	98%
C9ZQB6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
D3ZZ07	Rattus norvegicus	33%	100%
E8NHD8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
E8NHH6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
E8NHJ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	88%
E8NHL3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	83%
E8NHS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
E9ADT5	Leishmania major	31%	100%
E9ALZ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AMH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
E9AMH6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
E9AMH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
E9AS96	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
F4JNL3	Arabidopsis thaliana	30%	100%
O10364	Orgyia pseudotsugata multicapsid polyhedrosis virus	37%	100%
O23791	Ananas comosus	33%	100%
O35186	Rattus norvegicus	36%	100%
O45734	Caenorhabditis elegans	40%	100%
O46427	Sus scrofa	35%	100%
O60911	Homo sapiens	39%	100%
O65039	Ricinus communis	38%	100%
O65493	Arabidopsis thaliana	35%	100%
O70370	Mus musculus	35%	100%
O91466	Cydia pomonella granulosis virus (isolate Mexico/1963)	37%	100%
O97397	Phaedon cochleariae	34%	100%
P00785	Actinidia chinensis var. chinensis	32%	100%
P00786	Rattus norvegicus	36%	100%
P04988	Dictyostelium discoideum	36%	100%
P04989	Dictyostelium discoideum	33%	100%
P05167	Hordeum vulgare	40%	100%
P06797	Mus musculus	39%	100%
P07154	Rattus norvegicus	39%	100%
P07711	Homo sapiens	36%	100%
P08176	Dermatophagoides pteronyssinus	27%	100%
P09668	Homo sapiens	36%	100%
P12412	Vigna mungo	36%	100%
P13277	Homarus americanus	39%	100%
P14658	Trypanosoma brucei brucei	46%	98%
P15242	Rattus norvegicus	37%	100%
P16311	Dermatophagoides farinae	30%	100%
P22497	Theileria parva	35%	100%
P22895	Glycine max	36%	100%
P25249	Hordeum vulgare	37%	100%
P25250	Hordeum vulgare	37%	100%
P25251	Brassica napus	34%	100%
P25326	Bos taurus	36%	100%
P25773	Felis catus	37%	100%
P25774	Homo sapiens	33%	100%
P25775	Leishmania mexicana	48%	100%
P25776	Oryza sativa subsp. japonica	37%	97%
P25778	Oryza sativa subsp. japonica	40%	100%
P25779	Trypanosoma cruzi	48%	95%
P25780	Euroglyphus maynei	29%	100%
P25781	Theileria annulata	32%	100%
P25782	Homarus americanus	36%	100%
P25783	Autographa californica nuclear polyhedrosis virus	38%	100%
P25784	Homarus americanus	37%	100%
P25803	Phaseolus vulgaris	36%	100%
P25804	Pisum sativum	41%	100%
P25805	Plasmodium falciparum	29%	78%
P25975	Bos taurus	37%	100%
P35591	Leishmania pifanoi	48%	100%
P36184	Entamoeba histolytica	31%	100%
P36400	Leishmania mexicana	74%	100%
P41715	Choristoneura fumiferana nuclear polyhedrosis virus	38%	100%
P41721	Bombyx mori nuclear polyhedrosis virus	37%	100%
P42666	Plasmodium vivax (strain Salvador I)	27%	76%
P43156	Hemerocallis sp.	37%	100%
P43235	Homo sapiens	37%	100%
P43236	Oryctolagus cuniculus	36%	100%
P43295	Arabidopsis thaliana	41%	100%
P43296	Arabidopsis thaliana	40%	100%
P43510	Caenorhabditis elegans	24%	100%
P46102	Plasmodium vinckei	30%	88%
P49935	Mus musculus	36%	100%
P54639	Dictyostelium discoideum	33%	100%
P54640	Dictyostelium discoideum	34%	100%
P55097	Mus musculus	36%	100%
P56202	Homo sapiens	32%	100%
P56203	Mus musculus	33%	100%
P61276	Macaca fascicularis	37%	100%
P61277	Macaca mulatta	37%	100%
P80884	Ananas comosus	32%	100%
P90850	Caenorhabditis elegans	27%	98%
Q01957	Entamoeba histolytica	29%	100%
Q02765	Rattus norvegicus	33%	100%
Q05094	Leishmania pifanoi	74%	100%
Q10716	Zea mays	40%	100%
Q10717	Zea mays	39%	100%
Q1EIQ3	Psoroptes ovis	31%	100%
Q23894	Dictyostelium discoideum	34%	100%
Q24940	Fasciola hepatica	38%	100%
Q26534	Schistosoma mansoni	38%	100%
Q26636	Sarcophaga peregrina	37%	100%
Q28944	Sus scrofa	38%	100%
Q3T0I2	Bos taurus	37%	100%
Q3ZKN1	Canis lupus familiaris	36%	100%
Q40143	Solanum lycopersicum	38%	100%
Q4QD68	Leishmania major	51%	100%
Q4QI62	Leishmania major	100%	100%
Q4QI64	Leishmania major	100%	100%
Q4QI65	Leishmania major	100%	100%
Q4QI66	Leishmania major	100%	100%
Q4QI67	Leishmania major	99%	100%
Q4QI68	Leishmania major	99%	100%
Q54TR1	Dictyostelium discoideum	36%	83%
Q5E968	Bos taurus	37%	100%
Q5E998	Bos taurus	37%	100%
Q63088	Rattus norvegicus	37%	100%
Q6VTL7	Choristoneura fumiferana defective polyhedrosis virus	39%	100%
Q6YD92	Petrosia ficiformis	34%	100%
Q7F3A8	Oryza sativa subsp. japonica	37%	100%
Q7XR52	Oryza sativa subsp. japonica	38%	90%
Q7XWK5	Oryza sativa subsp. japonica	36%	100%
Q80LP4	Adoxophyes honmai nucleopolyhedrovirus	37%	100%
Q80UB0	Mus musculus	35%	100%
Q86GF7	Pandalus borealis	35%	100%
Q8B9D5	Rachiplusia ou multiple nucleopolyhedrovirus (strain R1)	38%	100%
Q8H166	Arabidopsis thaliana	39%	100%
Q8HY81	Canis lupus familiaris	37%	100%
Q8HY82	Saimiri boliviensis boliviensis	33%	100%
Q8QLK1	Mamestra configurata nucleopolyhedrovirus	38%	100%
Q8RWQ9	Arabidopsis thaliana	38%	100%
Q8V5U0	Heliothis zea nuclear polyhedrosis virus	39%	100%
Q8VYS0	Arabidopsis thaliana	39%	100%
Q91BH1	Spodoptera litura multicapsid nucleopolyhedrovirus	38%	100%
Q91CL9	Antheraea pernyi nuclear polyhedrosis virus	38%	100%
Q91GE3	Epiphyas postvittana nucleopolyhedrovirus	38%	100%
Q91ZF2	Mus musculus	33%	100%
Q94504	Dictyostelium discoideum	36%	96%
Q94714	Paramecium tetraurelia	35%	100%
Q94715	Paramecium tetraurelia	32%	100%
Q94B08	Arabidopsis thaliana	35%	100%
Q95029	Drosophila melanogaster	38%	100%
Q9BIE1	Leishmania donovani	46%	100%
Q9FGR9	Arabidopsis thaliana	39%	100%
Q9FJ47	Arabidopsis thaliana	39%	100%
Q9GKL8	Chlorocebus aethiops	37%	100%
Q9GL24	Canis lupus familiaris	37%	100%
Q9GLE3	Sus scrofa	36%	100%
Q9GQM5	Leishmania donovani	32%	100%
Q9J8B9	Spodoptera exigua nuclear polyhedrosis virus (strain US)	37%	100%
Q9JI81	Mus musculus	35%	100%
Q9JIA9	Mus musculus	34%	100%
Q9JL96	Mus musculus	33%	100%
Q9LT77	Arabidopsis thaliana	37%	100%
Q9LT78	Arabidopsis thaliana	40%	98%
Q9PYY5	Xestia c-nigrum granulosis virus	39%	100%
Q9QZE3	Rattus norvegicus	32%	100%
Q9R013	Mus musculus	43%	96%
Q9R014	Mus musculus	38%	100%
Q9STL4	Arabidopsis thaliana	35%	100%
Q9SUL1	Arabidopsis thaliana	39%	100%
Q9SUS9	Arabidopsis thaliana	36%	100%
Q9SUT0	Arabidopsis thaliana	34%	100%
Q9TST1	Felis catus	32%	100%
Q9UBX1	Homo sapiens	41%	92%
Q9VN93	Drosophila melanogaster	39%	72%
Q9WGE0	Hyphantria cunea nuclear polyhedrosis virus	37%	100%
Q9YMP9	Lymantria dispar multicapsid nuclear polyhedrosis virus	40%	100%
Q9YWK4	Buzura suppressaria nuclear polyhedrosis virus	36%	100%
V5B261	Trypanosoma cruzi	35%	100%
V5LU01	Ambrosia artemisiifolia	35%	100%