Putative histone deacetylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

histone deacetylase, putative

Species:

Leishmania major

UniProt:

Q4QI60_LEIMA

TriTrypDb:

LmjF.08.1090 , LMJLV39_080014900 , LMJSD75_080015000

Length:

533

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000118	histone deacetylase complex	3	2
GO:0005737	cytoplasm	2	2
GO:0032991	protein-containing complex	1	2
GO:0110165	cellular anatomical entity	1	2
GO:0140513	nuclear protein-containing complex	2	2
GO:1902494	catalytic complex	2	2

Expansion

Sequence features

Q4QI60

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QI60

Function

Biological processes
Term	Name	Level	Count
GO:0000122	negative regulation of transcription by RNA polymerase II	8	2
GO:0006355	regulation of DNA-templated transcription	6	2
GO:0006357	regulation of transcription by RNA polymerase II	7	2
GO:0006476	protein deacetylation	6	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009889	regulation of biosynthetic process	4	2
GO:0009890	negative regulation of biosynthetic process	5	2
GO:0009892	negative regulation of metabolic process	4	2
GO:0010468	regulation of gene expression	5	2
GO:0010556	regulation of macromolecule biosynthetic process	5	2
GO:0010558	negative regulation of macromolecule biosynthetic process	6	2
GO:0010605	negative regulation of macromolecule metabolic process	5	2
GO:0016570	histone modification	5	2
GO:0016575	histone deacetylation	6	2
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	2
GO:0019222	regulation of metabolic process	3	2
GO:0019538	protein metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031324	negative regulation of cellular metabolic process	5	2
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0031327	negative regulation of cellular biosynthetic process	6	2
GO:0035601	protein deacylation	5	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044238	primary metabolic process	2	2
GO:0045892	negative regulation of DNA-templated transcription	7	2
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	2
GO:0048519	negative regulation of biological process	3	2
GO:0048523	negative regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051172	negative regulation of nitrogen compound metabolic process	5	2
GO:0051252	regulation of RNA metabolic process	5	2
GO:0051253	negative regulation of RNA metabolic process	6	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0071704	organic substance metabolic process	2	2
GO:0080090	regulation of primary metabolic process	4	2
GO:0098732	macromolecule deacylation	5	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1902679	negative regulation of RNA biosynthetic process	7	2
GO:1903506	regulation of nucleic acid-templated transcription	7	2
GO:1903507	negative regulation of nucleic acid-templated transcription	8	2
GO:2001141	regulation of RNA biosynthetic process	6	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0004407	histone deacetylase activity	4	2
GO:0016787	hydrolase activity	2	3
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	2
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	4	2
GO:0019213	deacetylase activity	3	2
GO:0033558	protein lysine deacetylase activity	3	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	461	463	PF00675	0.533
CLV_PCSK_FUR_1	509	513	PF00082	0.500
CLV_PCSK_KEX2_1	293	295	PF00082	0.335
CLV_PCSK_KEX2_1	461	463	PF00082	0.541
CLV_PCSK_KEX2_1	511	513	PF00082	0.506
CLV_PCSK_PC1ET2_1	293	295	PF00082	0.335
CLV_PCSK_PC1ET2_1	511	513	PF00082	0.461
CLV_PCSK_SKI1_1	128	132	PF00082	0.272
CLV_PCSK_SKI1_1	355	359	PF00082	0.257
CLV_PCSK_SKI1_1	54	58	PF00082	0.434
DEG_Nend_UBRbox_2	1	3	PF02207	0.425
DOC_CKS1_1	66	71	PF01111	0.474
DOC_CYCLIN_yCln2_LP_2	93	99	PF00134	0.561
DOC_MAPK_DCC_7	84	93	PF00069	0.561
DOC_MAPK_MEF2A_6	256	264	PF00069	0.458
DOC_MAPK_MEF2A_6	358	365	PF00069	0.443
DOC_MAPK_MEF2A_6	403	411	PF00069	0.503
DOC_MAPK_MEF2A_6	84	93	PF00069	0.561
DOC_PP2B_LxvP_1	431	434	PF13499	0.458
DOC_PP2B_LxvP_1	93	96	PF13499	0.561
DOC_PP2B_PxIxI_1	254	260	PF00149	0.458
DOC_PP2B_PxIxI_1	42	48	PF00149	0.535
DOC_PP4_FxxP_1	138	141	PF00568	0.538
DOC_USP7_MATH_1	119	123	PF00917	0.538
DOC_USP7_MATH_1	192	196	PF00917	0.569
DOC_USP7_MATH_1	207	211	PF00917	0.510
DOC_USP7_MATH_1	249	253	PF00917	0.521
DOC_USP7_MATH_1	29	33	PF00917	0.642
DOC_USP7_MATH_1	480	484	PF00917	0.652
DOC_USP7_MATH_1	491	495	PF00917	0.534
DOC_WW_Pin1_4	22	27	PF00397	0.760
DOC_WW_Pin1_4	445	450	PF00397	0.543
DOC_WW_Pin1_4	62	67	PF00397	0.507
LIG_14-3-3_CanoR_1	128	133	PF00244	0.472
LIG_14-3-3_CanoR_1	173	180	PF00244	0.510
LIG_14-3-3_CanoR_1	245	254	PF00244	0.557
LIG_APCC_ABBA_1	97	102	PF00400	0.561
LIG_BRCT_BRCA1_1	366	370	PF00533	0.458
LIG_CaM_IQ_9	518	533	PF13499	0.477
LIG_FHA_1	165	171	PF00498	0.492
LIG_FHA_1	25	31	PF00498	0.733
LIG_FHA_1	303	309	PF00498	0.488
LIG_FHA_1	402	408	PF00498	0.506
LIG_FHA_1	434	440	PF00498	0.505
LIG_FHA_1	502	508	PF00498	0.434
LIG_FHA_1	7	13	PF00498	0.639
LIG_FHA_2	12	18	PF00498	0.625
LIG_FHA_2	129	135	PF00498	0.472
LIG_Integrin_RGD_1	302	304	PF01839	0.288
LIG_LIR_Apic_2	137	141	PF02991	0.512
LIG_LIR_Apic_2	371	377	PF02991	0.472
LIG_LIR_Gen_1	131	138	PF02991	0.557
LIG_LIR_Gen_1	210	217	PF02991	0.511
LIG_LIR_Gen_1	227	237	PF02991	0.434
LIG_LIR_Gen_1	282	291	PF02991	0.533
LIG_LIR_Gen_1	384	394	PF02991	0.510
LIG_LIR_Gen_1	465	474	PF02991	0.616
LIG_LIR_LC3C_4	404	409	PF02991	0.561
LIG_LIR_Nem_3	131	135	PF02991	0.502
LIG_LIR_Nem_3	210	214	PF02991	0.511
LIG_LIR_Nem_3	227	232	PF02991	0.434
LIG_LIR_Nem_3	282	288	PF02991	0.523
LIG_LIR_Nem_3	384	390	PF02991	0.510
LIG_LIR_Nem_3	465	469	PF02991	0.578
LIG_SH2_SRC	132	135	PF00017	0.561
LIG_SH2_STAP1	144	148	PF00017	0.545
LIG_SH2_STAT5	162	165	PF00017	0.472
LIG_SH2_STAT5	285	288	PF00017	0.452
LIG_SH2_STAT5	307	310	PF00017	0.472
LIG_SH2_STAT5	7	10	PF00017	0.708
LIG_SH3_2	66	71	PF14604	0.472
LIG_SH3_3	211	217	PF00018	0.472
LIG_SH3_3	37	43	PF00018	0.633
LIG_SH3_3	63	69	PF00018	0.330
LIG_SUMO_SIM_par_1	258	263	PF11976	0.458
LIG_SUMO_SIM_par_1	362	367	PF11976	0.453
LIG_SUMO_SIM_par_1	406	412	PF11976	0.471
LIG_SUMO_SIM_par_1	502	508	PF11976	0.450
LIG_TYR_ITIM	283	288	PF00017	0.472
LIG_WRC_WIRS_1	135	140	PF05994	0.538
LIG_WRC_WIRS_1	208	213	PF05994	0.561
LIG_WW_3	253	257	PF00397	0.510
MOD_CDK_SPK_2	445	450	PF00069	0.498
MOD_CDK_SPxK_1	65	71	PF00069	0.354
MOD_CK1_1	104	110	PF00069	0.478
MOD_CK1_1	19	25	PF00069	0.750
MOD_CK1_1	224	230	PF00069	0.512
MOD_CK1_1	316	322	PF00069	0.528
MOD_CK1_1	389	395	PF00069	0.555
MOD_CK1_1	65	71	PF00069	0.454
MOD_CK2_1	11	17	PF00069	0.744
MOD_CK2_1	128	134	PF00069	0.469
MOD_CK2_1	269	275	PF00069	0.472
MOD_CK2_1	343	349	PF00069	0.499
MOD_GlcNHglycan	104	107	PF01048	0.358
MOD_GlcNHglycan	116	119	PF01048	0.293
MOD_GlcNHglycan	149	152	PF01048	0.373
MOD_GlcNHglycan	174	177	PF01048	0.341
MOD_GlcNHglycan	194	197	PF01048	0.125
MOD_GlcNHglycan	199	202	PF01048	0.350
MOD_GlcNHglycan	226	229	PF01048	0.297
MOD_GlcNHglycan	247	250	PF01048	0.317
MOD_GlcNHglycan	251	254	PF01048	0.303
MOD_GlcNHglycan	31	34	PF01048	0.654
MOD_GlcNHglycan	482	485	PF01048	0.659
MOD_GSK3_1	100	107	PF00069	0.519
MOD_GSK3_1	16	23	PF00069	0.700
MOD_GSK3_1	190	197	PF00069	0.482
MOD_GSK3_1	245	252	PF00069	0.543
MOD_GSK3_1	429	436	PF00069	0.476
MOD_GSK3_1	480	487	PF00069	0.644
MOD_N-GLC_1	119	124	PF02516	0.324
MOD_N-GLC_1	62	67	PF02516	0.578
MOD_NEK2_1	147	152	PF00069	0.561
MOD_NEK2_1	284	289	PF00069	0.456
MOD_NEK2_1	343	348	PF00069	0.538
MOD_NEK2_1	429	434	PF00069	0.457
MOD_PIKK_1	119	125	PF00454	0.506
MOD_PIKK_1	20	26	PF00454	0.686
MOD_PIKK_1	221	227	PF00454	0.538
MOD_PKA_2	172	178	PF00069	0.510
MOD_PKA_2	484	490	PF00069	0.637
MOD_PKB_1	243	251	PF00069	0.561
MOD_Plk_1	119	125	PF00069	0.523
MOD_Plk_1	180	186	PF00069	0.554
MOD_Plk_1	43	49	PF00069	0.429
MOD_Plk_1	501	507	PF00069	0.566
MOD_Plk_2-3	134	140	PF00069	0.561
MOD_Plk_4	269	275	PF00069	0.472
MOD_Plk_4	279	285	PF00069	0.472
MOD_Plk_4	343	349	PF00069	0.538
MOD_Plk_4	386	392	PF00069	0.538
MOD_Plk_4	501	507	PF00069	0.559
MOD_ProDKin_1	22	28	PF00069	0.758
MOD_ProDKin_1	445	451	PF00069	0.542
MOD_ProDKin_1	62	68	PF00069	0.502
MOD_SUMO_rev_2	150	159	PF00179	0.394
MOD_SUMO_rev_2	483	492	PF00179	0.728
TRG_DiLeu_BaEn_1	502	507	PF01217	0.496
TRG_DiLeu_BaLyEn_6	111	116	PF01217	0.394
TRG_DiLeu_BaLyEn_6	435	440	PF01217	0.542
TRG_ENDOCYTIC_2	132	135	PF00928	0.520
TRG_ENDOCYTIC_2	144	147	PF00928	0.415
TRG_ENDOCYTIC_2	285	288	PF00928	0.472
TRG_ER_diArg_1	242	245	PF00400	0.561
TRG_ER_diArg_1	455	458	PF00400	0.460
TRG_ER_diArg_1	461	464	PF00400	0.444
TRG_Pf-PMV_PEXEL_1	442	446	PF00026	0.453

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD56	Leptomonas seymouri	63%	100%
A0A0S4J6F0	Bodo saltans	37%	79%
A0A1X0NP71	Trypanosomatidae	43%	86%
A0A3S5H686	Leishmania donovani	96%	88%
A0A422NJU7	Trypanosoma rangeli	47%	89%
A4HTP2	Leishmania infantum	96%	82%
E9AI33	Leishmania braziliensis	81%	87%
E9AMH8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	88%
O13298	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
P53096	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
P53973	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	75%
P56523	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	78%
V5BR24	Trypanosoma cruzi	48%	89%