Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QI59_LEIMA

TriTrypDb:

LmjF.08.1100 , LMJLV39_080015000 , LMJSD75_080015100

Length:

365

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QI59

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QI59

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	330	334	PF00656	0.656
CLV_NRD_NRD_1	2	4	PF00675	0.628
CLV_NRD_NRD_1	217	219	PF00675	0.497
CLV_NRD_NRD_1	292	294	PF00675	0.567
CLV_NRD_NRD_1	52	54	PF00675	0.594
CLV_NRD_NRD_1	63	65	PF00675	0.453
CLV_NRD_NRD_1	87	89	PF00675	0.554
CLV_PCSK_FUR_1	157	161	PF00082	0.549
CLV_PCSK_KEX2_1	144	146	PF00082	0.511
CLV_PCSK_KEX2_1	159	161	PF00082	0.451
CLV_PCSK_KEX2_1	191	193	PF00082	0.499
CLV_PCSK_KEX2_1	2	4	PF00082	0.615
CLV_PCSK_KEX2_1	224	226	PF00082	0.460
CLV_PCSK_KEX2_1	292	294	PF00082	0.567
CLV_PCSK_KEX2_1	361	363	PF00082	0.692
CLV_PCSK_KEX2_1	52	54	PF00082	0.534
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.511
CLV_PCSK_PC1ET2_1	159	161	PF00082	0.451
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.499
CLV_PCSK_PC1ET2_1	224	226	PF00082	0.490
CLV_PCSK_PC1ET2_1	361	363	PF00082	0.692
CLV_PCSK_SKI1_1	108	112	PF00082	0.412
CLV_PCSK_SKI1_1	2	6	PF00082	0.723
CLV_PCSK_SKI1_1	237	241	PF00082	0.462
CLV_PCSK_SKI1_1	292	296	PF00082	0.573
CLV_PCSK_SKI1_1	338	342	PF00082	0.519
CLV_PCSK_SKI1_1	99	103	PF00082	0.555
DEG_Nend_UBRbox_1	1	4	PF02207	0.633
DEG_SCF_FBW7_2	130	137	PF00400	0.496
DOC_CKS1_1	131	136	PF01111	0.497
DOC_CKS1_1	9	14	PF01111	0.774
DOC_MAPK_gen_1	224	232	PF00069	0.445
DOC_MAPK_gen_1	271	280	PF00069	0.513
DOC_MAPK_gen_1	292	299	PF00069	0.573
DOC_MAPK_gen_1	338	346	PF00069	0.515
DOC_MAPK_gen_1	41	48	PF00069	0.494
DOC_MAPK_MEF2A_6	271	280	PF00069	0.513
DOC_MAPK_MEF2A_6	292	299	PF00069	0.573
DOC_MAPK_MEF2A_6	41	50	PF00069	0.481
DOC_PP2B_LxvP_1	4	7	PF13499	0.713
DOC_USP7_MATH_1	30	34	PF00917	0.694
DOC_USP7_MATH_1	318	322	PF00917	0.626
DOC_USP7_MATH_1	325	329	PF00917	0.643
DOC_USP7_UBL2_3	116	120	PF12436	0.533
DOC_USP7_UBL2_3	41	45	PF12436	0.567
DOC_WW_Pin1_4	130	135	PF00397	0.485
DOC_WW_Pin1_4	284	289	PF00397	0.517
DOC_WW_Pin1_4	321	326	PF00397	0.708
DOC_WW_Pin1_4	8	13	PF00397	0.719
LIG_14-3-3_CanoR_1	2	7	PF00244	0.744
LIG_14-3-3_CanoR_1	298	303	PF00244	0.555
LIG_14-3-3_CanoR_1	64	73	PF00244	0.507
LIG_14-3-3_CanoR_1	88	97	PF00244	0.604
LIG_Actin_WH2_2	93	110	PF00022	0.509
LIG_CSL_BTD_1	285	288	PF09270	0.507
LIG_EVH1_1	26	30	PF00568	0.726
LIG_EVH1_2	27	31	PF00568	0.727
LIG_FHA_1	65	71	PF00498	0.532
LIG_FHA_1	9	15	PF00498	0.700
LIG_FHA_2	131	137	PF00498	0.499
LIG_FHA_2	181	187	PF00498	0.641
LIG_FHA_2	89	95	PF00498	0.634
LIG_LIR_Gen_1	122	131	PF02991	0.486
LIG_LIR_Gen_1	177	187	PF02991	0.530
LIG_LIR_Nem_3	122	126	PF02991	0.486
LIG_LIR_Nem_3	177	182	PF02991	0.528
LIG_LIR_Nem_3	234	239	PF02991	0.460
LIG_NRBOX	228	234	PF00104	0.444
LIG_PCNA_yPIPBox_3	252	264	PF02747	0.476
LIG_Pex14_1	175	179	PF04695	0.505
LIG_SH2_CRK	179	183	PF00017	0.527
LIG_SH2_CRK	195	199	PF00017	0.445
LIG_SH2_CRK	217	221	PF00017	0.481
LIG_SH2_NCK_1	179	183	PF00017	0.672
LIG_SH2_NCK_1	195	199	PF00017	0.590
LIG_SH2_STAP1	195	199	PF00017	0.601
LIG_SH2_STAT5	132	135	PF00017	0.509
LIG_SH2_STAT5	25	28	PF00017	0.585
LIG_SH2_STAT5	62	65	PF00017	0.536
LIG_SH3_3	128	134	PF00018	0.481
LIG_SH3_3	163	169	PF00018	0.594
LIG_SH3_3	24	30	PF00018	0.662
LIG_SUMO_SIM_anti_2	227	234	PF11976	0.475
LIG_SUMO_SIM_anti_2	98	104	PF11976	0.472
LIG_SUMO_SIM_par_1	227	234	PF11976	0.440
LIG_TRAF2_1	288	291	PF00917	0.556
LIG_TRAF2_1	35	38	PF00917	0.607
LIG_TRAF2_1	357	360	PF00917	0.759
LIG_TYR_ITIM	193	198	PF00017	0.577
LIG_UBA3_1	245	252	PF00899	0.474
MOD_CDK_SPxxK_3	8	15	PF00069	0.622
MOD_CK1_1	180	186	PF00069	0.626
MOD_CK1_1	321	327	PF00069	0.721
MOD_CK2_1	180	186	PF00069	0.667
MOD_CK2_1	284	290	PF00069	0.523
MOD_CK2_1	298	304	PF00069	0.504
MOD_CK2_1	32	38	PF00069	0.552
MOD_GlcNHglycan	279	283	PF01048	0.612
MOD_GlcNHglycan	319	323	PF01048	0.649
MOD_GlcNHglycan	329	332	PF01048	0.655
MOD_GSK3_1	321	328	PF00069	0.750
MOD_GSK3_1	60	67	PF00069	0.555
MOD_NEK2_1	309	314	PF00069	0.569
MOD_PIKK_1	309	315	PF00454	0.571
MOD_PIKK_1	325	331	PF00454	0.703
MOD_PK_1	298	304	PF00069	0.568
MOD_PKA_1	2	8	PF00069	0.740
MOD_PKA_1	41	47	PF00069	0.490
MOD_PKA_1	64	70	PF00069	0.531
MOD_PKA_1	88	94	PF00069	0.603
MOD_PKA_2	2	8	PF00069	0.740
MOD_PKA_2	247	253	PF00069	0.473
MOD_PKB_1	192	200	PF00069	0.576
MOD_Plk_1	177	183	PF00069	0.563
MOD_Plk_2-3	178	184	PF00069	0.492
MOD_ProDKin_1	130	136	PF00069	0.481
MOD_ProDKin_1	284	290	PF00069	0.528
MOD_ProDKin_1	321	327	PF00069	0.710
MOD_ProDKin_1	8	14	PF00069	0.718
MOD_SUMO_rev_2	135	141	PF00179	0.493
MOD_SUMO_rev_2	354	363	PF00179	0.757
TRG_DiLeu_BaEn_1	290	295	PF01217	0.568
TRG_DiLeu_BaEn_1	76	81	PF01217	0.486
TRG_DiLeu_BaEn_4	290	296	PF01217	0.570
TRG_DiLeu_BaLyEn_6	335	340	PF01217	0.553
TRG_DiLeu_LyEn_5	290	295	PF01217	0.568
TRG_ENDOCYTIC_2	179	182	PF00928	0.506
TRG_ENDOCYTIC_2	195	198	PF00928	0.472
TRG_ER_diArg_1	1	3	PF00400	0.634
TRG_ER_diArg_1	192	195	PF00400	0.524
TRG_ER_diArg_1	292	294	PF00400	0.567
TRG_ER_diArg_1	297	300	PF00400	0.566
TRG_ER_diArg_1	51	53	PF00400	0.642
TRG_Pf-PMV_PEXEL_1	185	190	PF00026	0.613
TRG_Pf-PMV_PEXEL_1	338	342	PF00026	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5W5	Leptomonas seymouri	83%	100%
A0A0S4IPK0	Bodo saltans	65%	99%
A0A1X0NPG5	Trypanosomatidae	75%	99%
A0A3S5H687	Leishmania donovani	98%	100%
A0A422NFX7	Trypanosoma rangeli	68%	99%
A4H5E9	Leishmania braziliensis	93%	100%
A4HTP3	Leishmania infantum	98%	100%
C9ZPE5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	99%
E9AMI0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5DAE9	Trypanosoma cruzi	70%	99%