Stress-induced protein sti1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

stress-induced protein sti1

Species:

Leishmania major

UniProt:

Q4QI58_LEIMA

TriTrypDb:

LmjF.08.1110 , LMJLV39_080015100 , LMJSD75_080015200

Length:

546

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	yes	yes: 2
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QI58

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QI58

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	12
GO:0009987	cellular process	1	12

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0030544	Hsp70 protein binding	4	12
GO:0031072	heat shock protein binding	3	12
GO:0051879	Hsp90 protein binding	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	461	465	PF00656	0.527
CLV_NRD_NRD_1	135	137	PF00675	0.407
CLV_NRD_NRD_1	311	313	PF00675	0.498
CLV_NRD_NRD_1	430	432	PF00675	0.345
CLV_NRD_NRD_1	489	491	PF00675	0.384
CLV_NRD_NRD_1	76	78	PF00675	0.401
CLV_NRD_NRD_1	85	87	PF00675	0.349
CLV_PCSK_KEX2_1	322	324	PF00082	0.389
CLV_PCSK_KEX2_1	386	388	PF00082	0.446
CLV_PCSK_KEX2_1	489	491	PF00082	0.310
CLV_PCSK_KEX2_1	76	78	PF00082	0.397
CLV_PCSK_KEX2_1	85	87	PF00082	0.319
CLV_PCSK_PC1ET2_1	322	324	PF00082	0.402
CLV_PCSK_PC1ET2_1	386	388	PF00082	0.446
CLV_PCSK_SKI1_1	128	132	PF00082	0.557
CLV_PCSK_SKI1_1	175	179	PF00082	0.394
CLV_PCSK_SKI1_1	214	218	PF00082	0.677
CLV_PCSK_SKI1_1	221	225	PF00082	0.517
CLV_PCSK_SKI1_1	299	303	PF00082	0.391
CLV_PCSK_SKI1_1	322	326	PF00082	0.343
CLV_PCSK_SKI1_1	335	339	PF00082	0.455
CLV_PCSK_SKI1_1	54	58	PF00082	0.560
CLV_PCSK_SKI1_1	96	100	PF00082	0.414
DEG_APCC_DBOX_1	174	182	PF00400	0.555
DEG_Nend_UBRbox_2	1	3	PF02207	0.506
DEG_SCF_TRCP1_1	526	531	PF00400	0.461
DOC_CKS1_1	129	134	PF01111	0.600
DOC_MAPK_gen_1	310	320	PF00069	0.343
DOC_MAPK_gen_1	463	473	PF00069	0.462
DOC_MAPK_MEF2A_6	137	146	PF00069	0.533
DOC_USP7_MATH_1	102	106	PF00917	0.488
DOC_USP7_MATH_2	389	395	PF00917	0.580
DOC_USP7_UBL2_3	342	346	PF12436	0.455
DOC_USP7_UBL2_3	413	417	PF12436	0.488
DOC_WW_Pin1_4	128	133	PF00397	0.563
LIG_14-3-3_CanoR_1	175	181	PF00244	0.508
LIG_BRCT_BRCA1_1	235	239	PF00533	0.606
LIG_BRCT_BRCA1_1	43	47	PF00533	0.526
LIG_FHA_1	255	261	PF00498	0.433
LIG_FHA_1	380	386	PF00498	0.433
LIG_FHA_2	215	221	PF00498	0.610
LIG_FHA_2	336	342	PF00498	0.508
LIG_LIR_Apic_2	327	331	PF02991	0.609
LIG_LIR_Apic_2	349	355	PF02991	0.499
LIG_LIR_Gen_1	152	161	PF02991	0.508
LIG_LIR_Gen_1	293	301	PF02991	0.343
LIG_LIR_Gen_1	44	53	PF02991	0.473
LIG_LIR_Gen_1	503	513	PF02991	0.508
LIG_LIR_Nem_3	133	138	PF02991	0.574
LIG_LIR_Nem_3	293	297	PF02991	0.385
LIG_LIR_Nem_3	464	470	PF02991	0.465
LIG_LIR_Nem_3	503	508	PF02991	0.519
LIG_Pex14_1	438	442	PF04695	0.343
LIG_Pex14_1	70	74	PF04695	0.401
LIG_SH2_CRK	294	298	PF00017	0.385
LIG_SH2_CRK	467	471	PF00017	0.474
LIG_SH2_CRK	505	509	PF00017	0.541
LIG_SH2_GRB2like	395	398	PF00017	0.343
LIG_SH2_GRB2like	40	43	PF00017	0.421
LIG_SH2_NCK_1	294	298	PF00017	0.402
LIG_SH2_PTP2	352	355	PF00017	0.483
LIG_SH2_PTP2	402	405	PF00017	0.408
LIG_SH2_SRC	19	22	PF00017	0.574
LIG_SH2_SRC	246	249	PF00017	0.468
LIG_SH2_SRC	352	355	PF00017	0.471
LIG_SH2_SRC	449	452	PF00017	0.377
LIG_SH2_SRC	87	90	PF00017	0.377
LIG_SH2_STAP1	273	277	PF00017	0.358
LIG_SH2_STAP1	294	298	PF00017	0.358
LIG_SH2_STAP1	314	318	PF00017	0.272
LIG_SH2_STAP1	381	385	PF00017	0.411
LIG_SH2_STAP1	395	399	PF00017	0.343
LIG_SH2_STAP1	87	91	PF00017	0.377
LIG_SH2_STAT3	267	270	PF00017	0.488
LIG_SH2_STAT5	153	156	PF00017	0.515
LIG_SH2_STAT5	182	185	PF00017	0.665
LIG_SH2_STAT5	19	22	PF00017	0.500
LIG_SH2_STAT5	234	237	PF00017	0.619
LIG_SH2_STAT5	25	28	PF00017	0.427
LIG_SH2_STAT5	259	262	PF00017	0.370
LIG_SH2_STAT5	267	270	PF00017	0.413
LIG_SH2_STAT5	294	297	PF00017	0.368
LIG_SH2_STAT5	352	355	PF00017	0.490
LIG_SH2_STAT5	368	371	PF00017	0.453
LIG_SH2_STAT5	381	384	PF00017	0.345
LIG_SH2_STAT5	402	405	PF00017	0.343
LIG_SH2_STAT5	436	439	PF00017	0.437
LIG_SH2_STAT5	74	77	PF00017	0.358
LIG_SH3_3	126	132	PF00018	0.511
LIG_SH3_3	248	254	PF00018	0.445
LIG_TRAF2_1	210	213	PF00917	0.807
LIG_TRAF2_1	347	350	PF00917	0.591
LIG_UBA3_1	180	187	PF00899	0.657
MOD_CK1_1	41	47	PF00069	0.397
MOD_CK1_1	478	484	PF00069	0.582
MOD_CK1_1	527	533	PF00069	0.523
MOD_CK2_1	214	220	PF00069	0.679
MOD_CK2_1	335	341	PF00069	0.508
MOD_DYRK1A_RPxSP_1	128	132	PF00069	0.609
MOD_GlcNHglycan	104	107	PF01048	0.537
MOD_GlcNHglycan	12	17	PF01048	0.482
MOD_GlcNHglycan	183	186	PF01048	0.470
MOD_GlcNHglycan	200	203	PF01048	0.758
MOD_GlcNHglycan	263	266	PF01048	0.493
MOD_GlcNHglycan	43	46	PF01048	0.400
MOD_GlcNHglycan	477	480	PF01048	0.573
MOD_GlcNHglycan	526	529	PF01048	0.333
MOD_GlcNHglycan	537	540	PF01048	0.417
MOD_GSK3_1	34	41	PF00069	0.612
MOD_GSK3_1	524	531	PF00069	0.461
MOD_N-GLC_1	254	259	PF02516	0.504
MOD_N-GLC_1	261	266	PF02516	0.372
MOD_N-GLC_1	41	46	PF02516	0.414
MOD_N-GLC_2	290	292	PF02516	0.377
MOD_NEK2_1	156	161	PF00069	0.568
MOD_NEK2_1	176	181	PF00069	0.444
MOD_NEK2_1	233	238	PF00069	0.602
MOD_NEK2_1	261	266	PF00069	0.343
MOD_NEK2_1	501	506	PF00069	0.521
MOD_NEK2_1	524	529	PF00069	0.544
MOD_NEK2_2	254	259	PF00069	0.492
MOD_PIKK_1	162	168	PF00454	0.612
MOD_PK_1	62	68	PF00069	0.478
MOD_PKA_1	335	341	PF00069	0.593
MOD_PKA_2	198	204	PF00069	0.741
MOD_Plk_1	254	260	PF00069	0.445
MOD_Plk_1	261	267	PF00069	0.386
MOD_Plk_1	292	298	PF00069	0.343
MOD_Plk_1	390	396	PF00069	0.425
MOD_Plk_4	142	148	PF00069	0.516
MOD_Plk_4	156	162	PF00069	0.516
MOD_Plk_4	176	182	PF00069	0.505
MOD_Plk_4	254	260	PF00069	0.447
MOD_Plk_4	292	298	PF00069	0.343
MOD_Plk_4	34	40	PF00069	0.477
MOD_Plk_4	501	507	PF00069	0.511
MOD_ProDKin_1	128	134	PF00069	0.555
MOD_SUMO_for_1	210	213	PF00179	0.766
MOD_SUMO_for_1	226	229	PF00179	0.481
MOD_SUMO_rev_2	206	216	PF00179	0.722
MOD_SUMO_rev_2	414	423	PF00179	0.437
TRG_DiLeu_BaEn_4	228	234	PF01217	0.461
TRG_ENDOCYTIC_2	153	156	PF00928	0.509
TRG_ENDOCYTIC_2	294	297	PF00928	0.385
TRG_ENDOCYTIC_2	402	405	PF00928	0.343
TRG_ENDOCYTIC_2	467	470	PF00928	0.578
TRG_ENDOCYTIC_2	505	508	PF00928	0.508
TRG_ER_diArg_1	75	77	PF00400	0.413
TRG_ER_diArg_1	84	86	PF00400	0.337
TRG_Pf-PMV_PEXEL_1	136	140	PF00026	0.403
TRG_Pf-PMV_PEXEL_1	323	327	PF00026	0.343
TRG_Pf-PMV_PEXEL_1	335	339	PF00026	0.455

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK79	Leptomonas seymouri	85%	100%
A0A0S4IP08	Bodo saltans	54%	94%
A0A1X0NFP0	Trypanosomatidae	68%	100%
A0A1X0P1G8	Trypanosomatidae	23%	77%
A0A422NFX1	Trypanosoma rangeli	63%	98%
A4H5F0	Leishmania braziliensis	93%	100%
A4HTP4	Leishmania infantum	98%	100%
C9ZPE6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	99%
E9AMI1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
F8RP11	Triticum aestivum	42%	94%
O35814	Rattus norvegicus	39%	100%
O54981	Cricetulus griseus	40%	100%
P15705	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	93%
P31948	Homo sapiens	40%	100%
Q3ZBZ8	Bos taurus	40%	100%
Q43468	Glycine max	40%	95%
Q4JHN0	Leishmania donovani	98%	100%
Q4R8N7	Macaca fascicularis	40%	100%
Q54DA8	Dictyostelium discoideum	37%	97%
Q54IP0	Dictyostelium discoideum	23%	100%
Q5R8D8	Pongo abelii	23%	100%
Q5XEP2	Arabidopsis thaliana	42%	96%
Q60864	Mus musculus	40%	100%
Q7ZWU1	Xenopus laevis	39%	100%
Q99615	Homo sapiens	24%	100%
Q9LNB6	Arabidopsis thaliana	39%	95%
Q9QYI3	Mus musculus	24%	100%
Q9STH1	Arabidopsis thaliana	40%	98%
Q9USI5	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	92%
V5AUF3	Trypanosoma cruzi	64%	98%
V5BSG3	Trypanosoma cruzi	23%	78%