Putative suppressive immunomodulating factor

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

suppressive immunomodulating factor, putative

Species:

Leishmania major

UniProt:

Q4QI55_LEIMA

TriTrypDb:

LmjF.08.1140 , LMJLV39_080015400 , LMJSD75_080015500

Length:

946

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	2
GO:0005886	plasma membrane	3	2
GO:0016020	membrane	2	2
GO:0036064	ciliary basal body	3	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

Q4QI55

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QI55

Function

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Biological processes
Term	Name	Level	Count
GO:0001775	cell activation	2	2
GO:0002274	myeloid leukocyte activation	3	2
GO:0002376	immune system process	1	2
GO:0009889	regulation of biosynthetic process	4	2
GO:0009987	cellular process	1	2
GO:0019222	regulation of metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0042116	macrophage activation	4	2
GO:0045321	leukocyte activation	2	2

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	517	521	PF00656	0.643
CLV_C14_Caspase3-7	534	538	PF00656	0.545
CLV_C14_Caspase3-7	626	630	PF00656	0.559
CLV_NRD_NRD_1	539	541	PF00675	0.665
CLV_NRD_NRD_1	582	584	PF00675	0.649
CLV_NRD_NRD_1	735	737	PF00675	0.591
CLV_NRD_NRD_1	739	741	PF00675	0.544
CLV_NRD_NRD_1	743	745	PF00675	0.552
CLV_NRD_NRD_1	889	891	PF00675	0.567
CLV_PCSK_KEX2_1	539	541	PF00082	0.665

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKP7	Leptomonas seymouri	50%	100%
A0A3S7WQE7	Leishmania donovani	93%	100%
A4H5F2	Leishmania braziliensis	78%	100%
A4HTP7	Leishmania infantum	93%	100%
E9AMI4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%

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