Putative suppressive immunomodulating factor

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

suppressive immunomodulating factor, putative

Species:

Leishmania major

UniProt:

Q4QI55_LEIMA

TriTrypDb:

LmjF.08.1140 , LMJLV39_080015400 , LMJSD75_080015500

Length:

946

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	2
GO:0005886	plasma membrane	3	2
GO:0016020	membrane	2	2
GO:0036064	ciliary basal body	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QI55

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QI55

Function

Biological processes
Term	Name	Level	Count
GO:0001775	cell activation	2	2
GO:0002274	myeloid leukocyte activation	3	2
GO:0002376	immune system process	1	2
GO:0009889	regulation of biosynthetic process	4	2
GO:0009987	cellular process	1	2
GO:0019222	regulation of metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0042116	macrophage activation	4	2
GO:0045321	leukocyte activation	2	2
GO:0045428	regulation of nitric oxide biosynthetic process	6	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0080164	regulation of nitric oxide metabolic process	5	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	517	521	PF00656	0.643
CLV_C14_Caspase3-7	534	538	PF00656	0.545
CLV_C14_Caspase3-7	626	630	PF00656	0.559
CLV_NRD_NRD_1	539	541	PF00675	0.665
CLV_NRD_NRD_1	582	584	PF00675	0.649
CLV_NRD_NRD_1	735	737	PF00675	0.591
CLV_NRD_NRD_1	739	741	PF00675	0.544
CLV_NRD_NRD_1	743	745	PF00675	0.552
CLV_NRD_NRD_1	889	891	PF00675	0.567
CLV_PCSK_KEX2_1	539	541	PF00082	0.665
CLV_PCSK_KEX2_1	567	569	PF00082	0.669
CLV_PCSK_KEX2_1	582	584	PF00082	0.543
CLV_PCSK_KEX2_1	723	725	PF00082	0.700
CLV_PCSK_KEX2_1	739	741	PF00082	0.462
CLV_PCSK_KEX2_1	789	791	PF00082	0.559
CLV_PCSK_KEX2_1	888	890	PF00082	0.622
CLV_PCSK_PC1ET2_1	567	569	PF00082	0.626
CLV_PCSK_PC1ET2_1	723	725	PF00082	0.752
CLV_PCSK_PC1ET2_1	789	791	PF00082	0.559
CLV_PCSK_SKI1_1	465	469	PF00082	0.677
CLV_PCSK_SKI1_1	575	579	PF00082	0.666
CLV_PCSK_SKI1_1	65	69	PF00082	0.342
CLV_PCSK_SKI1_1	723	727	PF00082	0.741
CLV_PCSK_SKI1_1	869	873	PF00082	0.671
CLV_Separin_Metazoa	337	341	PF03568	0.377
DEG_APCC_DBOX_1	368	376	PF00400	0.393
DEG_APCC_DBOX_1	64	72	PF00400	0.359
DEG_COP1_1	639	648	PF00400	0.633
DEG_SCF_FBW7_2	457	464	PF00400	0.661
DEG_SPOP_SBC_1	174	178	PF00917	0.515
DOC_CDC14_PxL_1	83	91	PF14671	0.415
DOC_CKS1_1	430	435	PF01111	0.587
DOC_CKS1_1	496	501	PF01111	0.662
DOC_CKS1_1	905	910	PF01111	0.607
DOC_CYCLIN_RxL_1	720	729	PF00134	0.558
DOC_CYCLIN_yCln2_LP_2	179	182	PF00134	0.440
DOC_CYCLIN_yCln2_LP_2	933	939	PF00134	0.572
DOC_MAPK_MEF2A_6	223	230	PF00069	0.455
DOC_MAPK_MEF2A_6	723	732	PF00069	0.616
DOC_MAPK_NFAT4_5	223	231	PF00069	0.452
DOC_PP1_RVXF_1	873	879	PF00149	0.641
DOC_PP2B_LxvP_1	179	182	PF13499	0.440
DOC_PP2B_LxvP_1	239	242	PF13499	0.461
DOC_PP2B_LxvP_1	407	410	PF13499	0.690
DOC_PP2B_LxvP_1	549	552	PF13499	0.622
DOC_PP2B_LxvP_1	933	936	PF13499	0.576
DOC_PP2B_LxvP_1	937	940	PF13499	0.564
DOC_PP4_FxxP_1	905	908	PF00568	0.558
DOC_SPAK_OSR1_1	340	344	PF12202	0.386
DOC_USP7_MATH_1	170	174	PF00917	0.544
DOC_USP7_MATH_1	175	179	PF00917	0.488
DOC_USP7_MATH_1	305	309	PF00917	0.457
DOC_USP7_MATH_1	330	334	PF00917	0.495
DOC_USP7_MATH_1	379	383	PF00917	0.601
DOC_USP7_MATH_1	506	510	PF00917	0.690
DOC_USP7_MATH_1	544	548	PF00917	0.739
DOC_USP7_MATH_1	558	562	PF00917	0.559
DOC_USP7_MATH_1	588	592	PF00917	0.709
DOC_USP7_MATH_1	607	611	PF00917	0.693
DOC_USP7_MATH_1	650	654	PF00917	0.571
DOC_USP7_MATH_1	834	838	PF00917	0.599
DOC_USP7_MATH_1	941	945	PF00917	0.553
DOC_USP7_UBL2_3	563	567	PF12436	0.626
DOC_WW_Pin1_4	414	419	PF00397	0.731
DOC_WW_Pin1_4	429	434	PF00397	0.561
DOC_WW_Pin1_4	457	462	PF00397	0.663
DOC_WW_Pin1_4	495	500	PF00397	0.699
DOC_WW_Pin1_4	554	559	PF00397	0.642
DOC_WW_Pin1_4	620	625	PF00397	0.627
DOC_WW_Pin1_4	693	698	PF00397	0.652
DOC_WW_Pin1_4	90	95	PF00397	0.508
DOC_WW_Pin1_4	904	909	PF00397	0.557
LIG_14-3-3_CanoR_1	126	135	PF00244	0.400
LIG_14-3-3_CanoR_1	158	162	PF00244	0.504
LIG_14-3-3_CanoR_1	223	227	PF00244	0.371
LIG_14-3-3_CanoR_1	582	586	PF00244	0.676
LIG_14-3-3_CanoR_1	65	71	PF00244	0.348
LIG_14-3-3_CanoR_1	790	794	PF00244	0.508
LIG_14-3-3_CanoR_1	81	86	PF00244	0.363
LIG_BIR_III_4	380	384	PF00653	0.508
LIG_BRCT_BRCA1_1	560	564	PF00533	0.622
LIG_deltaCOP1_diTrp_1	366	370	PF00928	0.377
LIG_EH1_1	719	727	PF00400	0.546
LIG_eIF4E_1	111	117	PF01652	0.364
LIG_EVH1_1	549	553	PF00568	0.684
LIG_EVH1_1	937	941	PF00568	0.542
LIG_FHA_1	120	126	PF00498	0.423
LIG_FHA_1	149	155	PF00498	0.364
LIG_FHA_1	175	181	PF00498	0.499
LIG_FHA_1	223	229	PF00498	0.425
LIG_FHA_1	243	249	PF00498	0.480
LIG_FHA_1	255	261	PF00498	0.405
LIG_FHA_1	355	361	PF00498	0.381
LIG_FHA_1	452	458	PF00498	0.708
LIG_FHA_1	466	472	PF00498	0.565
LIG_FHA_1	496	502	PF00498	0.743
LIG_FHA_1	683	689	PF00498	0.692
LIG_FHA_1	727	733	PF00498	0.654
LIG_FHA_1	781	787	PF00498	0.567
LIG_FHA_1	822	828	PF00498	0.580
LIG_FHA_2	157	163	PF00498	0.453
LIG_FHA_2	3	9	PF00498	0.445
LIG_FHA_2	390	396	PF00498	0.706
LIG_FHA_2	430	436	PF00498	0.602
LIG_FHA_2	532	538	PF00498	0.697
LIG_FHA_2	557	563	PF00498	0.667
LIG_FHA_2	582	588	PF00498	0.653
LIG_FHA_2	664	670	PF00498	0.605
LIG_FHA_2	67	73	PF00498	0.369
LIG_FHA_2	789	795	PF00498	0.445
LIG_FHA_2	824	830	PF00498	0.585
LIG_FHA_2	925	931	PF00498	0.635
LIG_LIR_Apic_2	366	371	PF02991	0.427
LIG_LIR_Apic_2	767	771	PF02991	0.538
LIG_LIR_Gen_1	829	838	PF02991	0.623
LIG_LIR_Gen_1	926	937	PF02991	0.573
LIG_LIR_LC3C_4	251	254	PF02991	0.356
LIG_LIR_LC3C_4	356	361	PF02991	0.371
LIG_LIR_Nem_3	207	213	PF02991	0.353
LIG_LIR_Nem_3	61	67	PF02991	0.378
LIG_LIR_Nem_3	799	803	PF02991	0.494
LIG_LIR_Nem_3	829	835	PF02991	0.554
LIG_LIR_Nem_3	870	876	PF02991	0.579
LIG_LIR_Nem_3	926	932	PF02991	0.571
LIG_PDZ_Class_1	941	946	PF00595	0.563
LIG_Pex14_1	165	169	PF04695	0.496
LIG_Rb_LxCxE_1	141	163	PF01857	0.378
LIG_SH2_CRK	210	214	PF00017	0.395
LIG_SH2_CRK	873	877	PF00017	0.581
LIG_SH2_GRB2like	111	114	PF00017	0.384
LIG_SH2_NCK_1	768	772	PF00017	0.543
LIG_SH2_STAP1	107	111	PF00017	0.382
LIG_SH2_STAT3	825	828	PF00017	0.575
LIG_SH2_STAT5	144	147	PF00017	0.341
LIG_SH2_STAT5	313	316	PF00017	0.400
LIG_SH2_STAT5	326	329	PF00017	0.296
LIG_SH2_STAT5	438	441	PF00017	0.641
LIG_SH2_STAT5	70	73	PF00017	0.393
LIG_SH2_STAT5	825	828	PF00017	0.575
LIG_SH3_1	768	774	PF00018	0.545
LIG_SH3_3	400	406	PF00018	0.624
LIG_SH3_3	407	413	PF00018	0.626
LIG_SH3_3	424	430	PF00018	0.536
LIG_SH3_3	547	553	PF00018	0.684
LIG_SH3_3	619	625	PF00018	0.628
LIG_SH3_3	768	774	PF00018	0.676
LIG_SH3_3	817	823	PF00018	0.730
LIG_SH3_3	858	864	PF00018	0.761
LIG_SH3_3	919	925	PF00018	0.573
LIG_SH3_3	935	941	PF00018	0.596
LIG_SH3_CIN85_PxpxPR_1	406	411	PF14604	0.647
LIG_SUMO_SIM_anti_2	320	326	PF11976	0.332
LIG_SUMO_SIM_anti_2	356	363	PF11976	0.374
LIG_SUMO_SIM_anti_2	930	936	PF11976	0.578
LIG_SUMO_SIM_par_1	225	231	PF11976	0.373
LIG_SUMO_SIM_par_1	356	363	PF11976	0.374
LIG_TRAF2_1	160	163	PF00917	0.430
LIG_TRAF2_1	432	435	PF00917	0.559
LIG_TRAF2_1	591	594	PF00917	0.661
LIG_TRAF2_1	928	931	PF00917	0.562
LIG_TRFH_1	83	87	PF08558	0.370
LIG_TYR_ITIM	871	876	PF00017	0.642
LIG_UBA3_1	179	185	PF00899	0.417
LIG_WW_2	403	406	PF00397	0.682
MOD_CDK_SPxK_1	457	463	PF00069	0.663
MOD_CDK_SPxxK_3	414	421	PF00069	0.621
MOD_CK1_1	133	139	PF00069	0.353
MOD_CK1_1	173	179	PF00069	0.569
MOD_CK1_1	243	249	PF00069	0.541
MOD_CK1_1	258	264	PF00069	0.379
MOD_CK1_1	278	284	PF00069	0.561
MOD_CK1_1	504	510	PF00069	0.691
MOD_CK1_1	514	520	PF00069	0.612
MOD_CK1_1	623	629	PF00069	0.636
MOD_CK2_1	156	162	PF00069	0.418
MOD_CK2_1	2	8	PF00069	0.514
MOD_CK2_1	379	385	PF00069	0.591
MOD_CK2_1	389	395	PF00069	0.585
MOD_CK2_1	429	435	PF00069	0.600
MOD_CK2_1	488	494	PF00069	0.657
MOD_CK2_1	588	594	PF00069	0.653
MOD_CK2_1	788	794	PF00069	0.446
MOD_CK2_1	924	930	PF00069	0.634
MOD_GlcNHglycan	172	175	PF01048	0.616
MOD_GlcNHglycan	206	209	PF01048	0.346
MOD_GlcNHglycan	273	276	PF01048	0.690
MOD_GlcNHglycan	319	322	PF01048	0.354
MOD_GlcNHglycan	380	384	PF01048	0.746
MOD_GlcNHglycan	449	452	PF01048	0.755
MOD_GlcNHglycan	506	509	PF01048	0.693
MOD_GlcNHglycan	513	516	PF01048	0.623
MOD_GlcNHglycan	604	607	PF01048	0.738
MOD_GlcNHglycan	609	612	PF01048	0.821
MOD_GlcNHglycan	639	643	PF01048	0.679
MOD_GlcNHglycan	652	655	PF01048	0.512
MOD_GlcNHglycan	836	839	PF01048	0.570
MOD_GSK3_1	105	112	PF00069	0.394
MOD_GSK3_1	148	155	PF00069	0.362
MOD_GSK3_1	170	177	PF00069	0.581
MOD_GSK3_1	254	261	PF00069	0.474
MOD_GSK3_1	271	278	PF00069	0.534
MOD_GSK3_1	441	448	PF00069	0.701
MOD_GSK3_1	453	460	PF00069	0.593
MOD_GSK3_1	497	504	PF00069	0.837
MOD_GSK3_1	554	561	PF00069	0.742
MOD_GSK3_1	571	578	PF00069	0.509
MOD_GSK3_1	607	614	PF00069	0.633
MOD_GSK3_1	620	627	PF00069	0.593
MOD_GSK3_1	689	696	PF00069	0.628
MOD_GSK3_1	698	705	PF00069	0.625
MOD_GSK3_1	81	88	PF00069	0.383
MOD_N-GLC_1	354	359	PF02516	0.422
MOD_N-GLC_1	751	756	PF02516	0.587
MOD_N-GLC_1	780	785	PF02516	0.581
MOD_NEK2_1	105	110	PF00069	0.385
MOD_NEK2_1	183	188	PF00069	0.386
MOD_NEK2_1	189	194	PF00069	0.343
MOD_NEK2_1	237	242	PF00069	0.437
MOD_NEK2_1	248	253	PF00069	0.450
MOD_NEK2_1	277	282	PF00069	0.499
MOD_NEK2_1	359	364	PF00069	0.362
MOD_NEK2_1	56	61	PF00069	0.385
MOD_NEK2_1	638	643	PF00069	0.678
MOD_NEK2_1	66	71	PF00069	0.347
MOD_NEK2_1	76	81	PF00069	0.244
MOD_NEK2_1	903	908	PF00069	0.632
MOD_NEK2_2	506	511	PF00069	0.679
MOD_PIKK_1	436	442	PF00454	0.706
MOD_PIKK_1	769	775	PF00454	0.636
MOD_PKA_1	789	795	PF00069	0.576
MOD_PKA_2	133	139	PF00069	0.353
MOD_PKA_2	157	163	PF00069	0.432
MOD_PKA_2	222	228	PF00069	0.369
MOD_PKA_2	258	264	PF00069	0.357
MOD_PKA_2	268	274	PF00069	0.592
MOD_PKA_2	28	34	PF00069	0.412
MOD_PKA_2	581	587	PF00069	0.700
MOD_PKA_2	650	656	PF00069	0.569
MOD_PKA_2	789	795	PF00069	0.593
MOD_PKA_2	847	853	PF00069	0.627
MOD_PKB_1	463	471	PF00069	0.699
MOD_Plk_1	189	195	PF00069	0.355
MOD_Plk_1	354	360	PF00069	0.373
MOD_Plk_1	419	425	PF00069	0.745
MOD_Plk_1	434	440	PF00069	0.576
MOD_Plk_1	445	451	PF00069	0.634
MOD_Plk_1	452	458	PF00069	0.643
MOD_Plk_1	76	82	PF00069	0.363
MOD_Plk_1	869	875	PF00069	0.583
MOD_Plk_2-3	389	395	PF00069	0.706
MOD_Plk_2-3	441	447	PF00069	0.658
MOD_Plk_2-3	589	595	PF00069	0.653
MOD_Plk_4	133	139	PF00069	0.365
MOD_Plk_4	152	158	PF00069	0.231
MOD_Plk_4	175	181	PF00069	0.497
MOD_Plk_4	189	195	PF00069	0.351
MOD_Plk_4	243	249	PF00069	0.547
MOD_Plk_4	28	34	PF00069	0.412
MOD_Plk_4	330	336	PF00069	0.420
MOD_Plk_4	354	360	PF00069	0.394
MOD_Plk_4	66	72	PF00069	0.355
MOD_Plk_4	911	917	PF00069	0.577
MOD_ProDKin_1	414	420	PF00069	0.730
MOD_ProDKin_1	429	435	PF00069	0.564
MOD_ProDKin_1	457	463	PF00069	0.663
MOD_ProDKin_1	495	501	PF00069	0.703
MOD_ProDKin_1	554	560	PF00069	0.646
MOD_ProDKin_1	620	626	PF00069	0.626
MOD_ProDKin_1	693	699	PF00069	0.650
MOD_ProDKin_1	90	96	PF00069	0.508
MOD_ProDKin_1	904	910	PF00069	0.553
MOD_SUMO_rev_2	782	791	PF00179	0.544
TRG_DiLeu_BaEn_1	930	935	PF01217	0.576
TRG_DiLeu_BaEn_2	62	68	PF01217	0.365
TRG_DiLeu_BaEn_4	930	936	PF01217	0.578
TRG_DiLeu_BaLyEn_6	721	726	PF01217	0.586
TRG_ENDOCYTIC_2	210	213	PF00928	0.400
TRG_ENDOCYTIC_2	873	876	PF00928	0.580
TRG_ER_diArg_1	739	741	PF00400	0.567
TRG_ER_diArg_1	888	890	PF00400	0.618
TRG_Pf-PMV_PEXEL_1	583	587	PF00026	0.650
TRG_Pf-PMV_PEXEL_1	784	788	PF00026	0.547

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKP7	Leptomonas seymouri	50%	100%
A0A3S7WQE7	Leishmania donovani	93%	100%
A4H5F2	Leishmania braziliensis	78%	100%
A4HTP7	Leishmania infantum	93%	100%
E9AMI4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%