Thiopurine S-methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Thiopurine S-methyltransferase (TPMT), putative

Species:

Leishmania major

UniProt:

Q4QI53_LEIMA

TriTrypDb:

LmjF.08.1160 , LMJLV39_080015600 , LMJSD75_080015700

Length:

426

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4QI53

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QI53

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	9
GO:0032259	methylation	2	9

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0008119	thiopurine S-methyltransferase activity	6	2
GO:0008168	methyltransferase activity	4	10
GO:0008172	S-methyltransferase activity	5	2
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	10
GO:0016740	transferase activity	2	10
GO:0016741	transferase activity, transferring one-carbon groups	3	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	235	239	PF00656	0.508
CLV_C14_Caspase3-7	363	367	PF00656	0.492
CLV_NRD_NRD_1	101	103	PF00675	0.646
CLV_NRD_NRD_1	198	200	PF00675	0.408
CLV_NRD_NRD_1	29	31	PF00675	0.432
CLV_NRD_NRD_1	8	10	PF00675	0.521
CLV_PCSK_FUR_1	6	10	PF00082	0.503
CLV_PCSK_KEX2_1	198	200	PF00082	0.408
CLV_PCSK_KEX2_1	310	312	PF00082	0.381
CLV_PCSK_KEX2_1	344	346	PF00082	0.331
CLV_PCSK_KEX2_1	379	381	PF00082	0.320
CLV_PCSK_KEX2_1	8	10	PF00082	0.521
CLV_PCSK_PC1ET2_1	310	312	PF00082	0.381
CLV_PCSK_PC1ET2_1	344	346	PF00082	0.391
CLV_PCSK_PC1ET2_1	379	381	PF00082	0.391
CLV_PCSK_SKI1_1	123	127	PF00082	0.575
CLV_PCSK_SKI1_1	159	163	PF00082	0.712
CLV_PCSK_SKI1_1	166	170	PF00082	0.715
CLV_PCSK_SKI1_1	198	202	PF00082	0.408
CLV_PCSK_SKI1_1	268	272	PF00082	0.282
CLV_PCSK_SKI1_1	311	315	PF00082	0.284
CLV_PCSK_SKI1_1	35	39	PF00082	0.480
CLV_PCSK_SKI1_1	376	380	PF00082	0.377
CLV_PCSK_SKI1_1	396	400	PF00082	0.217
CLV_PCSK_SKI1_1	41	45	PF00082	0.428
DEG_APCC_DBOX_1	158	166	PF00400	0.506
DEG_Nend_Nbox_1	1	3	PF02207	0.726
DOC_CKS1_1	386	391	PF01111	0.541
DOC_MAPK_gen_1	3	12	PF00069	0.740
DOC_MAPK_gen_1	310	321	PF00069	0.591
DOC_MAPK_gen_1	379	387	PF00069	0.531
DOC_MAPK_MEF2A_6	257	265	PF00069	0.424
DOC_MAPK_MEF2A_6	6	14	PF00069	0.750
DOC_PP4_FxxP_1	118	121	PF00568	0.381
DOC_PP4_FxxP_1	270	273	PF00568	0.561
DOC_PP4_FxxP_1	64	67	PF00568	0.369
DOC_PP4_MxPP_1	336	339	PF00568	0.591
DOC_USP7_MATH_1	110	114	PF00917	0.522
DOC_USP7_MATH_1	183	187	PF00917	0.544
DOC_USP7_MATH_1	200	204	PF00917	0.458
DOC_USP7_MATH_1	236	240	PF00917	0.547
DOC_USP7_UBL2_3	31	35	PF12436	0.740
DOC_USP7_UBL2_3	310	314	PF12436	0.531
DOC_USP7_UBL2_3	379	383	PF12436	0.591
DOC_WW_Pin1_4	140	145	PF00397	0.465
DOC_WW_Pin1_4	146	151	PF00397	0.415
DOC_WW_Pin1_4	171	176	PF00397	0.517
DOC_WW_Pin1_4	179	184	PF00397	0.508
DOC_WW_Pin1_4	218	223	PF00397	0.482
DOC_WW_Pin1_4	269	274	PF00397	0.561
DOC_WW_Pin1_4	385	390	PF00397	0.569
DOC_WW_Pin1_4	416	421	PF00397	0.710
DOC_WW_Pin1_4	90	95	PF00397	0.480
LIG_14-3-3_CanoR_1	171	175	PF00244	0.499
LIG_14-3-3_CanoR_1	198	207	PF00244	0.446
LIG_14-3-3_CanoR_1	33	38	PF00244	0.712
LIG_14-3-3_CanoR_1	403	408	PF00244	0.670
LIG_14-3-3_CanoR_1	47	52	PF00244	0.633
LIG_Actin_WH2_2	17	32	PF00022	0.681
LIG_Actin_WH2_2	364	381	PF00022	0.563
LIG_BRCT_BRCA1_1	114	118	PF00533	0.462
LIG_CaM_IQ_9	365	381	PF13499	0.591
LIG_Clathr_ClatBox_1	318	322	PF01394	0.561
LIG_deltaCOP1_diTrp_1	95	101	PF00928	0.417
LIG_EVH1_1	207	211	PF00568	0.508
LIG_FHA_1	2	8	PF00498	0.722
LIG_FHA_1	224	230	PF00498	0.561
LIG_FHA_1	325	331	PF00498	0.476
LIG_FHA_1	397	403	PF00498	0.621
LIG_FHA_1	404	410	PF00498	0.648
LIG_FHA_2	127	133	PF00498	0.357
LIG_FHA_2	402	408	PF00498	0.654
LIG_FHA_2	90	96	PF00498	0.538
LIG_LIR_Apic_2	115	121	PF02991	0.368
LIG_LIR_Apic_2	274	279	PF02991	0.537
LIG_LIR_Apic_2	384	389	PF02991	0.486
LIG_LIR_Gen_1	304	313	PF02991	0.479
LIG_LIR_Gen_1	388	398	PF02991	0.635
LIG_LIR_Nem_3	258	263	PF02991	0.474
LIG_LIR_Nem_3	304	308	PF02991	0.479
LIG_LIR_Nem_3	388	393	PF02991	0.570
LIG_LIR_Nem_3	79	84	PF02991	0.512
LIG_LYPXL_S_1	259	263	PF13949	0.224
LIG_LYPXL_yS_3	260	263	PF13949	0.424
LIG_MLH1_MIPbox_1	114	118	PF16413	0.462
LIG_Pex14_1	267	271	PF04695	0.508
LIG_Pex14_2	64	68	PF04695	0.369
LIG_SH2_CRK	122	126	PF00017	0.379
LIG_SH2_CRK	285	289	PF00017	0.508
LIG_SH2_CRK	305	309	PF00017	0.490
LIG_SH2_NCK_1	285	289	PF00017	0.561
LIG_SH2_PTP2	386	389	PF00017	0.575
LIG_SH2_PTP2	81	84	PF00017	0.576
LIG_SH2_SRC	320	323	PF00017	0.490
LIG_SH2_STAP1	285	289	PF00017	0.508
LIG_SH2_STAP1	305	309	PF00017	0.490
LIG_SH2_STAT3	289	292	PF00017	0.490
LIG_SH2_STAT5	307	310	PF00017	0.508
LIG_SH2_STAT5	320	323	PF00017	0.490
LIG_SH2_STAT5	358	361	PF00017	0.493
LIG_SH2_STAT5	386	389	PF00017	0.575
LIG_SH2_STAT5	81	84	PF00017	0.585
LIG_SH3_1	80	86	PF00018	0.487
LIG_SH3_3	202	208	PF00018	0.412
LIG_SH3_3	409	415	PF00018	0.721
LIG_SH3_3	80	86	PF00018	0.489
LIG_SH3_3	9	15	PF00018	0.673
LIG_TRAF2_1	16	19	PF00917	0.602
LIG_TRAF2_1	419	422	PF00917	0.782
MOD_CDK_SPxxK_3	218	225	PF00069	0.490
MOD_CK1_1	143	149	PF00069	0.505
MOD_CK1_1	182	188	PF00069	0.539
MOD_CK1_1	239	245	PF00069	0.560
MOD_CK1_1	36	42	PF00069	0.701
MOD_CK2_1	13	19	PF00069	0.626
MOD_CK2_1	340	346	PF00069	0.508
MOD_CK2_1	401	407	PF00069	0.625
MOD_CK2_1	416	422	PF00069	0.652
MOD_CK2_1	89	95	PF00069	0.515
MOD_Cter_Amidation	281	284	PF01082	0.331
MOD_DYRK1A_RPxSP_1	171	175	PF00069	0.453
MOD_GlcNHglycan	134	137	PF01048	0.629
MOD_GlcNHglycan	145	148	PF01048	0.603
MOD_GlcNHglycan	15	18	PF01048	0.399
MOD_GlcNHglycan	185	188	PF01048	0.668
MOD_GlcNHglycan	202	205	PF01048	0.396
MOD_GSK3_1	139	146	PF00069	0.460
MOD_GSK3_1	169	176	PF00069	0.538
MOD_GSK3_1	179	186	PF00069	0.534
MOD_GSK3_1	194	201	PF00069	0.305
MOD_GSK3_1	239	246	PF00069	0.508
MOD_GSK3_1	29	36	PF00069	0.712
MOD_NEK2_1	1	6	PF00069	0.662
MOD_NEK2_1	139	144	PF00069	0.392
MOD_NEK2_1	169	174	PF00069	0.570
MOD_NEK2_1	29	34	PF00069	0.701
MOD_NEK2_1	76	81	PF00069	0.558
MOD_PIKK_1	237	243	PF00454	0.561
MOD_PIKK_1	84	90	PF00454	0.556
MOD_PK_1	33	39	PF00069	0.746
MOD_PKA_1	198	204	PF00069	0.408
MOD_PKA_2	170	176	PF00069	0.504
MOD_PKA_2	198	204	PF00069	0.485
MOD_PKA_2	2	8	PF00069	0.673
MOD_PKA_2	29	35	PF00069	0.678
MOD_Plk_1	396	402	PF00069	0.599
MOD_Plk_4	33	39	PF00069	0.746
MOD_Plk_4	47	53	PF00069	0.520
MOD_ProDKin_1	140	146	PF00069	0.472
MOD_ProDKin_1	171	177	PF00069	0.518
MOD_ProDKin_1	179	185	PF00069	0.509
MOD_ProDKin_1	218	224	PF00069	0.482
MOD_ProDKin_1	269	275	PF00069	0.561
MOD_ProDKin_1	385	391	PF00069	0.562
MOD_ProDKin_1	416	422	PF00069	0.714
MOD_ProDKin_1	90	96	PF00069	0.477
TRG_DiLeu_BaEn_1	72	77	PF01217	0.514
TRG_ENDOCYTIC_2	122	125	PF00928	0.376
TRG_ENDOCYTIC_2	260	263	PF00928	0.561
TRG_ENDOCYTIC_2	285	288	PF00928	0.513
TRG_ENDOCYTIC_2	305	308	PF00928	0.490
TRG_ENDOCYTIC_2	81	84	PF00928	0.519
TRG_ER_diArg_1	402	405	PF00400	0.687
TRG_ER_diArg_1	6	9	PF00400	0.720
TRG_NLS_MonoExtC_3	29	34	PF00514	0.734
TRG_NLS_MonoExtN_4	28	34	PF00514	0.703
TRG_Pf-PMV_PEXEL_1	345	349	PF00026	0.335
TRG_PTS2	1	14	PF00400	0.697

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4U9	Leptomonas seymouri	68%	100%
A0A0S4INW4	Bodo saltans	40%	100%
A0A1X0NF48	Trypanosomatidae	49%	100%
A0A3S5H690	Leishmania donovani	94%	100%
A4H5F4	Leishmania braziliensis	84%	100%
A4HTP9	Leishmania infantum	94%	100%
C9ZPF3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AMI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%