RAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MRB1 complex subunit MRB3010

Species:

Leishmania major

UniProt:

Q4QI52_LEIMA

TriTrypDb:

LmjF.08.1170 , LMJLV39_080015700 , LMJSD75_080015800

Length:

442

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QI52

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QI52

Function

Biological processes
Term	Name	Level	Count
GO:0000959	mitochondrial RNA metabolic process	6	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006396	RNA processing	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009451	RNA modification	5	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1900864	mitochondrial RNA modification	6	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0003729	mRNA binding	5	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	175	177	PF00675	0.409
CLV_NRD_NRD_1	19	21	PF00675	0.416
CLV_NRD_NRD_1	375	377	PF00675	0.330
CLV_PCSK_KEX2_1	175	177	PF00082	0.362
CLV_PCSK_KEX2_1	19	21	PF00082	0.416
CLV_PCSK_KEX2_1	208	210	PF00082	0.395
CLV_PCSK_KEX2_1	319	321	PF00082	0.348
CLV_PCSK_KEX2_1	375	377	PF00082	0.330
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.395
CLV_PCSK_PC1ET2_1	319	321	PF00082	0.377
CLV_PCSK_SKI1_1	111	115	PF00082	0.376
CLV_PCSK_SKI1_1	19	23	PF00082	0.406
CLV_PCSK_SKI1_1	346	350	PF00082	0.500
CLV_PCSK_SKI1_1	375	379	PF00082	0.308
CLV_PCSK_SKI1_1	390	394	PF00082	0.319
CLV_PCSK_SKI1_1	398	402	PF00082	0.304
DEG_APCC_DBOX_1	374	382	PF00400	0.310
DEG_Nend_UBRbox_1	1	4	PF02207	0.449
DOC_CKS1_1	391	396	PF01111	0.332
DOC_CYCLIN_RxL_1	17	26	PF00134	0.399
DOC_CYCLIN_RxL_1	372	380	PF00134	0.462
DOC_CYCLIN_RxL_1	395	405	PF00134	0.366
DOC_MAPK_gen_1	54	62	PF00069	0.419
DOC_MAPK_gen_1	65	74	PF00069	0.312
DOC_MAPK_gen_1	88	96	PF00069	0.379
DOC_MAPK_MEF2A_6	65	74	PF00069	0.393
DOC_PP1_RVXF_1	159	165	PF00149	0.424
DOC_PP1_RVXF_1	17	24	PF00149	0.405
DOC_PP1_RVXF_1	373	380	PF00149	0.326
DOC_PP4_FxxP_1	407	410	PF00568	0.421
DOC_PP4_FxxP_1	427	430	PF00568	0.397
DOC_USP7_UBL2_3	198	202	PF12436	0.399
DOC_USP7_UBL2_3	383	387	PF12436	0.351
DOC_WW_Pin1_4	390	395	PF00397	0.398
LIG_14-3-3_CanoR_1	137	142	PF00244	0.328
LIG_14-3-3_CanoR_1	175	181	PF00244	0.368
LIG_14-3-3_CanoR_1	183	187	PF00244	0.354
LIG_14-3-3_CanoR_1	320	328	PF00244	0.339
LIG_14-3-3_CanoR_1	376	382	PF00244	0.340
LIG_14-3-3_CanoR_1	398	403	PF00244	0.518
LIG_14-3-3_CterR_2	438	442	PF00244	0.452
LIG_APCC_ABBA_1	400	405	PF00400	0.385
LIG_BIR_III_4	109	113	PF00653	0.419
LIG_BRCT_BRCA1_1	206	210	PF00533	0.378
LIG_FHA_1	112	118	PF00498	0.404
LIG_FHA_1	345	351	PF00498	0.377
LIG_FHA_2	183	189	PF00498	0.373
LIG_LIR_Apic_2	405	410	PF02991	0.406
LIG_LIR_Apic_2	426	430	PF02991	0.451
LIG_LIR_Gen_1	269	278	PF02991	0.392
LIG_LIR_Gen_1	279	289	PF02991	0.314
LIG_LIR_Gen_1	417	427	PF02991	0.492
LIG_LIR_Gen_1	67	77	PF02991	0.496
LIG_LIR_Nem_3	128	134	PF02991	0.324
LIG_LIR_Nem_3	241	247	PF02991	0.404
LIG_LIR_Nem_3	269	273	PF02991	0.342
LIG_LIR_Nem_3	279	284	PF02991	0.263
LIG_LIR_Nem_3	315	321	PF02991	0.359
LIG_LIR_Nem_3	330	335	PF02991	0.404
LIG_LIR_Nem_3	417	423	PF02991	0.363
LIG_LIR_Nem_3	67	72	PF02991	0.369
LIG_NRBOX	129	135	PF00104	0.343
LIG_Pex14_2	344	348	PF04695	0.480
LIG_Pex14_2	423	427	PF04695	0.506
LIG_PTB_Apo_2	63	70	PF02174	0.501
LIG_SH2_CRK	240	244	PF00017	0.352
LIG_SH2_STAP1	240	244	PF00017	0.352
LIG_SH2_STAT3	217	220	PF00017	0.371
LIG_SH2_STAT5	217	220	PF00017	0.371
LIG_SH2_STAT5	235	238	PF00017	0.371
LIG_SH2_STAT5	262	265	PF00017	0.336
LIG_SH2_STAT5	364	367	PF00017	0.399
LIG_SH2_STAT5	46	49	PF00017	0.376
LIG_SH3_3	383	389	PF00018	0.399
LIG_SH3_3	419	425	PF00018	0.511
LIG_SUMO_SIM_anti_2	224	230	PF11976	0.319
LIG_SUMO_SIM_anti_2	36	41	PF11976	0.366
LIG_SUMO_SIM_anti_2	71	76	PF11976	0.369
LIG_SUMO_SIM_par_1	352	360	PF11976	0.439
LIG_SUMO_SIM_par_1	75	80	PF11976	0.369
LIG_TYR_ITIM	238	243	PF00017	0.369
LIG_UBA3_1	377	383	PF00899	0.326
LIG_WRC_WIRS_1	267	272	PF05994	0.507
LIG_WW_1	429	432	PF00397	0.370
MOD_CK1_1	118	124	PF00069	0.372
MOD_CK2_1	176	182	PF00069	0.412
MOD_GlcNHglycan	117	120	PF01048	0.398
MOD_GlcNHglycan	170	173	PF01048	0.233
MOD_GSK3_1	111	118	PF00069	0.355
MOD_GSK3_1	262	269	PF00069	0.358
MOD_GSK3_1	320	327	PF00069	0.303
MOD_GSK3_1	434	441	PF00069	0.473
MOD_GSK3_1	77	84	PF00069	0.348
MOD_N-GLC_2	397	399	PF02516	0.355
MOD_NEK2_1	120	125	PF00069	0.376
MOD_NEK2_1	22	27	PF00069	0.380
MOD_NEK2_1	302	307	PF00069	0.442
MOD_NEK2_1	337	342	PF00069	0.327
MOD_NEK2_1	344	349	PF00069	0.359
MOD_NEK2_1	377	382	PF00069	0.305
MOD_NEK2_1	40	45	PF00069	0.461
MOD_NEK2_1	434	439	PF00069	0.397
MOD_NEK2_2	132	137	PF00069	0.310
MOD_PKA_2	182	188	PF00069	0.385
MOD_Plk_2-3	182	188	PF00069	0.396
MOD_ProDKin_1	390	396	PF00069	0.394
MOD_SUMO_for_1	312	315	PF00179	0.391
MOD_SUMO_rev_2	197	207	PF00179	0.389
MOD_SUMO_rev_2	294	300	PF00179	0.461
TRG_DiLeu_BaEn_1	148	153	PF01217	0.349
TRG_DiLeu_BaEn_1	224	229	PF01217	0.321
TRG_DiLeu_BaLyEn_6	373	378	PF01217	0.457
TRG_DiLeu_LyEn_5	188	193	PF01217	0.338
TRG_ENDOCYTIC_2	235	238	PF00928	0.374
TRG_ENDOCYTIC_2	240	243	PF00928	0.350
TRG_ENDOCYTIC_2	46	49	PF00928	0.379
TRG_ER_diArg_1	161	164	PF00400	0.355
TRG_ER_diArg_1	19	21	PF00400	0.416
TRG_ER_diArg_1	374	376	PF00400	0.334
TRG_NES_CRM1_1	128	139	PF08389	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Z9	Leptomonas seymouri	24%	92%
A0A0N1HY66	Leptomonas seymouri	88%	82%
A0A0S4IS85	Bodo saltans	83%	84%
A0A1X0NEZ9	Trypanosomatidae	86%	86%
A0A1X0P8G7	Trypanosomatidae	26%	91%
A0A3S5H691	Leishmania donovani	99%	100%
A0A422NFX5	Trypanosoma rangeli	85%	85%
A0A422P283	Trypanosoma rangeli	27%	92%
A4H5F5	Leishmania braziliensis	96%	100%
A4HNQ2	Leishmania braziliensis	25%	92%
A4HTQ0	Leishmania infantum	99%	100%
C9ZPF4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	86%	86%
D0A2L1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	94%
E9AMI7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E9ASG1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	92%
V5BEF0	Trypanosoma cruzi	85%	85%
V5BQI6	Trypanosoma cruzi	26%	92%