Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QI48_LEIMA

TriTrypDb:

LmjF.08.1210 , LMJLV39_080016100 , LMJSD75_080016200

Length:

394

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QI48

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QI48

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.679
CLV_PCSK_KEX2_1	11	13	PF00082	0.679
CLV_PCSK_SKI1_1	192	196	PF00082	0.628
CLV_PCSK_SKI1_1	294	298	PF00082	0.349
CLV_PCSK_SKI1_1	52	56	PF00082	0.554
CLV_Separin_Metazoa	134	138	PF03568	0.558
DEG_APCC_DBOX_1	356	364	PF00400	0.502
DEG_Nend_UBRbox_2	1	3	PF02207	0.552
DEG_SPOP_SBC_1	36	40	PF00917	0.559
DOC_CYCLIN_yCln2_LP_2	358	364	PF00134	0.566
DOC_MAPK_gen_1	11	18	PF00069	0.590
DOC_MAPK_MEF2A_6	11	18	PF00069	0.662
DOC_MAPK_MEF2A_6	141	150	PF00069	0.463
DOC_MAPK_NFAT4_5	11	19	PF00069	0.656
DOC_PP2B_LxvP_1	16	19	PF13499	0.640
DOC_PP2B_LxvP_1	358	361	PF13499	0.586
DOC_PP4_FxxP_1	332	335	PF00568	0.491
DOC_USP7_MATH_1	157	161	PF00917	0.516
DOC_USP7_MATH_1	177	181	PF00917	0.636
DOC_USP7_MATH_1	232	236	PF00917	0.487
DOC_USP7_MATH_1	275	279	PF00917	0.680
DOC_WW_Pin1_4	185	190	PF00397	0.706
DOC_WW_Pin1_4	251	256	PF00397	0.649
DOC_WW_Pin1_4	75	80	PF00397	0.477
LIG_14-3-3_CanoR_1	273	283	PF00244	0.525
LIG_14-3-3_CanoR_1	318	325	PF00244	0.517
LIG_14-3-3_CanoR_1	382	391	PF00244	0.491
LIG_14-3-3_CanoR_1	52	62	PF00244	0.575
LIG_APCC_ABBA_1	148	153	PF00400	0.340
LIG_APCC_ABBAyCdc20_2	147	153	PF00400	0.344
LIG_BRCT_BRCA1_1	301	305	PF00533	0.498
LIG_Clathr_ClatBox_1	230	234	PF01394	0.533
LIG_FHA_1	37	43	PF00498	0.582
LIG_FHA_1	4	10	PF00498	0.628
LIG_FHA_2	171	177	PF00498	0.780
LIG_FHA_2	69	75	PF00498	0.549
LIG_LIR_Apic_2	329	335	PF02991	0.491
LIG_LIR_Apic_2	348	352	PF02991	0.488
LIG_LIR_Gen_1	96	104	PF02991	0.490
LIG_LIR_Nem_3	193	198	PF02991	0.686
LIG_LIR_Nem_3	220	226	PF02991	0.353
LIG_LIR_Nem_3	96	101	PF02991	0.444
LIG_MYND_1	45	49	PF01753	0.568
LIG_PCNA_APIM_2	292	298	PF02747	0.346
LIG_Pex14_2	390	394	PF04695	0.487
LIG_REV1ctd_RIR_1	293	302	PF16727	0.485
LIG_REV1ctd_RIR_1	388	394	PF16727	0.489
LIG_SH2_CRK	115	119	PF00017	0.672
LIG_SH2_CRK	223	227	PF00017	0.333
LIG_SH2_CRK	289	293	PF00017	0.480
LIG_SH2_CRK	29	33	PF00017	0.512
LIG_SH2_CRK	349	353	PF00017	0.458
LIG_SH2_CRK	84	88	PF00017	0.733
LIG_SH2_NCK_1	289	293	PF00017	0.480
LIG_SH2_PTP2	197	200	PF00017	0.509
LIG_SH2_STAP1	109	113	PF00017	0.507
LIG_SH2_STAT5	197	200	PF00017	0.509
LIG_SH2_STAT5	389	392	PF00017	0.345
LIG_SH2_STAT5	64	67	PF00017	0.436
LIG_SH3_3	195	201	PF00018	0.592
LIG_SH3_3	279	285	PF00018	0.477
LIG_SH3_3	358	364	PF00018	0.606
LIG_TRFH_1	349	353	PF08558	0.595
LIG_TYR_ITIM	287	292	PF00017	0.480
LIG_TYR_ITIM	82	87	PF00017	0.578
MOD_CDK_SPK_2	75	80	PF00069	0.477
MOD_CDK_SPxxK_3	185	192	PF00069	0.752
MOD_CK1_1	100	106	PF00069	0.534
MOD_CK1_1	181	187	PF00069	0.711
MOD_CK1_1	261	267	PF00069	0.694
MOD_CK1_1	277	283	PF00069	0.427
MOD_CK2_1	261	267	PF00069	0.736
MOD_CK2_1	68	74	PF00069	0.436
MOD_GlcNHglycan	109	112	PF01048	0.572
MOD_GlcNHglycan	206	209	PF01048	0.693
MOD_GlcNHglycan	212	215	PF01048	0.620
MOD_GlcNHglycan	234	237	PF01048	0.534
MOD_GlcNHglycan	263	266	PF01048	0.741
MOD_GlcNHglycan	277	280	PF01048	0.451
MOD_GlcNHglycan	301	304	PF01048	0.531
MOD_GlcNHglycan	319	322	PF01048	0.540
MOD_GlcNHglycan	84	87	PF01048	0.551
MOD_GSK3_1	157	164	PF00069	0.419
MOD_GSK3_1	177	184	PF00069	0.506
MOD_GSK3_1	199	206	PF00069	0.577
MOD_GSK3_1	271	278	PF00069	0.690
MOD_GSK3_1	64	71	PF00069	0.400
MOD_N-GLC_1	151	156	PF02516	0.577
MOD_NEK2_1	107	112	PF00069	0.465
MOD_NEK2_1	151	156	PF00069	0.500
MOD_NEK2_1	161	166	PF00069	0.505
MOD_NEK2_1	299	304	PF00069	0.497
MOD_NEK2_1	37	42	PF00069	0.533
MOD_NEK2_1	383	388	PF00069	0.454
MOD_NEK2_1	50	55	PF00069	0.483
MOD_NEK2_1	68	73	PF00069	0.280
MOD_NEK2_1	97	102	PF00069	0.482
MOD_PIKK_1	178	184	PF00454	0.734
MOD_PKA_2	170	176	PF00069	0.591
MOD_PKA_2	261	267	PF00069	0.631
MOD_PKA_2	317	323	PF00069	0.549
MOD_Plk_1	119	125	PF00069	0.663
MOD_Plk_1	12	18	PF00069	0.657
MOD_Plk_4	119	125	PF00069	0.688
MOD_Plk_4	146	152	PF00069	0.420
MOD_Plk_4	157	163	PF00069	0.392
MOD_Plk_4	278	284	PF00069	0.620
MOD_Plk_4	37	43	PF00069	0.552
MOD_Plk_4	4	10	PF00069	0.621
MOD_Plk_4	64	70	PF00069	0.385
MOD_ProDKin_1	185	191	PF00069	0.703
MOD_ProDKin_1	251	257	PF00069	0.650
MOD_ProDKin_1	75	81	PF00069	0.484
MOD_SUMO_rev_2	143	149	PF00179	0.561
TRG_DiLeu_BaEn_1	17	22	PF01217	0.626
TRG_ENDOCYTIC_2	223	226	PF00928	0.511
TRG_ENDOCYTIC_2	227	230	PF00928	0.540
TRG_ENDOCYTIC_2	289	292	PF00928	0.481
TRG_ENDOCYTIC_2	29	32	PF00928	0.511
TRG_ENDOCYTIC_2	84	87	PF00928	0.732
TRG_ER_diArg_1	10	12	PF00400	0.681
TRG_ER_diArg_1	260	263	PF00400	0.627
TRG_ER_diArg_1	354	357	PF00400	0.503
TRG_Pf-PMV_PEXEL_1	12	17	PF00026	0.658

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE21	Leptomonas seymouri	60%	87%
A0A0S4INY1	Bodo saltans	32%	86%
A0A1X0NGS9	Trypanosomatidae	37%	100%
A0A3R7NCH6	Trypanosoma rangeli	35%	100%
A0A3S5H694	Leishmania donovani	93%	100%
A4HC41	Leishmania braziliensis	82%	100%
A4HTQ4	Leishmania infantum	94%	100%
C9ZPG1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AMJ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BEE3	Trypanosoma cruzi	35%	100%