LeishMANIAdb
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Protein kinase domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
STE group serine/threonine-protein kinase, putative
Species:
Leishmania major
UniProt:
Q4QI43_LEIMA
TriTrypDb:
LmjF.08.1228 , LMJLV39_080016700 , LMJSD75_080017100
Length:
852

Annotations

LeishMANIAdb annotations

A protein kinase likely belonging to the STE20 kinase family. The TM segments are a kinetoplastid innovation, but the kinase is otherwise conservative.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0016020 membrane 2 8
GO:0110165 cellular anatomical entity 1 8

Expansion

Sequence features

Q4QI43
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QI43

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 9
GO:0006793 phosphorus metabolic process 3 9
GO:0006796 phosphate-containing compound metabolic process 4 9
GO:0006807 nitrogen compound metabolic process 2 9
GO:0008152 metabolic process 1 9
GO:0009987 cellular process 1 9
GO:0016310 phosphorylation 5 9
GO:0019538 protein metabolic process 3 9
GO:0036211 protein modification process 4 9
GO:0043170 macromolecule metabolic process 3 9
GO:0043412 macromolecule modification 4 9
GO:0044237 cellular metabolic process 2 9
GO:0044238 primary metabolic process 2 9
GO:0071704 organic substance metabolic process 2 9
GO:1901564 organonitrogen compound metabolic process 3 9
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 9
GO:0003824 catalytic activity 1 9
GO:0004672 protein kinase activity 3 9
GO:0004674 protein serine/threonine kinase activity 4 3
GO:0005488 binding 1 9
GO:0005524 ATP binding 5 9
GO:0016301 kinase activity 4 9
GO:0016740 transferase activity 2 9
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 9
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 9
GO:0017076 purine nucleotide binding 4 9
GO:0030554 adenyl nucleotide binding 5 9
GO:0032553 ribonucleotide binding 3 9
GO:0032555 purine ribonucleotide binding 4 9
GO:0032559 adenyl ribonucleotide binding 5 9
GO:0035639 purine ribonucleoside triphosphate binding 4 9
GO:0036094 small molecule binding 2 9
GO:0043167 ion binding 2 9
GO:0043168 anion binding 3 9
GO:0097159 organic cyclic compound binding 2 9
GO:0097367 carbohydrate derivative binding 2 9
GO:0140096 catalytic activity, acting on a protein 2 9
GO:1901265 nucleoside phosphate binding 3 9
GO:1901363 heterocyclic compound binding 2 9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 77 81 PF00656 0.352
CLV_NRD_NRD_1 118 120 PF00675 0.358
CLV_NRD_NRD_1 299 301 PF00675 0.388
CLV_NRD_NRD_1 384 386 PF00675 0.410
CLV_NRD_NRD_1 474 476 PF00675 0.453
CLV_NRD_NRD_1 613 615 PF00675 0.235
CLV_NRD_NRD_1 734 736 PF00675 0.233
CLV_NRD_NRD_1 828 830 PF00675 0.233
CLV_PCSK_FUR_1 611 615 PF00082 0.235
CLV_PCSK_KEX2_1 118 120 PF00082 0.358
CLV_PCSK_KEX2_1 298 300 PF00082 0.388
CLV_PCSK_KEX2_1 384 386 PF00082 0.410
CLV_PCSK_KEX2_1 474 476 PF00082 0.453
CLV_PCSK_KEX2_1 611 613 PF00082 0.235
CLV_PCSK_KEX2_1 734 736 PF00082 0.233
CLV_PCSK_KEX2_1 803 805 PF00082 0.223
CLV_PCSK_KEX2_1 828 830 PF00082 0.244
CLV_PCSK_PC1ET2_1 298 300 PF00082 0.400
CLV_PCSK_PC1ET2_1 803 805 PF00082 0.227
CLV_PCSK_PC1ET2_1 828 830 PF00082 0.243
CLV_PCSK_SKI1_1 191 195 PF00082 0.433
CLV_PCSK_SKI1_1 352 356 PF00082 0.397
CLV_PCSK_SKI1_1 411 415 PF00082 0.447
CLV_PCSK_SKI1_1 598 602 PF00082 0.368
CLV_PCSK_SKI1_1 734 738 PF00082 0.399
CLV_PCSK_SKI1_1 800 804 PF00082 0.256
CLV_PCSK_SKI1_1 812 816 PF00082 0.304
CLV_PCSK_SKI1_1 830 834 PF00082 0.250
CLV_Separin_Metazoa 314 318 PF03568 0.587
DEG_Nend_UBRbox_1 1 4 PF02207 0.648
DEG_SCF_FBW7_1 523 529 PF00400 0.644
DEG_SCF_FBW7_1 554 560 PF00400 0.571
DEG_SPOP_SBC_1 39 43 PF00917 0.568
DEG_SPOP_SBC_1 446 450 PF00917 0.639
DEG_SPOP_SBC_1 845 849 PF00917 0.565
DOC_ANK_TNKS_1 692 699 PF00023 0.446
DOC_CDC14_PxL_1 423 431 PF14671 0.612
DOC_CDC14_PxL_1 45 53 PF14671 0.270
DOC_CKS1_1 440 445 PF01111 0.625
DOC_CKS1_1 523 528 PF01111 0.644
DOC_CKS1_1 554 559 PF01111 0.579
DOC_CKS1_1 806 811 PF01111 0.433
DOC_CYCLIN_yCln2_LP_2 836 842 PF00134 0.406
DOC_MAPK_gen_1 298 307 PF00069 0.580
DOC_MAPK_gen_1 340 348 PF00069 0.595
DOC_MAPK_gen_1 612 623 PF00069 0.435
DOC_MAPK_gen_1 811 819 PF00069 0.433
DOC_MAPK_HePTP_8 297 309 PF00069 0.579
DOC_MAPK_MEF2A_6 298 306 PF00069 0.584
DOC_MAPK_MEF2A_6 580 588 PF00069 0.435
DOC_MAPK_MEF2A_6 811 819 PF00069 0.443
DOC_MAPK_MEF2A_6 95 103 PF00069 0.235
DOC_PP2B_LxvP_1 46 49 PF13499 0.270
DOC_PP2B_LxvP_1 836 839 PF13499 0.433
DOC_PP4_FxxP_1 239 242 PF00568 0.657
DOC_USP7_MATH_1 196 200 PF00917 0.653
DOC_USP7_MATH_1 446 450 PF00917 0.639
DOC_USP7_MATH_1 538 542 PF00917 0.639
DOC_USP7_MATH_1 675 679 PF00917 0.435
DOC_USP7_MATH_1 84 88 PF00917 0.389
DOC_USP7_MATH_1 845 849 PF00917 0.576
DOC_USP7_UBL2_3 833 837 PF12436 0.443
DOC_WW_Pin1_4 11 16 PF00397 0.628
DOC_WW_Pin1_4 202 207 PF00397 0.692
DOC_WW_Pin1_4 217 222 PF00397 0.612
DOC_WW_Pin1_4 245 250 PF00397 0.647
DOC_WW_Pin1_4 439 444 PF00397 0.616
DOC_WW_Pin1_4 447 452 PF00397 0.627
DOC_WW_Pin1_4 522 527 PF00397 0.647
DOC_WW_Pin1_4 539 544 PF00397 0.597
DOC_WW_Pin1_4 553 558 PF00397 0.563
DOC_WW_Pin1_4 744 749 PF00397 0.489
DOC_WW_Pin1_4 805 810 PF00397 0.433
LIG_14-3-3_CanoR_1 277 283 PF00244 0.655
LIG_14-3-3_CanoR_1 352 358 PF00244 0.598
LIG_14-3-3_CanoR_1 36 46 PF00244 0.590
LIG_14-3-3_CanoR_1 474 482 PF00244 0.645
LIG_14-3-3_CanoR_1 585 595 PF00244 0.435
LIG_14-3-3_CanoR_1 640 650 PF00244 0.446
LIG_14-3-3_CanoR_1 734 744 PF00244 0.433
LIG_14-3-3_CanoR_1 74 79 PF00244 0.386
LIG_14-3-3_CanoR_1 829 836 PF00244 0.469
LIG_14-3-3_CanoR_1 95 99 PF00244 0.246
LIG_Actin_WH2_2 646 662 PF00022 0.446
LIG_AP2alpha_1 378 382 PF02296 0.601
LIG_APCC_ABBA_1 346 351 PF00400 0.596
LIG_APCC_ABBAyCdc20_2 705 711 PF00400 0.443
LIG_BRCT_BRCA1_1 146 150 PF00533 0.729
LIG_BRCT_BRCA1_1 278 282 PF00533 0.644
LIG_BRCT_BRCA1_1 326 330 PF00533 0.579
LIG_BRCT_BRCA1_1 540 544 PF00533 0.627
LIG_CSL_BTD_1 246 249 PF09270 0.646
LIG_deltaCOP1_diTrp_1 765 769 PF00928 0.433
LIG_EH1_1 55 63 PF00400 0.255
LIG_FHA_1 187 193 PF00498 0.613
LIG_FHA_1 281 287 PF00498 0.641
LIG_FHA_1 39 45 PF00498 0.573
LIG_FHA_1 398 404 PF00498 0.619
LIG_FHA_1 519 525 PF00498 0.665
LIG_FHA_1 52 58 PF00498 0.247
LIG_FHA_1 642 648 PF00498 0.435
LIG_FHA_1 735 741 PF00498 0.515
LIG_FHA_1 776 782 PF00498 0.443
LIG_FHA_2 26 32 PF00498 0.588
LIG_FHA_2 309 315 PF00498 0.581
LIG_FHA_2 405 411 PF00498 0.618
LIG_FHA_2 426 432 PF00498 0.610
LIG_FHA_2 474 480 PF00498 0.650
LIG_FHA_2 5 11 PF00498 0.619
LIG_FHA_2 554 560 PF00498 0.578
LIG_FHA_2 622 628 PF00498 0.435
LIG_FHA_2 754 760 PF00498 0.501
LIG_FHA_2 820 826 PF00498 0.486
LIG_FHA_2 829 835 PF00498 0.433
LIG_FHA_2 845 851 PF00498 0.552
LIG_GBD_Chelix_1 302 310 PF00786 0.385
LIG_Integrin_RGD_1 604 606 PF01839 0.246
LIG_IRF3_LxIS_1 106 113 PF10401 0.255
LIG_IRF3_LxIS_1 583 589 PF10401 0.446
LIG_LIR_Apic_2 747 753 PF02991 0.433
LIG_LIR_Gen_1 113 121 PF02991 0.352
LIG_LIR_Gen_1 356 364 PF02991 0.593
LIG_LIR_Gen_1 453 462 PF02991 0.642
LIG_LIR_Gen_1 556 562 PF02991 0.541
LIG_LIR_Gen_1 591 602 PF02991 0.446
LIG_LIR_Gen_1 97 108 PF02991 0.264
LIG_LIR_Nem_3 113 117 PF02991 0.200
LIG_LIR_Nem_3 147 152 PF02991 0.733
LIG_LIR_Nem_3 171 175 PF02991 0.560
LIG_LIR_Nem_3 308 312 PF02991 0.564
LIG_LIR_Nem_3 356 360 PF02991 0.585
LIG_LIR_Nem_3 431 437 PF02991 0.614
LIG_LIR_Nem_3 453 457 PF02991 0.648
LIG_LIR_Nem_3 556 561 PF02991 0.547
LIG_LIR_Nem_3 591 597 PF02991 0.446
LIG_LIR_Nem_3 789 793 PF02991 0.534
LIG_LIR_Nem_3 97 103 PF02991 0.264
LIG_MLH1_MIPbox_1 146 150 PF16413 0.579
LIG_PCNA_TLS_4 812 819 PF02747 0.443
LIG_PDZ_Class_3 847 852 PF00595 0.610
LIG_Pex14_1 168 172 PF04695 0.559
LIG_Pex14_1 357 361 PF04695 0.596
LIG_Pex14_2 378 382 PF04695 0.601
LIG_SH2_CRK 96 100 PF00017 0.270
LIG_SH2_GRB2like 63 66 PF00017 0.399
LIG_SH2_PTP2 437 440 PF00017 0.622
LIG_SH2_PTP2 63 66 PF00017 0.399
LIG_SH2_SRC 24 27 PF00017 0.623
LIG_SH2_SRC 63 66 PF00017 0.399
LIG_SH2_SRC 824 827 PF00017 0.426
LIG_SH2_STAP1 349 353 PF00017 0.601
LIG_SH2_STAP1 558 562 PF00017 0.534
LIG_SH2_STAP1 783 787 PF00017 0.438
LIG_SH2_STAP1 96 100 PF00017 0.255
LIG_SH2_STAT5 393 396 PF00017 0.631
LIG_SH2_STAT5 399 402 PF00017 0.661
LIG_SH2_STAT5 434 437 PF00017 0.616
LIG_SH2_STAT5 63 66 PF00017 0.399
LIG_SH2_STAT5 649 652 PF00017 0.445
LIG_SH2_STAT5 665 668 PF00017 0.435
LIG_SH2_STAT5 791 794 PF00017 0.433
LIG_SH2_STAT5 840 843 PF00017 0.565
LIG_SH2_STAT5 96 99 PF00017 0.254
LIG_SH3_3 520 526 PF00018 0.655
LIG_SH3_3 537 543 PF00018 0.592
LIG_SH3_3 551 557 PF00018 0.586
LIG_SH3_3 714 720 PF00018 0.489
LIG_SH3_3 73 79 PF00018 0.373
LIG_SUMO_SIM_anti_2 102 107 PF11976 0.268
LIG_SUMO_SIM_anti_2 634 639 PF11976 0.446
LIG_SUMO_SIM_par_1 130 135 PF11976 0.560
LIG_SUMO_SIM_par_1 303 308 PF11976 0.585
LIG_SUMO_SIM_par_1 344 351 PF11976 0.604
LIG_TYR_ITIM 310 315 PF00017 0.442
LIG_TYR_ITIM 61 66 PF00017 0.397
LIG_WRC_WIRS_1 306 311 PF05994 0.461
LIG_WRC_WIRS_1 558 563 PF05994 0.369
LIG_WRC_WIRS_1 649 654 PF05994 0.254
LIG_WRC_WIRS_1 766 771 PF05994 0.251
MOD_CDK_SPxK_1 805 811 PF00069 0.251
MOD_CDK_SPxxK_3 805 812 PF00069 0.266
MOD_CK1_1 216 222 PF00069 0.584
MOD_CK1_1 253 259 PF00069 0.588
MOD_CK1_1 276 282 PF00069 0.551
MOD_CK1_1 308 314 PF00069 0.439
MOD_CK1_1 37 43 PF00069 0.473
MOD_CK1_1 450 456 PF00069 0.549
MOD_CK1_1 547 553 PF00069 0.500
MOD_CK2_1 127 133 PF00069 0.423
MOD_CK2_1 19 25 PF00069 0.504
MOD_CK2_1 308 314 PF00069 0.477
MOD_CK2_1 4 10 PF00069 0.516
MOD_CK2_1 404 410 PF00069 0.509
MOD_CK2_1 425 431 PF00069 0.487
MOD_CK2_1 473 479 PF00069 0.559
MOD_CK2_1 553 559 PF00069 0.463
MOD_CK2_1 621 627 PF00069 0.255
MOD_CK2_1 648 654 PF00069 0.254
MOD_CK2_1 739 745 PF00069 0.266
MOD_CK2_1 753 759 PF00069 0.210
MOD_GlcNHglycan 171 175 PF01048 0.424
MOD_GlcNHglycan 198 201 PF01048 0.572
MOD_GlcNHglycan 215 218 PF01048 0.497
MOD_GlcNHglycan 226 229 PF01048 0.527
MOD_GlcNHglycan 257 260 PF01048 0.678
MOD_GlcNHglycan 273 276 PF01048 0.702
MOD_GlcNHglycan 362 365 PF01048 0.506
MOD_GlcNHglycan 389 392 PF01048 0.504
MOD_GlcNHglycan 476 479 PF01048 0.532
MOD_GlcNHglycan 721 724 PF01048 0.251
MOD_GlcNHglycan 741 744 PF01048 0.323
MOD_GSK3_1 140 147 PF00069 0.438
MOD_GSK3_1 202 209 PF00069 0.685
MOD_GSK3_1 211 218 PF00069 0.541
MOD_GSK3_1 25 32 PF00069 0.534
MOD_GSK3_1 276 283 PF00069 0.551
MOD_GSK3_1 34 41 PF00069 0.462
MOD_GSK3_1 393 400 PF00069 0.566
MOD_GSK3_1 405 412 PF00069 0.482
MOD_GSK3_1 446 453 PF00069 0.540
MOD_GSK3_1 518 525 PF00069 0.613
MOD_GSK3_1 526 533 PF00069 0.522
MOD_GSK3_1 539 546 PF00069 0.503
MOD_GSK3_1 553 560 PF00069 0.416
MOD_GSK3_1 730 737 PF00069 0.341
MOD_GSK3_1 749 756 PF00069 0.451
MOD_N-GLC_2 335 337 PF02516 0.464
MOD_NEK2_1 110 115 PF00069 0.254
MOD_NEK2_1 224 229 PF00069 0.523
MOD_NEK2_1 293 298 PF00069 0.703
MOD_NEK2_1 305 310 PF00069 0.446
MOD_NEK2_1 360 365 PF00069 0.493
MOD_NEK2_1 452 457 PF00069 0.553
MOD_NEK2_1 473 478 PF00069 0.551
MOD_NEK2_1 51 56 PF00069 0.270
MOD_NEK2_1 544 549 PF00069 0.495
MOD_NEK2_1 571 576 PF00069 0.461
MOD_NEK2_1 674 679 PF00069 0.487
MOD_NEK2_1 730 735 PF00069 0.325
MOD_NEK2_1 819 824 PF00069 0.342
MOD_NEK2_1 99 104 PF00069 0.254
MOD_NEK2_2 490 495 PF00069 0.480
MOD_NEK2_2 557 562 PF00069 0.388
MOD_NEK2_2 783 788 PF00069 0.258
MOD_PIKK_1 206 212 PF00454 0.562
MOD_PIKK_1 791 797 PF00454 0.291
MOD_PIKK_1 819 825 PF00454 0.230
MOD_PKA_1 474 480 PF00069 0.548
MOD_PKA_1 734 740 PF00069 0.251
MOD_PKA_1 828 834 PF00069 0.266
MOD_PKA_2 161 167 PF00069 0.435
MOD_PKA_2 196 202 PF00069 0.562
MOD_PKA_2 276 282 PF00069 0.549
MOD_PKA_2 35 41 PF00069 0.494
MOD_PKA_2 473 479 PF00069 0.551
MOD_PKA_2 641 647 PF00069 0.270
MOD_PKA_2 734 740 PF00069 0.251
MOD_PKA_2 828 834 PF00069 0.348
MOD_PKA_2 94 100 PF00069 0.266
MOD_Plk_1 132 138 PF00069 0.431
MOD_Plk_1 293 299 PF00069 0.490
MOD_Plk_1 409 415 PF00069 0.522
MOD_Plk_1 464 470 PF00069 0.537
MOD_Plk_1 783 789 PF00069 0.258
MOD_Plk_1 84 90 PF00069 0.676
MOD_Plk_2-3 19 25 PF00069 0.534
MOD_Plk_4 127 133 PF00069 0.554
MOD_Plk_4 145 151 PF00069 0.454
MOD_Plk_4 19 25 PF00069 0.534
MOD_Plk_4 305 311 PF00069 0.446
MOD_Plk_4 40 46 PF00069 0.250
MOD_Plk_4 409 415 PF00069 0.522
MOD_Plk_4 418 424 PF00069 0.515
MOD_Plk_4 425 431 PF00069 0.497
MOD_Plk_4 51 57 PF00069 0.221
MOD_Plk_4 557 563 PF00069 0.371
MOD_Plk_4 571 577 PF00069 0.254
MOD_Plk_4 94 100 PF00069 0.271
MOD_ProDKin_1 11 17 PF00069 0.526
MOD_ProDKin_1 202 208 PF00069 0.616
MOD_ProDKin_1 217 223 PF00069 0.503
MOD_ProDKin_1 245 251 PF00069 0.553
MOD_ProDKin_1 439 445 PF00069 0.509
MOD_ProDKin_1 447 453 PF00069 0.522
MOD_ProDKin_1 522 528 PF00069 0.549
MOD_ProDKin_1 539 545 PF00069 0.483
MOD_ProDKin_1 553 559 PF00069 0.420
MOD_ProDKin_1 744 750 PF00069 0.329
MOD_ProDKin_1 805 811 PF00069 0.251
MOD_SUMO_for_1 600 603 PF00179 0.255
MOD_SUMO_for_1 802 805 PF00179 0.243
MOD_SUMO_rev_2 572 581 PF00179 0.254
MOD_SUMO_rev_2 603 610 PF00179 0.270
MOD_SUMO_rev_2 651 659 PF00179 0.255
TRG_DiLeu_BaEn_1 410 415 PF01217 0.626
TRG_DiLeu_BaEn_2 589 595 PF01217 0.270
TRG_DiLeu_BaEn_2 696 702 PF01217 0.251
TRG_DiLeu_BaEn_3 656 662 PF01217 0.213
TRG_ENDOCYTIC_2 121 124 PF00928 0.403
TRG_ENDOCYTIC_2 312 315 PF00928 0.440
TRG_ENDOCYTIC_2 437 440 PF00928 0.516
TRG_ENDOCYTIC_2 558 561 PF00928 0.391
TRG_ENDOCYTIC_2 63 66 PF00928 0.399
TRG_ENDOCYTIC_2 649 652 PF00928 0.254
TRG_ENDOCYTIC_2 790 793 PF00928 0.415
TRG_ENDOCYTIC_2 96 99 PF00928 0.254
TRG_ER_diArg_1 117 119 PF00400 0.434
TRG_ER_diArg_1 383 385 PF00400 0.497
TRG_ER_diArg_1 473 475 PF00400 0.564
TRG_ER_diArg_1 610 613 PF00400 0.254
TRG_NES_CRM1_1 128 139 PF08389 0.427
TRG_NLS_Bipartite_1 811 832 PF00514 0.251
TRG_NLS_MonoExtN_4 826 832 PF00514 0.251

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5H9 Leptomonas seymouri 48% 98%
A0A3S5H699 Leishmania donovani 95% 86%
A0A3S7WQE5 Leishmania donovani 96% 100%
A4HC47 Leishmania braziliensis 84% 100%
E9AG93 Leishmania infantum 96% 100%
E9AMJ7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4QI37 Leishmania major 100% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS