RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania major

UniProt:

Q4QI41_LEIMA

TriTrypDb:

LmjF.08.1215 , LMJLV39_080016200 , LMJSD75_080016600

Length:

506

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4QI41

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QI41

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	2
GO:0006357	regulation of transcription by RNA polymerase II	7	2
GO:0009889	regulation of biosynthetic process	4	2
GO:0009891	positive regulation of biosynthetic process	5	2
GO:0009893	positive regulation of metabolic process	4	2
GO:0010468	regulation of gene expression	5	2
GO:0010556	regulation of macromolecule biosynthetic process	5	2
GO:0010557	positive regulation of macromolecule biosynthetic process	6	2
GO:0010604	positive regulation of macromolecule metabolic process	5	2
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	2
GO:0019222	regulation of metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031325	positive regulation of cellular metabolic process	5	2
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0031328	positive regulation of cellular biosynthetic process	6	2
GO:0045893	positive regulation of DNA-templated transcription	7	2
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	6	2
GO:0045944	positive regulation of transcription by RNA polymerase II	8	2
GO:0048518	positive regulation of biological process	3	2
GO:0048522	positive regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051173	positive regulation of nitrogen compound metabolic process	5	2
GO:0051252	regulation of RNA metabolic process	5	2
GO:0051254	positive regulation of RNA metabolic process	6	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0080090	regulation of primary metabolic process	4	2
GO:1902680	positive regulation of RNA biosynthetic process	7	2
GO:1903506	regulation of nucleic acid-templated transcription	7	2
GO:1903508	positive regulation of nucleic acid-templated transcription	8	2
GO:2001141	regulation of RNA biosynthetic process	6	2

Molecular functions
Term	Name	Level	Count
GO:0000976	transcription cis-regulatory region binding	5	2
GO:0001067	transcription regulatory region nucleic acid binding	4	2
GO:0003676	nucleic acid binding	3	2
GO:0003677	DNA binding	4	2
GO:0003690	double-stranded DNA binding	5	2
GO:0005488	binding	1	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0043565	sequence-specific DNA binding	5	2
GO:0046872	metal ion binding	4	12
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2
GO:1990837	sequence-specific double-stranded DNA binding	6	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	213	217	PF00656	0.536
CLV_NRD_NRD_1	122	124	PF00675	0.558
CLV_NRD_NRD_1	143	145	PF00675	0.424
CLV_NRD_NRD_1	27	29	PF00675	0.492
CLV_NRD_NRD_1	316	318	PF00675	0.462
CLV_NRD_NRD_1	364	366	PF00675	0.540
CLV_NRD_NRD_1	489	491	PF00675	0.679
CLV_NRD_NRD_1	96	98	PF00675	0.414
CLV_PCSK_KEX2_1	122	124	PF00082	0.534
CLV_PCSK_KEX2_1	134	136	PF00082	0.265
CLV_PCSK_KEX2_1	143	145	PF00082	0.372
CLV_PCSK_KEX2_1	27	29	PF00082	0.531
CLV_PCSK_KEX2_1	316	318	PF00082	0.555
CLV_PCSK_KEX2_1	364	366	PF00082	0.549
CLV_PCSK_KEX2_1	441	443	PF00082	0.644
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.430
CLV_PCSK_PC1ET2_1	441	443	PF00082	0.644
CLV_PCSK_SKI1_1	221	225	PF00082	0.452
CLV_PCSK_SKI1_1	251	255	PF00082	0.739
CLV_PCSK_SKI1_1	282	286	PF00082	0.491
CLV_PCSK_SKI1_1	347	351	PF00082	0.529
CLV_PCSK_SKI1_1	491	495	PF00082	0.646
DEG_APCC_DBOX_1	220	228	PF00400	0.542
DEG_APCC_DBOX_1	9	17	PF00400	0.548
DEG_Nend_Nbox_1	1	3	PF02207	0.450
DEG_SCF_FBW7_2	180	187	PF00400	0.537
DEG_SCF_FBW7_2	252	259	PF00400	0.742
DEG_SPOP_SBC_1	465	469	PF00917	0.733
DEG_SPOP_SBC_1	493	497	PF00917	0.549
DOC_CKS1_1	105	110	PF01111	0.520
DOC_CKS1_1	181	186	PF01111	0.544
DOC_CKS1_1	253	258	PF01111	0.735
DOC_CYCLIN_RxL_1	218	225	PF00134	0.517
DOC_CYCLIN_yCln2_LP_2	105	111	PF00134	0.515
DOC_MAPK_gen_1	27	35	PF00069	0.528
DOC_MAPK_gen_1	316	327	PF00069	0.418
DOC_PP2B_LxvP_1	150	153	PF13499	0.582
DOC_PP2B_LxvP_1	341	344	PF13499	0.505
DOC_PP2B_LxvP_1	414	417	PF13499	0.664
DOC_PP4_FxxP_1	57	60	PF00568	0.355
DOC_USP7_MATH_1	465	469	PF00917	0.686
DOC_USP7_MATH_1	477	481	PF00917	0.408
DOC_USP7_MATH_1	493	497	PF00917	0.618
DOC_USP7_UBL2_3	285	289	PF12436	0.504
DOC_USP7_UBL2_3	483	487	PF12436	0.701
DOC_WW_Pin1_4	104	109	PF00397	0.528
DOC_WW_Pin1_4	180	185	PF00397	0.543
DOC_WW_Pin1_4	242	247	PF00397	0.615
DOC_WW_Pin1_4	252	257	PF00397	0.421
DOC_WW_Pin1_4	393	398	PF00397	0.618
DOC_WW_Pin1_4	50	55	PF00397	0.485
DOC_WW_Pin1_4	501	506	PF00397	0.733
LIG_14-3-3_CanoR_1	143	150	PF00244	0.534
LIG_14-3-3_CanoR_1	178	184	PF00244	0.504
LIG_14-3-3_CanoR_1	251	256	PF00244	0.735
LIG_14-3-3_CanoR_1	370	378	PF00244	0.551
LIG_14-3-3_CanoR_1	70	78	PF00244	0.385
LIG_Actin_WH2_2	276	293	PF00022	0.514
LIG_AP2alpha_2	147	149	PF02296	0.567
LIG_APCC_ABBA_1	263	268	PF00400	0.507
LIG_FHA_1	298	304	PF00498	0.447
LIG_FHA_1	313	319	PF00498	0.462
LIG_FHA_1	406	412	PF00498	0.694
LIG_FHA_2	252	258	PF00498	0.726
LIG_FHA_2	51	57	PF00498	0.462
LIG_Integrin_RGD_1	459	461	PF01839	0.760
LIG_LIR_Apic_2	55	60	PF02991	0.395
LIG_LIR_Gen_1	259	267	PF02991	0.539
LIG_LIR_Gen_1	410	417	PF02991	0.667
LIG_LIR_Nem_3	259	265	PF02991	0.456
LIG_LIR_Nem_3	375	381	PF02991	0.468
LIG_LIR_Nem_3	410	416	PF02991	0.621
LIG_PTAP_UEV_1	65	70	PF05743	0.442
LIG_PTB_Apo_2	1	8	PF02174	0.390
LIG_SH2_CRK	78	82	PF00017	0.427
LIG_SH2_GRB2like	385	388	PF00017	0.554
LIG_SH2_SRC	266	269	PF00017	0.413
LIG_SH2_STAP1	192	196	PF00017	0.571
LIG_SH2_STAT5	109	112	PF00017	0.479
LIG_SH2_STAT5	179	182	PF00017	0.386
LIG_SH2_STAT5	262	265	PF00017	0.444
LIG_SH2_STAT5	275	278	PF00017	0.400
LIG_SH2_STAT5	381	384	PF00017	0.464
LIG_SH2_STAT5	413	416	PF00017	0.701
LIG_SH2_STAT5	78	81	PF00017	0.346
LIG_SH3_2	118	123	PF14604	0.501
LIG_SH3_3	112	118	PF00018	0.368
LIG_SH3_3	150	156	PF00018	0.575
LIG_SH3_3	244	250	PF00018	0.601
LIG_SH3_3	499	505	PF00018	0.663
LIG_SH3_3	63	69	PF00018	0.409
LIG_SUMO_SIM_par_1	12	18	PF11976	0.583
LIG_TRAF2_1	53	56	PF00917	0.483
LIG_TRFH_1	109	113	PF08558	0.489
LIG_TYR_ITIM	411	416	PF00017	0.699
LIG_UBA3_1	223	232	PF00899	0.528
LIG_UBA3_1	83	91	PF00899	0.427
MOD_CDK_SPK_2	501	506	PF00069	0.704
MOD_CK1_1	174	180	PF00069	0.449
MOD_CK1_1	386	392	PF00069	0.646
MOD_CK1_1	396	402	PF00069	0.444
MOD_CK1_1	405	411	PF00069	0.584
MOD_CK1_1	418	424	PF00069	0.660
MOD_CK2_1	194	200	PF00069	0.380
MOD_CK2_1	212	218	PF00069	0.600
MOD_CK2_1	251	257	PF00069	0.763
MOD_CK2_1	449	455	PF00069	0.676
MOD_CK2_1	50	56	PF00069	0.433
MOD_GlcNHglycan	157	160	PF01048	0.642
MOD_GlcNHglycan	17	20	PF01048	0.676
MOD_GlcNHglycan	291	294	PF01048	0.369
MOD_GlcNHglycan	388	391	PF01048	0.654
MOD_GlcNHglycan	420	423	PF01048	0.710
MOD_GlcNHglycan	451	454	PF01048	0.696
MOD_GlcNHglycan	479	482	PF01048	0.595
MOD_GSK3_1	305	312	PF00069	0.519
MOD_GSK3_1	370	377	PF00069	0.530
MOD_GSK3_1	455	462	PF00069	0.718
MOD_N-GLC_1	386	391	PF02516	0.582
MOD_N-GLC_2	138	140	PF02516	0.503
MOD_NEK2_1	14	19	PF00069	0.659
MOD_NEK2_1	35	40	PF00069	0.522
MOD_NEK2_1	383	388	PF00069	0.613
MOD_NEK2_1	449	454	PF00069	0.731
MOD_PKA_2	136	142	PF00069	0.492
MOD_PKA_2	383	389	PF00069	0.619
MOD_PKA_2	437	443	PF00069	0.641
MOD_PKA_2	69	75	PF00069	0.418
MOD_Plk_1	374	380	PF00069	0.501
MOD_Plk_1	402	408	PF00069	0.648
MOD_Plk_2-3	194	200	PF00069	0.433
MOD_Plk_2-3	305	311	PF00069	0.522
MOD_Plk_4	237	243	PF00069	0.703
MOD_Plk_4	35	41	PF00069	0.511
MOD_Plk_4	44	50	PF00069	0.467
MOD_Plk_4	444	450	PF00069	0.748
MOD_ProDKin_1	104	110	PF00069	0.522
MOD_ProDKin_1	180	186	PF00069	0.539
MOD_ProDKin_1	242	248	PF00069	0.616
MOD_ProDKin_1	252	258	PF00069	0.417
MOD_ProDKin_1	393	399	PF00069	0.618
MOD_ProDKin_1	50	56	PF00069	0.491
MOD_SUMO_for_1	486	489	PF00179	0.715
MOD_SUMO_rev_2	229	237	PF00179	0.615
TRG_DiLeu_BaEn_2	217	223	PF01217	0.530
TRG_ENDOCYTIC_2	262	265	PF00928	0.523
TRG_ENDOCYTIC_2	275	278	PF00928	0.421
TRG_ENDOCYTIC_2	319	322	PF00928	0.430
TRG_ENDOCYTIC_2	413	416	PF00928	0.677
TRG_ER_diArg_1	121	123	PF00400	0.560
TRG_ER_diArg_1	142	144	PF00400	0.451
TRG_ER_diArg_1	27	29	PF00400	0.531
TRG_ER_diArg_1	316	318	PF00400	0.553
TRG_ER_diArg_1	364	367	PF00400	0.541
TRG_NLS_Bipartite_1	122	138	PF00514	0.501
TRG_Pf-PMV_PEXEL_1	203	207	PF00026	0.517
TRG_Pf-PMV_PEXEL_1	221	225	PF00026	0.229
TRG_Pf-PMV_PEXEL_1	27	31	PF00026	0.464

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWK4	Leptomonas seymouri	70%	86%
A0A1X0NGG7	Trypanosomatidae	41%	93%
A0A3S5H6A1	Leishmania donovani	97%	88%
A0A3S7WQF9	Leishmania donovani	97%	100%
A0A422NFU0	Trypanosoma rangeli	38%	94%
A4HC42	Leishmania braziliensis	85%	87%
C9ZPG2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	94%
E9AG88	Leishmania infantum	97%	100%
E9AMJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O94271	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	75%
Q06436	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	76%
Q32NQ8	Xenopus laevis	23%	67%
V5DAD1	Trypanosoma cruzi	41%	93%