LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4QI40_LEIMA
TriTrypDb:
LmjF.08.1250 , LMJLV39_080016300 * , LMJSD75_080016700 *
Length:
479

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QI40
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QI40

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 306 308 PF00675 0.573
CLV_NRD_NRD_1 464 466 PF00675 0.683
CLV_PCSK_KEX2_1 306 308 PF00082 0.588
CLV_PCSK_KEX2_1 463 465 PF00082 0.756
CLV_PCSK_PC7_1 460 466 PF00082 0.748
CLV_PCSK_SKI1_1 224 228 PF00082 0.595
DOC_PP4_FxxP_1 6 9 PF00568 0.634
DOC_USP7_MATH_1 187 191 PF00917 0.693
DOC_USP7_MATH_1 252 256 PF00917 0.713
DOC_USP7_MATH_1 297 301 PF00917 0.665
DOC_USP7_MATH_1 325 329 PF00917 0.614
DOC_USP7_MATH_1 406 410 PF00917 0.696
DOC_USP7_MATH_1 451 455 PF00917 0.760
DOC_USP7_MATH_1 47 51 PF00917 0.770
DOC_USP7_MATH_1 61 65 PF00917 0.518
DOC_WW_Pin1_4 170 175 PF00397 0.697
DOC_WW_Pin1_4 258 263 PF00397 0.662
DOC_WW_Pin1_4 69 74 PF00397 0.760
LIG_14-3-3_CanoR_1 306 310 PF00244 0.605
LIG_14-3-3_CanoR_1 365 371 PF00244 0.612
LIG_14-3-3_CanoR_1 37 41 PF00244 0.779
LIG_Actin_WH2_2 91 107 PF00022 0.743
LIG_BIR_III_2 380 384 PF00653 0.763
LIG_BIR_III_4 296 300 PF00653 0.610
LIG_BIR_III_4 60 64 PF00653 0.666
LIG_Clathr_ClatBox_1 330 334 PF01394 0.701
LIG_EVH1_2 2 6 PF00568 0.690
LIG_FHA_1 171 177 PF00498 0.519
LIG_FHA_1 90 96 PF00498 0.746
LIG_FHA_2 108 114 PF00498 0.746
LIG_FHA_2 427 433 PF00498 0.809
LIG_GBD_Chelix_1 362 370 PF00786 0.574
LIG_LIR_Nem_3 64 69 PF02991 0.543
LIG_MYND_1 102 106 PF01753 0.631
LIG_NRBOX 264 270 PF00104 0.566
LIG_NRBOX 94 100 PF00104 0.756
LIG_SH2_STAT5 278 281 PF00017 0.502
LIG_SH2_STAT5 358 361 PF00017 0.549
LIG_SH2_STAT5 455 458 PF00017 0.715
LIG_SH3_3 412 418 PF00018 0.739
LIG_SH3_3 74 80 PF00018 0.771
LIG_SUMO_SIM_par_1 266 272 PF11976 0.584
LIG_SUMO_SIM_par_1 327 334 PF11976 0.693
LIG_TRAF2_1 237 240 PF00917 0.662
LIG_TRAF2_1 444 447 PF00917 0.786
LIG_WW_3 1 5 PF00397 0.692
MOD_CK1_1 170 176 PF00069 0.630
MOD_CK1_1 190 196 PF00069 0.736
MOD_CK1_1 261 267 PF00069 0.528
MOD_CK1_1 272 278 PF00069 0.473
MOD_CK1_1 369 375 PF00069 0.599
MOD_CK1_1 72 78 PF00069 0.583
MOD_CK1_1 94 100 PF00069 0.770
MOD_CK2_1 113 119 PF00069 0.637
MOD_CK2_1 177 183 PF00069 0.488
MOD_CK2_1 234 240 PF00069 0.682
MOD_CK2_1 441 447 PF00069 0.701
MOD_CK2_1 47 53 PF00069 0.656
MOD_GlcNHglycan 10 13 PF01048 0.729
MOD_GlcNHglycan 109 113 PF01048 0.772
MOD_GlcNHglycan 169 172 PF01048 0.623
MOD_GlcNHglycan 179 182 PF01048 0.703
MOD_GlcNHglycan 236 239 PF01048 0.651
MOD_GlcNHglycan 299 302 PF01048 0.691
MOD_GlcNHglycan 374 378 PF01048 0.579
MOD_GlcNHglycan 404 407 PF01048 0.698
MOD_GlcNHglycan 48 52 PF01048 0.801
MOD_GSK3_1 104 111 PF00069 0.714
MOD_GSK3_1 114 121 PF00069 0.586
MOD_GSK3_1 23 30 PF00069 0.723
MOD_GSK3_1 248 255 PF00069 0.666
MOD_GSK3_1 256 263 PF00069 0.630
MOD_GSK3_1 369 376 PF00069 0.549
MOD_GSK3_1 402 409 PF00069 0.691
MOD_GSK3_1 43 50 PF00069 0.778
MOD_N-GLC_1 253 258 PF02516 0.624
MOD_N-GLC_1 338 343 PF02516 0.693
MOD_NEK2_1 152 157 PF00069 0.600
MOD_NEK2_1 177 182 PF00069 0.662
MOD_NEK2_1 227 232 PF00069 0.641
MOD_NEK2_1 23 28 PF00069 0.721
MOD_NEK2_1 269 274 PF00069 0.519
MOD_NEK2_1 29 34 PF00069 0.704
MOD_NEK2_1 35 40 PF00069 0.716
MOD_NEK2_1 366 371 PF00069 0.553
MOD_NEK2_2 305 310 PF00069 0.584
MOD_PIKK_1 72 78 PF00454 0.728
MOD_PKA_1 464 470 PF00069 0.751
MOD_PKA_2 104 110 PF00069 0.744
MOD_PKA_2 167 173 PF00069 0.571
MOD_PKA_2 305 311 PF00069 0.601
MOD_PKA_2 36 42 PF00069 0.775
MOD_PKA_2 442 448 PF00069 0.655
MOD_PKA_2 464 470 PF00069 0.681
MOD_Plk_1 118 124 PF00069 0.587
MOD_Plk_1 198 204 PF00069 0.619
MOD_Plk_1 253 259 PF00069 0.518
MOD_Plk_2-3 442 448 PF00069 0.717
MOD_Plk_4 172 178 PF00069 0.711
MOD_Plk_4 29 35 PF00069 0.718
MOD_Plk_4 36 42 PF00069 0.717
MOD_Plk_4 366 372 PF00069 0.616
MOD_Plk_4 451 457 PF00069 0.736
MOD_Plk_4 94 100 PF00069 0.756
MOD_ProDKin_1 170 176 PF00069 0.703
MOD_ProDKin_1 258 264 PF00069 0.648
MOD_ProDKin_1 69 75 PF00069 0.763
MOD_SUMO_rev_2 308 314 PF00179 0.490
TRG_DiLeu_BaEn_1 119 124 PF01217 0.602
TRG_DiLeu_LyEn_5 119 124 PF01217 0.626
TRG_ER_diArg_1 462 465 PF00400 0.726
TRG_ER_diArg_1 468 471 PF00400 0.703
TRG_Pf-PMV_PEXEL_1 141 145 PF00026 0.566
TRG_Pf-PMV_PEXEL_1 307 311 PF00026 0.554

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IK83 Leptomonas seymouri 43% 100%
A0A1X0NFI1 Trypanosomatidae 31% 100%
A0A3S5H6A2 Leishmania donovani 91% 94%
A0A422NFT6 Trypanosoma rangeli 31% 100%
A4HC43 Leishmania braziliensis 73% 94%
C9ZPG3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
E9AG89 Leishmania infantum 91% 100%
E9AMJ3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 94%
V5AUD8 Trypanosoma cruzi 31% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS