WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QI35_LEIMA

TriTrypDb:

LmjF.09.0005 , LMJLV39_090005100 , LMJSD75_090005100

Length:

373

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	11
GO:0030684	preribosome	3	2
GO:0030687	preribosome, large subunit precursor	4	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

Q4QI35

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QI35

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	11
GO:0022613	ribonucleoprotein complex biogenesis	4	11
GO:0042273	ribosomal large subunit biogenesis	5	11
GO:0044085	cellular component biogenesis	3	11
GO:0071840	cellular component organization or biogenesis	2	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	336	340	PF00656	0.649
CLV_NRD_NRD_1	127	129	PF00675	0.422
CLV_NRD_NRD_1	200	202	PF00675	0.434
CLV_NRD_NRD_1	218	220	PF00675	0.412
CLV_NRD_NRD_1	246	248	PF00675	0.464
CLV_NRD_NRD_1	281	283	PF00675	0.406
CLV_NRD_NRD_1	33	35	PF00675	0.416
CLV_NRD_NRD_1	366	368	PF00675	0.701
CLV_NRD_NRD_1	370	372	PF00675	0.660
CLV_PCSK_KEX2_1	200	202	PF00082	0.434
CLV_PCSK_KEX2_1	218	220	PF00082	0.412
CLV_PCSK_KEX2_1	246	248	PF00082	0.464
CLV_PCSK_KEX2_1	35	37	PF00082	0.402
CLV_PCSK_KEX2_1	366	368	PF00082	0.659
CLV_PCSK_PC1ET2_1	35	37	PF00082	0.379
CLV_PCSK_PC7_1	196	202	PF00082	0.410
CLV_PCSK_PC7_1	214	220	PF00082	0.448
DEG_SPOP_SBC_1	52	56	PF00917	0.439
DEG_SPOP_SBC_1	69	73	PF00917	0.320
DOC_CYCLIN_yCln2_LP_2	167	173	PF00134	0.407
DOC_MAPK_gen_1	160	169	PF00069	0.425
DOC_MAPK_gen_1	301	309	PF00069	0.373
DOC_MAPK_MEF2A_6	163	171	PF00069	0.534
DOC_MAPK_MEF2A_6	293	300	PF00069	0.495
DOC_PP2B_LxvP_1	167	170	PF13499	0.438
DOC_USP7_MATH_1	148	152	PF00917	0.350
DOC_USP7_MATH_1	52	56	PF00917	0.472
DOC_USP7_UBL2_3	329	333	PF12436	0.554
DOC_USP7_UBL2_3	368	372	PF12436	0.676
LIG_14-3-3_CanoR_1	218	224	PF00244	0.392
LIG_Actin_WH2_2	10	28	PF00022	0.517
LIG_BRCT_BRCA1_1	111	115	PF00533	0.530
LIG_BRCT_BRCA1_1	49	53	PF00533	0.474
LIG_FHA_1	219	225	PF00498	0.433
LIG_FHA_1	289	295	PF00498	0.398
LIG_FHA_1	46	52	PF00498	0.391
LIG_FHA_1	7	13	PF00498	0.362
LIG_FHA_2	276	282	PF00498	0.493
LIG_FHA_2	3	9	PF00498	0.356
LIG_FHA_2	334	340	PF00498	0.590
LIG_FHA_2	359	365	PF00498	0.610
LIG_IBAR_NPY_1	182	184	PF08397	0.495
LIG_LIR_Gen_1	190	198	PF02991	0.356
LIG_LIR_Gen_1	339	349	PF02991	0.516
LIG_LIR_Nem_3	168	174	PF02991	0.395
LIG_LIR_Nem_3	190	195	PF02991	0.349
LIG_SH2_CRK	192	196	PF00017	0.352
LIG_SH2_CRK	287	291	PF00017	0.390
LIG_SH2_NCK_1	145	149	PF00017	0.450
LIG_SH2_STAT3	299	302	PF00017	0.395
LIG_SH2_STAT5	184	187	PF00017	0.385
LIG_SH2_STAT5	299	302	PF00017	0.437
LIG_SH2_STAT5	68	71	PF00017	0.479
LIG_SH3_3	166	172	PF00018	0.463
LIG_SUMO_SIM_par_1	58	64	PF11976	0.369
LIG_SUMO_SIM_par_1	92	97	PF11976	0.452
LIG_TRAF2_1	151	154	PF00917	0.548
LIG_TRAF2_1	206	209	PF00917	0.433
LIG_TYR_ITSM	188	195	PF00017	0.350
MOD_CK1_1	103	109	PF00069	0.474
MOD_CK1_1	113	119	PF00069	0.509
MOD_CK1_1	18	24	PF00069	0.462
MOD_CK1_1	46	52	PF00069	0.408
MOD_CK2_1	148	154	PF00069	0.490
MOD_CK2_1	25	31	PF00069	0.427
MOD_CK2_1	358	364	PF00069	0.574
MOD_GlcNHglycan	115	118	PF01048	0.554
MOD_GlcNHglycan	20	23	PF01048	0.555
MOD_GlcNHglycan	235	239	PF01048	0.366
MOD_GlcNHglycan	322	325	PF01048	0.556
MOD_GSK3_1	100	107	PF00069	0.454
MOD_GSK3_1	109	116	PF00069	0.483
MOD_GSK3_1	17	24	PF00069	0.395
MOD_GSK3_1	2	9	PF00069	0.353
MOD_GSK3_1	43	50	PF00069	0.511
MOD_NEK2_1	109	114	PF00069	0.491
MOD_NEK2_1	242	247	PF00069	0.400
MOD_NEK2_1	25	30	PF00069	0.428
MOD_NEK2_1	275	280	PF00069	0.475
MOD_NEK2_1	294	299	PF00069	0.218
MOD_NEK2_1	53	58	PF00069	0.381
MOD_NEK2_2	100	105	PF00069	0.430
MOD_NEK2_2	258	263	PF00069	0.390
MOD_PKA_1	218	224	PF00069	0.392
MOD_PKA_2	199	205	PF00069	0.443
MOD_PKA_2	218	224	PF00069	0.392
MOD_Plk_1	100	106	PF00069	0.423
MOD_Plk_4	100	106	PF00069	0.425
MOD_Plk_4	219	225	PF00069	0.380
MOD_Plk_4	294	300	PF00069	0.376
MOD_Plk_4	58	64	PF00069	0.351
MOD_Plk_4	84	90	PF00069	0.414
MOD_SUMO_rev_2	350	357	PF00179	0.680
TRG_ENDOCYTIC_2	192	195	PF00928	0.356
TRG_ER_diArg_1	218	220	PF00400	0.415

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9A9	Leptomonas seymouri	79%	100%
A0A1X0NMW6	Trypanosomatidae	68%	100%
A0A3S7WQG6	Leishmania donovani	92%	100%
A0A422NE17	Trypanosoma rangeli	66%	100%
A4H5H7	Leishmania braziliensis	86%	100%
A4HTR8	Leishmania infantum	92%	100%
D0A977	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	96%
E9AMK1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O94698	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	96%
Q58D06	Bos taurus	27%	97%
Q6CEC9	Yarrowia lipolytica (strain CLIB 122 / E 150)	24%	91%
Q6RFH5	Homo sapiens	29%	97%
Q8VCG3	Mus musculus	28%	97%
V5BIB3	Trypanosoma cruzi	63%	100%