Secreted protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Secreted protein

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QI34_LEIMA

TriTrypDb:

LmjF.09.0010 , LMJLV39_090005200 , LMJSD75_090005200

Length:

167

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QI34

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QI34

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	129	131	PF00675	0.596
CLV_NRD_NRD_1	58	60	PF00675	0.317
CLV_PCSK_FUR_1	127	131	PF00082	0.525
CLV_PCSK_KEX2_1	129	131	PF00082	0.534
CLV_PCSK_PC7_1	125	131	PF00082	0.521
CLV_PCSK_SKI1_1	52	56	PF00082	0.323
DEG_Nend_Nbox_1	1	3	PF02207	0.337
DOC_CDC14_PxL_1	42	50	PF14671	0.528
DOC_CYCLIN_yCln2_LP_2	20	26	PF00134	0.173
DOC_MAPK_MEF2A_6	43	50	PF00069	0.558
DOC_MAPK_RevD_3	46	60	PF00069	0.521
DOC_PP2B_LxvP_1	48	51	PF13499	0.532
DOC_PP2B_LxvP_1	69	72	PF13499	0.501
DOC_USP7_MATH_1	8	12	PF00917	0.321
DOC_WW_Pin1_4	19	24	PF00397	0.155
DOC_WW_Pin1_4	4	9	PF00397	0.326
LIG_14-3-3_CanoR_1	108	116	PF00244	0.333
LIG_14-3-3_CanoR_1	59	69	PF00244	0.673
LIG_14-3-3_CanoR_1	86	94	PF00244	0.365
LIG_Actin_WH2_2	20	35	PF00022	0.402
LIG_Actin_WH2_2	92	110	PF00022	0.173
LIG_EH_1	120	124	PF12763	0.318
LIG_FHA_1	64	70	PF00498	0.518
LIG_FHA_2	159	165	PF00498	0.356
LIG_LIR_Apic_2	115	119	PF02991	0.319
LIG_LIR_Gen_1	120	131	PF02991	0.319
LIG_LIR_Nem_3	110	116	PF02991	0.317
LIG_LIR_Nem_3	120	126	PF02991	0.315
LIG_LIR_Nem_3	155	160	PF02991	0.344
LIG_LIR_Nem_3	4	9	PF02991	0.328
LIG_Pex14_2	136	140	PF04695	0.326
LIG_SH2_STAT5	113	116	PF00017	0.330
LIG_SH2_STAT5	160	163	PF00017	0.323
LIG_SH3_1	116	122	PF00018	0.315
LIG_SH3_3	116	122	PF00018	0.315
LIG_SH3_3	69	75	PF00018	0.498
LIG_TYR_ITIM	102	107	PF00017	0.295
LIG_UBA3_1	54	60	PF00899	0.521
MOD_CK1_1	35	41	PF00069	0.531
MOD_CK1_1	4	10	PF00069	0.323
MOD_CK1_1	63	69	PF00069	0.567
MOD_CK2_1	158	164	PF00069	0.392
MOD_GSK3_1	32	39	PF00069	0.530
MOD_GSK3_1	4	11	PF00069	0.330
MOD_LATS_1	58	64	PF00433	0.519
MOD_N-GLC_1	77	82	PF02516	0.292
MOD_NEK2_1	1	6	PF00069	0.332
MOD_NEK2_1	107	112	PF00069	0.289
MOD_NEK2_1	32	37	PF00069	0.560
MOD_NEK2_1	76	81	PF00069	0.579
MOD_NEK2_1	85	90	PF00069	0.370
MOD_PKA_2	107	113	PF00069	0.329
MOD_PKA_2	85	91	PF00069	0.365
MOD_Plk_1	77	83	PF00069	0.493
MOD_Plk_4	1	7	PF00069	0.329
MOD_Plk_4	32	38	PF00069	0.562
MOD_Plk_4	9	15	PF00069	0.165
MOD_ProDKin_1	19	25	PF00069	0.155
MOD_ProDKin_1	4	10	PF00069	0.323
TRG_ENDOCYTIC_2	104	107	PF00928	0.258
TRG_ENDOCYTIC_2	3	6	PF00928	0.329
TRG_ER_diArg_1	126	129	PF00400	0.328
TRG_Pf-PMV_PEXEL_1	43	47	PF00026	0.326

Homologs


Protein	Taxonomy	Sequence identity	Coverage
D0A978	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	100%