JmjC domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QI33_LEIMA

TriTrypDb:

LmjF.09.0020 , LMJLV39_090005400 , LMJSD75_090005400

Length:

619

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QI33

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QI33

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	3
GO:0006396	RNA processing	6	3
GO:0006397	mRNA processing	7	3
GO:0006725	cellular aromatic compound metabolic process	3	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0009987	cellular process	1	3
GO:0016070	RNA metabolic process	5	3
GO:0016071	mRNA metabolic process	6	3
GO:0031123	RNA 3'-end processing	7	3
GO:0031124	mRNA 3'-end processing	8	3
GO:0034641	cellular nitrogen compound metabolic process	3	3
GO:0043170	macromolecule metabolic process	3	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0046483	heterocycle metabolic process	3	3
GO:0071704	organic substance metabolic process	2	3
GO:0090304	nucleic acid metabolic process	4	3
GO:1901360	organic cyclic compound metabolic process	3	3

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	248	252	PF00656	0.577
CLV_NRD_NRD_1	117	119	PF00675	0.578
CLV_NRD_NRD_1	189	191	PF00675	0.378
CLV_NRD_NRD_1	226	228	PF00675	0.537
CLV_NRD_NRD_1	278	280	PF00675	0.524
CLV_NRD_NRD_1	414	416	PF00675	0.454
CLV_NRD_NRD_1	567	569	PF00675	0.714
CLV_NRD_NRD_1	93	95	PF00675	0.529
CLV_PCSK_KEX2_1	117	119	PF00082	0.551
CLV_PCSK_KEX2_1	189	191	PF00082	0.378
CLV_PCSK_KEX2_1	278	280	PF00082	0.511
CLV_PCSK_KEX2_1	413	415	PF00082	0.461
CLV_PCSK_KEX2_1	479	481	PF00082	0.759
CLV_PCSK_KEX2_1	567	569	PF00082	0.685
CLV_PCSK_KEX2_1	580	582	PF00082	0.539
CLV_PCSK_PC1ET2_1	413	415	PF00082	0.536
CLV_PCSK_PC1ET2_1	479	481	PF00082	0.771
CLV_PCSK_PC1ET2_1	580	582	PF00082	0.682
CLV_PCSK_SKI1_1	12	16	PF00082	0.447
CLV_PCSK_SKI1_1	149	153	PF00082	0.537
CLV_PCSK_SKI1_1	18	22	PF00082	0.415
CLV_PCSK_SKI1_1	368	372	PF00082	0.487
CLV_PCSK_SKI1_1	410	414	PF00082	0.522
CLV_PCSK_SKI1_1	548	552	PF00082	0.602
CLV_PCSK_SKI1_1	603	607	PF00082	0.688
DEG_Nend_UBRbox_2	1	3	PF02207	0.560
DOC_CYCLIN_yCln2_LP_2	76	82	PF00134	0.513
DOC_MAPK_gen_1	278	286	PF00069	0.533
DOC_MAPK_gen_1	567	576	PF00069	0.703
DOC_MAPK_JIP1_4	570	576	PF00069	0.545
DOC_MAPK_MEF2A_6	18	25	PF00069	0.334
DOC_MAPK_MEF2A_6	399	408	PF00069	0.566
DOC_MAPK_MEF2A_6	567	576	PF00069	0.664
DOC_MAPK_NFAT4_5	18	26	PF00069	0.340
DOC_PP2B_LxvP_1	102	105	PF13499	0.376
DOC_PP2B_LxvP_1	76	79	PF13499	0.522
DOC_PP4_FxxP_1	497	500	PF00568	0.649
DOC_USP7_MATH_1	236	240	PF00917	0.417
DOC_USP7_MATH_1	296	300	PF00917	0.531
DOC_USP7_MATH_1	489	493	PF00917	0.632
DOC_USP7_UBL2_3	330	334	PF12436	0.536
DOC_WW_Pin1_4	343	348	PF00397	0.504
DOC_WW_Pin1_4	460	465	PF00397	0.636
DOC_WW_Pin1_4	485	490	PF00397	0.630
LIG_14-3-3_CanoR_1	227	231	PF00244	0.525
LIG_14-3-3_CanoR_1	295	301	PF00244	0.576
LIG_14-3-3_CanoR_1	423	428	PF00244	0.536
LIG_14-3-3_CanoR_1	546	551	PF00244	0.493
LIG_14-3-3_CanoR_1	581	586	PF00244	0.576
LIG_14-3-3_CanoR_1	9	19	PF00244	0.476
LIG_14-3-3_CanoR_1	94	98	PF00244	0.542
LIG_Actin_WH2_2	282	300	PF00022	0.552
LIG_Clathr_ClatBox_1	397	401	PF01394	0.481
LIG_CtBP_PxDLS_1	571	575	PF00389	0.655
LIG_deltaCOP1_diTrp_1	205	215	PF00928	0.373
LIG_deltaCOP1_diTrp_1	311	318	PF00928	0.395
LIG_deltaCOP1_diTrp_1	43	51	PF00928	0.380
LIG_deltaCOP1_diTrp_1	490	497	PF00928	0.649
LIG_FHA_1	269	275	PF00498	0.561
LIG_FHA_1	577	583	PF00498	0.657
LIG_FHA_1	58	64	PF00498	0.468
LIG_FHA_2	153	159	PF00498	0.531
LIG_FHA_2	424	430	PF00498	0.566
LIG_FHA_2	486	492	PF00498	0.730
LIG_FHA_2	593	599	PF00498	0.567
LIG_FHA_2	602	608	PF00498	0.584
LIG_LIR_Apic_2	495	500	PF02991	0.706
LIG_LIR_Gen_1	148	156	PF02991	0.512
LIG_LIR_Gen_1	168	178	PF02991	0.475
LIG_LIR_Gen_1	393	400	PF02991	0.407
LIG_LIR_Gen_1	443	453	PF02991	0.518
LIG_LIR_Nem_3	148	153	PF02991	0.472
LIG_LIR_Nem_3	206	212	PF02991	0.398
LIG_LIR_Nem_3	311	315	PF02991	0.399
LIG_LIR_Nem_3	393	397	PF02991	0.404
LIG_LIR_Nem_3	43	48	PF02991	0.371
LIG_LIR_Nem_3	443	449	PF02991	0.456
LIG_LIR_Nem_3	462	468	PF02991	0.581
LIG_LIR_Nem_3	491	497	PF02991	0.596
LIG_PCNA_yPIPBox_3	414	428	PF02747	0.577
LIG_PCNA_yPIPBox_3	430	441	PF02747	0.635
LIG_Pex14_1	109	113	PF04695	0.503
LIG_Pex14_1	146	150	PF04695	0.410
LIG_Pex14_1	166	170	PF04695	0.435
LIG_Pex14_1	45	49	PF04695	0.379
LIG_Pex14_2	6	10	PF04695	0.547
LIG_SH2_CRK	360	364	PF00017	0.542
LIG_SH2_STAT3	373	376	PF00017	0.561
LIG_SH2_STAT5	41	44	PF00017	0.380
LIG_SH2_STAT5	436	439	PF00017	0.484
LIG_SH2_STAT5	48	51	PF00017	0.341
LIG_SH3_3	493	499	PF00018	0.653
LIG_SUMO_SIM_par_1	19	24	PF11976	0.553
LIG_SUMO_SIM_par_1	30	38	PF11976	0.500
LIG_SUMO_SIM_par_1	592	598	PF11976	0.678
LIG_TRAF2_1	280	283	PF00917	0.592
LIG_TRAF2_1	459	462	PF00917	0.641
LIG_TRAF2_1	506	509	PF00917	0.760
LIG_UBA3_1	403	410	PF00899	0.476
LIG_WRC_WIRS_1	424	429	PF05994	0.544
LIG_WW_3	469	473	PF00397	0.748
MOD_CK1_1	13	19	PF00069	0.412
MOD_CK1_1	257	263	PF00069	0.665
MOD_CK1_1	393	399	PF00069	0.520
MOD_CK1_1	90	96	PF00069	0.532
MOD_CK2_1	127	133	PF00069	0.528
MOD_CK2_1	152	158	PF00069	0.593
MOD_CK2_1	423	429	PF00069	0.463
MOD_CK2_1	456	462	PF00069	0.615
MOD_CK2_1	489	495	PF00069	0.645
MOD_CK2_1	503	509	PF00069	0.647
MOD_CK2_1	592	598	PF00069	0.564
MOD_CK2_1	601	607	PF00069	0.581
MOD_CK2_1	93	99	PF00069	0.478
MOD_GlcNHglycan	12	15	PF01048	0.403
MOD_GlcNHglycan	258	262	PF01048	0.715
MOD_GlcNHglycan	263	266	PF01048	0.708
MOD_GlcNHglycan	268	271	PF01048	0.613
MOD_GlcNHglycan	585	588	PF01048	0.600
MOD_GlcNHglycan	76	79	PF01048	0.390
MOD_GSK3_1	135	142	PF00069	0.502
MOD_GSK3_1	19	26	PF00069	0.539
MOD_GSK3_1	256	263	PF00069	0.670
MOD_GSK3_1	456	463	PF00069	0.653
MOD_GSK3_1	485	492	PF00069	0.648
MOD_GSK3_1	499	506	PF00069	0.624
MOD_GSK3_1	542	549	PF00069	0.708
MOD_GSK3_1	572	579	PF00069	0.647
MOD_GSK3_1	611	618	PF00069	0.660
MOD_N-GLC_1	572	577	PF02516	0.593
MOD_NEK2_1	100	105	PF00069	0.479
MOD_NEK2_1	177	182	PF00069	0.475
MOD_NEK2_1	268	273	PF00069	0.603
MOD_NEK2_1	31	36	PF00069	0.432
MOD_NEK2_1	404	409	PF00069	0.551
MOD_NEK2_1	601	606	PF00069	0.612
MOD_PIKK_1	197	203	PF00454	0.349
MOD_PIKK_1	313	319	PF00454	0.532
MOD_PIKK_1	489	495	PF00454	0.724
MOD_PK_1	581	587	PF00069	0.646
MOD_PKA_1	117	123	PF00069	0.608
MOD_PKA_2	117	123	PF00069	0.617
MOD_PKA_2	226	232	PF00069	0.526
MOD_PKA_2	422	428	PF00069	0.530
MOD_PKA_2	93	99	PF00069	0.419
MOD_PKB_1	546	554	PF00069	0.657
MOD_Plk_1	204	210	PF00069	0.509
MOD_Plk_1	439	445	PF00069	0.593
MOD_Plk_1	489	495	PF00069	0.680
MOD_Plk_1	572	578	PF00069	0.563
MOD_Plk_1	601	607	PF00069	0.706
MOD_Plk_2-3	154	160	PF00069	0.441
MOD_Plk_2-3	456	462	PF00069	0.652
MOD_Plk_4	31	37	PF00069	0.452
MOD_Plk_4	393	399	PF00069	0.439
MOD_Plk_4	423	429	PF00069	0.432
MOD_Plk_4	93	99	PF00069	0.506
MOD_ProDKin_1	343	349	PF00069	0.501
MOD_ProDKin_1	460	466	PF00069	0.642
MOD_ProDKin_1	485	491	PF00069	0.629
MOD_SUMO_rev_2	322	332	PF00179	0.504
TRG_DiLeu_BaEn_2	26	32	PF01217	0.446
TRG_ENDOCYTIC_2	150	153	PF00928	0.542
TRG_ENDOCYTIC_2	360	363	PF00928	0.479
TRG_ENDOCYTIC_2	48	51	PF00928	0.491
TRG_ER_diArg_1	116	118	PF00400	0.562
TRG_ER_diArg_1	188	190	PF00400	0.383
TRG_ER_diArg_1	566	568	PF00400	0.714
TRG_NES_CRM1_1	520	532	PF08389	0.673
TRG_Pf-PMV_PEXEL_1	603	607	PF00026	0.664
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.455

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9R7	Leptomonas seymouri	63%	99%
A0A0S4IQN5	Bodo saltans	28%	100%
A0A1X0NMW7	Trypanosomatidae	34%	98%
A0A3S7WQJ2	Leishmania donovani	94%	100%
A0A422NEC5	Trypanosoma rangeli	35%	99%
A4H5H9	Leishmania braziliensis	85%	93%
A4HTS0	Leishmania infantum	94%	100%
D0A979	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	97%
E9AMK3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BN50	Trypanosoma cruzi	36%	100%