Peroxisomal biogenesis factor 11

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Peroxisomal biogenesis factor 11 (PEX11), putative

Species:

Leishmania major

UniProt:

Q4QI32_LEIMA

TriTrypDb:

LmjF.09.0030 , LMJLV39_090005500 , LMJSD75_090005500

Length:

321

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005778	peroxisomal membrane	6	2
GO:0016020	membrane	2	2
GO:0031090	organelle membrane	3	2
GO:0031903	microbody membrane	5	2
GO:0042579	microbody	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0098588	bounding membrane of organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QI32

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QI32

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0016559	peroxisome fission	6	11
GO:0032535	regulation of cellular component size	4	2
GO:0044375	regulation of peroxisome size	5	2
GO:0048285	organelle fission	5	11
GO:0065007	biological regulation	1	2
GO:0065008	regulation of biological quality	2	2
GO:0071840	cellular component organization or biogenesis	2	11
GO:0090066	regulation of anatomical structure size	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	224	226	PF00675	0.330
CLV_NRD_NRD_1	85	87	PF00675	0.328
CLV_PCSK_KEX2_1	224	226	PF00082	0.329
CLV_PCSK_KEX2_1	85	87	PF00082	0.328
CLV_PCSK_SKI1_1	136	140	PF00082	0.430
CLV_PCSK_SKI1_1	142	146	PF00082	0.366
CLV_PCSK_SKI1_1	154	158	PF00082	0.185
CLV_PCSK_SKI1_1	280	284	PF00082	0.328
CLV_PCSK_SKI1_1	30	34	PF00082	0.335
CLV_PCSK_SKI1_1	41	45	PF00082	0.344
CLV_PCSK_SKI1_1	85	89	PF00082	0.341
DEG_APCC_DBOX_1	170	178	PF00400	0.413
DEG_APCC_DBOX_1	38	46	PF00400	0.344
DEG_MDM2_SWIB_1	269	276	PF02201	0.328
DOC_CYCLIN_RxL_1	133	143	PF00134	0.413
DOC_CYCLIN_RxL_1	26	35	PF00134	0.328
DOC_MAPK_DCC_7	171	179	PF00069	0.385
DOC_MAPK_gen_1	73	81	PF00069	0.449
DOC_MAPK_MEF2A_6	106	115	PF00069	0.353
DOC_MAPK_MEF2A_6	171	179	PF00069	0.328
DOC_MAPK_MEF2A_6	280	289	PF00069	0.328
DOC_PP1_RVXF_1	134	141	PF00149	0.449
DOC_PP1_RVXF_1	51	57	PF00149	0.449
DOC_USP7_MATH_1	197	201	PF00917	0.398
DOC_USP7_MATH_2	67	73	PF00917	0.444
DOC_USP7_UBL2_3	222	226	PF12436	0.428
DOC_USP7_UBL2_3	237	241	PF12436	0.145
LIG_14-3-3_CanoR_1	315	320	PF00244	0.517
LIG_14-3-3_CanoR_1	99	105	PF00244	0.328
LIG_BRCT_BRCA1_1	57	61	PF00533	0.413
LIG_EH_1	17	21	PF12763	0.608
LIG_FHA_1	176	182	PF00498	0.354
LIG_FHA_1	183	189	PF00498	0.317
LIG_FHA_1	301	307	PF00498	0.478
LIG_FHA_2	228	234	PF00498	0.468
LIG_FHA_2	248	254	PF00498	0.476
LIG_FHA_2	265	271	PF00498	0.436
LIG_GBD_Chelix_1	121	129	PF00786	0.363
LIG_LIR_Gen_1	209	217	PF02991	0.329
LIG_LIR_Gen_1	259	269	PF02991	0.330
LIG_LIR_Gen_1	270	281	PF02991	0.325
LIG_LIR_Gen_1	284	292	PF02991	0.328
LIG_LIR_Gen_1	69	79	PF02991	0.384
LIG_LIR_Gen_1	96	105	PF02991	0.344
LIG_LIR_Nem_3	109	115	PF02991	0.333
LIG_LIR_Nem_3	209	214	PF02991	0.317
LIG_LIR_Nem_3	215	220	PF02991	0.312
LIG_LIR_Nem_3	259	264	PF02991	0.330
LIG_LIR_Nem_3	270	276	PF02991	0.325
LIG_LIR_Nem_3	284	289	PF02991	0.328
LIG_LIR_Nem_3	40	46	PF02991	0.243
LIG_NRBOX	28	34	PF00104	0.363
LIG_PCNA_PIPBox_1	87	96	PF02747	0.449
LIG_Pex14_1	120	124	PF04695	0.344
LIG_Pex14_2	140	144	PF04695	0.359
LIG_Pex14_2	269	273	PF04695	0.331
LIG_Pex14_2	93	97	PF04695	0.344
LIG_SH2_CRK	189	193	PF00017	0.449
LIG_SH2_CRK	261	265	PF00017	0.349
LIG_SH2_NCK_1	217	221	PF00017	0.328
LIG_SH2_PTP2	112	115	PF00017	0.340
LIG_SH2_SRC	112	115	PF00017	0.321
LIG_SH2_SRC	257	260	PF00017	0.457
LIG_SH2_SRC	65	68	PF00017	0.363
LIG_SH2_STAP1	261	265	PF00017	0.413
LIG_SH2_STAT5	112	115	PF00017	0.292
LIG_SH2_STAT5	167	170	PF00017	0.443
LIG_SH2_STAT5	257	260	PF00017	0.413
LIG_SH2_STAT5	48	51	PF00017	0.342
LIG_SH2_STAT5	65	68	PF00017	0.271
LIG_SH3_3	108	114	PF00018	0.344
LIG_SUMO_SIM_par_1	175	180	PF11976	0.359
LIG_TRAF2_1	231	234	PF00917	0.478
LIG_TYR_ITIM	110	115	PF00017	0.340
LIG_WRC_WIRS_1	141	146	PF05994	0.359
MOD_CK1_1	207	213	PF00069	0.340
MOD_CK2_1	140	146	PF00069	0.328
MOD_CK2_1	197	203	PF00069	0.396
MOD_CK2_1	227	233	PF00069	0.473
MOD_CK2_1	247	253	PF00069	0.376
MOD_CK2_1	264	270	PF00069	0.355
MOD_CK2_1	69	75	PF00069	0.330
MOD_GlcNHglycan	194	198	PF01048	0.470
MOD_GlcNHglycan	289	292	PF01048	0.466
MOD_GlcNHglycan	307	310	PF01048	0.164
MOD_GSK3_1	193	200	PF00069	0.437
MOD_GSK3_1	305	312	PF00069	0.326
MOD_GSK3_1	77	84	PF00069	0.355
MOD_N-GLC_1	247	252	PF02516	0.483
MOD_N-GLC_1	69	74	PF02516	0.398
MOD_NEK2_1	100	105	PF00069	0.328
MOD_NEK2_1	140	145	PF00069	0.391
MOD_NEK2_1	156	161	PF00069	0.226
MOD_NEK2_1	182	187	PF00069	0.351
MOD_NEK2_1	193	198	PF00069	0.344
MOD_NEK2_1	32	37	PF00069	0.344
MOD_NEK2_2	309	314	PF00069	0.328
MOD_PKA_2	100	106	PF00069	0.344
MOD_Plk_1	69	75	PF00069	0.385
MOD_Plk_4	100	106	PF00069	0.328
MOD_Plk_4	140	146	PF00069	0.449
MOD_Plk_4	309	315	PF00069	0.328
MOD_Plk_4	77	83	PF00069	0.361
MOD_SUMO_rev_2	229	236	PF00179	0.449
TRG_AP2beta_CARGO_1	284	293	PF09066	0.449
TRG_DiLeu_BaEn_1	278	283	PF01217	0.328
TRG_DiLeu_BaEn_2	145	151	PF01217	0.344
TRG_DiLeu_BaLyEn_6	161	166	PF01217	0.413
TRG_ENDOCYTIC_2	112	115	PF00928	0.340
TRG_ENDOCYTIC_2	189	192	PF00928	0.449
TRG_ENDOCYTIC_2	217	220	PF00928	0.315
TRG_ENDOCYTIC_2	261	264	PF00928	0.320
TRG_ER_diArg_1	223	225	PF00400	0.328
TRG_ER_diArg_1	50	53	PF00400	0.413
TRG_ER_diArg_1	85	87	PF00400	0.328
TRG_ER_diArg_1	98	101	PF00400	0.328
TRG_Pf-PMV_PEXEL_1	30	34	PF00026	0.357

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHS3	Leptomonas seymouri	82%	100%
A0A0S4JT81	Bodo saltans	46%	84%
A0A1X0NNH2	Trypanosomatidae	68%	100%
A0A3S5H6A5	Leishmania donovani	97%	100%
A0A422NE20	Trypanosoma rangeli	66%	100%
A4H5I0	Leishmania braziliensis	92%	85%
A4HTS1	Leishmania infantum	97%	100%
D0A980	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9AMK4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5B2S3	Trypanosoma cruzi	65%	100%