Calmodulin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Calmodulin

Gene product:

flagellar pocket cytoskeletal protein bilbo1

Species:

Leishmania major

UniProt:

Q4QI25_LEIMA

TriTrypDb:

LmjF.09.0100 , LMJLV39_090006200 , LMJSD75_090006200

Length:

582

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	yes	yes: 4
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QI25

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QI25

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0030030	cell projection organization	4	2
GO:0044782	cilium organization	5	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0120036	plasma membrane bounded cell projection organization	5	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	14
GO:0005509	calcium ion binding	5	14
GO:0043167	ion binding	2	14
GO:0043169	cation binding	3	14
GO:0046872	metal ion binding	4	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	292	296	PF00656	0.672
CLV_C14_Caspase3-7	375	379	PF00656	0.522
CLV_C14_Caspase3-7	45	49	PF00656	0.655
CLV_C14_Caspase3-7	473	477	PF00656	0.709
CLV_C14_Caspase3-7	543	547	PF00656	0.517
CLV_NRD_NRD_1	152	154	PF00675	0.705
CLV_NRD_NRD_1	261	263	PF00675	0.533
CLV_NRD_NRD_1	324	326	PF00675	0.646
CLV_NRD_NRD_1	352	354	PF00675	0.529
CLV_NRD_NRD_1	368	370	PF00675	0.581
CLV_NRD_NRD_1	474	476	PF00675	0.506
CLV_NRD_NRD_1	521	523	PF00675	0.549
CLV_PCSK_KEX2_1	152	154	PF00082	0.705
CLV_PCSK_KEX2_1	368	370	PF00082	0.588
CLV_PCSK_KEX2_1	395	397	PF00082	0.605
CLV_PCSK_KEX2_1	474	476	PF00082	0.506
CLV_PCSK_KEX2_1	521	523	PF00082	0.626
CLV_PCSK_PC1ET2_1	395	397	PF00082	0.616
CLV_PCSK_SKI1_1	117	121	PF00082	0.844
CLV_PCSK_SKI1_1	179	183	PF00082	0.368
CLV_PCSK_SKI1_1	508	512	PF00082	0.571
DEG_APCC_DBOX_1	23	31	PF00400	0.588
DEG_APCC_DBOX_1	352	360	PF00400	0.539
DEG_Nend_Nbox_1	1	3	PF02207	0.475
DEG_SCF_FBW7_1	121	128	PF00400	0.804
DEG_SPOP_SBC_1	131	135	PF00917	0.746
DOC_CYCLIN_yClb1_LxF_4	12	17	PF00134	0.557
DOC_PP1_RVXF_1	12	18	PF00149	0.455
DOC_PP1_RVXF_1	177	183	PF00149	0.359
DOC_USP7_MATH_1	119	123	PF00917	0.755
DOC_USP7_MATH_1	125	129	PF00917	0.649
DOC_USP7_MATH_1	130	134	PF00917	0.722
DOC_USP7_MATH_1	157	161	PF00917	0.729
DOC_USP7_MATH_1	272	276	PF00917	0.614
DOC_USP7_MATH_1	282	286	PF00917	0.550
DOC_USP7_MATH_1	360	364	PF00917	0.578
DOC_USP7_MATH_1	372	376	PF00917	0.569
DOC_USP7_MATH_1	571	575	PF00917	0.666
DOC_USP7_UBL2_3	350	354	PF12436	0.649
DOC_USP7_UBL2_3	488	492	PF12436	0.464
DOC_USP7_UBL2_3	96	100	PF12436	0.607
DOC_WW_Pin1_4	121	126	PF00397	0.782
DOC_WW_Pin1_4	170	175	PF00397	0.688
LIG_14-3-3_CanoR_1	117	122	PF00244	0.734
LIG_14-3-3_CanoR_1	129	138	PF00244	0.795
LIG_14-3-3_CanoR_1	152	156	PF00244	0.652
LIG_14-3-3_CanoR_1	228	232	PF00244	0.433
LIG_14-3-3_CanoR_1	32	38	PF00244	0.600
LIG_APCC_ABBA_1	60	65	PF00400	0.428
LIG_APCC_ABBAyCdc20_2	59	65	PF00400	0.434
LIG_BRCT_BRCA1_1	251	255	PF00533	0.428
LIG_FHA_1	110	116	PF00498	0.816
LIG_FHA_1	160	166	PF00498	0.786
LIG_FHA_1	188	194	PF00498	0.399
LIG_FHA_1	243	249	PF00498	0.397
LIG_FHA_1	52	58	PF00498	0.530
LIG_FHA_2	211	217	PF00498	0.386
LIG_FHA_2	43	49	PF00498	0.545
LIG_FHA_2	526	532	PF00498	0.585
LIG_LIR_Gen_1	230	238	PF02991	0.368
LIG_LIR_Gen_1	68	74	PF02991	0.548
LIG_LIR_Gen_1	80	90	PF02991	0.425
LIG_LIR_Nem_3	230	234	PF02991	0.372
LIG_LIR_Nem_3	235	240	PF02991	0.337
LIG_LIR_Nem_3	68	73	PF02991	0.543
LIG_LIR_Nem_3	80	85	PF02991	0.424
LIG_LYPXL_S_1	240	244	PF13949	0.433
LIG_LYPXL_yS_3	241	244	PF13949	0.415
LIG_Pex14_2	17	21	PF04695	0.441
LIG_Pex14_2	198	202	PF04695	0.433
LIG_RPA_C_Fungi	481	493	PF08784	0.589
LIG_SH2_CRK	82	86	PF00017	0.477
LIG_SH2_STAT3	86	89	PF00017	0.418
LIG_SH2_STAT5	141	144	PF00017	0.738
LIG_SH2_STAT5	249	252	PF00017	0.483
LIG_SH2_STAT5	562	565	PF00017	0.673
LIG_SH2_STAT5	82	85	PF00017	0.471
LIG_SH3_3	19	25	PF00018	0.477
LIG_SH3_3	87	93	PF00018	0.522
LIG_SH3_3	98	104	PF00018	0.572
LIG_Sin3_3	370	377	PF02671	0.669
LIG_SUMO_SIM_par_1	190	197	PF11976	0.402
LIG_TRAF2_1	173	176	PF00917	0.535
LIG_TRAF2_1	26	29	PF00917	0.498
MOD_CDK_SPxxK_3	170	177	PF00069	0.667
MOD_CK1_1	210	216	PF00069	0.374
MOD_CK1_1	23	29	PF00069	0.561
MOD_CK1_1	275	281	PF00069	0.606
MOD_CK1_1	36	42	PF00069	0.502
MOD_CK1_1	557	563	PF00069	0.544
MOD_CK2_1	165	171	PF00069	0.718
MOD_CK2_1	227	233	PF00069	0.378
MOD_CK2_1	23	29	PF00069	0.512
MOD_CK2_1	264	270	PF00069	0.577
MOD_CK2_1	525	531	PF00069	0.520
MOD_GlcNHglycan	117	120	PF01048	0.746
MOD_GlcNHglycan	125	128	PF01048	0.778
MOD_GlcNHglycan	210	213	PF01048	0.418
MOD_GlcNHglycan	297	300	PF01048	0.587
MOD_GlcNHglycan	35	38	PF01048	0.534
MOD_GlcNHglycan	458	461	PF01048	0.540
MOD_GSK3_1	109	116	PF00069	0.686
MOD_GSK3_1	117	124	PF00069	0.693
MOD_GSK3_1	139	146	PF00069	0.734
MOD_GSK3_1	147	154	PF00069	0.711
MOD_GSK3_1	33	40	PF00069	0.553
MOD_GSK3_1	51	58	PF00069	0.615
MOD_GSK3_1	550	557	PF00069	0.541
MOD_GSK3_1	569	576	PF00069	0.587
MOD_NEK2_1	115	120	PF00069	0.848
MOD_NEK2_1	151	156	PF00069	0.860
MOD_NEK2_1	207	212	PF00069	0.418
MOD_NEK2_1	55	60	PF00069	0.608
MOD_NEK2_2	51	56	PF00069	0.621
MOD_PIKK_1	525	531	PF00454	0.520
MOD_PIKK_1	95	101	PF00454	0.590
MOD_PKA_2	151	157	PF00069	0.701
MOD_PKA_2	227	233	PF00069	0.431
MOD_PKA_2	23	29	PF00069	0.530
MOD_PKA_2	31	37	PF00069	0.556
MOD_PKA_2	360	366	PF00069	0.609
MOD_PKA_2	544	550	PF00069	0.524
MOD_Plk_1	275	281	PF00069	0.644
MOD_Plk_1	28	34	PF00069	0.519
MOD_Plk_1	530	536	PF00069	0.633
MOD_Plk_2-3	264	270	PF00069	0.462
MOD_ProDKin_1	121	127	PF00069	0.782
MOD_ProDKin_1	170	176	PF00069	0.683
MOD_SUMO_for_1	434	437	PF00179	0.647
MOD_SUMO_rev_2	171	178	PF00179	0.508
MOD_SUMO_rev_2	183	190	PF00179	0.345
MOD_SUMO_rev_2	375	384	PF00179	0.588
MOD_SUMO_rev_2	392	397	PF00179	0.616
MOD_SUMO_rev_2	546	556	PF00179	0.537
MOD_SUMO_rev_2	64	68	PF00179	0.556
TRG_ENDOCYTIC_2	231	234	PF00928	0.443
TRG_ENDOCYTIC_2	241	244	PF00928	0.419
TRG_ENDOCYTIC_2	82	85	PF00928	0.478
TRG_ER_diArg_1	151	153	PF00400	0.730
TRG_ER_diArg_1	521	524	PF00400	0.624
TRG_ER_diArg_1	539	542	PF00400	0.375
TRG_Pf-PMV_PEXEL_1	315	320	PF00026	0.520
TRG_Pf-PMV_PEXEL_1	508	512	PF00026	0.558
TRG_Pf-PMV_PEXEL_1	524	529	PF00026	0.420
TRG_Pf-PMV_PEXEL_1	532	536	PF00026	0.479

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II86	Leptomonas seymouri	82%	99%
A0A0S4JFD7	Bodo saltans	33%	95%
A0A0S4JWH7	Bodo saltans	50%	98%
A0A0S4KKB4	Bodo saltans	23%	85%
A0A1X0NMV7	Trypanosomatidae	58%	98%
A0A3S5H6A9	Leishmania donovani	99%	100%
A0A3S7X1F4	Leishmania donovani	24%	100%
A0A422NE50	Trypanosoma rangeli	56%	100%
A4H5I7	Leishmania braziliensis	92%	100%
A4HGH2	Leishmania braziliensis	25%	99%
A4HTS8	Leishmania infantum	98%	100%
A4I3K4	Leishmania infantum	23%	100%
D0A836	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
D0A989	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	99%
E9AML1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9AZU4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
Q4Q8E1	Leishmania major	22%	100%
V5DJB6	Trypanosoma cruzi	57%	90%