Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QI24_LEIMA

TriTrypDb:

LmjF.09.0105 , LMJLV39_090006300 , LMJSD75_090006300

Length:

221

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4QI24

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QI24

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	107	111	PF00656	0.477
CLV_C14_Caspase3-7	88	92	PF00656	0.668
CLV_NRD_NRD_1	131	133	PF00675	0.373
CLV_NRD_NRD_1	204	206	PF00675	0.576
CLV_NRD_NRD_1	209	211	PF00675	0.565
CLV_NRD_NRD_1	22	24	PF00675	0.541
CLV_NRD_NRD_1	68	70	PF00675	0.358
CLV_PCSK_KEX2_1	123	125	PF00082	0.369
CLV_PCSK_KEX2_1	131	133	PF00082	0.326
CLV_PCSK_KEX2_1	206	208	PF00082	0.572
CLV_PCSK_KEX2_1	22	24	PF00082	0.541
CLV_PCSK_KEX2_1	68	70	PF00082	0.352
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.436
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.641
CLV_PCSK_SKI1_1	104	108	PF00082	0.421
CLV_PCSK_SKI1_1	120	124	PF00082	0.349
CLV_PCSK_SKI1_1	23	27	PF00082	0.537
CLV_PCSK_SKI1_1	68	72	PF00082	0.419
DEG_SPOP_SBC_1	37	41	PF00917	0.715
DOC_CKS1_1	114	119	PF01111	0.676
DOC_CYCLIN_RxL_1	64	75	PF00134	0.643
DOC_CYCLIN_yClb5_NLxxxL_5	61	70	PF00134	0.493
DOC_MAPK_gen_1	184	192	PF00069	0.397
DOC_MAPK_MEF2A_6	184	192	PF00069	0.371
DOC_PP2B_LxvP_1	188	191	PF13499	0.381
DOC_USP7_MATH_1	35	39	PF00917	0.733
DOC_USP7_MATH_1	8	12	PF00917	0.705
DOC_USP7_UBL2_3	211	215	PF12436	0.434
DOC_WW_Pin1_4	113	118	PF00397	0.671
DOC_WW_Pin1_4	31	36	PF00397	0.738
LIG_14-3-3_CanoR_1	10	18	PF00244	0.727
LIG_14-3-3_CanoR_1	184	189	PF00244	0.397
LIG_14-3-3_CanoR_1	22	26	PF00244	0.677
LIG_Actin_WH2_2	59	74	PF00022	0.623
LIG_APCC_ABBA_1	100	105	PF00400	0.589
LIG_BIR_II_1	1	5	PF00653	0.675
LIG_eIF4E_1	133	139	PF01652	0.609
LIG_FHA_1	185	191	PF00498	0.396
LIG_FHA_1	92	98	PF00498	0.593
LIG_FHA_2	105	111	PF00498	0.630
LIG_GBD_Chelix_1	151	159	PF00786	0.475
LIG_Integrin_isoDGR_2	44	46	PF01839	0.405
LIG_LIR_Nem_3	116	121	PF02991	0.561
LIG_LIR_Nem_3	162	168	PF02991	0.367
LIG_LIR_Nem_3	182	188	PF02991	0.238
LIG_NRBOX	154	160	PF00104	0.449
LIG_SH2_CRK	185	189	PF00017	0.413
LIG_SH2_CRK	67	71	PF00017	0.553
LIG_SH2_STAP1	134	138	PF00017	0.586
LIG_SH2_STAT5	157	160	PF00017	0.384
LIG_TRAF2_1	73	76	PF00917	0.645
MOD_CDK_SPxxK_3	113	120	PF00069	0.604
MOD_CK1_1	36	42	PF00069	0.699
MOD_CK1_1	6	12	PF00069	0.692
MOD_GlcNHglycan	1	4	PF01048	0.606
MOD_GlcNHglycan	11	14	PF01048	0.651
MOD_GlcNHglycan	27	30	PF01048	0.667
MOD_GlcNHglycan	35	38	PF01048	0.691
MOD_GlcNHglycan	41	44	PF01048	0.533
MOD_GlcNHglycan	56	60	PF01048	0.553
MOD_GSK3_1	105	112	PF00069	0.242
MOD_GSK3_1	21	28	PF00069	0.652
MOD_GSK3_1	31	38	PF00069	0.655
MOD_GSK3_1	85	92	PF00069	0.504
MOD_NEK2_1	159	164	PF00069	0.447
MOD_NEK2_1	25	30	PF00069	0.525
MOD_NEK2_1	89	94	PF00069	0.510
MOD_PK_1	186	192	PF00069	0.530
MOD_PKA_2	21	27	PF00069	0.612
MOD_PKA_2	9	15	PF00069	0.674
MOD_PKB_1	184	192	PF00069	0.531
MOD_Plk_1	104	110	PF00069	0.562
MOD_Plk_2-3	105	111	PF00069	0.493
MOD_ProDKin_1	113	119	PF00069	0.605
MOD_ProDKin_1	31	37	PF00069	0.696
TRG_DiLeu_BaLyEn_6	43	48	PF01217	0.531
TRG_DiLeu_BaLyEn_6	66	71	PF01217	0.552
TRG_DiLeu_BaLyEn_6	95	100	PF01217	0.438
TRG_ENDOCYTIC_2	157	160	PF00928	0.362
TRG_ENDOCYTIC_2	185	188	PF00928	0.467
TRG_ENDOCYTIC_2	67	70	PF00928	0.434
TRG_ER_diArg_1	131	133	PF00400	0.473
TRG_ER_diArg_1	145	148	PF00400	0.409
TRG_ER_diArg_1	67	69	PF00400	0.448
TRG_NLS_MonoExtN_4	120	127	PF00514	0.515
TRG_Pf-PMV_PEXEL_1	207	212	PF00026	0.593

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCG1	Leptomonas seymouri	75%	100%
A0A0S4JU75	Bodo saltans	33%	100%
A0A1X0NNG1	Trypanosomatidae	54%	100%
A0A3S7WQI9	Leishmania donovani	93%	100%
A0A422NED0	Trypanosoma rangeli	42%	100%
A4H5I8	Leishmania braziliensis	88%	100%
A4HTS9	Leishmania infantum	93%	100%
D0A990	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AML2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5B321	Trypanosoma cruzi	50%	100%